229 results about "Multiwell plate" patented technology

The invention relates to the technical field of rare earth extraction devices, and discloses rare earth extraction equipment with a microencapsulation auxiliary structure, the rare earth extraction equipment comprises an extraction tower, the extraction tower is sequentially provided with a tower cover, an upper filler part, a middle filler part, a lower filler part and a heavy phase collector from top to bottom, the internal structures of the upper filler part, the middle filler part and the lower filler part are the same, and the heavy phase collector is arranged in the tower cover. Separators are arranged in the middles of the three, a filler area for increasing the contact area of two-phase liquid and prolonging the contact time of the two-phase liquid is arranged below the separators, a perforated plate for bearing the filler area is arranged below the filler area, and an auxiliary area for improving extraction selectivity and efficiency is arranged above the separators. According to the separator disclosed by the invention, the microcapsules and the filler are separately arranged, meanwhile, the microcapsules can continuously move in a fluid in a suspension manner, and the contact between the microcapsules and the liquid phase is dynamic and continuously changed, so that the microcapsules can be in contact with new rare earth ions to be extracted and an extracting agent in time, and a mass transfer interface is continuously updated, so that the mass transfer process is more efficient.

The invention discloses a preparation and quality detection device and method for uniformly layered granular materials with different compactness, and belongs to the technical field of geotechnical test equipment.The device comprises a receiving container arranged on an inner supporting frame, the receiving container is connected with a diffuser through a control valve, and a miniature CPT device is arranged between the diffuser and the inner supporting frame; the top of the receiving container is connected with a hopper through a flexible hose, and the hopper is arranged on the top of the outer supporting frame. A porous plate structure in the diffuser is used for controlling the deposition strength, particle distribution is monitored through a micro pressure sensor and a high-speed camera, the aperture is adjusted, multi-dimensional characteristic in-situ detection is achieved by means of multiple sensors of a micro CPT device, and parameters are optimized and optimal deposition parameters are predicted through a controller. According to the preparation and quality detection device and detection method for the layered uniform granular materials with the different compactness, the deposition strength and particle distribution can be accurately controlled, multi-dimensional detection and automatic control are achieved, the test precision and efficiency are improved, and manual errors are reduced.

The utility model discloses high-throughput cell sample integrated treatment equipment, which comprises an equipment cabin, a treatment flow control device and an equipment function module, the treatment flow control device is in signal connection with the equipment function module, the treatment flow control device is arranged outside the equipment cabin, and the equipment function module is in signal connection with the equipment cabin. The equipment function module is fixedly mounted in the equipment cabin; the equipment function module comprises a centrifugal mechanism, a perforated plate transfer mechanism, a multi-channel pipetting mechanism, a constant-temperature culture module, a sample treatment platform, a glass slide suction mechanical arm, a supporting mechanism, a glass slide bin and a dispersion chamber. According to the application, cycle synchronization, suspension, separation, fixation and dispersion of cells are automatically completed, functional modules in culture, harvesting and slide preparation links in a sample treatment process are highly integrated, a perforated plate is used for replacing a traditional centrifugal tube for sample treatment, batch harvesting of samples and slide preparation treatment are realized, and the production efficiency is improved. The sample treatment flux and the sample treatment efficiency are improved, and meanwhile, the sample treatment consistency is also improved.

A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.

The utility model discloses a magnetic porous reaction plate, relates to a biological medicine research and development device, and is used for life science experiment research using magnetic beads. The reaction plate comprises a perforated plate, a base, a cover plate and a magnet, and the magnet can be embedded between the perforated plate and the base and is matched with the bottom of the perforated plate in shape. According to the utility model, the porous reaction plate can be moved, centrifuged, shaken and the like under the condition of keeping magnetic force, so that more flexible and diversified experiment designs and experiment schemes are realized.

