115 results about "Tissue specimen" patented technology

For a biopsy guided by contrast-enhanced x-ray imaging, a breast imaging system may image a patient's breast subsequent to injection of contrast agent to locate a site for biopsy and / or position a biopsy device relative to the site. Once a tissue specimen is removed from the site for diagnostic evaluation, a confirmation that the specimen was removed from an intended area of interest for biopsy is performed using the systems and methods described herein. For example, the breast imaging system and / or a separate specimen imaging system may capture high and low energy images of the specimen, subtract the low energy image from the high energy image to generate a subtracted image of the specimen, and determine, based on the subtracted image, that the contrast agent is present within the specimen to confirm the site from which the specimen was removed is the intended site for biopsy.

The invention provides a clustering method and system for transcriptome sequencing data. The method is applied to the technical field of data processing, and comprises the following steps: collecting cervical adenocarcinoma and para-carcinoma tissue specimens of a plurality of patients, and carrying out data preprocessing to obtain a standardized gene expression matrix; performing clustering operation on the standardized gene expression matrix based on a clustering analysis method combining a potential category model and sub-alliance division to obtain a clustered gene set; performing gene function annotation on the clustered gene set, and performing correlation analysis on a clustering result after function annotation and clinical characteristics of cervical adenocarcinoma to obtain correlation between gene expression and the clinical characteristics; and on the basis of clustering analysis and correlation analysis results, constructing a deep clustering prediction model based on a variational auto-encoder and a Gamma hybrid model so as to predict the prognosis risk or chemotherapy sensitivity of the patient. The problems that high-dimensional transcriptome data is poor in clustering stability and low in prognosis prediction precision are solved.

Components, systems and kits for capturing and / or removing tissue from mammalian bodies may include a tissue container that may be introduced into a body cavity within which a tissue specimen may be placed, cut and removed from the body cavity. Methods of using these components, systems and kits are also described.

A method for removing a tissue specimen from a patient includes introducing a bag at least partially into a cavity in the body of the patient, the bag comprising an open end and a port, positioning a tissue specimen to be removed from the patient into an interior of the bag by passing the tissue specimen through the open end of the bag, sealing the open end of the bag, removing gas from the interior of the bag through the port while the tissue specimen is contained in the interior of the bag, and entirely withdrawing the bag containing the tissue specimen from the cavity. The bag may include a closure device configured to hermetically seal the open end of the bag, and the port may include a one-way gas valve configured to prevent or retard gas from entering the interior of the bag through the port.

The utility model provides a liquid subpackage specimen bottle capable of measuring tissue volume, and belongs to the technical field of tissue measurement. Comprising a specimen bottle main body, a pressing mechanism is arranged above the specimen bottle main body, scale marks are arranged on the surface of the specimen bottle main body, the pressing mechanism comprises a first fixing plate, a first mounting bin is arranged above the first fixing plate, a fixing bin is arranged below the first fixing plate, and a second mounting bin is arranged below the fixing bin. The fixing bin is spirally fixed to the upper portion of the specimen bottle body, and a first pressing plate is arranged in the first mounting bin. According to the formalin fixing device, formalin fixing liquid and water can be preloaded separately, the size of a tissue specimen can be accurately measured, meanwhile, a user can be prevented from making contact with formalin when the specimen is fixed, smell leakage is avoided, and the body health of the user is protected.

A device(100) for immobilizing a tissue specimen or tissue specimens(900) for an automated embedder includes a base(120), a cover(130) and a frame(110). The base(120) has a cavity(121) configured to accommodate the tissue specimen or tissue specimens(900). The cover(130) is coupled to the base(120) and has an orientation structure(131) configured to orientate and secure the tissue specimen or tissue specimens(900) in the cavity(121) of the base(120). The base(120) and the cover(130) are detachably coupled to the frame(110). The orientation structure(131) includes a plurality of elastic ribs(1311) configured to provide a pressure on the tissue specimen or tissue specimens (900) and adjust the pressure according to a height of the tissue specimen(900) or heights of tissue specimens(900); and a flexible sheet(1313) coupled to the plurality of elastic ribs(1311) and having a plurality of flexible portions(13131) configured to contact and wrap the tissue specimen or tissue specimens (900) independently.

