2 results about "Ranitidine" patented technology

The invention discloses a high-stability lafutidine tablet and a production process thereof, and relates to the technical field of medicine preparation. According to the invention, the solid dispersion system of lafutidine is prepared, so that the dissolution rate of lafutidine is increased, and the bioavailability is improved; through the synergistic effect of dry rolling and a stabilizer, the dry rolling densifies a solid dispersion system, improves the particle density, increases the intermolecular Van der Waals force, reduces the porosity and improves the stability of a microstructure; the particle size is controlled within the range of 50-70 meshes through screening, so that the uniformity of the system can be ensured, and the stability of the lafutidine can be remarkably improved; the high-stability lafutidine tablet is prepared by carrying out phenolation modification on vitamin C, endowing the characteristics of swallowing free radicals and absorbing ultraviolet rays and enhancing the antioxidant activity of the vitamin C, compounding phenolic vitamin C, tocopherol and mannitol to obtain a stabilizer, and improving the compatibility and flowability of the stabilizer and lafutidine.

This invention belongs to the field of novel pharmaceutical uses, and more specifically, relates to the application of cinnabar extract in the preparation of drugs for the prevention and treatment of gastric ulcers. The preparation method of the extract is as follows: Cinnabar is extracted by reflux with a 60%–80% (v / v) ethanol solution. The extracts are combined, evaporated to dryness, and then mixed with water to obtain an extract. The extract is then diluted, adsorbed onto a macroporous resin, and eluted with a 35%–45% (v / v) ethanol solution. The eluent is then evaporated to dryness to obtain the final extract. Experiments show that this extract can significantly reduce gastric mucosal damage in mice, decrease the ulcer index, and increase the ulcer inhibition rate, with effects superior to the positive control drug ranitidine. Its mechanism of action includes reducing inflammatory cell infiltration, decreasing the content of pro-inflammatory factors, pepsin activity, and malondialdehyde content, and increasing antioxidant enzyme activity. This invention provides a new natural drug source for the treatment of gastric ulcers, with a clearly defined active pharmaceutical ingredient and promising clinical application prospects.