97 results about "Glucose lowering" patented technology

The invention relates to the technical field of biological medicines, in particular to application of Amomum villosum Lour. In preparation of products for preventing and / or improving symptoms related to obesity and glucose and lipid metabolism disorder. The symptoms comprise hyperglycemia level, cardiovascular and cerebrovascular diseases, cognitive impairment and the like. The result shows that the fructus amomi can effectively reduce the blood sugar level, obviously inhibit the rise of low-density lipoprotein, improve the cognitive function and regulate the lipid metabolism balance. Based on good glycolipid metabolism regulation activity, fructus amomi can be used for improving hyperglycemia, cardiovascular and cerebrovascular diseases, related cognitive function decline and other symptoms caused by abnormal glycolipid metabolism.

The invention discloses nutrition-balanced flour assisting in pancreas islet repair as well as a preparation method and application of the nutrition-balanced flour. The nutrition-balanced flour is prepared from the following raw materials in parts by mass: 40-60 parts of whole grains, 10-15 parts of beans, 5-15 parts of vital gluten, 7-10 parts of potatoes, 7-10 parts of vegetables, 5-8 parts of bacteria and algae, 5-8 parts of nut seeds, 3-5 parts of medicinal and edible food and 3-5 parts of beer yeast. The invention provides more comprehensive nutrition powder containing whole grains, beans, potatoes, nuts and the like, and further comprises common food with the effect of reducing blood sugar and medicinal and edible food which has the effect of reducing blood sugar and can prevent diabetic complications, and the nutrition flour has the following functions: balanced nutrition is provided for the body; blood sugar reduction is assisted; the islet cells are assisted to repair; and diabetic complications are prevented. The invention relates to an application of nutrition-balanced flour assisting in pancreas islet repair. The flour is used for making steamed buns, dumplings, steamed stuffed buns, wontons, noodles, cakes, biscuits or other flour products.

The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.

The invention belongs to the field of new application of medicines, and particularly relates to application of triptolide in preparation of medicines for treating diabetic vascular obstruction complications. Diabetes vascular obstruction is a common serious complication of diabetes and can cause various tissue injuries such as cardiovascular diseases, nephropathy and retinopathy. Experiments prove that the triptolide can remarkably improve the problems of blood vessel blockage, blood flow slowing, abnormal neovascularization and the like caused in a high-glucose environment, and meanwhile, the expression of blood glucose related indexes (such as Glucose and HbA1c) and inflammatory factors (such as TNF-alpha and IL-1beta) is reduced. In addition, triptolide can also protect pancreas from high glucose damage and improve functions of pancreatic beta cells. According to the invention, the clinical application range of the triptolide is expanded, and a new candidate substance is provided for drug treatment of diabetic vascular complications.

The present invention relates to an anti-diabetic effect of a Cucumis melo leaf extract, particularly an alcohol extract of Cucumis melo leaves. The Cucumis melo leaf extract of the present invention can provide an anti-diabetic effect through a blood glucose-lowering effect. In addition, the Cucumis melo leaf extract of the present invention has a high yield of about 21%, and thus can be high feasibility as an excellent anti-diabetic material.

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.

The invention provides emblic leafflower fruit polysaccharide with a weight losing effect and an efficient preparation method and application thereof, and belongs to the field of plant polysaccharide. The preparation method comprises the following steps: performing powdering, water extraction and concentration on a phyllanthus emblica raw material, adding an alcohol solvent for precipitation, and drying to obtain phyllanthus emblica crude polysaccharide; after the phyllanthus emblica crude polysaccharide is dissolved, impurities are removed through membrane filtration, protein substances are adsorbed through a reversed-phase chromatographic column, flow-through liquid and water leacheate are collected and combined, small-molecular-weight substances are removed through a membrane bag, intercepted liquid is collected and dried, and the phyllanthus emblica polysaccharide is obtained. The phyllanthus emblica polysaccharide has alpha-type and beta-type glycosidic bonds, and has linear polysaccharide chains and aggregates formed by a plurality of chains. The emblic leafflower fruit polysaccharide is used for preparing products for reducing fat and blood sugar, and can also be used for preparing medicines for preventing and treating abnormal glucose metabolism, abnormal lipid metabolism, related diseases, obesity and liver injury caused by obesity. The phyllanthus emblica polysaccharide extraction and purification preparation method is simple and efficient, and is convenient for industrial implementation.

