11results about How to "Meet medication needs" patented technology

The invention discloses a pharmaceutical composition for reversing pancreatic cancer gemcitabine resistance. The pharmaceutical composition is prepared from active ingredients such as a radix sophorae flavescentis extract, a poria cocos extract, emodin, glucosamine, gambogic acid, tranilast and aspirin. The preparation method of the sophora flavescens extract and the poria cocos extract comprises the steps of raw material pretreatment, dynamic ultrasonic-microwave synergistic extraction, membrane separation and nanofiltration, high-efficiency countercurrent chromatography purification, vacuum low-temperature concentration, drying and the like. The pharmaceutical composition can be prepared into a plurality of pharmaceutical preparations such as tablets, capsules, granules, cream, injections and the like. The invention further provides a preparation method of the oral tablet for reversing pancreatic cancer gemcitabine drug resistance, and the pharmaceutical composition has a remarkable treatment effect on a drug resistance mechanism formed by up-regulating expression of SREBP1 by histone lactylation mediated PKM2 through an AKT / mTOR pathway. The pharmaceutical composition provided by the invention provides a new treatment choice for pancreatic cancer patients, and has an important clinical application value.

The utility model discloses a pharmacy is with medicine dispenser, is used for carrying out slitting to medicine piece, include: first board body, second board body, first storage groove and second storage groove, first storage groove sets up on first board body, second storage groove sets up on second board body, first board body has first wall, second board body has second wall, when first board body and second board body adaptation abut, first wall and second wall fit and can be in first storage groove and second storage groove together and fit out the wedge -shaped groove of adaptation storage medicine piece, when first board body and second board body separate, wedge -shaped groove restores first storage groove and second storage groove and makes medicine piece divide into first piece body and second piece body. The utility model can ensure that medicine piece can be accurately divided into even two, effectively avoid the dosage error caused by uneven slitting, guarantee patient medicine safety.

The present application relates to the technical field of nasal administration, and more particularly to an ultrasound-enhanced olfactory mucosa brain-targeted infusion probe, system and method, wherein the probe comprises a probe catheter, an ultrasound activation module capable of enhancing the permeability of the olfactory mucosa of a patient, and a fit degree module capable of obtaining the size of the fit between the probe catheter and the lateral wall of the nasal cavity of the patient, the ultrasound activation module and the fit degree module are both installed on the lateral wall of the probe catheter, the ultrasound activation module and the fit degree module are connected with a control module through a wire bundle arranged on the inner lateral wall of the probe catheter, and the administration channel in the lumen of the probe catheter is in communication with the outside of the probe catheter through an administration port. The scheme of the present application can obtain the fit between the probe catheter and the lateral wall of the nasal cavity after the probe catheter is inserted into the nasal cavity, so as to facilitate the doctor to timely adjust the position of the probe catheter when the fit does not meet the working conditions of the probe catheter, and successfully fit the probe catheter to the specified position of the lateral wall of the nasal cavity.

The utility model discloses a multifunctional reusable intelligent inhaling device which comprises a base, a medicine spraying device is installed in the base, a medicine mixing bag is arranged in the base and located above the medicine spraying device, when the medicine spraying device works, medicine liquid is sucked from the medicine mixing bag, and when the medicine spraying device works, the medicine liquid is sucked from the medicine mixing bag. A spray nozzle is arranged on the outer side of the base and communicated with the pesticide spraying device, a button connected with the pesticide spraying device is installed at the top of the spray nozzle, after the button is pressed down, the pesticide spraying device sprays pesticide outwards through the spray nozzle, three micro pumps are annularly arranged at the top of the pesticide mixing bag, and the three micro pumps are communicated with the pesticide mixing bag. A connecting device is arranged at the top of the micro pump, a cabin is arranged above the base, and a medicine hole corresponding to the connecting device is formed in the top of the cabin; the device can be adjusted according to the administration dosage requirement, so that the administration is more accurate, and the flexible proportioning of medicines can be realized.

