161 results about "Isoxazole" patented technology

The invention discloses an environment-friendly flame-retardant polyester yarn and a preparation method thereof, and relates to the technical field of textile, and the environment-friendly flame-retardant polyester yarn is prepared from the following raw materials in parts by weight: 100 parts of polyester chips, 10-15 parts of a flame-retardant polymer containing an organic salt structure, 1-3 parts of an antioxidant, 0.8-2 parts of a lubricant, 1-2 parts of benzotriazole sodium and 0.8-1.2 parts of quinoline yellow. The flame-retardant polymer containing the organic salt structure comprises a structural unit introduced by the following monomers: bis (3-aminophenyl) (3, 5-bis (trifluoromethyl) phenyl) phosphine oxide, 3, 7-diamino-5-phenylphenazine chloride and 3, 5-isoxazole dicarboxylic acid. The environment-friendly flame-retardant polyester yarn is good in ultraviolet aging resistance and flame retardance, high in strength and sufficient in softness.

Telomerase reverse transcriptase (TERT) expression enhancing isoxazole-3-carboxamide compounds, and methods for using the same, are provided. These compounds and methods find use in a variety of applications in which increased expression of telomerase reverse transcriptase is desired.

The invention relates to the field of food storage, more specifically to the use of methyl(2R*,4R*)-4-[[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxy-late (I) for sprout inhibition in crops, the use of combinations or compositions comprising thereof for sprout inhibition in crops and a method for controlling sprouts on crops.

The invention relates to the technical field of organic pollutant removal application, and particularly discloses a preparation method and application of a Co and N loaded Ti3Al C2 composite catalyst, and the preparation method comprises the step of successfully doping N and Co into the surface of Ti3Al C2 to synthesize a Co-N-Ti3Al C2 composite material by adopting a simple hydrothermal combined high-temperature carbonization method. Compared with a double combination of the materials, the Co-N-Ti3Al C2 has higher PMS activation and sulfonamide isoxazole (S IZ) degradation capability, and 98.6% of S IZ simulation wastewater with the concentration of 10 mg / L can be removed within 30 minutes by combining the Co-N-Ti3Al C2 with a PMS system. The high catalytic activity of the material is attributed to the strong interaction between pyridine N and Co atoms on the surface of Ti3AlC2, and meanwhile, the strong interaction is also beneficial for inhibiting leaching of Co ions in the material. The Co-N-Ti3Al C2 composite material has the advantages that the Co-N-Ti3Al C2 composite material is high in interference resistance, high in activity in natural water and high in practical applicability.

The invention relates to the technical field of coatings, and discloses a deep-sea pressure-resistant shell protective coating and a preparation method thereof.The preparation method comprises the following steps that a base material is treated, epoxy resin modified polyurethane, reinforcing filler, anti-corrosion filler, a curing agent and a solvent are sequentially added according to a preset proportion and mixed to be uniform, primer is prepared, and the base material is sprayed with the primer; and then taking the isoxazole modified polyurea as finish paint, and spraying the finish paint on one side, deviating from the base material, of the primer to obtain the protective coating. The protective coating has excellent waterproof performance, impact resistance, wear resistance and organism adhesion resistance, and can effectively prevent corrosion factors such as moisture and various ions in seawater and various fouling organisms such as barnacles, mussels, oysters and sponges in seawater from being in contact with the surface of a base material.

This invention relates to the field of coating technology, and discloses a deep-sea pressure-resistant hull protective coating and its preparation method, comprising the following steps: substrate treatment, sequentially adding epoxy resin-modified polyurethane, reinforcing filler, anti-corrosion filler, curing agent and solvent in a predetermined proportion and mixing evenly to obtain a primer, and spraying the primer onto the substrate; then using isoxazole-modified polyurea as a topcoat, spraying the topcoat on the side of the primer away from the substrate to obtain the protective coating. This protective coating has excellent waterproof performance, impact resistance, wear resistance and anti-bioadhesion ability, and can effectively prevent water, various corrosive factors such as ions in seawater, and various polluting organisms in seawater such as barnacles, mussels, oysters and sponges from contacting the substrate surface.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of an isoxazole compound under a visible light catalysis condition. The method comprises the following steps: dissolving a compound 1 in 1, 2-dichloroethane, then adding tert-butyl nitrite, tribromomethane, alkali and a photocatalyst, in an inert gas environment, irradiating with visible light and stirring at room temperature to react, after the reaction is completed, reducing pressure to remove a solvent, and then performing silica gel column purification on a crude product to obtain a product, namely the isoxazole compound. The brand-new method for preparing the isoxazole compound through visible light catalysis is developed, the conditions of high temperature and high pressure in a traditional synthesis method are avoided, energy consumption and environmental pollution are remarkably reduced, and the yield of the isoxazole compound is effectively increased by regulating and controlling reaction conditions and optimizing raw material selection and proportion.

