40 results about "Tissue specimen" patented technology

An apparatus for storing tissue and other biological materials includes a separable flexible container that includes a first layer coupled to a second layer via a set of seals to define a first storage volume and a second storage volume. Separate tissue specimens are containable within the first storge volume and the second storage volume. A first portion of the first layer or the second layer defines a first opening into the first storage volume. A second portion of the first layer or the second layer defines a second opening into the second storage volume. The opening into the first volume and the opening into the second volume are positioned near opposite edges of the flexible container. The separable flexible container also includes a hinge to allow the first opening and the second opening to move from location on opposing edges of the separable flexible container to adjacent locations.

The present application relates to the antibody of phorbolylated isocitrate dehydrogenase 1 and its preparation method and purpose, and specifically provides a polyclonal antibody, the polyclonal antibody is obtained by immunizing animals with the antigen epitope peptide of IDH1 phorbolylated, the specific site of the antigen epitope peptide is phorbolylated, and high-titer antibodies can be prepared, the phorbolylated modification of IDH1 in clinical specimens can be recognized with high specificity, and the polyclonal antibody can be used for the research of cell / tissue specimen immunoblotting and immunohistochemical method and the diagnosis of IDH1 related diseases.

Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.

An imaging well (100), comprising: an adhesive layer (110), and a liquid layer (120) covering the adhesive layer (110), the adhesive layer (110) and the liquid layer (120) forming a well body. The adhesive layer (110) is used for adhering a tissue specimen, the liquid layer (120) allows photons and liquids to pass through, and the well body accommodates an imaging liquid. The imaging well (100) allows specimen tissue to be adhered, and the operation process is simple and reduces tissue damage, thus significantly improving imaging stability and quality. In addition, the imaging well (100) can maintain the physiological state of tissues for a long time, and is suitable for long-time dynamic imaging research. Moreover, a stage comprising the imaging well (100), a two-photon microscope, and an imaging method are also provided.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

A marking composition for marking a tissue specimen is provided. The marking composition includes a film forming resin including an acrylic resin, a rheology modifier including an associative polyurethane, a phyllosilicate, a cellulose, or a combination thereof, and a colorant. The composition has a viscosity of about 70 KU to about 110 KU at room temperature. If the composition includes a rheology modifier comprising cellulose, it is in an amount of about 0.01 wt % to about 0.25 wt % based on the total weight of the composition.

The utility model relates to the field of pathological tissue specimen storage, in particular to a pathological tissue specimen storage box. According to the pathological tissue specimen storage box, the placement box can be rapidly limited and fixed, the situation that pathological tissue specimens overflow due to the fact that the placement box is opened is avoided, and the fixing mode is rapid and convenient. A lesion tissue specimen storage box comprises a storage cabinet, a sealing door, temperature control boxes and the like, the left front portion of the storage cabinet is rotationally connected with the sealing door, and a plurality of temperature control boxes are connected into the storage cabinet. The rotary knob is rotated to drive the rotary disc to rotate, so that the extrusion frame moves along the sliding rail on the rotary disc, the extrusion frame synchronously moves outwards to make contact with and extrude the limiting frame, the limiting frame is driven to move outwards, the limiting frame makes contact with the upper portion of the containing box, and the containing box can be rapidly limited and fixed; the pathological tissue specimens are prevented from overflowing due to opening of the placing box, and the fixing mode is fast and convenient.

The utility model provides a tissue specimen fixing device which comprises clamping pieces, the clamping pieces are bent to form a clamping space to clamp tissue, or two sets of clamping pieces are arranged, and the two sets of clamping pieces are located on the two sides of the tissue respectively and used for clamping the tissue; the fixing mechanism is installed on the clamping pieces and used for fixing the clamping pieces on the two sides of the tissue, the tissue is clamped and fixed through the clamping pieces, the clamping pieces play a role in shaping, the tissue is flattened, cells of the tissue are made to be relatively compact, the slicing effect of the soaked tissue is improved, and the tissue is not prone to damage. The fixing mechanism is used for fixing the clamping pieces, the tissue is prevented from falling off from a clamping space formed by the clamping pieces, and the stability of tissue fixing is improved; by using the fixing mechanism and the clamping pieces, the weight of the tissue can be increased, the tissue is completely soaked in the soaking liquid, the problem of tissue floating is solved, and the tissue soaking effect is improved.

