261 results about "Glucose lowering" patented technology

Compositions and methods for administering ketone bodies to a subject include beta-hydroxybutyrate complexed with or coupled to at least one amino acid. The compositions and methods cause one or more of: weight loss, weight maintenance, reduced blood glucose level, maintenance of blood glucose level, increased muscle and physical performance, enhanced metabolic and cellular repair, improved detoxification and gut health, targeted bioavailability, sustained release and controlled absorption, increased metabolic efficiency, enhanced cellular uptake, minimized side effects, multifunctional therapeutics, improved focus, improved energy, improved cognitive function, improved mental acuity, treatment of traumatic brain injury, treatment of diabetes, treatment of neurological disorder, treatment of cancer, treatment of inflammatory condition, appetite suppression, anti-aging effects, anti-glycation effects, treatment of epilepsy, treatment of depression, improved performance, improved muscle mass, improved motor function, increased strength, increased metabolism, increased fat loss, increased fat oxidation, improved body composition, and improved mood.

Provided is the use of a conjugated cholic acid, tryptophan-conjugated bile acids (TrpCA) or a TrpCA-producing strain for preventing and / or treating a metabolic disease. The present disclosure relates to the use of tryptophan-conjugated cholic acid or its producing bacteria strain in the preparation of a composition for preventing and / or treating a metabolic disease, or for promoting GLP-1 and / or insulin production. The inventors have discovered for the first time that the tryptophan-conjugated cholic acid can significantly promote the secretion of GLP-1 in both in vivo animal model and in vitro cell model, thereby reducing weight, lowering blood glucose and relieving symptoms of non-alcoholic fatty liver disease. Moreover, colonization of the selected probiotics can also have the same metabolic improvement effects.

The invention discloses a wheat peptide with a hypoglycemic effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a bioactive peptide LPQ or LPQF with a hypoglycemic effect, and animal model experiments prove that the bioactive peptide can effectively reduce the blood sugar level and improve related metabolic indexes, and has no obvious side effects. The invention also provides a wheat peptide rich in oligopeptide containing the peptide fragment LPQ, and animal model experiments prove that the wheat peptide has a remarkable effect in the aspect of reducing blood sugar. The invention provides a safe and effective alternative scheme for development of diabetes treatment drugs, and has good market prospects and application potential.

The embodiment of the invention discloses a blood glucose index evaluation method, electronic equipment and a storage medium, and the method comprises the steps: obtaining the corresponding heart rate data of a target user in an evaluation time period, carrying out the feature extraction processing of the heart rate data, obtaining the corresponding target heart rate feature of the target user in the evaluation time period, and obtaining the target heart rate feature of the target user in the evaluation time period; inputting the target heart rate feature and a target calibration parameter corresponding to the target user into a blood glucose evaluation model, and predicting blood glucose control index data corresponding to the target user in the evaluation time period through the blood glucose evaluation model. The target heart rate features and the target calibration parameters are used as input of a blood glucose evaluation model, and the blood glucose management and control index data of the target user in the evaluation time period are predicted through the blood glucose evaluation model, so that it is ensured that the obtained heart rate data corresponding to the target user in the evaluation time period are utilized; and the accuracy of the blood glucose management and control index data corresponding to the target user in the evaluation time period is determined, and meanwhile, the cost of blood glucose monitoring is greatly reduced.

The invention discloses application of N-acetyl serotonin in preparation of a medicine for treating type 2 diabetes mellitus, and belongs to the field of biological medicine. In-vivo and in-vitro experiments prove that the N-acetyl serotonin can promote secretion of GLP-1, has the effects of obviously reducing blood sugar, being good in sugar tolerance and insulin tolerance, and is obviously improved aiming at high fasting blood glucose, high postprandial blood glucose, poor glucose tolerance and reduced insulin tolerance; the GLP-1 secretion insufficiency is obviously improved. The invention is of great significance in maintaining blood sugar stability and improving glucose and insulin tolerance of diabetic patients, and provides a new solution for treatment of type 2 diabetes mellitus.