The invention discloses a powder sample preparation mold of a photoelectron spectrometer. The powder sample preparation mold comprises a sample groove and a base, the sample groove is made of a compressible material, has compressibility and is used for synchronously compressing and compacting the sample groove together with a sample; the base is a perforated plate with a plurality of holes, the holes are matched with the sample grooves in an embedded mode, the sample grooves are higher than the holes before compression, and the sample grooves are flush with the holes after compression. The sample preparation mold can be used for pressing powder samples in batches, the powder sample preparation process of the photoelectron spectrometer is simplified, the sample preparation time is shortened, the convenience of powder sample preparation can be effectively improved, sample pollution is avoided, and the sample preparation efficiency is greatly improved. Compared with a traditional mode of preparing a sample by using an adhesive tape, the sample preparation mold disclosed by the invention can be used for preventing glue on the adhesive tape from immersing into a powder sample to cause pollution, the sample can be recycled after a test is completed, the prepared sample does not need to be cut, powder cannot be generated to pollute a sample chamber, the exposed surface of the sample is relatively large and relatively flat, and the detection signal intensity is favorably improved.

We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and / or liquid samples derived therefrom in environmental monitoring.

The invention provides a mixed bed water distribution device for water treatment, which comprises a tank body, the top of the tank body is provided with a water inlet, a first perforated plate and a second perforated plate are sequentially arranged in the tank body from top to bottom, and a protection assembly is arranged between the first perforated plate and the water inlet and is vertical to the axis of the tank body; the protection assembly comprises an assembly ring, multiple sets of unit pieces are evenly arranged in the assembly ring along the circle center at equal angles, each unit piece comprises an installation base and a closing plate which are movably connected with each other, the installation bases are fixedly connected with the assembly ring, and reset mechanisms are arranged between the closing plates and the installation bases; a buffer control assembly fixedly connected with the first perforated plate, the second perforated plate and the protection assembly is arranged on the inner wall of the tank body. Through the arrangement of the protection assembly and the multi-stage porous plate, impact defense to transient impact water flow is achieved, and device damage and uneven water distribution are avoided.

The invention discloses a high-throughput drug screening and organoid culture device, and aims to overcome the defects that conventional drug testing in a laboratory mainly depends on a porous plate, operation is generally complex, cell culture and drug stimulation lack dynamic perfusion, and cross contamination is prone to occurring. The system comprises a drug concentration generation module and an organoid culture module, the drug concentration generation module comprises a plurality of drug concentration generation units, and the organoid culture module comprises a plurality of organoid culture units corresponding to the drug concentration generation units. A medicine inlet, a culture medium solution inlet and a plurality of liquid outlets are formed in the medicine concentration generation unit; the organoid culture unit comprises a plurality of groups of organoid culture chambers corresponding to the liquid outlets, and the organoid culture chambers in the same group are communicated with one another. The high-throughput drug screening and organoid culture device is convenient to operate, whole-course dynamic culture of organoid culture and drug stimulation can be achieved, and cross contamination is not prone to occurring.

The invention relates to a phenylacetylglutamine / phenylacetylglycine induced vascular smooth muscle cell senescence model and an establishment method and application thereof, and belongs to the technical field of cell models.The method comprises the following steps that vascular smooth muscle cell suspension is placed in a porous plate, 10% of FBS and 1% of mycillin are added into a culture medium, 24 h after cells adhere to the wall, the vascular smooth muscle cell senescence model is obtained, and the vascular smooth muscle cell senescence model is obtained. The method comprises the following steps of: adding a proper amount of phenylacetyl glutamine or phenylacetyl glycine dimethyl sulfoxide solution into a porous plate, changing a serum-free culture medium, continuously culturing for 24 hours, adding a proper amount of phenylacetyl glutamine or phenylacetyl glycine dimethyl sulfoxide solution into the porous plate, changing the culture medium added with phenylacetyl glutamine or phenylacetyl glycine once every 24 hours, and collecting cells after 72 hours. According to the invention, phenylacetylglutamine / phenylacetylglycine is used for inducing and establishing the vascular smooth muscle cell senescence model for the first time, the method is easy to operate and low in cost, and a foundation is laid for researching the relationship between cardiovascular diseases and senescence.

