91 results about "Isoxazole" patented technology

The invention relates to the technical field of organic pollutant removal application, and particularly discloses a preparation method and application of a Co and N loaded Ti3Al C2 composite catalyst, and the preparation method comprises the step of successfully doping N and Co into the surface of Ti3Al C2 to synthesize a Co-N-Ti3Al C2 composite material by adopting a simple hydrothermal combined high-temperature carbonization method. Compared with a double combination of the materials, the Co-N-Ti3Al C2 has higher PMS activation and sulfonamide isoxazole (S IZ) degradation capability, and 98.6% of S IZ simulation wastewater with the concentration of 10 mg / L can be removed within 30 minutes by combining the Co-N-Ti3Al C2 with a PMS system. The high catalytic activity of the material is attributed to the strong interaction between pyridine N and Co atoms on the surface of Ti3AlC2, and meanwhile, the strong interaction is also beneficial for inhibiting leaching of Co ions in the material. The Co-N-Ti3Al C2 composite material has the advantages that the Co-N-Ti3Al C2 composite material is high in interference resistance, high in activity in natural water and high in practical applicability.

This invention relates to the field of coating technology, and discloses a deep-sea pressure-resistant hull protective coating and its preparation method, comprising the following steps: substrate treatment, sequentially adding epoxy resin-modified polyurethane, reinforcing filler, anti-corrosion filler, curing agent and solvent in a predetermined proportion and mixing evenly to obtain a primer, and spraying the primer onto the substrate; then using isoxazole-modified polyurea as a topcoat, spraying the topcoat on the side of the primer away from the substrate to obtain the protective coating. This protective coating has excellent waterproof performance, impact resistance, wear resistance and anti-bioadhesion ability, and can effectively prevent water, various corrosive factors such as ions in seawater, and various polluting organisms in seawater such as barnacles, mussels, oysters and sponges from contacting the substrate surface.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of an isoxazole compound under a visible light catalysis condition. The method comprises the following steps: dissolving a compound 1 in 1, 2-dichloroethane, then adding tert-butyl nitrite, tribromomethane, alkali and a photocatalyst, in an inert gas environment, irradiating with visible light and stirring at room temperature to react, after the reaction is completed, reducing pressure to remove a solvent, and then performing silica gel column purification on a crude product to obtain a product, namely the isoxazole compound. The brand-new method for preparing the isoxazole compound through visible light catalysis is developed, the conditions of high temperature and high pressure in a traditional synthesis method are avoided, energy consumption and environmental pollution are remarkably reduced, and the yield of the isoxazole compound is effectively increased by regulating and controlling reaction conditions and optimizing raw material selection and proportion.

The invention discloses a self-repairing mute tire and a preparation method thereof, and relates to the technical field of tires, the self-repairing mute tire comprises a tire body, and a self-repairing rubber layer and a mute material which are sequentially attached to the inner wall of the tire body from inside to outside; the self-repairing adhesive layer is prepared from the following components: epichlorohydrin rubber, acrylate rubber, a rosinyl phenyl phosphine oxide isoxazolyl functional polymer, 4, 4-chloroformyl phenyl ether, a catalyst, 2, 2-bis [4-(4-aminophenoxy) phenyl]-1, 1, 1, 3, 3, 3-hexafluoropropane, trithiocyanuric acid, a filler, an accelerant TMTD (Tetramethylthiuram Disulfide) and an auxiliary agent; the rosinyl phenyl phosphine oxide isoxazolyl functional polymer comprises structural units introduced through a condensation polymerization reaction of the following monomers: glycerol triabietate, bis (4-carboxyl phenyl) phenyl phosphine oxide and 3, 5-isoxazoledicarboxylic acid. The tire is remarkable in self-repairing effect, good in mute performance, sufficient in performance stability and long in service life.

The application provides a benzene [d] isoxazole compound and an application thereof. The compound has the structure shown in the following formula I. The benzene [d] isoxazole compound provided by the application can induce degradation of BET protein and / or GSPT1 protein, and has an anti-proliferation effect on cancer cells. Therefore, the compound and the composition provided by the application can be used for preparing a drug for treating or preventing tumor formation, inflammation, viral infection, cell proliferative disorder, autoimmune disease, sepsis and the like.