An apparatus for storing tissue and other biological materials includes a separable flexible container that includes a first layer coupled to a second layer via a set of seals to define a first storage volume and a second storage volume. Separate tissue specimens are containable within the first storge volume and the second storage volume. A first portion of the first layer or the second layer defines a first opening into the first storage volume. A second portion of the first layer or the second layer defines a second opening into the second storage volume. The opening into the first volume and the opening into the second volume are positioned near opposite edges of the flexible container. The separable flexible container also includes a hinge to allow the first opening and the second opening to move from location on opposing edges of the separable flexible container to adjacent locations.

A method of operating a tissue processor for processing tissue samples is provided. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes the steps of conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring, by means of the at least one sensor, a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and automatically determining, based on a result of checking, whether the reagent is suitable for processing tissue samples in the tissue processor. A tissue processor for processing tissue samples is also provided. A container is also provided for storing tissue samples for processing in a tissue processor.

A method for treating or diagnosing cancer with and endosurgical device comprising at least two lengthwise extending channels (2, 3, 4, 5; 2′, 3′, 4′, 5′), two opposite jaws (9, 10; 9′, 10′; 9″, 10″) with use of diathermy and flushing a tissue specimen to a proximal end of the endosurgical device. The method allows the surgeon to take several tissue specimens from an organ and to perform several functionalities when the device is inside the organ. The endosurgical device for use in the method is also disclosed.

The present application relates to the antibody of phorbolylated isocitrate dehydrogenase 1 and its preparation method and purpose, and specifically provides a polyclonal antibody, the polyclonal antibody is obtained by immunizing animals with the antigen epitope peptide of IDH1 phorbolylated, the specific site of the antigen epitope peptide is phorbolylated, and high-titer antibodies can be prepared, the phorbolylated modification of IDH1 in clinical specimens can be recognized with high specificity, and the polyclonal antibody can be used for the research of cell / tissue specimen immunoblotting and immunohistochemical method and the diagnosis of IDH1 related diseases.

Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

Systems and methods for tissue specimen analysis. Methods for tissue specimen analysis may include: retrieving a primary image data set including a plurality of images representing a tissue specimen margin; generating a reduced data set representing images having suspected artifacts based on a first detection model and the primary image set, the first detection model trained based on pathology-confirmed images and for prioritizing reducing false negative identification of artifacts while minimizing training penalization for false positive identification of artifacts; generating a prediction data set representing a subset of the reduced data set based on a second detection model and the reduced data set; and generating a signal representing the prediction data set for displaying one or more images predicting a true positive identification of a suspected artifact.

An apparatus includes a flexible container and a port. The container includes a first layer coupled to a second layer to define a storage volume within which a tissue specimen can be contained. The first layer has a first stiffness and the second layer has a second stiffness. An edge of the first layer is spaced apart from an edge of the second layer to define an opening into the storage volume. The edges of the first and second layer form a peelable seal that hermetically seals the storage volume such that the first layer can be peeled away from the second layer to expose the storage volume. The port is coupled to the flexible container and allows fluid communication between the storage volume and an external volume.

An imaging well (100), comprising: an adhesive layer (110), and a liquid layer (120) covering the adhesive layer (110), the adhesive layer (110) and the liquid layer (120) forming a well body. The adhesive layer (110) is used for adhering a tissue specimen, the liquid layer (120) allows photons and liquids to pass through, and the well body accommodates an imaging liquid. The imaging well (100) allows specimen tissue to be adhered, and the operation process is simple and reduces tissue damage, thus significantly improving imaging stability and quality. In addition, the imaging well (100) can maintain the physiological state of tissues for a long time, and is suitable for long-time dynamic imaging research. Moreover, a stage comprising the imaging well (100), a two-photon microscope, and an imaging method are also provided.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

A marking composition for marking a tissue specimen is provided. The marking composition includes a film forming resin including an acrylic resin, a rheology modifier including an associative polyurethane, a phyllosilicate, a cellulose, or a combination thereof, and a colorant. The composition has a viscosity of about 70 KU to about 110 KU at room temperature. If the composition includes a rheology modifier comprising cellulose, it is in an amount of about 0.01 wt % to about 0.25 wt % based on the total weight of the composition.