The invention discloses a flow intensity regulation and control device, a flow intensity regulation and control method and a laser proton accelerator. According to the device, a beam positioning sub-device is connected with a flow intensity adjusting and controlling sub-device, and the beam positioning sub-device is used for arranging the flow intensity adjusting and controlling sub-device in a vacuum cavity of the laser proton accelerator and adjusting the position of the flow intensity adjusting and controlling sub-device in the vacuum cavity; the flow intensity regulation and control sub-device comprises a movable perforated plate, a fixed perforated plate and a flow intensity regulation and control module; the movable perforated plate and the fixed perforated plate are overlapped and have the same shape, size and through hole arrangement; and the flow intensity regulation and control module is used for regulating and controlling the one-way relative displacement of the movable perforated plate and the fixed perforated plate so as to change the flow intensity regulation and control state of the flow intensity regulation and control sub-device on the laser proton beam. According to the embodiment of the invention, the beam flux can be rapidly and accurately adjusted, and the flow intensity of the proton beam can be rapidly and accurately adjusted.

The present invention concerns systems, materials, and methods of cell, cell organelle and / or particle separation and / or concentration utilizing magnetic levitation to affect separation. In some embodiments, the separation and / or concentration is performed in the wells of a multi-well plate.

1. The name of this design product: Multifunctional fluorescence analyzer. 2. Purpose of this design product: used for collecting fluorescence signals from multi-well plates. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

A device for CO2 microbubble flooding comprises a microbubble generating device, a stirring and liquid storage device, an injection pump, a gas compressor, a gas-liquid mixer and a pressure stabilizing system, wherein the microbubble generating device adopts an integrally formed multi-layer cylindrical metal powder-sintered porous plate, and the diameters of microchannels on the porous plate are sequentially reduced from inside to outside. A solution containing additives in the storage device is stirred uniformly and then enters into a downhole gas injection base pipe through the gas-liquid mixer to be injected into a stratum, then a carbon dioxide gas compressed by the gas compressor is pumped into the downhole gas injection base pipe through the gas injection pump, and the gas generates microbubbles in situ when passing through the multi-layer porous device under the action of pressure difference.

To stably perform bioluminescence measurement and prevent crosstalk.SOLUTION: A multiwell plate (1) according to the present invention comprises a plate outer wall (10) and a plurality of independent wells arranged in a two-dimensional array, wherein the plurality of wells include: a substrate input well (11) having a wall portion (11w) that is lower in height than the plate outer wall (10); and a sample input well (12) having a wall portion (12w) that is equal in height to the plate outer wall (10), with a notch (12a) being provided in the wall portion (12w).SELECTED DRAWING: Figure 1

1. Name of the product in this design: Perforated plate (assembly). 2. Purpose of this design: A general-purpose dynamic joint component for assembling models. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

Provided herein is a method for preparing an emulsion, comprising the steps of allowing a dispersed phase liquid to flow from one side to the other side of a multi-hole plate through a plurality of micro-wells of the multi-hole plate while allowing a continuous phase liquid to flow, parallel to the multi-hole plate, on the other side of the multi-hole plate, shearing the dispersed phase liquid passing through the multi-hole plate to form liquid microspheres in the flowing continuous phase liquid. Further provided herein are an apparatus for preparing an emulsion and a process system for preparing microcarrier particles, which can be used for preparing emulsions and microcarrier particles on a large scale.

A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.

The present invention belongs to the technical field of mineral separation and processing, and discloses a multi-stage mineralization flotation column. It comprises a flotation column, a concentrate tank, an internal tank body, a raw material feed assembly and a middling ore circulation assembly. The interior of the flotation column is divided into a separation zone, a mineralization zone and a tailings zone from top to bottom; the mineralization zone is divided into a main mineralization zone and a middling ore zone by the internal tank body, and the top and bottom of the internal tank body are porous plates. The raw material feed assembly transports the mineralized slurry to the main mineralization zone through a vertically downward discharge port, and the middling ore circulation assembly sprays the incompletely mineralized middling ore back into the internal tank body through at least one group of middling ore feed pipes, forming a multi-stage coordinated mineralization zone. The present invention solves the problems of incomplete mineralization, poor bubble stability, and easy clogging of equipment in the prior art through multi-stage mineralization, thereby improving the mineral recovery rate and flotation efficiency.

