182 results about "Peptide drug" patented technology

A fine particle comprising an amphiphilic polymer, further comprising an inner nucleus of hydrophilic segment of amphiphilic polymer, and a hydrophobic outer layer of hydrophobic segment of amphiphilic polymer, and having a surface modifier bonded to the hydrophobic outer layer.

A fine particle of the invention effectively enclose protein, peptide drug, nucleic acid medicine of hydrophilic property and large molecular weight in the inner nucleus of hydrophilic segment of amphiphilic polymer, and are preferable for stabilizing in the body and promoting absorption.

A solid lipophilic microparticle having an average particle size ranging from 0.1 to 200 μm, comprising a lipophilic substance, hyaluronic acid or an inorganic salt thereof and an active ingredient selected from the group consisting of a protein or peptide drug, retains the full activity of the active ingredient, and when formulated in the form of an oil dispersion or oil-in-water emulsion, it releases in an in vivo environment the active ingredient in a controlled manner over a long period.

The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.

Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings. Additional embodiments of the present invention include stents coated with the disclosed copolymer(s) and peptide drugs. Methods for treating or inhibiting post-stent implantation restenosis in patients are also provided.

The invention relates to a medicament carrier and a preparation method thereof, in particular to a medicament delivery system comprising biodegradable polymer vesicles with asymmetric membranes. The invention discloses the biodegradable polymer vesicles and preparation and application thereof. The biodegradable polymer vesicles are prepared from A-B-C type block polymer, wherein a block A is polyethylene glycol (PEG) distributed on outer surfaces of the vesicles; a block B is hydrophobic biodegradable polymer to form the nucleuses of the vesicles; and a block C is polyelectrolyte distributed on inner walls of the vesicular membranes and used for efficiently loading medicaments with opposite electric charge. The biodegradable polymer vesicles are formed in aqueous solution directly, can efficiently load protein and polypeptide medicaments, nucleic acid medicaments and micro-molecular medicaments, and are expected to be applied to the protein therapy and the combination therapy of cancers.

The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to a MTLP-active agent complex and a MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.

The invention relates to a novel bioconjugation protocol for peptide suitable for in vivo applications. Bioconjugation of the peptide to HA derivative increases its half life in circulation contributing for a high efficacy. More over, conjugate of HA derivative and peptide which is treated with hyaluronidase shows increased bioactivity. And also, in contrast to PEGylation, HA derivative can be conjugated with many numbers of peptide molecules per single HA derivative chain, which enables multiple action of peptide drugs.

The invention provides a low-concentration vesicular phospholipid gel formulation of a small-molecule peptide drug and also provides a preparation method of the vesicular phospholipid gel formulation of the small-molecule peptide drug. In the low-concentration vesicular gel formulation, the content of phospholipids ranges from 20% to 40%, and the small-molecule peptide drug with a molecular weight ranging from about 300 D to about 3300 D is encapsulated in the phospholipids. The low-concentration vesicular phospholipid gel formulation is available in various drug administration forms suitable for injection drug administration, external drug administration and the like, has good biocompatibility, high drug-carrying capacity and good stability, and particularly has a long-acting slow release effect.

The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.

The invention belongs to the field of medicament preparations, and discloses an octreotide acetate lipidosome precursor and a preparation method thereof. The precursor lipidosome contains octreotide acetate, negatively-charged phospholipid and a cryoprotectant, and can contain an appropriate quantity of other lipids including phosphatidylchline and cholesterol; components such as an antioxidant, a pH regulating agent and the like can be added as required; the molar ratio of the octreotide acetate to the negatively-charged phospholipid is smaller than 1:1; and the mass ratio of the negatively-charged phospholipid to the cryoprotectant is 1:1-1:10. In the invention, a tert-butyl alcohol-water cosolvent freeze-drying method is adopted. The entrapment rate of an octreotide acetate lipidosome/micelle obtained by hydrating a freeze-dried product can be over 50 percent, an octreotide acetate lipidosome/micelle obtained by hydrating the freeze-dried product has high stability, and the problem of difficulty in entrapping a protein polypeptide medicament during preparation of a lipidosome/micelle preparation is solved. The preparation method is simple and practicable, and is suitable for industrial mass production.

The invention discloses a single-effect external-cycle concentrator and an application thereof. The single-effect external-cycle concentrator comprises a heating chamber 1, an evaporating chamber 2, a separator I 4, a condenser 5, a cooler 6, a separator II 7 and a liquid receiver 8. The heating chamber, the evaporating chamber and the separator I are equipped with online cleaning devices respectively. The single-effect external-cycle concentrator has the advantages of a simple structure, convenience in mounting and dismounting, high evaporating efficiency, capacity of realizing online cleaning and the like, is safe and reliable in a using process, and capable of removing an organic solvent in a bone peptide crude drug liquid better. External-cycle heating is adopted, so that the heated liquid is sprayed after entering the evaporating chamber through a steam vent, and therefore, the evaporating area is increased, the solvent is quickly evaporated, and the concentration time can be shortened. Alcohol residues of the bone peptide drug liquid produced by the single-effect external-cycle concentrator are less than 10mg/ml. The single-effect external-cycle concentrator has the characteristics that a process for producing a bone peptide crude drug is easy to control, the quality of the produced bone peptide crude drug is stable, and the organic solvent residues are less.