The present invention relates to the technical field of test chip preparation, specifically a method for preparing an immunohistochemical antibody quality test chip, comprising the following steps: S1, chip microarray design: selecting a variety of positive and negative tissue specimens to design 15 points; designing a 5×3 point tissue array; S2, collecting relevant wax blocks: selecting the required tissue wax blocks, and marking representative points in the paraffin specimens according to HE sections. This application clearly explains the operating method and the technical issues that need to be paid attention to during the operation, as well as the time and temperature that need to be controlled, so as to fully guarantee the quality of the corresponding staff during the operation to ensure the test effect. At the same time, this method can effectively increase the number of test chips during the test, and can effectively meet the screening of high-specificity, high-affinity antibodies.

The utility model discloses an intraoperative specimen collecting device for hysteroscopic surgery, which comprises a main pipeline, a sampling pipeline, a sampling pipeline, a sampling pipeline, a sampling pipeline, a sampling pipeline, a sampling pipeline and a sampling pipeline, and is characterized in that the main pipeline comprises a main pipeline body, and one end of the main pipeline body is connected with a suction pipe while the other end is connected with a negative pressure suction device; the collecting pipeline comprises a branch pipe body communicated with the main pipe body, and the free end of the branch pipe body is detachably connected with a negative pressure source; and the control valves are respectively arranged on the main pipe body and the branch pipe bodies and are used for controlling the main pipe body and the branch pipe bodies to be alternately connected and disconnected. According to the aspirator tube, abnormal tissue specimens reserved in the main tube body can be quickly and accurately transferred into a specimen container during an operation, the aspirator tube does not need to be repeatedly inserted and pulled, it is ensured that the specimens are accurately collected, and the specimens are prevented from being polluted or the operation environment is prevented from being polluted.

A tissue specimen collector, which is adapted for collecting tissue specimens during a biopsy procedure, is a multi-chamber collector having a main collector housing and a collector rack arranged lengthwise displaceable inside the main collector housing. The collector rack has a series of adjacent chambers for accommodating tissue specimens, and said main collector housing has a collector port adapted to connect to a supply of tissue specimens to receive tissue specimens in each consecutive chamber of the serious of adjacent chambers in the order they are resected from suspicious tissue.

A marking composition for marking a tissue specimen is provided. The marking composition includes a film forming resin including an acrylic resin, a rheology modifier including an associative polyurethane, a phyllosilicate, a cellulose, or a combination thereof, and a colorant. The composition has a viscosity of about 70 KU to about 110 KU at room temperature. If the composition includes a rheology modifier comprising cellulose, it is in an amount of about 0.01 wt % to about 0.25 wt % based on the total weight of the composition.

The utility model discloses a pathological biopsy tissue specimen bottle which comprises a bottle body, a bottle cap, a bottle cap, a bottle cap, a bottle cap, a bottle cap and a bottle cap. The inner-layer bottle is embedded into the containing cavity, the upper portion of the inner-layer bottle is open, filtering holes are formed in the bottom of the inner-layer bottle, the inner-layer bottle is provided with a first bearing face and a second bearing face, and the first bearing face is higher than the second bearing face; the bottle cap is detachably connected to the upper end of the bottle body and used for sealing the inner-layer bottle in the containing cavity. When the formalin fixing bottle needs to be taken out, the bottle cap can be detached, the inner-layer bottle is lifted, the second bearing face is supported on the bearing face, at the moment, the inner-layer bottle is located at the high position, the inner-layer bottle is separated from formalin fixing solution, due to the existence of the filtering holes, liquid in the inner-layer bottle can be discharged into the containing cavity, only pathological tissue is left, and therefore the formalin fixing bottle can be taken out. Therefore, pathological tissues can be taken out without being interfered by formalin fixed solution, and the materials are simple and convenient to take.

The utility model relates to the field of pathological tissue specimen storage, in particular to a pathological tissue specimen storage box. According to the pathological tissue specimen storage box, the placement box can be rapidly limited and fixed, the situation that pathological tissue specimens overflow due to the fact that the placement box is opened is avoided, and the fixing mode is rapid and convenient. A lesion tissue specimen storage box comprises a storage cabinet, a sealing door, temperature control boxes and the like, the left front portion of the storage cabinet is rotationally connected with the sealing door, and a plurality of temperature control boxes are connected into the storage cabinet. The rotary knob is rotated to drive the rotary disc to rotate, so that the extrusion frame moves along the sliding rail on the rotary disc, the extrusion frame synchronously moves outwards to make contact with and extrude the limiting frame, the limiting frame is driven to move outwards, the limiting frame makes contact with the upper portion of the containing box, and the containing box can be rapidly limited and fixed; the pathological tissue specimens are prevented from overflowing due to opening of the placing box, and the fixing mode is fast and convenient.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

