42 results about "Diazepam" patented technology

The present invention provides a method for removing diazepam from water using a molecular sieve, and belongs to the technical field of wastewater treatment. The method provided by the present invention comprises: mixing a molecular sieve with an aqueous solution containing diazepam, and then sequentially performing vortex adsorption, centrifugation and filtration to obtain a treated aqueous solution; the molecular sieve comprises one or more of an H-Beta molecular sieve, a NaY molecular sieve, a HY molecular sieve, an H-ZSM molecular sieve, an H-MOR molecular sieve and a USY molecular sieve. The present invention limits a specific molecular sieve as an adsorbent, and this type of molecular sieve has a strong polarity and can selectively adsorb diazepam from water. The results of the examples show that the present invention uses a USY molecular sieve as an adsorbent, and the adsorption time required to reach equilibrium is only 10 minutes, the adsorption time is short, and the adsorption amount is large, and it has good selectivity for diazepam.

The invention discloses a method for analyzing propylene glycol content by a diazepam solution chromatograph and a verification method thereof, and relates to the field of medicine analysis, the key points of the technical scheme are as follows: a diazepam oral solution is analyzed by the chromatograph, and the conditions of the gas chromatograph are as follows: an SH-WAX polar capillary chromatographic column is used, the temperature of a sample inlet is 230 DEG C, and the temperature of a detector is 250 DEG C; the carrier gas is nitrogen, the flow velocity is 1.0 ml / min, and the split ratio is 10: 1; temperature programming is carried out, the initial temperature is kept at 130 DEG C for 1 minute, and the temperature is raised to 240 DEG C at the speed of 10 DEG C / min and kept for 3 minutes; determining the content of propylene glycol by using an internal standard method; the purposes of low analysis cost and high sensitivity are achieved.

An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.

Cardiomyopathies are heart muscle disorders which represent a heterogeneous group of diseases that often lead to progressive heart failure with significant morbidity and mortality. Here, the inventors show that neutralization of acyl CoA binding protein (ACBP) / diazepam binding inhibitor (DBI) reduces the deleterious effect of the Vehicle anthracycline doxombicin on cardiac function. Since anthracycline-induced heart failure and anthracycline-induced senescence are models of accelerated cardiac aging, it is also plausible to use ACBP / DBI inhibition or neutralization as a method to prevent or treat aging of the cardiovascular system. The inventors also found that genetic and pharmacological interventions to deplete ACBP / DBI efficiently improves cardiac dysfunction associated with experimental HFpEF, a condition associated with aging, hypertension and obesity. Accordingly, the present disclosure relates to methods for the treatment of cardiac dysfunction comprising neutralization of ACBP / DBI.

The invention relates to the field of traditional Chinese medicines, in particular to a preparation method of an Anqi flat-pressing capsule which comprises the following components in parts by weight: 6-7 parts of astragalus membranaceus, 6-7 parts of codonopsis pilosula, 4g of salvia miltiorrhiza, 5-6 parts of cortex moutan, 5-6 parts of malt, 5-6 parts of hawthorn, 3-4 parts of scutellaria baicalensis, 3-4 parts of radix bupleuri, 2.5 g of diazepam, 1-2 parts of nimodipine and 2-3 parts of radix isatidis. The capsule has the effects of nourishing heart, stabilizing mind, promoting blood circulation to remove blood stasis, soothing liver-qi stagnation, dredging and regulating internal organs, regulating qi activity, reducing heart pressure, maintaining normal functions of the heart, enabling qi and blood to be smooth and smooth, coordinating functions of the internal organs, reducing resistance and reducing blood pressure, so that the heart is protected against mind, and the main mind is relieved if the main mind is relieved. The capsule has the advantages of normal heart function, reduced pressure, relatively stable blood pressure, smooth qi and blood, healthy body and no occurrence of diseases, can be used for treating various hypertension and intractable hypertension diseases, and has no side effect.

Compositions for intranasal delivery of benzodiazepines, such as diazepam, midazolam, and lorazepam and methods for their use to treat and prevent seizures in pediatric subjects aged 2-5, inclusive. Compositions for rapid therapeutic onset with a decreased incidence and / or severity of adverse effects after administration and methods of improving patient compliance with a prescribed treatment regimen.