The present application relates to a kind of synthesis method of indole aldehyde and its derivative, after the reaction of o-nitro halogenated benzene compound and 4-isoxazole boronic acid pinacol ester, ring closure is obtained target product while reducing nitro group.The present application provides a kind of synthesis method of indole aldehyde and its derivative, which generates aldehyde group while synthesizing indole ring, compared with existing reference, the range of raw material selection is wide, route is short, synthesis operation is simple, reaction condition is mild, and environment is friendly.

The application belongs to the technical field of secondary batteries, and particularly relates to an electrolyte and a lithium ion battery. The electrolyte comprises an isoxazole compound and a fluorinated carboxylic acid ester compound, wherein the mass percentage content A% of the isoxazole compound is 3%-20% based on the total mass of the electrolyte, and the mass percentage content B% of the fluorinated carboxylic acid ester compound is 5%-40%. By combining the use of the isoxazole compound and the fluorinated carboxylic acid ester compound in the electrolyte, the electrolyte can have good kinetic performance and high-temperature stability, so as to widen the charging window of the lithium ion battery, improve the fast-charging capacity of the lithium ion battery, and have high-temperature stability at the same time.

The invention discloses a carbon fluoride battery electrolyte and a carbon fluoride primary battery, and belongs to the technical field of lithium metal primary batteries. The electrolyte comprises a fluorine-containing matrix solution and an isoxazole compound additive, wherein an R1 substituent group of an isoxazole compound is selected from a plurality of functional groups such as alkoxy, fluoroalkyl, carbonyl, ether group, carbamate group and the like. The electrolyte has excellent ionic conductivity at low temperature, and can effectively regulate and control the deposition morphology of a LiF passivation layer, reduce the interface impedance and inhibit the growth of lithium dendrites. A primary battery constructed based on the electrolyte shows excellent low-temperature discharge performance and cycling stability, and is suitable for a high-reliability energy storage scene.

The invention relates to novel acridine spiroisoxazole compounds, a preparation method thereof and application of the novel acridine spiroisoxazole compounds in antifungal drugs. The novel acridine spiroisoxazole compounds have the antibacterial activity of 36 compounds, and the 36 compounds have the inhibiting effect on botrytis cinerea, parasite scalaria, rhizoctonia solani, fusarium graminearum and candida albicans. The antifungal biological activity result shows that the compound series all show obvious antibacterial activity. The compound is determined as a broad-spectrum antibacterial candidate due to the comprehensive antibacterial characteristics of the compound, and the EC50 value (5.0 + / -0.4 mu g / mL) of H35 shows 1.5 times, 2.2 times and 3.2 times of titer advantages compared with positive control drugs famoxadone (7.6 mu g / mL), chlorothalonil (11.1 mu g / mL) and carbendazim (15.9 mu g / mL) respectively. The spiro structure of the compound can significantly improve the antibacterial activity of the compound, the preliminary mechanism research target shows that the compound is related to fungal membrane damage, and in addition, the compound H35 has protection and treatment effects on botrytis cinerea infection in corn, which shows that the compound H35 has agricultural application potential.

The present invention relates to the crystal forms of methyl(2R*,4R*)-4-[[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxylate (I) existing in the form of two stereoisomers: Methyl(2R,4R)-4-[[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]-amino]tetrahydrofuran-2-carboxylate of formula (Ia) and methyl (2S,4S)-4-[[(5S)-3-(3,5-difluoro-phenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxylate of formula (Ib), to a method for preparing the crystal forms, to the use for preparing stable agrochemical formulations, and to the use in the field of agriculture for controlling harmful plants.

The invention relates to the technical field of pesticides. The structural formula of an isoxazole persulfate compound is shown as a formula (I). The invention particularly relates to a synthesis method of a persulfide compound containing isoxazole and prevention and control of the persulfide compound on agricultural and forestry diseases, weeds and weeds. The method is mild in reaction condition and high in practicability and conforms to the modern green chemistry concept. Meanwhile, the compound has a good control effect on agricultural and forestry diseases, weeds and weeds, and the chemical structure and the application effect of the compound are not disclosed in existing reports related to sterilization, insecticide and herbicides.