The invention discloses a peptide dentritic macromolecular drug and a preparation method and application thereof, and belongs to the field of biomedicine. The drug comprises a peptide dentritic macromolecular skeleton, and terminal-group functionalized groups. The biological activity of the drug is ensured through the terminal-group functionalized groups; and the periphery of the peptide dentritic macromolecular drug can be grafted with a lot of terminal-group functionalized groups, so that the biological effect of the terminal-group functionalized groups is effectively amplified by the amplification effect of dendritic macromolecules. The drug has an accurate molecular structure and abundant surface functional groups, is good in water solubility, and also has the biological characteristics of being similar to globulin, easy to be taken in by cells and the like; the biological effect of the peptide dentritic macromolecules is enriched; and the development of peptide drugs is promoted. The preparation method is simple in technology; and the structure of the peptide dentritic macromolecular drug is accurately controlled by controlling preparation of various raw materials.

The invention discloses a new multiple-arm carbowax and making method and application in the macromolecular material technical domain, which is characterized by the following: possessing active functional group on one end of arm; fitting for decorating micromolecular drug, protein and peptide drug; modifying the solubility, stability and immunity of drug; lengthening the half-life of drug.

Enteric coated capsules or tablets for oral delivery of a protein, polypeptide or peptide drug, in particular for oral delivery of insulin, are provided, comprising microparticles of the protein, polypeptide or peptide drug, microparticles of a protease inhibitor and, optionally, microparticles of an absorption enhancer. The protease inhibitor and the absorption enhancer may be together in the same microparticles. The microparticles of each component are embedded in an enteric polymer matrix. The enteric coated tablet or capsule of the invention enables fast release of the protein, polypeptide or peptide drug at different times at desired loci in the gastrointestinal tract

The invention discloses a slow-release polylactic acid microsphere capable of maintaining protein and polypeptide drug activity and a preparation method thereof. The slow-release polylactic acid microsphere comprises 5-30 parts of a protein and polypeptide drug, 30-90 parts of a polylactic acid biodegradable material and 5-50 parts of nano bioactive glass. The slow-release polylactic acid microsphere is prepared by an electrospinning technique, and mainly comprises the polylactic acid biodegradable material (PLGA (polylactic acid-glycolic acid copolymer) or PLA (polylactic acid)), the bioactive glass and a main drug. The slow-release polylactic acid microsphere can greatly promote activity retention of the protein and polypeptide drug in a preparation process, and can improve stability of the protein and polypeptide drug in microsphere storage and release processes.

The invention is directed to a method of administering pharmaceutical compositions comprising peptide drugs such as a calcitonin in combination with one or more oral delivery agents, together with an amount of a liquid, and method of treatment of disorders responsive to the action of peptide drugs such as a calcitonin employing such method of administration so as to enhance the oral bioavailability of a calcitonin. The methods of the invention increase the oral absorption and systemic bioavailability of peptide drugs, such as a calcitonin.

This invention involves a full-automatic peptide synthesizer, including a CPU system, a GMP software operating system, a liquid control system, a gas control system, a materials input system, a reactor system, a limitless speed-regulating stirring system, a personal safety system, a reaction efficiency automatic feedback system, a fault alarm system, and a solution circulatory system. The invention has the advantages of higher synthesis efficiency of peptide, better product quality, shorter development cycles, lower production cost, and more convenient and safe operation. The invention is also consistent with the strict requirements of FDA on GMP production, meets a variety of synthetic peptide research and production requirements on the whole, and can be widely applied to basic research, peptide drugs, health, beauty, food, polymer materials, fine chemicals, organic synthesis, etc.

The invention belongs to the technique field of producing multi-peptide drugs by gene engineering. It clones human EGF gene into the silkworm bacilliform virus (Bombyx mori Nuclear polyhedrosis Virus) transferring carrier pBacPAK8 and makes them carry through homologous reformation in the silkworm cells to obtain the reformed virus BmBacEGF with human-coat growing gene. Use the reformed virus to to inocualte the silkworm grub and chrysalis by acupuncture in order to make the human-coat growing gene efficient expressed. Then make the grub and chrysalis into oral drugs which has remarkable action on the digestible ulcer by examination on animal.

The invention discloses a colon specific targeting drug-delivery preparation of cerebroprotein polypeptides and its preparing process, wherein the preparation is prepared through coating the drug-containing micro-pellets made from medicinal powder containing cerebroprotein polypeptides components with colon targeting coating layer, or directly loading the drug-containing micro-pellets into the shells of the colon targeting capsule. The process for preparing the colon targeting drug-delivery preparation of the cerebroprotein polypeptides consists of producing drug-containing micro-pellets containing cerebroprotein polypeptides components, then preparing the colon targeting coating liquid, finally coating the drug-containing micro-pellets with the colon targeting coating liquid. The preparation provided by the invention can make the colon release drugs enter blood circulation through colon, thereby avoiding metabolism destruction of the conventional oral preparation peptides drugs on the stomach, as a result, the therapeutic action of the drugs can be sufficiently exploited.

Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and/or proteins. The covalently modified peptides and/or proteins allow for improved pharmaceutical properties of peptide and protein-based therapeutics.

The invention discloses a colon specific targeting drug-delivery preparation of myocardial protein polypeptides and its preparing process, wherein the preparation is prepared through coating the drug-containing micro-pellets made from medicinal powder containing myocardial protein polypeptides components with colon targeting coating layer liquid, or directly loading the drug-containing micro-pellets into the shells of the colon targeting capsule. The process for preparing the colon targeting drug-delivery preparation of the myocardial protein polypeptides consists of producing drug-containing micro-pellets containing myocardial protein polypeptides components, then preparing the colon targeting coating liquid, finally coating the drug-containing micro-pellets with the colon targeting coating liquid. The preparation provided by the invention can make the colon release drugs enter blood circulation through colon, thereby avoiding metabolism destruction of the conventional oral preparation peptides drugs on the stomach, as a result, the therapeutic action of the drugs can be sufficiently exploited.