50 results about "Pain syndrome" patented technology

This invention relates to a method for the biochemical treatment of persistent pain disorders by inhibiting the biochemical mediators of inflammation in a subject comprising administering to said subject any one of several combinations of components that are inhibitors of biochemical mediators of inflammation. Said process for biochemical treatment of persistent pain disorders is based on Sota Omoigui's Law, which states: ‘The origin of all pain is inflammation and the inflammatory response’. Sota Omoigui's Law of Pain unifies all pain syndromes as sharing a common origin of inflammation and the inflammatory response. The various biochemical mediators of inflammation are present in differing amounts in all pain syndromes and are responsible for the pain experience. Classification and treatment of pain syndromes should depend on the complex inflammatory profile. A variety of mediators are generated by tissue injury and inflammation. These include substances produced by damaged tissue, substances of vascular origin as well as substances released by nerve fibers themselves, sympathetic fibers and various immune cells. Biochemical mediators of inflammation that are targeted for inhibition include but are not limited to: prostaglandin, nitric oxide, tumor necrosis factor alpha, interleukin 1-alpha, interleukin 1-beta, interleukin-4, Interleukin-6 and interleukin-8, histamine and serotonin, substance P, Matrix Metallo-Proteinase, calcitonin gene-related peptide, vasoactive intestinal peptide as well as the potent inflammatory mediator peptide proteins neurokinin A, bradykinin, kallidin and T-kinin.

A method of administering a prodrug of propofol, preferably O-phosphonooxymethyl propofol disodium salt, comprises the oral, intragastric, or intraintestinal administration of the prodrug in amounts sufficient to induce or maintain a generalized anesthetized state, a conscious sedated state, or to treat insomnia, anxiety, nausea, vomiting, pruritus, epilepsy, and a range of pain syndromes and other medical conditions.

Systems and methods for improving or preventing a condition, such as the treatment of pain syndromes and migraine headaches are disclosed. A method for treating pain can include one or more of the steps including identifying a region of the patient comprising glabrous tissue; positioning the region of the patient comprising glabrous tissue into an enclosed chamber; adjusting the relative humidity of the enclosed chamber sufficient to create a physiologic effect. The method need not involve altering the temperature within the enclosed chamber.

A method of administering a prodrug of propofol, preferably O-phosphonooxymethyl propofol disodium salt, comprises the subcutaneous or rectal administration of the prodrug in amounts sufficient to induce or maintain a generalized anesthetized state, a conscious sedated state, or to treat insomnia, anxiety, nausea, vomiting, pruritus, epilepsy, and a range of pain syndromes, including migraine pain, and other medical conditions.

The present invention refers to isoxazole derivatives, in particular diarylisoxazole derivatives inhibitors of cyclooxygenase (COX), in particular cyclooxygenase-1 (COX-1), to their pharmaceutical compositions, the process for their preparation and their use for the chemoprevention and treatment of inflammatory syndromes and in the prevention and treatment of carcinomas, in particular intestinal, ovarian and cutaneous carcinomas, in the treatment of pain syndromes, in particular after surgery, and in the cardiovascular field as antithrombotics/vasoprotectives/cardioprotectives.

The invented remedy allows cleaning up the area from necrotic tissues and facilitating reduced perifocal oedema and infiltration as well as lessening pain syndrome during suppurative inflammation diseases. The remedy can be applied both in the hospital and field settings.

The invention provides a traditional Chinese medicine composition for a moxibustion medicine cake. The traditional Chinese medicine composition for the moxibustion medicine cake is mainly prepared from, by weight, 0.2-2 parts of angelica sinensis, 0.5-5 parts of radix aconiti carmichaeli, 0.5-5 parts of cortex cinnamomi, 0.2-2 parts of safflower, 0.2-2 parts of radix salviae miltiorrhizae, 0.2-2 parts of radix aucklandiae and 0.2-2 parts of borneol. The invention further provides a preparation method of the traditional Chinese medicine composition for the moxibustion medicine cake. The traditional Chinese medicine composition for the moxibustion medicine cake can be used by being combined with moxa floss, the double therapeutic effect of the moxa floss and the traditional Chinese medicines is achieved, and the clinical curative effect of moxibustion is greatly improved; the traditional Chinese medicine composition has the effects of warming and nourishing the spleens and the stomach, promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain; the traditional Chinese medicine composition is suitable for the cold syndromes, the deficiency syndromes, the pain syndromes and the stasis syndromes which are caused by deficiency cold of the spleens and the stomach, spleen-kidney yang deficiency, qi stagnancy, blood stasis and the like and is particularly suitable for difficult miscellaneous diseases such as chronic gastritis, refractory chronic enteritis and the like; carrying is convenient, and operation is easy; the substantial economical benefits can be brought.

The present invention provides the use of certain compounds to treat peripheral or central pain syndrome and other disorders associated with the T-type calcium ion channels.