The invention discloses a dry suspending agent containing isotolfenpyrad as well as a preparation method and application thereof, and relates to the field of pesticides, the dry suspending agent is prepared from the following raw materials in parts by weight: 20 to 50 parts of pesticide active ingredients, 10 to 25 parts of wetting dispersant, 0.1 to 1 part of penetrant, 0.2 to 1.2 parts of pH regulator, 1 to 5 parts of polyalkylene oxide modified silane and 38 to 70 parts of filler, the pesticide effective component comprises isotolfenpyrad. The polyalkylene oxide modified silane adopted by the dry suspending agent disclosed by the invention can be compatible and synergistic with fillers such as potassium fulvate, amino acid and molasses powder, so that the contact angle and surface tension of the agent on leaf surfaces of crops such as rice are reduced, the adhesive force of the agent on the rice crops is increased, and meanwhile, the evaporation rate of liquid medicine during spraying is also reduced; and finally, the loss of the pesticide during spraying is reduced, the utilization rate of the pesticide liquid is improved, and the insecticidal efficiency is improved.

The application provides an application of isoxazole 9 (ISX-9) in promoting mesenchymal stem cell osteogenic differentiation and bone injury regeneration repair. ISX-9 is a small molecule compound, and has the characteristics of easy to obtain, controllable structure and low cost. The in vitro experiment of the application shows that ISX-9 has the ability to induce mesenchymal stem cell osteogenic differentiation and promote the formation of mineralized nodules; the in vivo experiment shows that the hydrogel wrapped with ISX-9 can promote the regeneration repair of mouse skull defects, indicating that ISX-9 has good osteogenic induction and is a potential bone regeneration repair drug. Therefore, ISX-9 can promote mesenchymal stem cell osteogenic differentiation and be applied to bone tissue regeneration repair. The application also provides a direct action target and action mechanism of ISX-9 in promoting osteogenic differentiation. The application further provides a new drug sustained release delivery system of ISX-9, which is helpful for the application from theoretical research to clinical application.

The invention provides an aryl [d] isoxazolyl imidazole compound as well as a preparation method and application thereof, and the structure of the aryl [d] isoxazolyl imidazole compound is as shown in formula I. The aryl [d] isoxazolyl imidazole compound provided by the invention can be effectively combined with CBP and / or p300 protein and inhibit the activity of the CBP and / or p300 protein, so that the expression of downstream genes of the CBP and / or p300 protein is regulated; the effect of treating related cancers, cell proliferative disorder, inflammation, autoimmune diseases or septicemia is achieved.

A composition and method for transdifferentiating non-neuronal cells into neurons. Disclosed is a composition for inducing cell transdifferentiation, comprising a Myosin inhibitor, and an isoxazole compound and / or its derivatives. Also disclosed is a method for inducing non-neuronal cells to transdifferentiate into neurons, comprising: culturing non-neuronal cells in an induction culture medium comprising a Myosin inhibitor, and then culturing them in a maturation culture medium comprising a Myosin inhibitor and an isoxazole compound and / or its derivatives until mature neurons are obtained. Also disclosed is a use of the composition in inducing non-neuronal cells to transdifferentiate into neurons, and a method for transdifferentiating non-neuronal cells in a subject into neurons, comprising administering an effective amount of a Myosin inhibitor and an isoxazole compound and / or its derivatives to the subject. The method of the present application is simple, requiring only two simple small molecule combination treatments, without the need for regulation by overexpression of specific genes, and can be performed efficiently both in vivo and in vitro, thereby achieving simple and efficient neuronal regeneration.

The application belongs to the field of dermatosis drugs and relates to application of 3-substituted naphtho[2,3-b]isoxazole (thiazole)-4,9-dione derivatives in anti-psoriasis, a structural formula of the 3-substituted naphtho[2,3-b]isoxazole (thiazole)-4,9-dione derivative is shown in general formula (I): wherein X is selected from oxygen or a sulfur atom; Y and Z are independently selected from carbon or nitrogen atoms; and substitution definitions of R1 and R2 are shown in the specification. The 3-substituted naphtho[2,3-b]isoxazole (thiazole)-4,9-dione derivative has significant HaCaT proliferation inhibition activity, cell activity of some compounds is more than 10 times higher than that of a positive control, and IC50 even reaches a nanomolar level. The 3-substituted naphtho[2,3-b]isoxazole (thiazole)-4,9-dione derivative can significantly down-regulate p-STAT3 level, dose-dependently inhibit the activation process of STAT3, and has better inhibition capacity than a control STA21. Animal experiments show that the anti-psoriasis effect is better than that of a drug anthralin.

