52 results about "Pain syndrome" patented technology

This invention relates to a method for the biochemical treatment of persistent pain disorders by inhibiting the biochemical mediators of inflammation in a subject comprising administering to said subject any one of several combinations of components that are inhibitors of biochemical mediators of inflammation. Said process for biochemical treatment of persistent pain disorders is based on Sota Omoigui's Law, which states: ‘The origin of all pain is inflammation and the inflammatory response’. Sota Omoigui's Law of Pain unifies all pain syndromes as sharing a common origin of inflammation and the inflammatory response. The various biochemical mediators of inflammation are present in differing amounts in all pain syndromes and are responsible for the pain experience. Classification and treatment of pain syndromes should depend on the complex inflammatory profile. A variety of mediators are generated by tissue injury and inflammation. These include substances produced by damaged tissue, substances of vascular origin as well as substances released by nerve fibers themselves, sympathetic fibers and various immune cells. Biochemical mediators of inflammation that are targeted for inhibition include but are not limited to: prostaglandin, nitric oxide, tumor necrosis factor alpha, interleukin 1-alpha, interleukin 1-beta, interleukin-4, Interleukin-6 and interleukin-8, histamine and serotonin, substance P, Matrix Metallo-Proteinase, calcitonin gene-related peptide, vasoactive intestinal peptide as well as the potent inflammatory mediator peptide proteins neurokinin A, bradykinin, kallidin and T-kinin.

The present invention relates to the treatment of conditions associated with neuronal activity. Specifically, the invention is drawn to methods and compositions for administering adenosine to inhibit pain syndromes or epilepsy in a patient.

A custom-moldable patellar support product for improved patella tracking in the femoral groove and relief of associated patella femoral pain syndrome, and including an outer container formed of moisture-impervious material and an initially-moldable, patellar support positioned in the container in substantially moisture-free conditions and sealed therein against entry of moisture until use. The support includes a substrate and a reactive system impregnated into or coated onto the substrate. The system remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to moisture to form a rigid, self supporting structure. A flexible protective pad is positioned on one side of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the patella support is in use. An outer cover covers the substrate on the side opposite the protective pad. The substrate, protective pad and outer cover are connected together into a unitary structure for being urged against the knee and into a position whereby the patella is repositioned into a therapeutic location relative to the femur for improved tracking in the femoral groove, and molded while flexible to the knee with the patella in the repositioned location. Several different types of retention devices, such as straps or bandages, may be used for retaining the patellar support on the knee in its molded location for maintaining the patella in the repositioned location.

A method of administering a prodrug of propofol, preferably O-phosphonooxymethyl propofol disodium salt, comprises the oral, intragastric, or intraintestinal administration of the prodrug in amounts sufficient to induce or maintain a generalized anesthetized state, a conscious sedated state, or to treat insomnia, anxiety, nausea, vomiting, pruritus, epilepsy, and a range of pain syndromes and other medical conditions.

A method of treating depression includes identifying a subject with a pain syndrome for increased responsiveness to the treatment of pain associated with the pain syndrome with botulinum toxin and locally administering a botulinum toxin subcutaneously to a face of the subject, thereby treating said pain. Identification of the pain is made prior to administering botulinum toxin for the treatment of said pain. The subject has a pain syndrome and a condition selected from the group consisting of a depressive disorder, an anxiety disorder and a sleep disorder.

Systems and methods for improving or preventing a condition, such as the treatment of pain syndromes and migraine headaches are disclosed. A method for treating pain can include one or more of the steps including identifying a region of the patient comprising glabrous tissue; positioning the region of the patient comprising glabrous tissue into an enclosed chamber; adjusting the relative humidity of the enclosed chamber sufficient to create a physiologic effect. The method need not involve altering the temperature within the enclosed chamber.

A method of administering a prodrug of propofol, preferably O-phosphonooxymethyl propofol disodium salt, comprises the subcutaneous or rectal administration of the prodrug in amounts sufficient to induce or maintain a generalized anesthetized state, a conscious sedated state, or to treat insomnia, anxiety, nausea, vomiting, pruritus, epilepsy, and a range of pain syndromes, including migraine pain, and other medical conditions.

The present invention refers to isoxazole derivatives, in particular diarylisoxazole derivatives inhibitors of cyclooxygenase (COX), in particular cyclooxygenase-1 (COX-1), to their pharmaceutical compositions, the process for their preparation and their use for the chemoprevention and treatment of inflammatory syndromes and in the prevention and treatment of carcinomas, in particular intestinal, ovarian and cutaneous carcinomas, in the treatment of pain syndromes, in particular after surgery, and in the cardiovascular field as antithrombotics / vasoprotectives / cardioprotectives.

