12 results about "Diazepam" patented technology

An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.

Compositions for intranasal delivery of benzodiazepines, such as diazepam, midazolam, and lorazepam and methods for their use to treat and prevent seizures in pediatric subjects aged 2-5, inclusive. Compositions for rapid therapeutic onset with a decreased incidence and / or severity of adverse effects after administration and methods of improving patient compliance with a prescribed treatment regimen.

The invention discloses application of Cacumen biotae-derived extracellular vesicles in preparation of drugs for treating anxiety, depression or insomnia. The EVs are separated and purified from cacumen biotae through a specific differential ultracentrifugation method, the EVs have a typical double-layer membrane structure, the average particle size is about 100 nm, about 1012 EVs can be extracted from each gram of cacumen biotae, and 62 volatile components are contained. Cacumen biotae EVs can be taken by PC12 cells, and corticosterone-induced neuron damage can be relieved; for chronic constraint stress model mice, anxiety behaviors and spatial learning and memory disorders can be improved, and central nervous inflammation can be inhibited; for chronic unpredictable mild stress model mice, the weight, the sucrose preference rate and the cognitive ability can be recovered, and the levels of 5-hydroxytryptamine and gamma-aminobutyric acid are increased; and for 4-chloro-DL-phenylalanine induced insomnia model mice, the sleep condition can be improved, the neurotransmitter level can be recovered, and the effect is equivalent to that of positive drugs such as citalopram, fluoxetine, diazepam and the like.

This invention belongs to the field of biological treatment technology, specifically relating to the application of aquatic plants in removing diazepam residues from water bodies and methods for removing diazepam residues from water. This invention uses water hyacinth and / or water lettuce to remove diazepam residues from water bodies, effectively improving the removal rate of diazepam in water. As the plants grow and absorb the pollutants, the concentration of pollutants in the water gradually decreases, thereby enabling the reuse of the water.

This invention discloses a method for identifying thalidomide R-type chiral molecules. The method includes the following steps: constructing a dataset, dividing the dataset into a training set and a test set according to a preset ratio; the dataset includes ECD spectra of thalidomide R-type chiral molecules, ECD spectra of diazepam molecules, ECD spectra of phenobarbital molecules, and corresponding label data; constructing a recognition model based on a CNN convolutional neural network, inputting the training set and test set into the recognition model for training and performance evaluation to obtain a trained recognition model; inputting the ECD spectrum of the thalidomide chiral molecule to be detected into the trained recognition model to obtain a recognition result, wherein the recognition result is thalidomide R-type chiral molecules or other molecules. This invention enables simple and rapid identification of thalidomide R-type chiral molecules.

This invention discloses a method and application for detecting diazepam based on ratio Raman signals, belonging to the field of food safety and chemical detection technology. The method involves mixing an Au@4-NTP@Ag@ZIF-8 composite material solution with the sample solution to be tested, then dropping the mixture onto a substrate. A Raman spectrometer is used to acquire spectral data at an excitation wavelength of 532 nm, and the intensity ratio I is calculated. 1590 / I 1107 Substitute diazepam concentration to intensity ratio I 1590 / I 1107 The concentration of diazepam in the sample was calculated using a standard curve. The detection method of this invention exhibits high selectivity for diazepam and is unaffected by interference from macromolecules such as proteins, lipids, and glucose, as well as small molecule chemicals in complex matrices. It enables trace, rapid, and accurate detection of diazepam residues in aquatic products, and has significant application prospects in practical scenarios such as port clearance and on-site law enforcement.