The present invention relates to a novel isoxazole compound as a TM4SF5 specific inhibitor and a use thereof, and more specifically, to a novel isoxazole compound, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the same, in which the compound can inhibit the expression, protein-protein binding or signal transduction activity of a TM4SF5 protein, and can inhibit the TM4SF5 protein. Or the immune checkpoint function is inhibited by activating the killing efficacy of T and NK immune cells or regulating the distribution of the T and NK immune cells. Specifically, the isoxazole compound provided by the invention is a TM4SF5 specific isoxazole compound, and can inhibit immune checkpoints of NK cells, so that the isoxazole compound has the advantage of being used as an inhibitor of liver diseases or liver cancer.

The present application provides a kind of formula I compound its stereoisomer and salt, formula I structure as follows: Wherein R is selected from hydrogen, optionally substituted C1-C6 Alkyl, optionally substituted phenyl or optionally substituted benzyl.The present application compound and herbicide composition use show good plant safety, with better application prospect.

The invention discloses an oridonin derivative and a preparation method and application thereof, and belongs to the technical field of biological medicines.The preparation method comprises the steps that S1, oridonin, 4-dimethylaminopyridine and anhydrous dichloromethane are added into an eggplant-shaped bottle to be stirred; s2, adding an intermediate into the mixed solution stirred in the step S1, then adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, heating and stirring; s3, after it is monitored through TLC that the reaction in S2 is complete, dichloromethane and distilled water are added for extraction, an organic phase obtained through extraction is washed, dried, concentrated under reduced pressure and purified, and the oridonin derivative is obtained. According to the oridonin derivative and the preparation method and application thereof, the C-14-site hydroxyl of oridonin is modified, heterocyclic segments of indole, oxadiazole, pyrazole, triazolone and isoxazole are introduced, the targeting property and affinity to HK1 are enhanced, and the anti-proliferative activity to tumor cells is improved.

The present disclosure provides compounds represented by Formula I:and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

In one aspect, the present disclosure relates to compounds of Formula (I)-(IV), which inhibit palmitoyl transferases and / or palmitoylation, pharmaceutical compositions thereof, and methods of using the same. In certain embodiments, the present disclosure relates to methods of treating, preventing, and / or ameliorating cancer in a subject. In certain embodiments, the cancer is lung cancer and / or pancreatic cancer. In certain embodiments, the present disclosure relates to methods of inhibiting palmitoylation in a subject. In certain embodiments, EGFR palmitoylation is inhibited in a subject.

The invention relates to the technical field of preparation of phenylisoxazole derivatives, in particular to phenylisoxazole derivatives containing pyrazole or triazole amide as well as a preparation method and application of the phenylisoxazole derivatives containing pyrazole or triazole amide. The phenylisoxazole derivative containing pyrazole or triazole amide provided by the invention has good insecticidal activity on lepidoptera pests such as plutella xylostella, spodoptera frugiperda, beet armyworm, cotton bollworm and the like, and can be used as a pesticide active component to be applied to prevention and control of agricultural pests and preparation of insecticides.

The invention provides a method for analyzing an anti-eczema effect target spot of traumatology based on network pharmacology. The method comprises the following steps: firstly, screening out seven representative active components through a SwisSADME platform, predicting by integrating SwisTarget Prediction, SEA and ChEMBL databases to obtain 367 drug targets, and analyzing to obtain 82 intersection targets; a PPI network is constructed based on an STRING database, and 10 core targets such as IL6, TNF and EGFR are screened out through topology analysis. GO / KEGG enrichment analysis reveals that the GO / KEGG is significantly enriched in the processes of IL-17 signal pathway, epidermal barrier repair and the like. Molecular docking verification proves that isofraxidin, scopoletin and verbenin are strongly combined with EGFR (epidermal growth factor receptor) targets. According to the method, a multi-component-multi-target-multi-channel synergistic eczema treatment mechanism of traumatology is systematically analyzed, and a theoretical basis is provided for preparation optimization.

The invention relates to the technical field of organic chemistry, and particularly discloses an isoxazole amide derivative with a structure shown in a general formula III as well as a preparation method and application of the isoxazole amide derivative. The isoxazole amide derivative disclosed by the invention shows remarkable antibacterial activity on staphylococcus aureus, escherichia coli, methicillin-resistant staphylococcus aureus (MRSA) and fluoroquinolone-resistant escherichia coli (FREC), the activity of part of compounds is superior to that of gentamicin, and the isoxazole amide derivative has broad-spectrum antibacterial potential and can be used for preparing medicines for treating related bacterial infections.