The invention provides a metal peroxide complex molecular catalyst, a preparation method and application thereof, and a continuous synthesis method of pyroxasulfone. A transition metal ion center, an organic ligand, a metal-peroxide bridged bond (M-O-O-M) and other structures are introduced into the prepared metal peroxide complex molecular catalyst, and under the synergistic effect of the structures, the prepared metal peroxide complex molecular catalyst is used for oxidizing thioether into sulfone. The catalyst has excellent selectivity and catalytic efficiency. Particularly, when the catalyst is used for catalyzing 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazole-4-yl)-methylthio]-4, 5-dihydro-5, 5-dimethyl-1, 2-isoxazole to be oxidized and synthesized into pyroxasulfone, the reaction efficiency, selectivity and safety of the oxidation reaction can be effectively improved, and therefore the preparation cost of pyroxasulfone can be further reduced advantageously, and the catalyst can be used for catalyzing 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazole-4-yl)-methylthio]-4, 5-dihydro-5, 5-dimethyl-1, 2-isoxazole to be oxidized and synthesized into pyroxasulfone.

The invention relates to a method for simply and conveniently preparing high-purity lotinia, which comprises the following steps of: reacting 5-acetyl-3-methyl-2-thiophenecarboxylic acid with 2, 2, 2-trifluoro-1-trichlorophenyl ethyl-1-ketone to obtain 3-methyl-5-(4, 4, 4-trifluoro-3-trichlorophenyl butyl-2-enoyl) thiophene-2-formic acid, and reacting the 3-methyl-5-(4, 4, 4-trifluoro-3-trichlorophenyl butyl-2-enoyl) thiophene-2-formic acid with 2, 2, 2-trifluoro-1-trichlorophenyl ethyl-1-ketone to obtain 3-methyl-5-(4, 4, 4-trifluoro-3-trichlorophenyl butyl-2-enoyl) thiophene-2-carboxylic acid. Reacting the isoxazole thiophene formic acid compound with hydroxylamine hydrochloride to obtain an isoxazole thiophene formic acid compound; the preparation method comprises the following steps: reacting 5-[(5S)-5-trichlorophenyl-5-trifluoromethyl-4, 5-dihydro-isoxazole-3-yl]-3-methyl-thiophene-2-formic acid with (R)-1-(p-tolyl) ethyl-1-amine to obtain 5-[(5S)-5-trichlorophenyl-5-trifluoromethyl-4, 5-dihydro-isoxazole-3-yl]-3-methyl-thiophene-2-formic acid; and finally, carrying out condensation on the product and 2-amino-N-trifluoroethyl acetamide hydrochloride, so as to obtain the (5S)-configuration final product lotinib. The method has the advantages of short synthetic route, simple process, mild reaction and high chiral purity and HPLC purity, and is especially suitable for large-scale production.

The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

The invention discloses a self-repairing mute tire and a preparation method thereof, and relates to the technical field of tires, the self-repairing mute tire comprises a tire body, and a self-repairing rubber layer and a mute material which are sequentially attached to the inner wall of the tire body from inside to outside; the self-repairing adhesive layer is prepared from the following components: epichlorohydrin rubber, acrylate rubber, a rosinyl phenyl phosphine oxide isoxazolyl functional polymer, 4, 4-chloroformyl phenyl ether, a catalyst, 2, 2-bis [4-(4-aminophenoxy) phenyl]-1, 1, 1, 3, 3, 3-hexafluoropropane, trithiocyanuric acid, a filler, an accelerant TMTD (Tetramethylthiuram Disulfide) and an auxiliary agent; the rosinyl phenyl phosphine oxide isoxazolyl functional polymer comprises structural units introduced through a condensation polymerization reaction of the following monomers: glycerol triabietate, bis (4-carboxyl phenyl) phenyl phosphine oxide and 3, 5-isoxazoledicarboxylic acid. The tire is remarkable in self-repairing effect, good in mute performance, sufficient in performance stability and long in service life.

This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Compounds of the formula I in which R1, R2, X, Y and Z have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

The invention relates to the field of crop protection, more specifically to the use of methyl (2R*,4R*)-4-[[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxylate (I) and / or a salt thereof for control of undesired vegetation in an area comprising pineapple plants by an application over the top of the pineapple plants.