Provided are a sustained-release microsphere for polypeptide drugs, a pharmaceutical formulation thereof, a method for preparing same, and use thereof. The method comprises the following steps: forming an inner aqueous phase; forming an oil phase; forming an outer aqueous phase; and dispersing the inner aqueous phase into the oil phase to give a primary emulsion, then re-dispersing the primary emulsion into the outer aqueous phase to give a pre-secondary emulsion, emulsifying the pre- secondary emulsion to form a secondary emulsion, and finally curing the secondary emulsion to give the sustained-release microsphere. The method features ease to operate, and the obtained sustained-release microsphere possesses ideal drug release behaviors (low early burst release, and stable mid- and later-stage releases) and safety and potency in reducing blood glucose, and is thus suitable for stable, long-term use with good patient compliance.

The invention provides an application of cichorium glandulosum polysaccharide in preparation, basic characterization and type 2 diabetes mellitus relieving medicines, and belongs to the technical field of medicines. Animal experiment results show that after the cichorium glandulosum polysaccharide is applied to type 2 diabetic mice, serum biochemical indexes can be adjusted, the blood sugar level can be reduced, organ injuries can be protected or repaired, and PI3K / AKT / mTOR signal channel related protein expression in the main glycometabolism target organ liver can be adjusted. Therefore, the prepared cichorium glandulosum polysaccharide can be used as a medicine for relieving type 2 diabetes mellitus.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with a hypoglycemic effect and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-23 parts of astragalus membranaceus, 12-18 parts of sambucus chinensis root, 10-15 parts of dogwood, 5-8 parts of wormwood stem, 1-5 parts of camptotheca acuminata fruit, 1-5 parts of cyclocarya paliurus, 3-8 parts of kudzu vine root, 1-5 parts of mulberry leaf and 1-3 parts of honey-fried licorice root. All the components of the traditional Chinese medicine composition are compatible according to a certain proportion, the traditional Chinese medicine composition can tonify qi and raise yang, unblock triple jiao, dispel and strengthen evil, activate blood and dredge vessels, jointly achieve the effects of tonifying qi and nourishing, promoting qi circulation to relieve pain and tonifying kidney and dredging collaterals, can reduce the blood sugar content, protect the cardiovascular system and achieve the curative effect of preventing and treating diabetes, and has practicability and application value.

The invention relates to the technical field of health-care products, in particular to a health-care product rich in momordica charantia polypeptide and capable of regulating blood sugar metabolism and promoting insulin secretion, momordica charantia polypeptide can stimulate pancreatic beta cells to secrete insulin, and insulin is the only hormone capable of reducing blood sugar in a human body. The balsam pear polypeptide component in the balsam pear extract is specially used for reducing the blood sugar level and improving related health problems, the application of the balsam pear polypeptide in the health care product can effectively regulate the blood sugar metabolism of a human body and promote the secretion of insulin, and the balsam pear polypeptide stimulates pancreas islet beta cells to promote the secretion of insulin. In addition, the balsam pear polypeptide can improve the insulin resistance, increase the number of insulin receptors or enhance the activity of the insulin receptors, so that the body cells are more sensitive to the insulin, the uptake and utilization of glucose are promoted, and the abnormal increase of the blood glucose level is avoided.