The invention discloses application of a selfheal compound in preparation of a medicine for adjusting an insomnia sleep structure. The selfheal compound comprises selfheal, rhizoma acori graminei, herba cepbalanoplosis segeti, semen boitae and caulis bambusae in taeniam. The selfheal compound can remarkably improve the sleep structure, and compared with a traditional benzodiazepine medicine (such as diazepam), the selfheal compound not only effectively recovers the physiological proportion of non-rapid eye movement sleep and rapid eye movement sleep, but also can reduce sleep fragmentation and rebuild sleep continuity.

An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.

The invention relates to the field of traditional Chinese medicines, in particular to a preparation method of an Anqi flat-pressing capsule which comprises the following components in parts by weight: 6-7 parts of astragalus membranaceus, 6-7 parts of codonopsis pilosula, 6-7 parts of salvia miltiorrhiza, 5-6 parts of cortex moutan, 5-6 parts of malt, 5-6 parts of hawthorn, 3-4 parts of scutellaria baicalensis, 3-4 parts of radix bupleuri, 0.2-0.5 part of diazepam, 1-2 parts of nimodipine and 2-3 parts of radix isatidis. The capsule has the effects of nourishing heart, stabilizing mind, promoting blood circulation to remove blood stasis, soothing liver-qi stagnation, dredging and regulating internal organs, regulating qi activity, reducing heart pressure, maintaining normal functions of the heart, enabling qi and blood to be smooth and smooth, coordinating functions of the internal organs, reducing resistance and reducing blood pressure, so that the heart is protected against mind, and the main mind is relieved if the main mind is relieved. The capsule has the advantages of normal heart function, reduced pressure, relatively stable blood pressure, smooth qi and blood, healthy body and no occurrence of diseases, can be used for treating various hypertension and intractable hypertension diseases, and has no side effect.

The invention discloses application of Cacumen biotae-derived extracellular vesicles in preparation of drugs for treating anxiety, depression or insomnia. The EVs are separated and purified from cacumen biotae through a specific differential ultracentrifugation method, the EVs have a typical double-layer membrane structure, the average particle size is about 100 nm, about 1012 EVs can be extracted from each gram of cacumen biotae, and 62 volatile components are contained. Cacumen biotae EVs can be taken by PC12 cells, and corticosterone-induced neuron damage can be relieved; for chronic constraint stress model mice, anxiety behaviors and spatial learning and memory disorders can be improved, and central nervous inflammation can be inhibited; for chronic unpredictable mild stress model mice, the weight, the sucrose preference rate and the cognitive ability can be recovered, and the levels of 5-hydroxytryptamine and gamma-aminobutyric acid are increased; and for 4-chloro-DL-phenylalanine induced insomnia model mice, the sleep condition can be improved, the neurotransmitter level can be recovered, and the effect is equivalent to that of positive drugs such as citalopram, fluoxetine, diazepam and the like.

The present disclosure provides improved methods, therapeutic regimens, and systems for treating a disease associated with a pituitary malignancy in a subject, such as treating Cushing Syndrome, or treating one or more symptoms of Cushing Syndrome in subjects, through the inhibition of extracellular diazepam binding inhibitor (DBI) by various methods. The present disclosure also relates to compositions for use and methods in treating synovial inflammation in a subject, the compositions for use and methods comprising an agent that reduces human diazepam binding inhibitor (DBI) activity or expression. The present disclosure also relates to compositions for use and methods in treating degenerative joint disease, joint inflammation, and manifestations thereof in a subject, the compositions for use and methods comprising an agent that reduces human diazepam binding inhibitor (DBI) activity or expression.

The invention relates to a method for detecting antiepileptic drugs in serum based on polarity conversion UPLC-MS / MS. The antiepileptic drugs (AEDs) are respectively levetiracetam, pregabalin, gabapentin, lamotrigine, phenobarbital, oxcarbazepine, phenytoin sodium, carbamazepine, clonazepam, diazepam and sodium valproate. Simplifying sample pretreatment by adopting a methanol (containing formic acid) one-step extraction method; in the chromatographic analysis, C18 is used as a chromatographic column and a pre-column, a 5% methanol aqueous solution (containing formic acid)-95% methanol aqueous solution (containing formic acid) is used as a mobile phase, gradient elution is carried out, and the mass spectrum adopts an MRM mode. The method has the advantages of being high in sensitivity, good in precision and accuracy, easy to operate, free of matrix interference and the like, can be used for measuring serum AEDs of different species, and provides technical support for the prevention and treatment mechanism of epilepsy drugs, clinical AEDs blood concentration monitoring, individualized drug delivery scheme formulation and pharmacokinetic research.

