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Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof

A technology of cycloalkyl and alkyl, which is applied in the direction of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as no examples and no clear records

Inactive Publication Date: 2017-10-17
BAYER PHARMA AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these compounds are neither explicitly described nor exemplified

Method used

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  • Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
  • Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
  • Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 23

[0226] 24)(R / S)3-[3-({[4-(5-chloro-6-methylpyridin-3-yl)phenyl](cyclopentyl)-acetyl}amino)-2-methyl phenyl]propionic acid (Example 24)

[0227] 25)(+)(S)3-[3-({[4-(5-chloro-6-methylpyridin-3-yl)phenyl](cyclopentyl)-acetyl}amino)-2- Methylphenyl]propionic acid (Example 25)

[0228] 26)(-)(R)3-[3-({[4-(5-chloro-6-methylpyridin-3-yl)phenyl](cyclopentyl)-acetyl}amino)-2- Methylphenyl]propionic acid (Example 26)

[0229] 27)(R / S)3-[3-({cyclopentyl[4-(5,6-dimethylpyridin-3-yl)phenyl]acetyl}-amino)-2-methylphenyl ] propionic acid (embodiment 27)

[0230] 28)(R / S)3-{3-[(cyclopentyl{4-[5-(difluoromethoxy)pyridin-3-yl]phenyl}-acetyl)amino]-2-methyl Phenyl}propionic acid (Example 28)

[0231] 29)(R / S)3-{3-[(cyclopentyl{4-[5-(difluoromethyl)pyridin-3-yl]phenyl}-acetyl)amino]-2-methylbenzene Propionic acid (Example 29)

Embodiment 30

[0233] 31) (R / S) 3-[3-({[4-(5-chloropyridin-3-yl)phenyl](cyclopropyl)acetyl}amino)-2-methylphenyl]propanoic acid (Example 31)

Embodiment 33

[0236]34) (-) {3-[(cyclopentyl{4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetyl)amino]-2-methylphenoxy}acetic acid ( Example 34)

[0237] 35) (+) {3-[(cyclopentyl{4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetyl)amino]-2-methylphenoxy}acetic acid ( Example 35)

[0238] 36) (R / S)[3-({[4-(5-chloropyridin-3-yl)phenyl](cyclopentyl)acetyl}amino)-2-methylphenoxy]acetic acid (implementation Example 36)

[0239] 37) (-)[3-({[4-(5-chloropyridin-3-yl)phenyl](cyclopentyl)acetyl}amino)-2-methylphenoxy]acetic acid (Example 37 )

[0240] 38)(R / S)3-[3-({[4-(5-chloropyridin-3-yl)phenyl](cyclopentyl)acetyl}-amino)-6-methoxy-2- Methylphenyl]propionic acid (Example 38)

[0241] 39) (-)3-[3-({[4-(5-chloropyridin-3-yl)phenyl](cyclopentyl)acetyl}amino)-6-methoxy-2-methylbenzene Base] propionic acid (Example 39)

[0242] 40)(R / S)3-{3-[(cyclopentyl{4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-acetyl)amino]-6-methoxy -2-Methylphenyl}propionic acid (Example 40)

[0243] 41)(R / S)3-{3-[(cyclopent...

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Abstract

The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.

Description

technical field [0001] The present invention relates to substituted pyridyl-cycloalkyl-carboxylic acids of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds, and to the use of said compounds for the preparation of pharmaceutical compositions purposes, the pharmaceutical composition is used for the treatment or prevention of diseases, particularly mammalian diseases, such as but not limited to pain-related diseases, or for the treatment or prevention of pain syndromes (acute and chronic), inflammation-induced pain associated with cancer, pelvic pain, pain associated with cancer, pain associated with endometriosis as well as endometriosis itself, cancer itself and proliferative disorders such as endometriosis itself. Background technique [0002] The present invention relates to chemical compounds that inhibit PTGES (also known as prostaglandin E synthase 1). Prostaglandin E synthase 1 is an enzyme e...

Claims

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Application Information

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IPC IPC(8): C07D213/84C07D405/12C07D213/56C07D213/61C07D213/64C07D213/65C07D401/12A61K31/4418A61K31/4422A61K31/4433A61P15/00A61P29/00A61P1/00
CPCC07D213/56C07D213/61C07D213/64C07D213/65C07D213/84C07D401/12C07D405/12A61K31/167A61K31/44A61K31/4418A61P1/00A61P15/00A61P29/00A61P35/00
Inventor N·布罗伊尔J·内格尔H·伊尔巴切A·罗特盖里W·施韦德H·道勒夫M·科皮茨M·皮特斯A-M·戈迪尼奥-科埃略
Owner BAYER PHARMA AG
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