A method and system for producing tomosynthesis images of a specimen in a cabinet x-ray system. An X-ray source delivers X-rays through a specimen of excised tissue and forms an image at a digital X-ray detector. Multiple X-ray images are taken as the X-ray source moves relative to the stationary breast specimen. The X-ray source moves in a range from about 330° to and including about 30°. The source may travel substantially along a path that generally defines an arc, or linearly, while the detector remains stationary throughout and the source remains substantially equidistant from the specimen platform. The set of X-ray image data taken at the different points are combined to form a tomosynthesis image that can be viewed in different formats, alone or as an adjunct to two dimensional specimen radiography.

The utility model provides a tissue specimen fixing device which comprises clamping pieces, the clamping pieces are bent to form a clamping space to clamp tissue, or two sets of clamping pieces are arranged, and the two sets of clamping pieces are located on the two sides of the tissue respectively and used for clamping the tissue; the fixing mechanism is installed on the clamping pieces and used for fixing the clamping pieces on the two sides of the tissue, the tissue is clamped and fixed through the clamping pieces, the clamping pieces play a role in shaping, the tissue is flattened, cells of the tissue are made to be relatively compact, the slicing effect of the soaked tissue is improved, and the tissue is not prone to damage. The fixing mechanism is used for fixing the clamping pieces, the tissue is prevented from falling off from a clamping space formed by the clamping pieces, and the stability of tissue fixing is improved; by using the fixing mechanism and the clamping pieces, the weight of the tissue can be increased, the tissue is completely soaked in the soaking liquid, the problem of tissue floating is solved, and the tissue soaking effect is improved.

The present invention provides a clustering method and system for transcriptome sequencing data. Applied to the technical field of data processing, the method includes: collecting cervical adenocarcinoma and adjacent tissue specimens of a number of patients, and performing data preprocessing to obtain a standardized gene expression matrix; performing clustering operations on the standardized gene expression matrix based on a clustering analysis method combining a latent class model and sub-coalition partitioning to obtain a clustered gene set; performing gene function annotation on the clustered gene set, and performing correlation analysis between the functionally annotated clustering results and the clinical characteristics of cervical adenocarcinoma to obtain the correlation between gene expression and clinical characteristics; constructing a deep clustering prediction model based on a variational autoencoder and a Gamma mixture model based on the clustering analysis and correlation analysis results to predict the prognosis risk or chemotherapy sensitivity of patients. The present invention solves the problems of poor clustering stability of high-dimensional transcriptome data and low prognostic prediction accuracy.

A device and method for preparing frozen tissue specimens are disclosed. The device includes a solid block having a top surface and a bottom surface, with two parallel side walls extending upward from the top surface. A slotted groove is formed in the middle of the solid block and extends from the top surface to the bottom surface to receive a specimen chuck, such that a head of the chuck rests on the top surface. Top edges of the side walls support a tissue slide containing an encapsulated specimen. The device may include finger grooves for manual handling and is preferably made of a heat-conducting material to assist in rapid freezing. The method involves placing the specimen chuck in the groove, depositing a freezing medium over it, and positioning the tissue slide so that the specimen contacts the freezing medium for effective specimen preparation.

The invention provides a specimen image generation method based on endoscope shooting and an endoscope. The method comprises the following steps: acquiring a first category of images; wherein the first class image is used for indicating an image acquisition end of an endoscope to shoot an image acquired by a specimen in vitro; based on a preset distortion correction algorithm, distortion correction is carried out on the first type of images to obtain distortion correction images, and the distortion correction algorithm is an algorithm used for carrying out distortion correction on the first type of images; and storing the distortion correction image as a specimen image. By means of the method, the hardware cost can be effectively reduced, the problems that in the treatment process of organ or tissue specimens cut by an endoscope, the flow is complex, and shooting is delayed are solved, meanwhile, distortion correction is conducted on the in-vitro shot images, the images can be displayed according to the normal proportion, and the observation and recording effects of a user are improved.