88 results about "Famotidine" patented technology

The present invention provides a fast-disintegrating tablet (RDT) and the method of preparing the RDT. The RDT contains a plurality of microcapsules which contains an active pharmaceutical ingredient surrounded by a polymeric matrix formed by a hydrogel. The microcapsules are separated from each other by a surfactant, particularly lecithin. The RDT is particularly suitable for use as a drug delivery system for antiacid or antiulcer drugs, such as famotidine. The RDT is further characterized by their its fast disintegration time of about 3 second to 3 minutes.

A method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine is administered three times per day.

Stable pharmaceutical compositions of famotidine and ibuprofen in a single unit dosage form are disclosed herein. The compositions comprise a famotidine core having a reduced or minimal surface area surrounded by a layer of ibuprofen. In some embodiments, the ibuprofen is in direct physical contact with the famotidine.

A method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine, in admixture, is administered three times per day.

An oral dosage form for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine, in separate compartments, in amounts suitable for three times per day administration.

A stick of gum is provided containing therapeutic benefits of non-steroid anti-inflammatory drugs for inflammation in conditions such as arthritis, and also alleviates subsequent side effects of NSAID administration, as well as antacid effects from compounds such as an H2 antagonist (ranitidine, cimetidine, famotidine) and/or a proton pump inhibitor (such as lansoprazole, pantoprazole, omeprazole, esomeprazole or rabeprazole) and/or an acid pump antagonist selected from the group of soraprazan, AZD0865, YH1885 and CS-526.

A compound medicine taken orally is prepared from famotidine, cyclodextrin and antiacid through including the famotidine particles by cyclodextrin, and mixing the inclusion compound with antiacid.

The invention relates to a process for preparing compound Famotidine chewable tablets, which comprises separating Famotidin from calcium carbonate and magnesium hydroxide, thus no reactions with be produced between the effective compositions, thus the product stability can be improved.

A Chinese medicine in the form of powder for treating gastric ulcer and duodenal ulcer is prepared through decocting astragalus root, white peony root and liquorice root, filtering, concentrating, depositing in alcohol, distilling to remove alcohol, concentrating, mixing with cuttlefish bone powder and famotidine, drying and pulverizing. Its advantages are high cure rate and low cost.

The invention relates to a famotidine composition for injection. The famotidine composition comprises famotidine and L-aspartic acid; and the preparation method of the composition comprises the following steps of: 1) preparing: placing the famotidine and the L-aspartic acid in a preparation tank in a weight proportion of 1 to 0.4, filling injection water, stirring to completely dissolve the materials and uniformly mixing; 2) performing aseptic filtration, sub-packaging and partially stoppering; and 3) freeze-drying under vacuum to prepare the composition. The composition has a simple formula, an advanced process, good appearance molding, uniform and stable quality, uniform and accurate content, no moisture and high stability.

The invention belongs to the technical field of pharmaceutical preparation and discloses a high-density gastric stasis osmotic pump controlled release famotidine preparation and a preparation method thereof. The osmotic pump controlled release preparation is made from a tablet core containing famotidine and a semi-permeable coating membrane with drug release pores which is coated outside the tablet core; the tablet core is made from 400mg of the famotidine, 100-150mg of medicinal ferrous powder, 30-90mg of a suspension, 20-80mg of an osmotic pressure active material and 0.5-2mg of a lubricant; the semi-permeable coating membrane is made from 10-20g of a semi-permeable polymer material and 2-5g of a water-soluble pore making agent, and accounts for 5-9% of the weight of the tablet core; and the drug release pores are drilled at one side or two sides of a coating tablet by laser and by mechanical means. The medicinal ferrous powder is added to the tablet core to cause the drug to be more completely released from the drug release pores; meanwhile, the medicinal ferrous powder increases the density of the preparation; therefore, the preparation is stagnated in the folds of the lower part of the stomach, which greatly prolongs the release time of the pharmaceutical preparation in the stomach and improves the absorption capacity of the pharmaceutical preparation.

The present invention is Lafutidine injection for intravenous injection and intramuscular injection. The recipe of the Lafutidine injection includes Lafutidine, organic solvent, surfactant, antioxidant, osmotic pressure regulator and water for injection. Compared with Lafutidine tablet, the Lafutidine injection has fast effect, short peak reaching time in the blood high medicine concentration andhigh treating effect; and compared with Famotidine or Ranitidine injection, the Lafutidine injection has less dosage and higher curative effect in treating gastric ulcer.

The invention discloses a method for measuring a buprofen/famotidine compound preparation content. The method comprises the following steps of: dissolving a compound preparation sample by methanol as a solvent; measuring by using a high performance liquid chromatography, wherein the measurement wavelength is 265nm; and with an octadecyl silane bonded silica gel filler as a stationary phase, performing gradient elution according to the following mobile phase conditions: the mobile phase A is a 0.02mol/L sodium acetate solution, pH is regulated to be 4.0 by using phosphoric acid, and the mobile phase B is acetonitrile. The method provided by the invention is time-saving and labor-saving, high in precision, accurate in content determination result and excellent in repeatability, and can be used for conventional analysis and quality control on the buprofen/famotidine compound preparation sample.

The invention provides a preparation method of a famotidine preparation for injection, and relates to the technical field of medicaments. The method comprises the following steps: s1, weighing a prescription amount of aspartic acid, adding a proper amount of water for injection, keeping the liquid preparation temperature within the range of 20-30 DEG C, performing stirring to dissolve the asparticacid, sequentially adding prescription amounts of famotidine, mannitol and poloxamer-188, and adding the water for injection to full dose; s2, adding activated carbon, and performing stirring at normal temperature, wherein the dosage of the activated carbon is 0.1% (g/mL) of the total amount of the liquid medicine; and s3, after sterilization, filtration and split charging, adopting a rubber plughalf-pressure plug of which the drying weight loss is controlled to be 0.15% or below after cleaning and sterilization, and performing freeze-drying according to set freeze-drying parameters. According to the invention, moisture can be kept stable in the storage period, the main drug dissolving speed can be increased, and the liquid preparation time is obviously shortened.