Multi-well plate with a plurality of sample chambers (14), in particular arranged in a grid-like manner, wherein an inlet and an outlet chamber (16, 18) are each assigned to the sample chambers (14), wherein each sample chamber (14) is connected to the inlet chamber (16) assigned to it and to the outlet chamber (18) assigned to it in the lower region via connecting channels (20a, 20b), and with a cover part for the multi-well plate (10), wherein the cover part (12) covers the sample chambers (14) of the multi-well plate (10) towards the top, and wherein the cover part (12) has openings (24) assigned to the inlet chambers (16) of the multi-well plate (10), through which openings, when the cover part (12) is arranged on the multi-well plate (10), fluid can be supplied to the inlet chambers (16) from the outside.

This invention relates to the field of plant transgenic detection technology, and discloses a method for rapid batch detection of transgenic crops, comprising: Step 1, placing centrifuge tubes containing crop samples to be tested in an array into a multi-well plate to complete batch plate arrangement of samples; Step 2, performing overall mechanized processing based on the multi-well plate, so that the crop samples in the centrifuge tubes are simultaneously ground into powder under mechanical force. This integrated operation process, which places independent centrifuge tubes in an array within a multi-well plate and uses a tissue homogenizer, batch liquid addition equipment, and a centrifuge to simultaneously process all samples, achieves a significant improvement in detection throughput and efficiency. Compared to existing technologies that rely on manual, one-by-one operation, this method overcomes the shortcomings of low detection efficiency and the inability to simultaneously process multiple samples, thus failing to meet the needs of large-scale crop sample screening.

The utility model relates to an adjustable location fixture, including base and install the adjusting mechanism, perforated plate, adjustable location subassembly and adjustable clamping mechanism on the base, perforated plate is installed on the adjusting mechanism, adjustable location subassembly is movably installed on the perforated plate, adjustable clamping mechanism is installed on the adjustable location subassembly, and the adjustable clamping mechanism is installed on the base. The adjustable clamping assembly and the perforated plate are arranged adjacently, a plurality of mounting holes arranged in an array are formed in the perforated plate, the adjustable positioning assembly comprises a positioning rod and a plurality of positioning clamping blocks, and the positioning rod and the positioning clamping blocks can be connected with any mounting hole. The clamping device has the advantages of being capable of meeting the positioning requirements of different workpieces, good in clamping stability and capable of improving production efficiency.

The invention discloses a gas-liquid separator for an electrolytic hydrogen production system, the gas-liquid separator comprises an inlet pipe, a gas outlet, a liquid outlet, a liquid distributor and a multilayer plate, the liquid distributor is located at the tail end of the inlet pipe and comprises a perforated plate, and a gas-liquid mixture entering the gas-liquid separator is converted into a plurality of trickles; and the multi-layer plate is positioned below the liquid distributor, comprises multiple layers of separating plates which are arranged up and down, and is used for enabling the gas-liquid mixture output by the liquid distributor to enter the bottom of the gas-liquid separator after being subjected to gas-liquid separation of each layer of separating plate. The separation efficiency is improved through the multiple layers of separation plates, the effective separation area in the gas-liquid separator under the same volume is increased, the floating time needed by bubble separation is shortened, and the purpose of improving the separation efficiency is achieved through a simple structural internal part.