The invention discloses an isoxazoline hybridized neolignan compound as well as a preparation method and application of the isoxazoline hybridized neolignan compound. The neolignan compound disclosed by the invention is one of isoxazoline magnolol, isoxazoline honokiol, isoxazoline nitrated magnolol and isoxazoline nitrated honokiol derivatives, and has the following chemical general formula: # imgabs0. The neolignan compound disclosed by the invention takes one of magnolol, honokiol, nitrated magnolol or nitrated mangnolia officinalis as a raw material; the preparation method comprises the following steps: by taking triethylamine as alkali and dichloromethane as a solvent, carrying out 1, 3-dipolar cycloaddition reaction on a raw material and alpha-chlorooxime, and separating and purifying to obtain the isoxazoline hybridized neolignan compound. The compound disclosed by the invention has relatively good insecticidal activity on plutella xylostella Linnaeus and Mythimna separata Walker, can be used for preparing a novel efficient insecticide, and is applied to prevention and treatment on the plutella xylostella Linnaeus and the Mythimna separata Walker.

The invention provides application of a substituted isoxazole-5-ketone derivative, and belongs to the field of biological medicine. The invention finds that the compound as shown in the formula I is a high-activity inhibitor of human TyrRs enzyme for the first time, can be used for treating and / or preventing cancers and treating and / or preventing neurodegenerative diseases, provides a new choice for development of human TyrRs enzyme inhibitors and anti-aging and DNA repair drugs, and has a very good application prospect. # imgabs0 #

The invention provides a method for simultaneously enriching disordered protein and a combined three-dimensional genome structure thereof, and relates to the technical field of molecular biology. The method comprises the following steps: after cross-linking cells with formaldehyde and disuccinimide glutaric acid (DSG), carrying out enzyme digestion treatment, terminal repair and adjacent connection by using restriction enzyme Dpn II; after connection, ultrasonically breaking the cell nucleus to obtain an ultrasonically broken product, dividing the ultrasonically broken product into two parts, capturing DNA and a protein complex of one part of the product by using biotinylated isoxazole, digesting protein by using protease, extracting and purifying the DNA, and carrying out library building and sequencing on the purified DNA; the other part of the product is treated by nuclease, protein is extracted, and then protein spectrum analysis is carried out. The method can realize whole genome non-destructive detection of the disordered protein and the three-dimensional structure of the chromatin combined with the disordered protein, and provides an effective way for structural analysis of the disordered protein.

The present invention discloses a dihydrobenzofuranyl-containing isoxazole compound, a preparation method thereof, and an application thereof. The dihydrobenzofuranyl-containing isoxazole compound is shown in formula (I). The compound or its pharmaceutically acceptable salt has a simple preparation method, high yield, and low cost. The obtained 3-(7-methoxy-2,3-dihydrobenzofuran-5-yl)-5-aryl isoxazole compound or its pharmaceutically acceptable salt exhibits high activity against plant pathogens such as cucumber downy mildew, has good control effects, and can be used as an alternative drug for plant fungicides.

The present invention relates to compounds of Formula (I) wherein Ar1, R1 and R2 are as described in the description, and A is 4,5-dihydroisoxazole-3,5-diyl, imidazolidin-4-one-1,3-diyl, oxazol-2-one-3,5-diyl and oxazolidine-2-one-3,5-diyl, 1,2,3-triazole-1,4-diyl, isoxazole-3,5-diyl, imidazole-1, 4-diyl, and isothiazole-3,5-diyl; and their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

The application provides a benzene [d] isoxazole compound and an application thereof. The compound has the structure shown in the following formula I. The benzene [d] isoxazole compound provided by the application can induce degradation of BET protein and / or GSPT1 protein, and has an anti-proliferation effect on cancer cells. Therefore, the compound and the composition provided by the application can be used for preparing a drug for treating or preventing tumor formation, inflammation, viral infection, cell proliferative disorder, autoimmune disease, sepsis and the like.

The present application relates to a kind of synthesis method of indole aldehyde and its derivative, after the reaction of o-nitro halogenated benzene compound and 4-isoxazole boronic acid pinacol ester, ring closure is obtained target product while reducing nitro group.The present application provides a kind of synthesis method of indole aldehyde and its derivative, which generates aldehyde group while synthesizing indole ring, compared with existing reference, the range of raw material selection is wide, route is short, synthesis operation is simple, reaction condition is mild, and environment is friendly.