A device and method for preparing frozen tissue specimens are disclosed. The device includes a solid block having a top surface and a bottom surface, with two parallel side walls extending upward from the top surface. A slotted groove is formed in the middle of the solid block and extends from the top surface to the bottom surface to receive a specimen chuck, such that a head of the chuck rests on the top surface. Top edges of the side walls support a tissue slide containing an encapsulated specimen. The device may include finger grooves for manual handling and is preferably made of a heat-conducting material to assist in rapid freezing. The method involves placing the specimen chuck in the groove, depositing a freezing medium over it, and positioning the tissue slide so that the specimen contacts the freezing medium for effective specimen preparation.

The invention relates to the technical field of tissue specimen preservation, in particular to tumor specimen auxiliary storage equipment for tumor surgery. The device comprises a base, the top of the base is rotationally connected with an adjusting sealing cover, a low-temperature cavity is defined by the interior of the adjusting sealing cover and the top of the base, and the top of the adjusting sealing cover communicates with an air inlet; when the tumor specimen in the low-temperature cavity is taken out, the top of the side, away from the axis, of the specimen temporary storage piece is in sliding fit with the inner bottom wall of the sealing block, it is ensured that the space size of the buffer cavity is gradually reduced, and it is ensured that the upper portion of the buffer cavity is always kept sealed, so that a positive pressure space is formed in the buffer cavity; cold air originally coming from the low-temperature cavity in the inner part is discharged from an opening which is opened due to the rising of the sealing block; when a new clinical tumor specimen is stored in the low-temperature cavity, external air in a buffer cavity space below the low-temperature cavity is driven away through the downwards-pressed sealing block.

An image display device comprising a processor, in which the processor is configured to acquire a plurality of specimen images in which tissue specimens of a subject provided for an evaluation test of a candidate substance of a drug are imaged, receive designation of a criterion for setting a display priority of the plurality of specimen images from a user, set the display priority in accordance with the designated criterion, and perform control of displaying the plurality of specimen images on a display unit in accordance with the set display priority.

A computer-implemented method is provided of analysing an image of a tissue specimen, which method comprises steps including detecting in the image each of a primary type of biological entity, detecting in the image one or more secondary types of biological entity, associated with each of the detected primary biological entities, generating an entity graph, in which each graph node is assigned to a primary biological entity, and in which each graph node is associated with predictive features measured from the image in respect of that graph node, including at least one predictive feature that is measured relative to two or more types of biological entity.

A tissue removal device (20) is provided, comprising: a removal bag (30) having an opening (32) for receiving a resected tissue specimen (22) within a patient's body (24). An electrosurgical cutting wire (34) includes a cutting segment (36) and a pulling segment (40), the cutting segment (36) being detachably coupled to a wall (38) of the removal bag (30), and the pulling segment (40) being not connected to the wall (38) and extending out of the opening (32). The cutting segment (36) is wound around the central longitudinal axis (46) of the removal bag (30) at different locations along the central longitudinal axis (46). While the resected tissue specimen (22) is within the removal bag (30), the pulling segment (40) is pulled during the application of RF electrosurgical power, causing a plurality of successive longitudinal portions of the cutting segment (36) to separate from the wall (38) and cut the resected tissue specimen (22) within the removal bag (30). Other embodiments are also described.

A tissue removal apparatus (20) is provided that includes a retrieval bag (30) having an opening (32) for receiving a resected tissue specimen (22) within a patient's body (24). An electrosurgical slicing wire (34) includes a slicing segment (36) detachably coupled to a wall (38) of the retrieval bag (30), and a pulling segment (40) free of the wall (38) and extending out of the opening (32). The slicing segment (36) winds around a central longitudinal axis (46) of the retrieval bag (30) at varying locations along the central longitudinal axis (46). Pulling the pulling segment (40), during application of RF electrosurgical power when the resected tissue specimen (22) is within the retrieval bag (30), detaches successive longitudinal portions of the slicing segment (36) from the wall (38) and slices the resected tissue specimen (22) within the retrieval bag (30). Other embodiments are also described.

The system provides a method for surgically removing tissue through small incision sites and / or body openings. [Solution] The tissue containment and containment system includes a primary chamber, and a secondary channel extending from this primary chamber is interconnected with the primary chamber. A tissue specimen is placed into the primary chamber through a first opening 12 while floating in a body cavity. The first opening is drawn in through a first incision or body opening, and a narrower secondary channel is positioned at a second incision or body opening. A second opening 14 provided at the end of the secondary channel allows observation of the tissue specimen in the primary chamber, which is being cut through the first opening, by a scope inserted through the secondary opening. Other systems and methods are provided for sealing the second opening to create a closed system that enables deployment, containment, volume reduction, and safe retrieval of the tissue specimen.