The present application relates to oral film compositions and dosage forms with precise active dissolution profiles. Disclosed herein are oral membranes for delivering individual unit doses of one or more actives, the membranes having precisely calculated and controlled active dissolution profiles. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating various diseases and conditions, such as epilepsy and seizures, by administering the oral membranes disclosed herein.

To solve the following problem: since oral films dissolve rapidly, improved dissolution testing is needed for these rapid dissolving products, which enables precise measurements almost immediately upon placement in a liquid and at very small time intervals.SOLUTION: An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.SELECTED DRAWING: None

The invention provides a method for detecting diazepam, nordiazepam and nordiazepam isomeride BP-271 in fish meat, and belongs to the technical field of analysis and detection. According to the method disclosed by the invention, the diazepam, nordiazepam and BP-271 in the fish meat are subjected to qualitative analysis and quantitative analysis by adopting ultra-high performance liquid chromatography-tandem mass spectrometry, and the situation that the BP-271 is detected in fish bodies when the fish is polluted by the diazepam is revealed; the method is suitable for simultaneous detection of diazepam, BP-271 and nordiazepam in a large batch of fish bodies, the detection accuracy and precision are good, and methodological requirements are met.

An anti-proliferative and cell self-renewal inhibiting drug combination comprising diazepam and acetylsalicylic acid, wherein said diazepam and said acetylsalicylic acid is in a ratio 1:3 to 3:1. Also provided are anti-proliferative and cell self-renewal inhibiting pharmaceutical composition comprising said combination.

The present invention discloses a method for processing and detecting a sample. The present invention is based on the addition of a phase separator, a purifier and an extractant to respectively realize extraction and oil removal treatment, solves the difficulty of large conflicts in the extraction and oil removal process due to the large difference in the chemical properties of enrofloxacin, malachite green and diazepam, realizes a four-in-one unified sample pretreatment method of chloramphenicol, diazepam, malachite green and enrofloxacin, and the sample is pretreated once. Relative to the sample pretreatment method of a single compound, under the premise of ensuring high sensitivity, the detection time is greatly shortened, and it is subsequently applicable to the on-site rapid large-scale screening test of the colloidal gold method, and the minimum detection limit of each compound is 0.1μg / kg, 0.5μg / kg, 0.5μg / kg and 2μg / kg, respectively, which meets the accuracy and stability requirements of the detection and is convenient for the detection operation of grassroots personnel.

This invention belongs to the field of biological treatment technology, specifically relating to the application of aquatic plants in removing diazepam residues from water bodies and methods for removing diazepam residues from water. This invention uses water hyacinth and / or water lettuce to remove diazepam residues from water bodies, effectively improving the removal rate of diazepam in water. As the plants grow and absorb the pollutants, the concentration of pollutants in the water gradually decreases, thereby enabling the reuse of the water.

The utility model discloses a tandem liquid chromatography-mass spectrometer for detecting diazepam residues in aquatic products, which comprises a device main body and a convenient insertion mechanism, and a detection component is mounted at one end of the device main body; the convenient inserting mechanism is arranged in the device body and used for classified taking and placing and comprises an inserting block, the lower end of the inserting block is connected with a positioning block, and the upper end of the inserting block is connected with a framed bent. According to the tandem liquid chromatography-mass spectrometer for detecting diazepam residues in the aquatic products, by installing a convenient-to-insert mechanism in the device main body, the effects that a whole row of test tubes can be conveniently and rapidly taken and placed, classification is convenient, and the bottom is easy to clean are achieved.