Telomerase reverse transcriptase (TERT) expression enhancing compounds, and methods for using the same, are provided. In some embodiments, the compounds are azoles, such as such as pyrazoles, imidazoles, triazoles, tetrazoles, thiazoles, isothiazoles, oxazoles, and isoxazoles. In certain embodiments, the azole compound includes an acyl substituent which includes an amide, for example, an alkyl amide. Methods of interest include contacting cells with a TERT expression enhancing effective amount of compound to increase TERT expression in the cells. These compounds and methods find use in a variety of applications in which increased expression of telomerase reverse transcriptase is desired.

The application belongs to the technical field of secondary batteries, and particularly relates to an electrolyte and a lithium ion battery. The electrolyte comprises an isoxazole compound and a fluorinated carboxylic acid ester compound, wherein the mass percentage content A% of the isoxazole compound is 3%-20% based on the total mass of the electrolyte, and the mass percentage content B% of the fluorinated carboxylic acid ester compound is 5%-40%. By combining the use of the isoxazole compound and the fluorinated carboxylic acid ester compound in the electrolyte, the electrolyte can have good kinetic performance and high-temperature stability, so as to widen the charging window of the lithium ion battery, improve the fast-charging capacity of the lithium ion battery, and have high-temperature stability at the same time.

The invention discloses a carbon fluoride battery electrolyte and a carbon fluoride primary battery, and belongs to the technical field of lithium metal primary batteries. The electrolyte comprises a fluorine-containing matrix solution and an isoxazole compound additive, wherein an R1 substituent group of an isoxazole compound is selected from a plurality of functional groups such as alkoxy, fluoroalkyl, carbonyl, ether group, carbamate group and the like. The electrolyte has excellent ionic conductivity at low temperature, and can effectively regulate and control the deposition morphology of a LiF passivation layer, reduce the interface impedance and inhibit the growth of lithium dendrites. A primary battery constructed based on the electrolyte shows excellent low-temperature discharge performance and cycling stability, and is suitable for a high-reliability energy storage scene.

Described herein are methods for detecting conformational diseases, aging, and proteinopathies by measuring the presence of b-isox precipitates and the level of b-isox capture proteins in biological fluids of healthy individuals and patients. The studies have identified additional biomarkers that make it possible to detect biomarkers by adding or not adding isoxazole to the obtained biological fluid sample, thereby making it possible to detect, diagnose or treat human diseases in a human subject. Diagnosis of disease using b-isox and / or biomarkers becomes possible.

The invention relates to novel acridine spiroisoxazole compounds, a preparation method thereof and application of the novel acridine spiroisoxazole compounds in antifungal drugs. The novel acridine spiroisoxazole compounds have the antibacterial activity of 36 compounds, and the 36 compounds have the inhibiting effect on botrytis cinerea, parasite scalaria, rhizoctonia solani, fusarium graminearum and candida albicans. The antifungal biological activity result shows that the compound series all show obvious antibacterial activity. The compound is determined as a broad-spectrum antibacterial candidate due to the comprehensive antibacterial characteristics of the compound, and the EC50 value (5.0 + / -0.4 mu g / mL) of H35 shows 1.5 times, 2.2 times and 3.2 times of titer advantages compared with positive control drugs famoxadone (7.6 mu g / mL), chlorothalonil (11.1 mu g / mL) and carbendazim (15.9 mu g / mL) respectively. The spiro structure of the compound can significantly improve the antibacterial activity of the compound, the preliminary mechanism research target shows that the compound is related to fungal membrane damage, and in addition, the compound H35 has protection and treatment effects on botrytis cinerea infection in corn, which shows that the compound H35 has agricultural application potential.

The present invention relates to the crystal forms of methyl(2R*,4R*)-4-[[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxylate (I) existing in the form of two stereoisomers: Methyl(2R,4R)-4-[[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]-amino]tetrahydrofuran-2-carboxylate of formula (Ia) and methyl (2S,4S)-4-[[(5S)-3-(3,5-difluoro-phenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxylate of formula (Ib), to a method for preparing the crystal forms, to the use for preparing stable agrochemical formulations, and to the use in the field of agriculture for controlling harmful plants.

The invention relates to the technical field of pesticides. The structural formula of an isoxazole persulfate compound is shown as a formula (I). The invention particularly relates to a synthesis method of a persulfide compound containing isoxazole and prevention and control of the persulfide compound on agricultural and forestry diseases, weeds and weeds. The method is mild in reaction condition and high in practicability and conforms to the modern green chemistry concept. Meanwhile, the compound has a good control effect on agricultural and forestry diseases, weeds and weeds, and the chemical structure and the application effect of the compound are not disclosed in existing reports related to sterilization, insecticide and herbicides.