The invention provides a treatment head and device for chronic pelvic pain syndromes. The treatment head for the chronic pelvic pain syndromes comprises a disposable coupling membrane, an electromagnetic cup, an arc-shaped vibration diaphragm component, an arc-shaped emitter, a metal coil and a seat sleeve component, the disposable coupling membrane is arranged on the electromagnetic cup, the arc-shaped vibration diaphragm component is arranged between the electromagnetic cup and the metal coil, the metal coil is attached to the inner wall of the arc-shaped emitter, and the arc-shaped emitteris arranged on the seat sleeve component, wherein the incident surface energy flow density of the arc-shaped emitter within a preset vertical height range is equal to the exit surface energy flow density. The generated shock waves converge into a stable energy space at a fixed distance from the generator end opening of the treatment head, and then the effective area covers an entire prostate to realize shock wave treatment; and the treatment head is non-invasive and safe and has no side effects in the process, the operation is simple, the treatment is fast, the manpower and time expenses are small, and the treatment costs are low.

The invention provides a pharmaceutical composition for treating pain syndromes or arthralgia syndromes, which is a preparation mainly prepared by the following raw herbs by weight: 3-15 parts of zedoary turmeric, 3-15 parts of cirald saphne bark, 3-15 parts of rhizoma sparganii; the preparation has the efficacy of invigorating blood circulation and relieving pain, dispelling wind and removing dampness, relaxing muscles and tendons and activating collaterals, and is mainly used to treat diseases such as pain and swelling in local joints, bones or muscles, rheumatism, rheumatoid diseases and the like caused by qi and blood stasis, and meridian obstruction. The preparation method of the invention combines auxiliary materials of traditional Chinese medicines, menthol, lithopone powder, borneol, and the like which not only have synergistic interaction, but also have no irritation to skin; the pharmaceutical composition of the invention is easy for uncovering and plastering, has the effect of cooling and relieving itching, detumescence and relieving pain, and has unique curative effect, lasting effect, safety and reliability.

A formulation and method of mitigation of symptoms of patients suffering from a neurocutaneous pain syndrome by topical application of the formulation. The formulation is obtained by steeping the bark of a tree from the genus Betula in an aqueous acidified solution and then subsequent filtering, packaging and sterilization.

The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.

The invention discloses a traditional Chinese medicine composition for treating osteoarthritis and a preparation method and application of the traditional Chinese medicine composition. The compositionhas the effects of removing cold and dampness, relaxing muscles and stasis, dissipating and relieving pain and nourishing liver and kidney. The traditional Chinese medicine composition is prepared from the raw material components: in parts by weight, 75-100 parts of Rehmannia glutinosa, 5-50 parts of fructus psoraleae, 5-50 parts of deer-horn glue, 5-45 parts of radix achyranthis bidentatae, 5-35parts of Semen Cuscutae, 5-35 parts of baked ginger, 5-15 parts of ephedra, 5-35 parts of cinnamon, 5-35 parts of Semen brassicae, 5-35 parts of rhizoma bletillae, 5-25 parts of corydalis tuber and 5-25 parts of licorice. It is clinically proven that the traditional Chinese medicine composition is suitable for knee osteoarthritis with the main clinical signs of wind-evil and dampness pain syndromes and cold-damp stagnation syndromes, and the clinical symptoms of patients with knee osteoarthritis can be improved. It is shown through pharmacodynamics study that the traditional Chinese medicinecomposition is capable of improving the symptoms and related indicators of papain-induced osteoarthritis of rats, is suitable for patients with knee osteoarthritis with the wind-evil and dampness painsyndromes and cold-damp stagnation syndromes, and has a high clinical application value.

The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS).

The invention discloses intelligent system plasters for regulating physique and preventing and treating various types of neck-shoulder pain and lumbocrural pain in an automatic dynamic overall dialectical manner and a preparation method of thereof. For etiology and pathogenesis of different physiques and various types of neck-shoulder pain and lumbocrural pain, 52 traditional Chinese medicines such as garden balsam stems are respectively used and are subjected to steps such as decocting so as to obtain nine plasters with different formulas. The plasters are respectively applied to related acupoints of the upper part (Baihui acupoint and/or Dazhui acupoint), the middle part (two Shenshu acupoints, Danzhong acupoint, Shenque acupoint, Guanyuan acupoint and/or Qihai acupoint) and the lower part (two Zusanli acupoints and two Yongquan acupoints) of a human body. By virtue of a three-in-one integral conditioning and prevention and treatment plaster integrated system consisting of the upperpart, the middle part and the lower part, and depending on an automatic dynamic integral regulation and control mechanism of a five-internal-organ integrated system of the human body, the invention realizes intelligent dialectical physique conditioning and prevention and treatment. The plasters have the effects of dispelling cold, clearing heat, dispelling wind, eliminating dampness, reducing phlegm, removing stasis, diminishing swelling, removing stasis, dredging collaterals, relieving pain, tonifying qi, regulating blood, promoting asthenic disease, tonifying kidney and strengthening governor meridian, and are used for conditioning physique and preventing and treating various neck-shoulder pain and lumbocrural pain syndromes.

Provided is a therapeutic or prophylactic agent for generalized pain syndrome, for which no cause and therapies have been established. A therapeutic or prophylactic agent for generalized pain syndrome containing an LPA1 antagonist or autotaxin-inhibiting substance as an active ingredient. The pharmaceutical is preferably administered to the central nervous system. The generalized pain syndrome is preferably fibromyalgia, chronic fatigue syndrome or hypersensitivity colitis.