The present invention discloses a kit for rapid determination of brucine and strychnine by mass spectrometry, which relates to the technical field of biological detection. The kit for rapid determination of mass spectrometry includes an MCX mixed cationic adsorbent and a pyrrolidone-styrene polymer adsorbent. The kit for rapid determination of mass spectrometry effectively improves the accuracy and sensitivity of detection. Through the method of extraction by multi-well plate - liquid chromatography - tandem mass spectrometry, on a silica-based C18 reversed-phase chromatography column, under specific mobile phase composition and flow rate conditions, the separation of brucine and strychnine from interfering impurities in blood on the silica-based C18 reversed-phase chromatography column and the multi-reaction monitoring (MRM) mass spectrometry detection in the positive ion mode of the electrospray ionization source are realized, and finally the rapid, accurate and highly sensitive detection of brucine and strychnine in blood is achieved.

Disclosed herein is a device for multianalyte detection, and systems and methods for drying reagents in wells in the device in a manner that preserves functional performance. Specifically, disclosed is a system for drying reagents in the wells of a multiwell plate. The multiwell plate is sprayed with air from nozzles positioned above the multiwell plate. Air is exhausted evenly below the multiwell plate. This allows for the rapid, consistent drying of large volumes of liquid in the well of a multiwell plate.

The present invention provides an apparatus for performing automated analysis of one or more samples in a single-well or multi-well plate or vial, wherein the automated analysis process includes automated fluid flow, wherein the sample comprises a fluid or particles in a sample vessel, and wherein the apparatus includes an assembly of components for processing the sample for analytical evaluation by a fluid-based and / or particle-based instrument. The automated fluid flow may include a system for moving the sample, including a vacuum system, a pressure-based system, a pneumatic system, a pump, a peristaltic pump, a diaphragm, or a syringe. The apparatus may include an assembly of components for achieving movement in the X, Y, and Z directions, as well as switches, microfluidic tubing, a well plate, an electronic pressure controller, a pneumatic or fluid mixing device, components for fluid processing, a sampling vessel, and mechanical components for mobilizing or transporting system components.

The invention relates to the technical field of experimental equipment, and provides an integrated desalting device and method for high-throughput sample treatment, and the device comprises a base, a movable partition plate and a standard porous plate. The movable partition has first and second working positions. And a wedge-shaped guide positioning mechanism is arranged between the movable partition plate and the perforated plate, and can automatically guide the movable partition plate to lift and transversely align through slope matching when the perforated plate is horizontally pushed in until the movable partition plate is stably supported on the perforated plate and accurate alignment of a sample treatment column and a collection hole is realized, so that rapid and accurate switching between a washing mode and an elution mode is completed. The device is ingenious in structure and easy and smooth to operate.

Devices and methods to measure cells and / or tissue's contractile force are disclosed. Included is a mount with rigid, and non-rigid posts sized to flex. Determined is force exerted by contractile cells and tissues in a multiwell plate. The device is designed to fit inside individual wells with posts directed downwards. Posts are attached to a 3D printed circular mount with tabs for depth within the well. The mount has a window for medium changes while the device is positioned inside the well. The cells are seeded within a hydrogel. As the hydrogel condenses, cells / tissue wrap around the post's outside pulling non-rigid post toward rigid post. Inverted light microscope is used to determine deflection of non-rigid post inside the multiwell plate. Movement of the non-rigid post is measured using an acrylic ruler on an underside of the multiwell plate. Contractile forces of cells / tissue are determined using cantilever mechanics.

The present invention discloses a multi-well plate sealing method and a pipetting module. By configuring the bottom surface of the pipetting module's adapter to be flat and the diameter of the through-holes therein to be larger than the diameters of the holes on the multi-well plate, the adapter of the pipetting module can be used to directly press and secure a pressure-sensitive film onto the multi-well plate after pipetting is completed, thereby completing the sealing of the multi-well plate. Compared to the prior art, the multi-well plate sealing method disclosed in the present invention utilizes the pipetting module of an automated liquid handling station to seal reagent containers, such as multi-well plates, requiring sealing. This simplifies the complexity of the instrument, thereby reducing laboratory instrument costs and the space required for the instrument.