Compositions are disclosed that include at least one protein disulfide isomerase or a biologically active fragment or variant thereof. Methods of producing and using the compositions are also disclosed. In particular (but not by way of limitation), methods are provided for reducing blood glucose, treating hyperglycemia, treating or reducing the occurrence of type 1 diabetes, treating or reducing the occurrence of type 2 diabetes, and / or treating or reducing the occurrence of type 3 diabetes (i.e., Alzheimer's Disease) by administering the composition that includes the at least one protein disulfide isomerase. The protein disulfide isomerase may be administered alone or may be administered simultaneously or sequentially with one or more additional active agents.

The application discloses a quinoa hexapeptide with a blood sugar lowering effect and application thereof, and belongs to the technical field of bioactive peptides. The amino acid sequence of the quinoa hexapeptide PGSPGR is Pro-Gly-Ser-Pro-Gly-Arg. The quinoa hexapeptide PGSPGR has alpha-glucosidase inhibitory activity and can effectively reduce blood sugar level, and therefore, can be applied to preparation of medicines or food for lowering blood sugar. The application further provides a polypeptide containing the peptide segment PGSPGR and a quinoa peptide rich in the polypeptide, and the polypeptide and the quinoa peptide are applied to preparation of medicines or food for lowering blood sugar, thereby providing a new scheme and theoretical basis for treatment of diabetes, and having good market prospect and application potential.

The present application relates to the field of microorganisms, in particular to a mucinophilic Akkermansia strain and application thereof, the mucinophilic Akkermansia has a preservation number of CCTCC NO: M 20241304.The mucinophilic Akkermansia AKK-86 of the present application has good effects of promoting iron absorption, improving iron metabolism, and relieving intestinal inflammation.In addition, the mucinophilic Akkermansia of the present application can also promote the production of GLP-1, and has potential application in reducing blood sugar and weight loss products.

Exemplary embodiments account for differing needs of a user over the menstrual cycle of the user to better control the blood glucose concentration of the user. The exemplary embodiments may be realized in control systems for medicament delivery devices that deliver medicaments, such as medicaments that regulate blood glucose concentration levels. Examples of such medicaments that regulate blood glucose concentration levels include insulin, glucagon, and glucagon peptide-1 (GLP-1) agonists. The exemplary embodiments are able to better tailor the dosages of the medicament delivered to the user with the medicament delivery device to reduce the risk of hyperglycemia and hypoglycemia and help reduce blood glucose concentration excursions.

Provided is a use of a G protein-coupled receptor kinase 2 (GRK2) degradation compound in lowering blood glucose, stimulating or increasing insulin secretion, or preventing or treating a disease or disorder related thereto. Specifically, provided is a use of a compound represented by Formula (1) that degrades G protein-coupled receptor kinase 2 (GRK2) or a pharmaceutically acceptable salt, an isomer, an isotope, a prodrug, a solvate, or a polymorph thereof or a pharmaceutical composition comprising the same in lowering blood glucose, stimulating or increasing insulin secretion, or preventing or treating a disease or disorder that is ameliorable by lowering blood glucose, for example a pre-diabetic condition, a diabetes, or a complication related to a pre-diabetic condition or a diabetes in a subject in need thereof.

The present invention relates to the technical field of microorganisms, in particular to a Lactobacillus acidophilus GOLDGUT-LA100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof. The Lactobacillus acidophilus GOLDGUT-LA100 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28398. The strain has strong acid resistance, can adapt to the digestive tract environment, and has high bile salt hydrolase activity. At the same time, in animal experiments, the strain significantly reduces blood glucose and serum cholesterol levels, reduces liver fat deposition, reduces adipose tissue inflammation, effectively reduces the weight, and has broad application prospects in the development of products for improving obesity, lowering lipid and lowering blood glucose.

The invention belongs to the technical field of foods, and particularly relates to a high-biological-activity muscle-building formula food for middle-aged and elderly people and a preparation method thereof. According to the high-biological-activity muscle-building formula food for the middle-aged and elderly people, the prepared mulberry leaf extract is added, the raw material raw milk is subjected to multi-stage membrane filtration to enrich beta-lactoglobulin, other auxiliary materials are adopted, muscle attenuation can be delayed, blood sugar can be remarkably reduced, sufficient nutrition support can be provided for the middle-aged and elderly people, and the high-biological-activity muscle-building formula food is suitable for the middle-aged and elderly people. The content of beta-lactoglobulin in the formula is not less than 3%, so that muscle health can be effectively improved, the immune barrier is improved, and functional decline is delayed.