The invention discloses a formula of a composition capable of assisting in reducing blood sugar and preventing diabetes, and relates to the field of health food, the composition has the effects of reducing blood sugar and preventing diabetes, and the composition comprises the following composition components: 0.25 to 0.37% of bitter gourd peptide, 0.018 to 0.026% of corosolic acid, 0.39 to 0.48% of mulberry leaf extract, 0.083 to 0.095% of pseudo-ginseng extract, 0.115 to 0.132% of radix polygonati officinalis extract, and 0.00003 to 0.00005% of chromium-enriched yeast. By adopting the composition formula for assisting in reducing blood sugar and preventing diabetes, the formula composition has the effects of assisting in reducing the blood sugar level and treating. Meanwhile, the composition also has a synergistic effect on prevention of diabetes caused by hyperglycemia symptoms, the components of the composition are equal-part compositions formed by physical stirring and uniform mixing, and the increase of postprandial blood sugar level can be effectively inhibited, so that the effects of assisting beta cells of a body to secrete insulin and improving the blood sugar level are achieved. And insulin can promote the utilization of sugar by cells, the synthesis of hepatic glycogen and the improvement of the metabolism of sugar, so that the effect of reducing blood sugar is finally achieved. The raw materials of the composition can be purchased and obtained in the market, the raw materials are simple and easy to obtain, the production benefit is high, and the composition is suitable for being widely used.

The invention discloses a cane molasses extract with a blood sugar reducing effect as well as a preparation method and application thereof, and belongs to the field of functional foods. According to the invention, cane molasses is subjected to dissolution, centrifugation, ultrafiltration impurity removal, desalination and nanofiltration concentration, and is mixed with calcium chloride, so that the cane molasses extract with the effect of reducing blood sugar is prepared. Experimental results prove that the cane molasses extract prepared by the invention has the characteristics of low glycemic index (GI), carbohydrate digestive enzyme inhibition, high temperature resistance, long-term storage resistance and the like, can also effectively repair pancreas and liver injury and regulate intestinal flora, and has a comprehensive hypoglycemic effect. The food with low glycemic index is prepared on the basis of the high sucrose carrier for the first time, and the food has sweet taste and the function of reducing blood sugar. The invention provides a new raw material scheme for the preparation of dietary supplement food and hypoglycemic drugs for hyperglycemia people, and has prominent practical application value and wide application prospect.

The present invention provides an aggregate, a preparation method thereof, and an oral insulin formulation. Specifically, an aggregate formed by the assembly of a chalcogen heterocyclic compound and insulin is provided. The aggregate can be further prepared into an oral insulin formulation. The oral formulation can be used to lower the blood glucose level of mammals and is used as part of a diabetes treatment regimen. The chalcogen heterocyclic compound in the oral insulin formulation prepared by this method can effectively protect insulin from overcoming the three major physiological barriers of the oral intake route, is stable in the gastrointestinal environment, and undergoes a dynamic chemical exchange reaction with the sulfhydryl groups of intestinal mucin in intestinal fluid and the proteins on the inner and outer sides of the epithelial cell membrane through the surface poly-chalcogen molecular bond, entering the circulatory system from intestinal epithelial cells and playing a role in lowering blood glucose. When the oral insulin formulation is administered orally, it has high bioavailability and good blood glucose lowering effect in mammals and can be used for the treatment of diabetes.

The invention relates to the technical field of biological medicines, in particular to application of Amomum villosum Lour. In preparation of products for preventing and / or improving symptoms related to obesity and glucose and lipid metabolism disorder. The symptoms comprise hyperglycemia level, cardiovascular and cerebrovascular diseases, cognitive impairment and the like. The result shows that the fructus amomi can effectively reduce the blood sugar level, obviously inhibit the rise of low-density lipoprotein, improve the cognitive function and regulate the lipid metabolism balance. Based on good glycolipid metabolism regulation activity, fructus amomi can be used for improving hyperglycemia, cardiovascular and cerebrovascular diseases, related cognitive function decline and other symptoms caused by abnormal glycolipid metabolism.

The invention relates to the field of microorganisms, in particular to a mucophilic protein Ackermann strain and application thereof, and the preservation number of the mucophilic protein Ackermann strain is CCTCC (China Center for Type Culture Collection) NO: M 20241304. The Ackermania muciniphila AKK-86 disclosed by the invention has good effects of promoting iron absorption, improving iron metabolism and relieving intestinal inflammation at the same time. In addition, the Ackermansiella muciniphila can also promote the generation of GLP-1, and has the potential of application in the aspects of reducing blood sugar and losing weight products.