This invention discloses a method for identifying thalidomide R-type chiral molecules. The method includes the following steps: constructing a dataset, dividing the dataset into a training set and a test set according to a preset ratio; the dataset includes ECD spectra of thalidomide R-type chiral molecules, ECD spectra of diazepam molecules, ECD spectra of phenobarbital molecules, and corresponding label data; constructing a recognition model based on a CNN convolutional neural network, inputting the training set and test set into the recognition model for training and performance evaluation to obtain a trained recognition model; inputting the ECD spectrum of the thalidomide chiral molecule to be detected into the trained recognition model to obtain a recognition result, wherein the recognition result is thalidomide R-type chiral molecules or other molecules. This invention enables simple and rapid identification of thalidomide R-type chiral molecules.

This invention discloses a method and application for detecting diazepam based on ratio Raman signals, belonging to the field of food safety and chemical detection technology. The method involves mixing an Au@4-NTP@Ag@ZIF-8 composite material solution with the sample solution to be tested, then dropping the mixture onto a substrate. A Raman spectrometer is used to acquire spectral data at an excitation wavelength of 532 nm, and the intensity ratio I is calculated. 1590 / I 1107 Substitute diazepam concentration to intensity ratio I 1590 / I 1107 The concentration of diazepam in the sample was calculated using a standard curve. The detection method of this invention exhibits high selectivity for diazepam and is unaffected by interference from macromolecules such as proteins, lipids, and glucose, as well as small molecule chemicals in complex matrices. It enables trace, rapid, and accurate detection of diazepam residues in aquatic products, and has significant application prospects in practical scenarios such as port clearance and on-site law enforcement.

The invention discloses a method for detecting the residual quantity of diazepam in aquatic products based on magnetic solid phase extraction-ultra-high performance liquid chromatography-tandem mass spectrometry. The method comprises the following steps: (1) pretreating a sample; (2) magnetic solid-phase extraction and purification; and (3) carrying out UPLC-MS / MS analysis. The method for detecting the diazepam residual quantity in the aquatic product based on the magnetic solid phase extraction-ultra-high performance liquid chromatography-tandem mass spectrometry is established, the method is easy to operate, high in sensitivity, good in purification effect and high in precision and accuracy, and the requirements for accurate qualitative and quantitative analysis of the diazepam residual quantity in the aquatic product can be met.

The application discloses a method for removing diazepam in fishery breeding water bodies, and comprises the following steps: placing an obtained adsorption device into a fishery breeding water body, adsorbing diazepam, and obtaining a fishery breeding water body with removed diazepam. The method can efficiently adsorb and remove diazepam without changing the original environmental conditions of the water body, and improves the success rate of water treatment. Compared with traditional methods, the success rate of the application is significantly improved, and the content of diazepam in aquatic products can be clearly reduced, thereby providing a reliable water purification scheme for breeders.

An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.

The present disclosure relates to compositions for use and methods in treating symptoms of senescence in a cell or tissue of a subject, the compositions for use and methods comprising an agent that reduces human diazepam binding inhibitor (DBI) activity or expression. In some instances, the cell or tissue expresses a GABAA receptor γ2 subunit. In some instances, the cellular senescence characterized by elevated levels of p21 polypeptide in the cell or tissue. The cells or tissues may be selected from a kidney, a liver, or heart. In some instances, the cells are cells that express a senescence marker such as cyclin-dependent kinase inhibitor 2A (CDKN2A) or p21.

Autophagy is typically activated by starvation, allowing cells and organisms to mobilize their energy reserves. It is known that pharmacological modulation of autophagy represents a therapeutic potential. Here the inventors report that a protein that is released from cells in an unconventional, autophagy-dependent manner, namely, diazepam binding inhibitor (DBI), regulates autophagy. In particular, the inventors demonstrate that DBI inhibits autophagy and that the supply of recombinant DBI to mice enhanced glycolysis, enhanced lipogenesis, and inhibited fatty acid oxidation. The inventors show that neutralisation of DBI by a monoclonal antibody and an active immunization by means of an immunogenic DBI derivative eliciting autoantibodies induce autophagy and lead to metabolic changes that increase starvation-induced weight loss, reduce food intake upon refeeding, and reduce weight gain in response to hypercaloric diets. Accordingly, the present invention relates to methods and pharmaceutical compositions for modulating autophagy based on the modulation of the activity or expression of DBI.