Described herein are detecting methods for conformational disease, aging and proteinopathies, by measuring the presence of b-isox-precipitates and the levels of b-isox-captured proteins in biofluids of healthy individuals and patients. Research identified additional biomarkers, which made it possible to detect, diagnose or treat, a human disease in a human subject by, with or without adding an isoxazole to an obtained biofluid sample, detecting the biomarker. Use of b-iso and / or biomarkers for diagnosing the disease are made possible.

The application discloses application of an amino isoxazole compound in preventing and treating Ralstonia solanacearum, and belongs to the technical field of plant bacterial wilt prevention and treatment; the amino isoxazole compound is 5,6-dihydro-4H-cyclopenta[c]isoxazol-3-amine; it is found for the first time that 5,6-dihydro-4H-cyclopenta[c]isoxazol-3-amine has strong inhibitory activity on Ralstonia solanacearum; experiments show that the MIC of 5,6-dihydro-4H-cyclopenta[c]isoxazol-3-amine on Ralstonia solanacearum is 6 mu g / mL at 24 h, is equivalent to that of benzio carb, and can be used for preventing and treating plant bacterial wilt, thereby providing a new candidate compound for development of a bactericide for Ralstonia solanacearum.

The application discloses a kind of diazomethyl isoxazole energetic compounds and synthesis method thereof, its structural formula is as shown in formula (I).The application also provides the synthesis method of the compound.The energetic compound disclosed in the application is liquid at room temperature, the thermal decomposition temperature is 204 DEG C, the heat of formation is 739.64 kJ / mol, and it has good application potential in energetic plasticizer.

The invention provides a preparation method of an isoxazole-oxadiazole compound, which comprises the following steps: reacting 4-chloro-2-fluoro-3-vinylbenzoic acid with tert-butyloxycarboryl hydrazine in the presence of a condensing agent and a catalyst, then removing a protecting group under an acidic condition to obtain an intermediate 4-chloro-2-fluoro-3-vinylbenzoyl hydrazine, and then reacting with N, N-dimethylformamide to obtain the isoxazole-oxadiazole compound. The method comprises the following steps: cyclizing N, N '-carbonyldiimidazole in the presence of alkali, carrying out an O-alkylation reaction with an alkylation reagent R1-X in the presence of alkali, and carrying out an olefin dihydroxylation-sodium periodate oxidation cleavage reaction in the presence of an oxidant and a catalyst; reacting with hydroxylamine in the presence of alkali, and finally carrying out 1, 3-dipolar cycloaddition reaction with an acrylate compound in the presence of alkali and an oxidizing agent. The method is carried out at room temperature, has the advantages of mild conditions, simplicity in operation and the like, is wider in application range compared with a traditional synthesis method, and has important synthesis application value.

The invention relates to the field of crop protection, more specifically to the use of methyl (2R*,4R*)-4- [[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4H-isoxazole-5-carbonyl]amino]tetrahydrofuran-2-carboxylate (I) and / or a salt thereof for control of undesired vegetation at a cultivation site for dicotyledonous crop plants through an application prior to the emergence of the dicotyledonous crop plants.

The invention relates to the technical field of material preparation, in particular to an isoxazole-containing bridged pyrazolopyran quinoline derivative and a synthesis method thereof. The isoxazole bridged pyrazolopyranoquinoline derivative is efficiently prepared by taking pyrazolone as a carbon attack point or an oxidation attack point and a 2-((halogenated quinoline-3-yl) vinyl) isoxazole compound through a base catalysis series cyclization reaction, and has the characteristics of easily available raw materials, simplicity and convenience in operation, high atom economy and the like, and meanwhile, the isoxazole bridged pyrazolopyranoquinoline derivative can be used for preparing the pyrazolopyranoquinoline derivative. The isoxazole bridged pyrazolopyranoquinoline derivative prepared by the invention combines two known dominant structures with biological activity, namely isoxazole and pyrazolopyranoquinoline, and is expected to generate a synergistic effect, so that the isoxazole bridged pyrazolopyranoquinoline derivative has important application prospect and implementation value in drug research and development.