The invented remedy allows cleaning up the area from necrotic tissues and facilitating reduced perifocal oedema and infiltration as well as lessening pain syndrome during suppurative inflammation diseases. The remedy can be applied both in the hospital and field settings.

The invention provides a traditional Chinese medicine composition for a moxibustion medicine cake. The traditional Chinese medicine composition for the moxibustion medicine cake is mainly prepared from, by weight, 0.2-2 parts of angelica sinensis, 0.5-5 parts of radix aconiti carmichaeli, 0.5-5 parts of cortex cinnamomi, 0.2-2 parts of safflower, 0.2-2 parts of radix salviae miltiorrhizae, 0.2-2 parts of radix aucklandiae and 0.2-2 parts of borneol. The invention further provides a preparation method of the traditional Chinese medicine composition for the moxibustion medicine cake. The traditional Chinese medicine composition for the moxibustion medicine cake can be used by being combined with moxa floss, the double therapeutic effect of the moxa floss and the traditional Chinese medicines is achieved, and the clinical curative effect of moxibustion is greatly improved; the traditional Chinese medicine composition has the effects of warming and nourishing the spleens and the stomach, promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain; the traditional Chinese medicine composition is suitable for the cold syndromes, the deficiency syndromes, the pain syndromes and the stasis syndromes which are caused by deficiency cold of the spleens and the stomach, spleen-kidney yang deficiency, qi stagnancy, blood stasis and the like and is particularly suitable for difficult miscellaneous diseases such as chronic gastritis, refractory chronic enteritis and the like; carrying is convenient, and operation is easy; the substantial economical benefits can be brought.

The present invention provides the use of certain compounds to treat peripheral or central pain syndrome and other disorders associated with the T-type calcium ion channels.

The medicine for treating pain syndrome of later stage cancer is one Chinese and Western combined medicine, which is prepared with astragalus root, privet fruit, sealwort and other Chinese medicinal materials as well as Indomethacin, Dexamethasone, Spironolactone, Famotidine and Diazepam. It has the functions of resisting cancer, diminishing inflammation, relieving pain, promoting diuresis and raising immunity; and in can inhibit the growth of cancer cell, relieve pain of the later stage cancer patient, raise survical quality and prolong life.

The invention provides a treatment head and device for chronic pelvic pain syndromes. The treatment head for the chronic pelvic pain syndromes comprises a disposable coupling membrane, an electromagnetic cup, an arc-shaped vibration diaphragm component, an arc-shaped emitter, a metal coil and a seat sleeve component, the disposable coupling membrane is arranged on the electromagnetic cup, the arc-shaped vibration diaphragm component is arranged between the electromagnetic cup and the metal coil, the metal coil is attached to the inner wall of the arc-shaped emitter, and the arc-shaped emitteris arranged on the seat sleeve component, wherein the incident surface energy flow density of the arc-shaped emitter within a preset vertical height range is equal to the exit surface energy flow density. The generated shock waves converge into a stable energy space at a fixed distance from the generator end opening of the treatment head, and then the effective area covers an entire prostate to realize shock wave treatment; and the treatment head is non-invasive and safe and has no side effects in the process, the operation is simple, the treatment is fast, the manpower and time expenses are small, and the treatment costs are low.

A formulation and method of mitigation of symptoms of patients suffering from a neurocutaneous pain syndrome by topical application of the formulation. The formulation is obtained by steeping the bark of a tree from the genus Betula in an aqueous acidified solution and then subsequent filtering, packaging and sterilization.

The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.