The present application relates to a kind of pharmaceutical composition for treating type 2 diabetes and its application.The pharmaceutical composition includes icariin, hydroxymethyl coumarin and cinnamaldehyde, by three-component synergistic effect, simultaneously act on insulin resistance, pancreatic beta cell apoptosis and systemic metabolic inflammation three type 2 diabetes core pathological links, auxiliary reduce serum lipid level, and reduce drug-related liver injury risk, good safety.Animal experiment results show that three-drug combination group can effectively reduce blood sugar (decrease about 50%), significantly improve islet structure atrophy, restore hepatocyte index arrangement, reduce glomerular hypertrophy, significantly reduce serum TG and CHOL level (P<0.05) and inflammatory factor IL-6 and TNF-alpha level (P<0.05), and avoid the hepatotoxicity risk (ALT / AST restores to close to normal level) of hydroxymethyl coumarin.The present application is composed of three kinds of natural monomers with clear structure, and has clear components and controllable quality, which provides a more optimal comprehensive treatment strategy for the treatment of type 2 diabetes and its complications.

The invention provides a tillite health-care wine production process, and relates to the technical field of health-care wine brewage, the tillite health-care wine production process comprises the following steps: S1, raw material preparation, S2, raw material treatment: crushing the dried raw materials through crushing operation; s3, stirring: putting the powdery raw materials formed in the step S2 into a reaction kettle; s4, purifying and filtering; s5, cooking: cooking the tillite extracting solution and common food materials for wine brewing; s6, performing fermentation: performing fermentation on the food material extracting solution obtained in the step S5, honey and yeast together; s7, sterilization and disinfection; s8, blending: blending the sterilized raw stock of the brewed wine in the S7 with distilled wine; s9; performing packaging; the traditional Chinese medicine composition is helpful for regulating the metabolic process in the body and regulating blood fat, insulin sensitivity and vasodilation, so that blood sugar, blood pressure and blood fat are reduced; and by taking a proper amount of the health-care tea, the immunity can be enhanced, the beauty is maintained, the senescence is delayed and the sexual function is improved.

The invention belongs to the technical field of medicinal chemistry, and relates to 3-amino-4-(2, 4, 5-trifluorophenyl) bornyl butyrate as well as a preparation method and application thereof. The 3-amino-4-(2, 4, 5-trifluorophenyl) bornyl butyrate has the following structure: the 3-amino-4-(2, 4, 5-trifluorophenyl) bornyl butyrate provided by the invention has an excellent hypoglycemic effect, has a low toxic effect on AC16 cells, and provides a treatment choice with better efficiency and higher safety for diabetics.

The invention discloses a preparation method of a traditional Chinese medicine for treating diabetes complicated with fatty liver and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine for treating diabetes complicated with fatty liver is prepared from the following raw materials in parts by weight: 8-15 parts of inula cappa, 10-16 parts of fructus catalpa, 6-12 parts of corydalis saxicola bunting, 6-10 parts of gypsophila elegans, 4-8 parts of equisetum arvense, 4-8 parts of hibiscus rosa-sinensis, 3-7 parts of laggera alata, 1-3 parts of rock ginseng, 2-6 parts of common vladimiria root, 1-5 parts of nauclea officinalis, 1-3 parts of hypericum japonicum and 3-7 parts of liquorice. The traditional Chinese medicine for treating diabetes mellitus complicated with fatty liver has the effects of reducing blood sugar, relieving body mass, reducing traditional Chinese medicine syndrome score, improving traditional Chinese medicine syndrome curative effect and relieving liver and kidney injury, and is definite and reliable in curative effect and good in safety.