An image processing apparatus comprising a processor, in which the processor is configured to acquire a specimen image in which a tissue specimen of a subject provided for an evaluation test of a candidate substance of a drug is imaged, and perform image processing on the specimen image in accordance with a type of a source organ of the tissue specimen and / or a type of a morphological abnormality estimated to have occurred in the tissue specimen.

The utility model relates to pathological detection field especially relates to a pathological puncture tissue sample fixing bottle, including the container, the top outer wall of container is equipped with the thread groove, and the container is located the outer wall screw thread connection with the sealing cover at thread groove department, the bottom center place of sealing cover is equipped with the protection subassembly, and the inner wall of container is equipped with fixed component, protection subassembly includes the extension rod welded in the bottom outer wall center place of sealing cover, the storage cylinder welded in the outer wall of extension rod another end and the adding mouth of opening in the outer wall center place of storage cylinder one side, the utility model discloses the sealing cover after rotation is taken out from the connecting seat in the container interior with sealing cover, extension rod and storage cylinder upward, can take out the complete tissue sample, is convenient for the protection sample, is convenient for the quick sample taking out, improves the efficiency, liquid passes through the communication hole and contacts tissue sample and protection cotton, and protection cotton absorbs liquid and fixes tissue sample in the storage cylinder interior, avoids the shaking damage tissue sample.

The utility model discloses a medical filterable small pathological tissue specimen bag, including specimen bag body and the top sealing press -fitting strip of setting in the inside of specimen bag body top end opening, the bottom sealing press -fitting strip of specimen bag body bottom end opening inside is provided with, the top sealing press -fitting strip and bottom sealing press -fitting strip and specimen bag body inner wall between close adhesion, and top sealing press -fitting strip and bottom sealing press -fitting strip and specimen bag body junction still adopt the encryption processing of sealing glue, the inside of specimen bag body is provided with filter screen, the filter screen is plastic dense mesh, the medical filterable small pathological tissue specimen bag of this new type is applicable to the collection pathological specimen when transurethral resection of prostate plasma cutting, laser enucleation, cystectomy, reduces the tissue collection time, reduces the pathological tissue loss risk, improves pathological tissue quality, increases the operation efficiency, solves the problem of time -consuming and labor -intensive when specimen collection, smaller tissue loss.

The utility model relates to a pathological tissue specimen preservation device which comprises a bottle body, a lower cover detachably connected with the bottle body, an upper cover, a protective cylinder, a placing basket and a connecting rod, a connecting ring extending upwards is arranged on the upper end face of the lower cover, a containing hole is formed in the inner circle of the connecting ring, and the containing hole extends downwards and penetrates through the lower cover. The upper cover is detachably sleeved on the connecting ring; the upper end of the protective cylinder is arranged on the lower cover, the lower end of the protective cylinder penetrates through the placing hole and extends downwards into the bottle body, the protective cylinder is provided with a placing cavity with an upper opening, and first filtering holes are formed in the side wall of the protective cylinder; the placing basket is placed in the protective cylinder, a connecting rod is fixedly connected between the placing basket and the upper cover, and the placing basket is provided with a second filter hole. According to the pathological tissue sample storage device, the activity space of samples can be reduced, the samples can be protected, the samples are prevented from being separated from the placement basket due to shaking in the transportation process, the situations that the samples freely move in the bottle body to enter an unstable state and collide with the bottle body to be damaged are avoided, and the stability and reliability of pathological tissue sample storage are improved.

Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.

The present application relates to the technical field of gene detection, in particular to a gene panel, method, device and use for somatic cell variation detection of SLC35A2 gene. The present application provides a gene panel, which can target capture the entire SLC35A2 gene related region, including exons, introns, promoters and enhancers, and carry out somatic cell variation detection, including SNVs, small Indels and SVs. The panel is used for detection of refractory epilepsy surgical brain tissue specimens, and can genetically diagnose mild cortical dysplasia with oligodendrogliosis epilepsy (MOGHE). This kind of disease is a new subtype of focal cortical dysplasia newly included by the International League Against Epilepsy in 2022. The panel has high variation detection rate and more comprehensive variation detection types.

A hysteroscopic specimen collection device includes a connecting piece and a collection bag. The connecting piece has an operating through hole and a first adhesive layer on its back. The lower end of the connecting piece is connected to the opening side of the collection bag. A first filter and a second filter are installed sequentially from top to bottom inside the collection bag. The first filter is detachably installed inside the collection bag. The diameter of some filter holes in the second filter is smaller than the diameter of some filter holes in the first filter. A fixing plate is provided on the back of the connecting piece or the collection bag to assist in fixing the collection device during use. The first and second filters of this invention facilitate the separation of tissue specimens and distension fluid flowing into the collection bag, enabling specimen collection and separation of specimens of different sizes, such as easily separating uterine fibroid tissue and endometrial tissue. The first adhesive layer and the fixing plate together fix the collection device. The overall structure is simple, convenient, and practical.