The invention belongs to the technical field of modernized analysis of traditional Chinese medicines, and provides a method for predicting the hypoglycemic activity of a mulberry leaf aqueous extract based on a BP neural network, and the method comprises the following steps: preparing mulberry leaf aqueous extracts under different extraction conditions, and measuring the contents of various active components and the alpha-glucosidase inhibition rate; screening out a key active component combination remarkably related to the inhibition ratio from the various components by utilizing Pearson correlation analysis; constructing and training a BP (Back Propagation) neural network prediction model by taking the content of the key component as input and the alpha-glucosidase inhibition ratio as output; preparing an independent verification set by adopting mulberry leaf raw materials from different sources, substituting the independent verification set into the trained model and generating a predicted value, and comparing the predicted value with an actual value to verify that the model has good prediction precision and universality. The method overcomes the defect that the prior art depends on tedious biological experiments to measure the blood sugar lowering activity of the mulberry leaves, realizes rapid and high-throughput prediction of the blood sugar lowering activity of the mulberry leaves, and brings convenience to accurate screening and quality control of mulberry leaf raw materials.

The invention relates to the field of biological medicine, and discloses a protein degradation targeting chimera (PROTAC) compound targeting 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) and medical application of the protein degradation targeting chimera (PROTAC) compound. The compound comprises a structural unit shown as a formula I, X is a 11 beta-HSD1 binding ligand, Y is a connecting chain, Z is an E3 ubiquitin ligase ligand, ubiquitination degradation of 11 beta-HSD1 can be induced, and therefore the function of the compound can be regulated and controlled at the protein level. Different from a traditional small-molecule inhibitor, the degradation agent can significantly reduce expression of 11 beta-HSD1 in cells and improve glucocorticoid signal abnormality, and shows a novel action mode at molecular and cellular levels. In diabetes, obesity, lipid metabolism disorder and related complication models, the compound can reduce blood sugar, improve insulin sensitivity, regulate blood fat and relieve inflammation, and shows a good treatment prospect. The half degradation concentration of a representative compound in vitro is about 1000 nM, and feasible degradation efficiency is achieved. The compound can be synthesized by Click chemistry and other methods, and can be prepared into a pharmaceutical composition for prevention and treatment of type II diabetes, metabolic syndrome, polycystic ovarian syndrome and other diseases, and a new strategy is provided for research and development of related drugs.

The invention discloses a multifunctional nano-enzyme with self-driven cascade catalytic activity and a preparation method and application thereof, and relates to the field of diabetes wound repair materials, and the nano-enzyme comprises the following components: copper peroxide nano-dots, a zinc-based metal organic framework and glucose oxidase. According to the invention, a step-by-step synthesis strategy is adopted, copper peroxide nano-dots are uniformly encapsulated in a zinc-based metal organic framework, and then glucose oxidase is immobilized through surface modification, so that the nano-enzyme is constructed. The nano enzyme can realize self-driven triple enzyme cascade reaction through ingenious structural design, and plays a synergistic treatment role in a diabetes infected wound microenvironment. The nano-enzyme can effectively reduce blood sugar, efficiently sterilize, relieve inflammation and promote revascularization, and an innovative and efficient treatment scheme is provided for treatment of diabetes infected wounds.

This invention belongs to the field of biomedical technology and discloses the application of NP in the preparation of a glycemic regulator for aging type 2 diabetes. The NP is a nanoscale complex formed by hydrogen bonding of turtle egg peptide with a molecular weight less than 3 kDa and naringenin at a mass ratio of 100:1. The formulation promotes liver glycogen synthesis and repairs pancreatic tissue structure and pancreatic β-cell function by activating the hepatic IRS1 / PI3K / AKT / GSK-3β signaling pathway and upregulating GLUT2 protein expression. The NP provided by this invention can significantly reduce fasting blood glucose levels in aging type 2 diabetic mice, improve oral glucose tolerance, and reduce the area under the blood glucose curve. Simultaneously, by restoring insulin signal transduction, it significantly reduces the insulin resistance index and improves the insulin sensitivity index, with an improvement level approaching that of the classic hypoglycemic drug metformin.

