3 results about "Urothelium" patented technology

The invention provides an amnion-integrated tubular porous scaffold as well as a preparation method and application thereof. The preparation method comprises the following steps: (S10) extracting silk fibroin from silkworm cocoons by adopting a lithium bromide dissolution method; (S20) adopting detergent treatment and enzyme digestion to prepare the decellularized amnion; (S30) mixing silk fibroin and pigskin gelatin to prepare a silk fibroin / gelatin solution; and (S40) integrating the decellularized amniotic membrane with the silk fibroin / gelatin stent to obtain the tubular porous stent integrated with the amniotic membrane, so that the tubular porous stent can increase urinary tract epithelization and inhibit fibrosis, is suitable for being applied to ureter scar-free repair treatment, ureter defect repair treatment or ureter reconstruction, and provides a new treatment strategy for ureter defect repair treatment.

The present invention provides a method for treating and / or ameliorating a disorder of the lower urinary tract, comprising administering a composition comprising a glucagon like peptide 2 (GLP-2) receptor agonist to a patient in need thereof in an amount sufficient to treat and / or ameliorate the disorder of the lower urinary tract.

The present invention provides a method of treating a patient suffering from bladder pain syndrome, said method comprising administering a solution containing a clostridial neurotoxin into the bladder of the patient; increasing the volume of solution comprising the clostridial neurotoxin present within the bladder, thereby applying a mechanical force against the inner surface of the urothelial layer; and maintaining said volume of solution comprising the clostridial neurotoxin present within the bladder at a volume that does not give rise to patient micturition and for a duration of at least 30 minutes, thereby allowing the clostridial neurotoxin to diffuse across the urothelial layer and into the lamina propria, where the clostridial neurotoxin binds to primary sensory afferent nerve fibres, suppresses secretion of neurotransmitters therefrom, and alleviates bladder pain.