The invention discloses a preparation method of a frozen section of a tissue specimen, which comprises the following steps: taking an OCT (Optical Coherence Tomography) embedding medium, and dividing the OCT embedding medium into two parts, one part of the OCT embedding medium is used for manufacturing an ice seat, and the other part of the OCT embedding medium is pre-cooled in an environment of 2-4 DEG C; the method comprises the following steps: taking a fresh tissue specimen cut in an operation, placing the fresh tissue specimen in the center of an ice base, dropwise adding a pre-cooled OCT embedding medium until the fresh tissue specimen is completely covered, and pressing the surface of the fresh tissue specimen by using a freezing hammer, so that the fresh tissue specimen is quickly frozen to obtain the tissue specimen frozen section. By adopting the method, the preparation speed of the frozen section can be effectively increased, the probability of displacement of the tissue specimen in the frozen section manufacturing process is greatly reduced, and meanwhile ice crystal formation in frozen section tissue is reduced.

This image processing device is provided with a processor that performs: a process for acquiring a specimen image obtained by capturing an image of a tissue specimen of a subject to be subjected to an evaluation test of a candidate substance of a drug; and performing image processing on the specimen image in accordance with the type of the origin organ of the tissue specimen and / or the type of the morphological abnormality estimated to occur in the tissue specimen.

A containment bag assembly for extracting a tissue specimen comprises a bag having one or more segmenting wires, an outer tube comprising a proximal and distal end, a flexible ring configured to form a top opening of the containment bag, wherein the flexible ring comprises two ring subassemblies, each having a proximal and distal end, a flexible member positioned between and coupled to the distal ends of the two ring subassemblies, wherein, when the flexible member is in a collapsed position, the two ring subassemblies are in a collapsed position and the containment bag is configured to be stored within the outer tube, and wherein, when the flexible member is in an expanded position, the two ring subassemblies and the flexible member bias the top opening of the containment bag to an open position to enable placement of the tissue specimen within the containment bag.

1. The name of the design product: desktop rapid tissue dehydrator. 2. The use of the design product: for the processing of pathological tissue specimens. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to an antibody of crotonylated isocitrate dehydrogenase 1 as well as a preparation method and application thereof, and particularly provides a polyclonal antibody, the polyclonal antibody is obtained by immunizing an animal through IDH1 crotonylated antigen epitope peptide, the specific site of the antigen epitope peptide is crotonylated, the high-titer antibody can be prepared, and the antibody can be used for preparing the isocitrate dehydrogenase 1. Crotonylation modification of IDH1 in a clinical specimen can be recognized with high specificity, and the compound can be used for immunoblotting and immunohistochemical research of cell / tissue specimens and diagnosis of IDH1 related diseases.

Systems and methods for receiving one or more electronic slide images associated with a tissue specimen associated with a patient and / or medical case, dividing a first slide image of the one or more electronic slide images into a plurality of tiles, detecting a plurality of tissue regions of the first slide image and / or plurality of tiles to generate a tissue mask, determining whether any tile of the plurality of tiles corresponds to non-tissue, removing any tile of the plurality of tiles determined to be non-tissue, determining a prediction for at least one label of the one or more electronic slide images using a machine learning prediction model, the machine learning prediction model generated by processing a plurality of training images, and outputting the prediction of the trained machine learning prediction model.

The utility model relates to the technical field of medical supplies, in particular to a prostate needle biopsy tissue specimen box which comprises a main body and a box cover mutually buckled with the main body, storage grooves are arranged on the main body, embedding boxes are placed in the storage grooves, tissue gaskets are placed in the embedding boxes, and the tissue gaskets are placed in the box cover. The tissue gasket is soaked with stationary liquid, a dyeing area is arranged at one end of the tissue gasket, and tissue dyeing liquid is carried in the dyeing area. The tissue specimen box is integrally designed and can be used for placing and temporarily storing all prostate needle biopsy tissues of a patient; a puncture sample is separated through the storage tank and the embedding box, and a tissue gasket in the embedding box is provided with tissue staining fluid, so that a doctor can conveniently perform staining marking on each puncture tissue so as to identify the head and tail ends of the tissue, and by combining a subsequent pathological report box imaging result, spatial pathological analysis can be performed, and accurate positioning of tumor tissue is facilitated.