This invention provides the use of *Lactobacillus paracasei* or its metabiotics in the preparation of pharmaceutical or food compositions for the generation of tryptophan-binding bile acids. *Lactobacillus paracasei* or its metabiotics may be used for the prevention and / or treatment of metabolic diseases, or for promoting the production of GLP-1 and / or insulin, or for maintaining healthy blood glucose levels, maintaining healthy blood lipids, and / or controlling body fat.

This invention relates to a method for preparing p-hydroxyphenylethanol A. Using *Solanum tuberosum* fruit as raw material, this invention prepares p-hydroxyphenylethanol A through methods such as ethanol extraction, organic solvent extraction, chromatography, and high-performance liquid chromatography. Further research has revealed that this compound has the effect of lowering blood sugar and treating cognitive and social impairments associated with diabetes, and therefore can be used to treat diabetes.

The present application discloses a two-arm branched fatty acid side chain, a receptor agonist modified therewith, and a use thereof. By adjusting the number and structure of side chain arms of the fatty acid chain, optimizing the type of a core molecule, and using the fatty acid chain to modify a receptor agonist, the present application significantly improves the physical and chemical stability of the receptor agonist and the therapeutic effect of the receptor agonist on reducing blood glucose and body weight. The fatty acid chain and the receptor agonist modified therewith disclosed in the present application can reduce blood glucose levels and improve sugar tolerance and has the effects of controlling appetite, food intake, and caloric intake, increasing energy consumption, preventing weight gain, promoting weight loss, and reducing excess body weight. In addition, the fatty acid chain and the receptor agonist modified therewith disclosed in the present application have relatively long half-life and can effectively prolong in vivo drug actions.

The invention discloses quinoa hexapeptide with a hypoglycemic effect and application of the quinoa hexapeptide, and belongs to the technical field of bioactive peptides. The amino acid sequence of the chenopodium quinoa willd hexapeptide PGSPGR is Pro-Gly-Ser-Pro-Gly-Arg, and the chenopodium quinoa willd hexapeptide PGSPGR has alpha-glucosidase inhibitory activity and can effectively reduce the blood sugar level, so that the chenopodium quinoa willd hexapeptide PGSPGR can be applied to preparation of drugs or food for reducing blood sugar. The invention also provides a polypeptide containing the peptide fragment PGSPGR and a quinoa peptide rich in the polypeptide, which are applied to preparation of drugs or food for reducing blood sugar, provide a new scheme and theoretical basis for treatment of diabetes, and have good market prospects and application potential.

The present application discloses a polymer, which comprises a biphenyl boronic acid structure unit capable of binding with glucose and a hydrophilic polymerizable structure unit, wherein the biphenyl boronic acid structure unit can improve the binding capacity and selectivity to glucose. The present application also discloses an insulin sustained-release preparation comprising the above polymer, which has different insulin release rates under different glucose concentrations, can accelerate the release of insulin to reduce blood glucose in a hyperglycemic environment, and can reduce the incorrect release of insulin caused by fructose and other diol substances. The present application further discloses a preparation method of the above insulin sustained-release preparation, which self-assembles the negatively charged insulin and the positively charged biphenyl boronic acid modified polymer into the insulin sustained-release preparation through electrostatic interaction, and has the characteristics of high loading rate. The prepared insulin sustained-release preparation can release insulin, and the released insulin can bind with the insulin receptor in the body to reduce the blood glucose level.

This invention relates to peptide complexes with anti-diabetic activity and their uses. The peptide complexes of this invention promote cellular glucose uptake, inhibit insulin resistance signaling, promote insulin sensitivity signaling, and inhibit apoptosis of pancreatic β-cells, which are insulin-producing cells, thereby exhibiting a blood glucose-lowering effect. Furthermore, this invention also relates to peptides with anti-diabetic and anti-obesity activities and their uses. The peptides of this invention have activities that inhibit insulin resistance signaling, promote insulin sensitivity signaling, and promote lipolysis in adipocytes.

The invention belongs to the technical field of biological medicines, and discloses 5-(benzyl carbamoyl)-indole compounds and application thereof in preparation of medicines for preventing and / or treating diabetic cardiomyopathy. In-vivo and in-vitro experiments prove that the 5-(benzyl carbamoyl)-indole compound disclosed by the invention can effectively reduce blood sugar and improve myocardial cell injury induced by high glucose and high fat, does not cause body weight increase, has a remarkable curative effect of improving diabetic cardiomyopathy, is small in side effect, and can be used for preparing medicines for treating diabetic cardiomyopathy. And the pharmaceutical composition has a remarkable effect at a low dosage, has a more excellent effect compared with a high-dosage positive drug, and provides a new drug for treating diabetic cardiomyopathy, so that the pharmaceutical composition has a wide application prospect.