The invention provides a famotidine composition for injection, and relates to the technical field of medicine manufacturing. The main medicine of the composition comprises famotidine and melatonin, wherein the melatonin comprises a quick release part and a cyclodextrin-included slow release part. According to the famotidine composition for injection provided by the invention, the therapeutic effect of famotidine is improved, instability caused by oral administration of MT (Melatonin) is avoided and MT is quick to distribute and eliminate and the like, and the first pass effect of MT is reduced. The design of dosage combining quick release and slow release is in accordance with secretion characteristic of MT, so that the problem of half-life period of MT is solved and the bioavailability of melatonin is improved. Melatonin combined with famotidine can be used for effectively inhibiting the secretion of gastric acid, so that the composition has a good synergistic effect for treating benign active gastric ulcer.

The invention provides a famotidine inclusion compound and a preparation method. The inclusion compound comprises famotidine and glyceryl behenate. The preparation method comprises the following steps: the glyceryl behenate is heated to 80 DEG C through water bath or steam, stirring and fusion are performed on the glyceryl behenate at the temperature of 80 DEG C; the famotidine, which is equal to the glyceryl behenate in weight, is added into the fused glyceryl behenate, stirring and mixing are performed for 25-35 minutes at the temperature of 80 DEG C or homogenizing is performed through a homogenizer; the mixture prepared through the step 2 is fed into a spray dryer for drying before cooling, so that the famotidine inclusion compound is obtained. The famotidine inclusion compound has the benefits as follows: because the glyceryl behenate has the characteristics of hydrophobicity, anti-oxidation, hydrolysis prevention and the like, and is used for famotidine inclusion, the water absorption capacity of the famotidine self is reduced, and the famotidine is separated from other substances in the compound, the stability of the drugs is enhanced, the drug therapeutic effect is maintained, the bitter taste of the famotidine is covered up, and the bad taste during taking is reduced.

The present invention belongs to the field of medicine producing technology, and is especially process of refining famotidine material. The technological scheme of the present invention is that the famotidine material refining process includes the following steps: weighing famotidine material in certain ratio, adding water solution of alcohol, heating reflux to form light orange solution, hot filtering, cooling to room temperature, cooling in cold storage room of refrigerator, suction filtering, washing and vacuum drying to obtain white powder. The present invention has the advantages of simple technological process, high safety, no toxicity and capacity of eliminating impurity from famotidine material effectively.

The invention discloses a famotidine and adipic acid eutectic crystal and a preparation method thereof. The eutectic crystal is a hydrate containing one molecule of water, and the molar ratio of famotidine to adipic acid is 2: 1. The invention also discloses a preparation method of the eutectic crystal. The famotidine-adipic acid eutectic crystal provided by the invention has a characteristic melting point, an X-ray powder diffraction pattern and the like. According to the eutectic crystal, the solubility of famotidine in water is improved, the stability of famotidine under high-temperature and high-humidity conditions is improved, and the eutectic crystal has the potential of improving the bioavailability of famotidine. The preparation method of the famotidine-adipic acid eutectic crystal is simple in step, easy to operate and good in reproducibility, and has great commercial application value.

The present invention relates to a preparation method of H2 receptor antagonist compound salt and its application. The optimized H2 receptor antagonist is famotidine, and the optimized metal ions forming compound salt are bismuth and ammonium. Said compound salt is applicable for curing gastrointestinal disorder, specially for curing gastroduodenal diseases. It also has the stronger protecting action for rat acute injury of gastric mucosa due to ethyl alcohol, and has the action of raising gastric juice acidity and reducing gastric acid secretion for gastric secretion due to pyloric ligation.

The invention discloses a method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine. The method comprises the following steps: (1) selecting chromatographic conditions; (2) selecting mass spectrometric conditions; (3) preparing a standard solution; (4), preparing samples; (5), detecting and calculating. Tests prove that the method is rapid and high in specificity; the method is suitable for detecting the illegally added ranitidine hydrochloride, famotidine, lafutidine, nizatidine, cimetidine and other chemical medicines in Chinese patent medicines and health-care foods which have the effects of invigorating the stomach, improving the gastrointestinal function (having an auxiliary protection effect on gastric mucosal injury) and having an auxiliary protection effect on gastric mucosal injury or in other foods illegally claimed to have said functions.

The invention relates to a famotidine composition prepared by a freeze-drying method for injection. The famotidine composition comprises famotidine, mannitol and aspartate; water content of the composition is lower than 5%; the composition is dissolved into solution with concentration 1mg/ml by water for injection and pH value of the solution ranges from 4.5 to 6.0. The composition is prepared by the steps of weighing a certain dosage of famotidine, mannitol and aspartate according to a formula, adding in an appropriate amount of water for injection, stirring to dissolve the components, adding in activated carbon with stirring and then removing the carbon by filtering, replenishing water for injection to full dose of the formula, stirring uniformly to obtain a solution, measuring/regulating pH value of the solution to 4.5-6.0, sterilizing and filtering the solution to obtain liquid medicine, filling the liquid medicine in penicillin bottles, and finally removing water content by the freeze drying method and plugging the bottles. The famotidine composition prepared by the freeze-drying method for injection has excellent pharmaceutical property.