The invention provides a convenient, economical, practical and efficient new drug, namely a tincture for treating various pain caused by rheumatism, which is capable of achieving the optimal treatment effect that previous similar achievements fail to reach and is applicable to external use so as to diminish inflammation and relieve pain; the tincture for treating various pains caused by rheumatism is a secret prescription handed down from YAN Keqin family in Yuncheng of Shanxi, and the tincture includes a solvent preparation method of the secret prescription; the secret prescription: 36 kinds of Chinese herbal medicines such as flos carthami, rhizoma galangae, radix angelicae sinensis, radix notoginseng, rhizoma ligustici wallichii, radix astragali and the like as well as a solvent namely alcohol; functions: expelling wind, removing cold and dredging collaterals, repairing damaged nerve cells, promoting regeneration of body's new tissues. Major function: the secret prescription is effective on treating various pain syndromes such as rheumatic pain, pain in neck, shoulders, waist and legs, and the like. The medicine (the tincture), in accordance with 'Impregnation Method', is prepared by mixing the 36 kinds of Chinese herbal medicines according to the secret prescription, preparing an obtained mixture into powder by virtue of a nano-granulating technology, sealing the obtained powder, together with the solvent, in a container, then storing the container in a cellar or a sealed chamber, shaking once every day and shaking once every other day after one week; filtering and removing dregs on the 16th day after 15 days, collecting an obtained medicine and performing packaging, so that a finished product is obtained. The tincture is applicable to external use and is smeared in affected parts. The optimal therapy method: firstly, cupping for 15 min, removing cups and smearing the medicine, covering the medicine with a film, massaging and ending.

The present disclosure relates to a compound, method of making and method of using such compound preferably in the form of a dietary supplement. The composition, when administered, is capable of treating arthritis and various joint-related pain syndromes. The unique combination of the composition is preferably administered orally. A preferred composition is comprised of at least 10 to 200 mcg of selenium, from about 200 to 1200 mg of MSM, from about 100 to 900 mg of boswellia, from about 1 to 5 mg of type II collagen, from about 25 to 200 mg of hyaluronic acid, and from about 50 to 500 mg of ginger.

A pharmaceutical composition for improving chronic pelvic cavity pain syndrome due to urinary dysfunction where said composition contains tamsulosin or pharmaceutically acceptable salts thereof.

This invention relates to a class of pyrrolidine compounds of formula (I), and pharmaceutical ly acceptable derivatives thereof, to their use in med icine, to compositions containing them, and to processes for their preparation. It also relates to intermediates used in the preparation of such compounds and derivatives. In particular the compounds of formula (I) are useful for the treatment of EP2-mediated conditions, such as endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), chronic pelvic pain syndrome, polycystic kidney disease and polycystic ovarian syndrome.

The invention relates to a positioning device for treating muscle diseases with acute pains. The positioning device is provided with a fixing band which is annular in shape and provided with a positioning wire and six through holes, and the fixing band may be a wrist fixing band or an ankle fixing band. The positioning device has the advantages that, the positioning device is provided with the fixing band which is provided with a positioning wire, thus being convenient to correctly wear the positioning device; the fixing band is provided with the through holes, so that an entry point can be quickly and accurately positioned; the material of the fixing band can be recycled, thus being low-carbon and environment-friendly; the diameter of the through holes and spacing of the through holes in the fixing band are obtained by investigating and performing data analysis on crowd epidemiology, the entry point is determined in the effective areas of the through holes, so that statistical significance is provided, and the acupuncture treatment has therapeutic effect.

The invention discloses a traditional Chinese medicine composition for treating osteoarthritis and a preparation method and application of the traditional Chinese medicine composition. The compositionhas the effects of removing cold and dampness, relaxing muscles and stasis, dissipating and relieving pain and nourishing liver and kidney. The traditional Chinese medicine composition is prepared from the raw material components: in parts by weight, 75-100 parts of Rehmannia glutinosa, 5-50 parts of fructus psoraleae, 5-50 parts of deer-horn glue, 5-45 parts of radix achyranthis bidentatae, 5-35parts of Semen Cuscutae, 5-35 parts of baked ginger, 5-15 parts of ephedra, 5-35 parts of cinnamon, 5-35 parts of Semen brassicae, 5-35 parts of rhizoma bletillae, 5-25 parts of corydalis tuber and 5-25 parts of licorice. It is clinically proven that the traditional Chinese medicine composition is suitable for knee osteoarthritis with the main clinical signs of wind-evil and dampness pain syndromes and cold-damp stagnation syndromes, and the clinical symptoms of patients with knee osteoarthritis can be improved. It is shown through pharmacodynamics study that the traditional Chinese medicinecomposition is capable of improving the symptoms and related indicators of papain-induced osteoarthritis of rats, is suitable for patients with knee osteoarthritis with the wind-evil and dampness painsyndromes and cold-damp stagnation syndromes, and has a high clinical application value.

The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and / or treat pain associated to interstitial cystitis / bladder pain syndrome (IC / BPS).