The application belongs to the technical field of food and medicine, and particularly relates to a cordyceps militaris polysaccharide, a preparation method and application thereof. The application provides a method for improving the yield of cordyceps militaris polysaccharide by optimizing a liquid fermentation process, and proves that the cordyceps militaris polysaccharide has a good blood glucose lowering effect on T2DM mice. The application provides a liquid fermentation method capable of significantly improving the yield of cordyceps militaris polysaccharide, and the yield of the cordyceps militaris polysaccharide is improved to 82.7 mg / g mycelium, and the culture time is short. The cordyceps militaris polysaccharide obtained has a clear key structure characteristic range. The cordyceps militaris polysaccharide obtained has a good blood glucose lowering effect on T2DM mice, and by remodeling the intestinal flora, improving the SCFAs level, and improving a plurality of high blood glucose related indexes, the T2DM related high blood glucose symptoms are relieved.

The present invention relates to a novel (Lactobacillus fermentum) strain. In addition, the present invention relates to a composition comprising the strain. In addition, the present invention relates to use of the Lactobacillus fermentum strain or the composition comprising the strain, in the treatment, alleviation, or prevention of metabolic diseases of a subject. The Lactobacillus fermentum strain of the present invention may inhibit the production of nitric oxide (NO) in a subject, increase the secretion of glucagon-like peptide-1 (GLP -1), which is a hormone that regulates blood glucose, by increasing insulin secretion and inhibiting glucagon secretion, reduce blood glucose, and suppress appetite or reduce body weight. Therefore, the strain and the composition comprising same of the present invention may be used for anti-inflammatory purposes, and may also be used for the treatment, alleviation, or prevention of metabolic diseases.

The application belongs to the technical field of biology, and particularly relates to two polypeptides with alpha-glucosidase inhibitory activity and application thereof. The application discloses the following two polypeptides with alpha-glucosidase inhibitory activity: polypeptide EGEPKLP and polypeptide TPELKL. The two polypeptides provided by the application both have strong alpha-glucosidase inhibitory activity, and have the advantages of safety, no toxic side effect, easy absorption and the like, and can be used in blood glucose lowering products (including blood glucose lowering drugs).

The invention discloses a preparation method and application of a semen allii tuberosi active extract, and belongs to the technical field of deep processing of medicinal and edible plants. According to the method, only water and edible ethanol are used as solvents in the whole process, independent deproteinization and decolorization steps in which toxic organic solvents participate are not included, and the target extract is prepared through water extraction, concentration, alcohol precipitation, resin purification and drying under the synergistic effect of 65%-75% alcohol precipitation and 40% edible ethanol single-stage elution. The mass fraction of polysaccharide in the prepared extract reaches 25%-30%, the SORAC index of the superoxide free radical scavenging capacity is 5500.00-6000.00 [mu] mol SE / g, and the extract has high oxidation resistance and the activity of assisting in reducing blood sugar in the early stage of diabetes. The method is simple in process, easy to scale, safe and free of toxic solvent residues, the product can be directly used for food and health food, and a stable and feasible technical scheme is provided for high-valued application of the semen allii tuberosi.

This invention relates to the field of traditional Chinese medicine and health food preparation technology, and discloses a selenium-enriched medicinal and edible compound preparation for improving diabetic encephalopathy, as well as its preparation and application. The preparation is made from a specific weight ratio of Codonopsis pilosula, Astragalus membranaceus, Polygonatum sibiricum, selenium-enriched Corydalis yanhusuo, and Morus alba leaves. The preparation method includes raw material pulverization, constant-temperature reflux extraction with water, filtration and purification using a 0.22μm microporous membrane, vacuum low-temperature concentration to extract, and addition of excipients to form granules, capsules, or tablets. This invention constructs a multi-target synergistic network integrating qi replenishment, blood sugar control, and nerve protection through scientific formulation. It utilizes the strong antioxidant properties of organic selenium to efficiently scavenge free radicals in the brain, improving cognitive impairment caused by diabetic encephalopathy and lowering blood sugar. Combined with a mild closed-loop process and microfiltration technology, it ensures the stability and dissolution rate of heat-sensitive active ingredients, improving the purity, safety, and batch-to-batch consistency of the preparation.