The invention discloses nutrition-balanced flour assisting in pancreas islet repair as well as a preparation method and application of the nutrition-balanced flour. The nutrition-balanced flour is prepared from the following raw materials in parts by mass: 40-60 parts of whole grains, 10-15 parts of beans, 5-15 parts of vital gluten, 7-10 parts of potatoes, 7-10 parts of vegetables, 5-8 parts of bacteria and algae, 5-8 parts of nut seeds, 3-5 parts of medicinal and edible food and 3-5 parts of beer yeast. The invention provides more comprehensive nutrition powder containing whole grains, beans, potatoes, nuts and the like, and further comprises common food with the effect of reducing blood sugar and medicinal and edible food which has the effect of reducing blood sugar and can prevent diabetic complications, and the nutrition flour has the following functions: balanced nutrition is provided for the body; blood sugar reduction is assisted; the islet cells are assisted to repair; and diabetic complications are prevented. The invention relates to an application of nutrition-balanced flour assisting in pancreas islet repair. The flour is used for making steamed buns, dumplings, steamed stuffed buns, wontons, noodles, cakes, biscuits or other flour products.

The application discloses a glucagon peptide-1 and glucagon receptor dual-agonistic polypeptide and application thereof, and the polypeptide structure is shown in the following general formula (I). The dual-agonistic polypeptide has dual-agonistic activity on human GLP-1 and glucagon receptors. The GLP-1 / glucagon receptor dual-agonistic polypeptide can effectively reduce blood sugar and weight, and has obvious lipid-regulating effect. The GLP-1 / glucagon receptor dual-agonistic polypeptide is stable in vivo, and is suitable to be used as an active component of drugs for diabetes, obesity, hyperlipidemia and the like.

The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.

The invention belongs to the field of new application of medicines, and particularly relates to application of triptolide in preparation of medicines for treating diabetic vascular obstruction complications. Diabetes vascular obstruction is a common serious complication of diabetes and can cause various tissue injuries such as cardiovascular diseases, nephropathy and retinopathy. Experiments prove that the triptolide can remarkably improve the problems of blood vessel blockage, blood flow slowing, abnormal neovascularization and the like caused in a high-glucose environment, and meanwhile, the expression of blood glucose related indexes (such as Glucose and HbA1c) and inflammatory factors (such as TNF-alpha and IL-1beta) is reduced. In addition, triptolide can also protect pancreas from high glucose damage and improve functions of pancreatic beta cells. According to the invention, the clinical application range of the triptolide is expanded, and a new candidate substance is provided for drug treatment of diabetic vascular complications.

The invention belongs to the technical field of medicines, and relates to an application of a pharmaceutical composition in preparation of medicines for preventing and / or treating type II diabetes mellitus. The invention provides an application of a pharmaceutical composition in preparation of a medicine for preventing and / or treating type II diabetes mellitus. The pharmaceutical composition comprises the following components: ginsenoside Rk1, ginsenoside Rg5, ginsenoside Rg3, ginsenoside Rh4, ginsenoside Rk3, a ginseng ethanol-water extract and a pharmaceutically acceptable carrier. The pharmaceutical composition component provided by the invention can effectively reduce blood sugar and / or reduce the glycosylated hemoglobin level, and prevent and / or treat type II diabetes mellitus.

The present invention relates to a Korean microbiome-derived Clostridium butyricum strain having anti-obesity efficacy and a use thereof. The strain has an excellent effect of reducing the body weight and adipose tissue weight of experimental animals compared to a control group (strain-untreated) under high-fat diet conditions, has an excellent effect of reducing the content of total cholesterol, triglycerides, low-density lipoprotein (LDL), leptin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in serum, and has an excellent effect of reducing blood glucose and increasing the content of glucagon-like peptide-1 (GLP-1) in an oral glucose load test, and is thus expected to be effectively used as an ingredient in a composition for preventing, alleviating, or treating obesity and metabolic diseases caused by obesity.