A computer-controlled sensory testing system is disclosed that can be used to further pain research and aid in the clinical diagnosis and treatment of pain syndromes. The system includes actuators to deliver pressure / deformation (strain), auditory, olfactory, and other stimuli to a subject. The system includes software to control the delivery of the stimuli. The system is further operable to receive feedback regarding the stimuli received.

The invention discloses intelligent system plasters for regulating physique and preventing and treating various types of neck-shoulder pain and lumbocrural pain in an automatic dynamic overall dialectical manner and a preparation method of thereof. For etiology and pathogenesis of different physiques and various types of neck-shoulder pain and lumbocrural pain, 52 traditional Chinese medicines such as garden balsam stems are respectively used and are subjected to steps such as decocting so as to obtain nine plasters with different formulas. The plasters are respectively applied to related acupoints of the upper part (Baihui acupoint and / or Dazhui acupoint), the middle part (two Shenshu acupoints, Danzhong acupoint, Shenque acupoint, Guanyuan acupoint and / or Qihai acupoint) and the lower part (two Zusanli acupoints and two Yongquan acupoints) of a human body. By virtue of a three-in-one integral conditioning and prevention and treatment plaster integrated system consisting of the upperpart, the middle part and the lower part, and depending on an automatic dynamic integral regulation and control mechanism of a five-internal-organ integrated system of the human body, the invention realizes intelligent dialectical physique conditioning and prevention and treatment. The plasters have the effects of dispelling cold, clearing heat, dispelling wind, eliminating dampness, reducing phlegm, removing stasis, diminishing swelling, removing stasis, dredging collaterals, relieving pain, tonifying qi, regulating blood, promoting asthenic disease, tonifying kidney and strengthening governor meridian, and are used for conditioning physique and preventing and treating various neck-shoulder pain and lumbocrural pain syndromes.

The invention discloses a traditional Chinese medicine preparation for treating soft tissue injury pain syndromes. The traditional Chinese medicine preparation comprises the following raw materials: magnetitum, arabic cowry shell, safflower carthamus, divaricate saposhnikovia root, rhizoma corydalis, glossy privet fruit, zaocys dhumnade, cortex acanthopanacis, earthworm, angelica, pollen typhae, teasel root, rheum officinale, radix achyranthis bidentatae, raw oyster shell and fructus liquidambaris. The traditional Chinese medicine preparation is prepared by mixing the raw materials through multi-time clinical verifications; after the traditional Chinese medicine preparation is orally taken by patients, the effect of activating blood to remove stasis is quickly brought into play, blood capillaries at the nidus are expanded, algogenic substances such as histamine and 5-hydroxytryptamine in blood vessels are removed, the microcirculation of location of pain is restored, the metabolism is promoted, the joint movement is promoted, and the effects of resolving tetany and relieving pain are achieved; meanwhile, by regulating internal organs, protecting the liver, tonifying the kidney, nourishing yin and converging yang, the soft tissue injury pain syndromes are radically cured.

A formulation and method of mitigation of symptoms of patients suffering from a neurocutaneous pain syndrome by topical application of the formulation. The formulation is obtained by steeping the bark of a tree from the genus Betula in an aqueous acidified solution and then subsequent filtering, packaging and sterilization.

The medicine for treating pain syndrome of later stage cancer is one Chinese and Western combined medicine, which is prepared with astragalus root, privet fruit, sealwort and other Chinese medicinal materials as well as Indomethacin, Dexamethasone, Spironolactone, Famotidine and Diazepam. It has the functions of resisting cancer, diminishing inflammation, relieving pain, promoting diuresis and raising immunity; and in can inhibit the growth of cancer cell, relieve pain of the later stage cancer patient, raise survical quality and prolong life.

The invention discloses a TRPM8 related polypeptide fragment. Amino acid sequences are shown in the SEQ ID No:1-6. The invention further discloses a TRPM8 protein, the TRPM8 related polypeptide fragment and application of the corresponding antibody of the TRPM8 related polypeptide fragment for preparing a chronic prostatitis or a chronic pelvic pain syndrome diagnostic reagent. A TRPM8 protein molecule or a TRPM8 related polypeptide fragment or the antibody level in liquid of a patient is detected, the chronic prostatitis or chronic pelvis pain comprehensive syndrome is effectively diagnosed, and other prostate diseases can be effectively distinguished. In addition, monoclonal or polyclonal antibodies of 1000-3000 IU TRPM8 protein or related polypeptide fragments are injected through vein or under the skin, and clinical features of the chronic prostatitis or the chronic pelvis pain syndrome can be cured or obviously relieved.