The invention discloses magnetic mushroom dreg biochar as well as a preparation method and application thereof, and belongs to the technical field of water treatment. Mushroom residue biochar BC is prepared from shiitake mushroom residues, then the mushroom residue biochar and potassium ferrate K2FeO4 are subjected to ball milling, sufficient stirring, porphyrizing and mixing and then subjected to high-temperature firing, the magnetic mushroom residue biochar MBC composite material is obtained and used for removing diazepam in aquaculture water, and experimental results show that the magnetic mushroom residue biochar MBC composite material can be used for removing diazepam in aquaculture water at the temperature of 20-40 DEG C, so that the magnetic mushroom residue biochar MBC composite material can be used for removing diazepam in aquaculture water. When the pH value is 6-8, the adsorption capacity of the magnetic mushroom dreg biochar MBC on diazepam in water is 32.00 mg / g or above, and the magnetic mushroom dreg biochar MBC shows a good removal effect. The biochar material prepared by the invention is easy to recover under the action of an external magnetic field, is a novel diazepam water pollution purification material which is green, environment-friendly and energy-saving, and meets the requirements of quickly and powerfully guaranteeing the quality safety of aquatic products.

The invention belongs to the technical field of medicines, and particularly discloses an application of IEM-1925 and pharmaceutically acceptable salts thereof in preparation of medicines for treating epileptic status and brain injury caused by nerve toxic agents. In-vivo animal experiments prove that the IEM-1925 is applied after soman poisoning, behavioral epilepsy and electroencephalogram epilepsy can be effectively terminated, neuronal death and neuroinflammation in a hippocampal region can be remarkably relieved, and the long-term cognitive function and anxiety-like behaviors of poisoned living animals can be improved. The curative effect of the medicine is obviously superior to that of the existing standard medicine diazepam in the aspects of epilepsy control, brain injury protection and sequelae improvement. The application range of the IEM-1925 is expanded, the provided medicine is simple in preparation process and low in cost, has good clinical application prospects and market value, provides a brand-new and efficient neuroprotective medicine for treating nerve poison poisoning, and has great medical and public safety value.

The invention discloses a composition for treating psychoneurosis and a preparation method thereof, and belongs to the technical field of medicines.The composition comprises phenobarbital, sodium bromide, diazepam, traditional Chinese medicine extracts and starch, the traditional Chinese medicine extracts are extracts of spina date seeds, platycladi seeds, albizia flowers, astragalus membranaceus and atractylodes macrocephala, and phenobarbital, sodium bromide and diazepam are smashed respectively and then are added into the starch, and the starch is added into the phenobarbital, the sodium bromide and the diazepam to prepare the composition for treating psychoneurosis. According to the composition, scientific and reasonable component matching is carried out in a mode of combining traditional Chinese medicine and western medicine, phenobarbital and sodium bromide can rapidly relieve acute symptoms of psychoneurosis, the traditional Chinese medicine extract conditions the body of a patient from the whole, and the traditional Chinese medicine composition has the effects of relieving acute symptoms of psychoneurosis and relieving acute symptoms of psychoneurosis. The problems that an existing medicine is poor in curative effect, obvious in side effect or single in component are solved, the preparation method is simple, convenient and controllable, large-scale production is easy, higher-quality choices are provided for psychoneurosis treatment, medical technology progress is promoted, clinical requirements are met, and the composition has the advantages in the aspects of curative effect and safety.

The invention discloses a preparation method and a formula of a diazepam oral solution, relates to the field of chemical pharmacy, and solves the problem of poor solution stability in the prior art, and the preparation method of the diazepam oral solution is characterized by comprising the following steps: A, preparing a first solution, heating propylene glycol, and stirring to obtain a second solution; diazepam, anhydrous citric acid and polyethylene glycol 1000 are added and stirred until the materials are completely dissolved, and a first solution is obtained; b, preparing a second solution, adding sodium citrate, sorbitol and erythrosine into purified water, and stirring until sodium citrate, sorbitol and erythrosine are completely dissolved to obtain the second solution; c, mixing to a constant volume: mixing the second solution with the first solution, cooling, adding the juicy peach essence, supplementing the purified water to full dose, and uniformly stirring and mixing; and D, filtering: filtering the mixed liquid medicine through a filter element to obtain the diazepam oral solution. The purpose of improving the solution stability is achieved.