The invention discloses polygonatum cyrtonema polysaccharide as well as a preparation method and application thereof, and relates to the technical field of plant polysaccharide extraction. The invention relates to the technical field of biological medicine, in particular to polygonatum cyrtonema polysaccharide as well as a preparation method and application thereof. The polygonatum cyrtonema polysaccharide is composed of fructose and glucose according to the molar ratio of 27.5: 1, the main chain of the polygonatum cyrtonema polysaccharide is of a 1-beta-D-Fruf-(2-) structure, and the side chain of the polygonatum cyrtonema polysaccharide comprises-> 6-beta-D-Fruf-(2-) and-> 1, 6-beta-D-Fruf-(2-). The polygonatum cyrtonema polysaccharide provided by the invention has the activity of reducing blood sugar, reducing blood fat and relieving insulin resistance, and has a wide application prospect in the aspect of developing functional foods or medicines for adjuvant therapy of diabetes mellitus.

The invention discloses a traditional Chinese medicine preparation for treating hand and foot numbness caused by diabetes and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation is prepared by the following method: (1) uniformly mixing 15-21 parts by weight of aleppo avens, 27-33 parts by weight of potentilla fruticosa and 2-12 parts by weight of pseudo-ginseng, crushing, and sieving with a 50-mesh sieve to obtain powder; (2) adding the powder obtained in the step (1) into an ethanol aqueous solution with the concentration of 48-52v / v% for dipping and extracting under the conditions that the material-liquid ratio is (1: 8)-(1: 12), the extraction temperature is 40-60 DEG C and the extraction time is 2-4 hours to obtain an extracting solution; (3) filtering the extracting solution obtained in the step (2), and removing ethanol and water from the filtrate to obtain a crude extract; (4) adding petroleum ether into the crude extract obtained in the step (3) for extraction, and removing petroleum ether to obtain a refined product at the lower layer; and (5) taking the refined product in the step (4), and performing spray drying to obtain finished medicinal powder. The traditional Chinese medicine preparation disclosed by the invention can cure hand and foot numbness caused by diabetes mellitus by reducing blood sugar content, dredging blood vessels, strengthening qi and nourishing blood.

The present invention relates to an anti-diabetic effect of a Cucumis melo leaf extract, particularly an alcohol extract of Cucumis melo leaves. The Cucumis melo leaf extract of the present invention can provide an anti-diabetic effect through a blood glucose-lowering effect. In addition, the Cucumis melo leaf extract of the present invention has a high yield of about 21%, and thus can be high feasibility as an excellent anti-diabetic material.

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.

The invention provides emblic leafflower fruit polysaccharide with a weight losing effect and an efficient preparation method and application thereof, and belongs to the field of plant polysaccharide. The preparation method comprises the following steps: performing powdering, water extraction and concentration on a phyllanthus emblica raw material, adding an alcohol solvent for precipitation, and drying to obtain phyllanthus emblica crude polysaccharide; after the phyllanthus emblica crude polysaccharide is dissolved, impurities are removed through membrane filtration, protein substances are adsorbed through a reversed-phase chromatographic column, flow-through liquid and water leacheate are collected and combined, small-molecular-weight substances are removed through a membrane bag, intercepted liquid is collected and dried, and the phyllanthus emblica polysaccharide is obtained. The phyllanthus emblica polysaccharide has alpha-type and beta-type glycosidic bonds, and has linear polysaccharide chains and aggregates formed by a plurality of chains. The emblic leafflower fruit polysaccharide is used for preparing products for reducing fat and blood sugar, and can also be used for preparing medicines for preventing and treating abnormal glucose metabolism, abnormal lipid metabolism, related diseases, obesity and liver injury caused by obesity. The phyllanthus emblica polysaccharide extraction and purification preparation method is simple and efficient, and is convenient for industrial implementation.

Compositions are disclosed that include at least one protein disulfide isomerase or a biologically active fragment or variant thereof. Methods of producing and using the compositions are also disclosed. In particular (but not by way of limitation), methods are provided for reducing blood glucose, treating hyperglycemia, treating or reducing the occurrence of type 1 diabetes, treating or reducing the occurrence of type 2 diabetes, and / or treating or reducing the occurrence of type 3 diabetes (i.e., Alzheimer's Disease) by administering the composition that includes the at least one protein disulfide isomerase. The protein disulfide isomerase may be administered alone or may be administered simultaneously or sequentially with one or more additional active agents.