The invention discloses magnetic mushroom dreg biochar as well as a preparation method and application thereof, and belongs to the technical field of water treatment. Mushroom residue biochar BC is prepared from shiitake mushroom residues, then the mushroom residue biochar and potassium ferrate K2FeO4 are subjected to ball milling, sufficient stirring, porphyrizing and mixing and then subjected to high-temperature firing, the magnetic mushroom residue biochar MBC composite material is obtained and used for removing diazepam in aquaculture water, and experimental results show that the magnetic mushroom residue biochar MBC composite material can be used for removing diazepam in aquaculture water at the temperature of 20-40 DEG C, so that the magnetic mushroom residue biochar MBC composite material can be used for removing diazepam in aquaculture water. When the pH value is 6-8, the adsorption capacity of the magnetic mushroom dreg biochar MBC on diazepam in water is 32.00 mg / g or above, and the magnetic mushroom dreg biochar MBC shows a good removal effect. The biochar material prepared by the invention is easy to recover under the action of an external magnetic field, is a novel diazepam water pollution purification material which is green, environment-friendly and energy-saving, and meets the requirements of quickly and powerfully guaranteeing the quality safety of aquatic products.

This invention discloses a method for preparing diazepam tablets, comprising the following steps: S1. Diazepam is mixed with corn starch, and 5% corn starch slurry is sprayed in under stirring to obtain wet granules. After being air-dried at room temperature until surface dry, the granules are sized to 0.5-1 mm; S2. The sized wet granules are added to a pelletizing machine, along with dicalcium phosphate and corn starch. The pellets are then sprayed with 5% corn starch slurry and sized to a particle size of 1.6-2 mm; S3. The agglomerated material from step S2 is dried and sized to obtain 1.5 mm granules. After total mixing, the granules are compressed into tablets to obtain diazepam tablets. The preparation method uses corn starch slurry to pre-coat small-diameter granules using a wet method, and then pelletizes them to obtain coarser granules. This method can reasonably control the granulation quality of diazepam and effectively avoid the problems of over-granulation or insufficient granulation.

Autophagy is typically activated by starvation, allowing cells and organisms to mobilize their energy reserves. It is known that pharmacological modulation of autophagy represents a therapeutic potential. Here the inventors report that a protein that is released from cells in an unconventional, autophagy-dependent manner, namely, diazepam binding inhibitor (DBI), regulates autophagy. In particular, the inventors demonstrate that DBI inhibits autophagy and that the supply of recombinant DBI to mice enhanced glycolysis, enhanced lipogenesis, and inhibited fatty acid oxidation. The inventors show that neutralisation of DBI by a monoclonal antibody and an active immunization by means of an immunogenic DBI derivative eliciting autoantibodies induce autophagy and lead to metabolic changes that increase starvation-induced weight loss, reduce food intake upon refeeding, and reduce weight gain in response to hypercaloric diets. Accordingly, the present invention relates to methods and pharmaceutical compositions for modulating autophagy based on the modulation of the activity or expression of DBI.

This provides a method for administering diazepam in a multimodal delivery profile. [Solution] A method is provided for administering diazepam in a multimodal delivery profile, which includes delivering diazepam from a matrix and facilitating the permeation of at least some of the diazepam through mucosal tissue.

This invention provides a rapid detection method for diazepam residues in aquatic products based on immunomagnetic materials. The method utilizes immunomagnetic materials to achieve high-level enrichment and rapid separation of diazepam, thereby improving the sensitivity of the detection method. Combined with colloidal gold detection, it can be used for rapid on-site detection of diazepam residues in aquatic products. This method uses immunomagnetic beads for selective adsorption and separation of diazepam residues in aquatic products. It is simple to operate, highly sensitive, with an average recovery rate of 75.9%–96.0%, a relative standard deviation of 2.96%–8.99%, and a detection limit of 1.0 μg / kg for diazepam. Methodological validation shows that this method has high specificity and good stability, and can be used for rapid on-site detection of diazepam residues in aquatic products, providing technical support for food safety supervision.

The present disclosure provides improved methods, compositions, agents, therapeutic regimens, and systems for cancer treatment, such as improving the outcome of chemo- and / or immunotherapies, and / or inducing autophagy in subjects through the inhibition of extracellular diazepam binding inhibitor (DBI) by various methods.