The invention discloses a radix ophiopogonis calculus-removing composition as well as a preparation method and a quality detection method thereof. A preparation method of the composition comprises the following steps: adding water to decoct the sixteen medicines (the talc and the spora lygodii are decocted in bags) twice, adding 8.5 times of water to soak for 30 minutes for the first time, adding 6 times of water to soak for 30 minutes for the second time, decocting for 30 minutes each time, and filtering to obtain a filtrate; and filtering, concentrating the filtrate into thick paste with the relative density of 1.28-1.32 (70 DEG C), drying, crushing, and adding a proper amount of auxiliary materials to prepare a corresponding dosage form, thereby obtaining the traditional Chinese medicine composition. The whole formula of the radix ophiopogonis and radix ophiopogonis calculus-removing composition has the effects of clearing away heat and toxic materials, inducing diuresis for treating stranguria, removing calculus, activating spleen and removing dampness, can remarkably improve clinical symptoms and signs of patients suffering from urolithiasis, is an effective and safe traditional Chinese medicine preparation for treating urinary calculus, and is worthy of popularization and application clinically.

The invention discloses a triacetylandrographolide nanocrystal and its preparation and application. The triacetylandrographolide nanocrystal is mainly composed of triacetylandrographolide, a stabilizer and an excipient. The average particle size of the drug particles in the triacetylandrographolide nanocrystal suspension obtained by redissolving in water is less than 500 nm, and the PDI is less than 0.2. The triacetylandrographolide and the stabilizer are prepared into a nanocrystal suspension by a high-speed shear antisolvent method combined with a high-pressure homogenization method, and then the excipient is added and spray-dried. The triacetylandrographolide nanocrystal can significantly improve drug absorption and improve its bioavailability. It can be further processed into solid preparations, liquid preparations and semisolid preparations. It can be used for the treatment of lung injury-related diseases through oral administration, pulmonary inhalation, injection or local administration, especially in the treatment of chronic obstructive pulmonary disease, it can significantly improve lung ventilation function, inhibit pathological changes in alveoli and airway walls, downregulate the level of lung tissue protease, significantly reduce the number of lung inflammatory cells and the secretion of inflammatory factors, and inhibit the infiltration of inflammatory cells in lung tissue.

The invention discloses a pharmaceutical composition for treating enteritis and a preparation method and application thereof, the composition comprises a plurality of effective components such as 5-aminosalicylic acid, metronidazole, berberine extract and the like, and the composition is prepared according to a specific weight ratio. Wherein the berberine extract is prepared through modern extraction methods such as enzymolysis pretreatment and ultrasonic extraction, and the release efficiency and purity of berberine are improved. The anti-inflammatory active polypeptide is obtained by compounding lactoferrin peptide and glutathione, and the zinc element supplement is formed by compounding zinc sulfate and zinc gluconate, so that the treatment effect of the medicine is enhanced. The invention also provides a preparation method of the pharmaceutical composition and an enteric capsule containing the composition. The pharmaceutical composition is especially suitable for treating autoimmune enteritis, and plays a therapeutic role through multiple mechanisms of regulating intestinal microecology, relieving inflammatory response, promoting intestinal mucosa repair and the like.

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

The present application relates to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition with cough-relieving effect and a preparation method thereof, which is composed of one or both of crude drug powder of summerleaf euonymus and summerleaf euonymus extract, and contains the following components in mass fraction: 1-15 parts of summerleaf euonymus crude drug powder and 1-10 parts of summerleaf euonymus extract.In the present application, the medicinal activity of summerleaf euonymus in the field of cough relief is found and verified, the therapeutic effect of summerleaf euonymus on various types of cough is determined, the application limitation of summerleaf euonymus in the prior art, i.e. only used for promoting blood circulation to remove meridian obstruction and relieving qi stagnation and pain, is broken, and the clinical application range and medicinal value of summerleaf euonymus are greatly expanded.

The utility model provides a portable medicine storage book which is used for solving the problem that in the prior art, medicine storage parts of a traditional Chinese medicine box cannot be added or reduced according to medicine use requirements. Comprising a shell mechanism, an opening and closing mechanism, a plurality of medicine storage mechanisms and a reminding module, the shell mechanism comprises a first shell, a second shell, a third shell, two storage clamps arranged on the first shell and the second shell correspondingly and a connecting sealing piece, and the first shell and the second shell are rotationally connected to the two sides of the third shell correspondingly; the first shell and the second shell are connected through the connecting sealing piece to form a containing space. The opening and closing mechanism is positioned in the accommodating space; each medicine storage mechanism comprises a medicine storage plate and a medicine containing bag installed on the medicine storage plate, through holes arranged at equal intervals are formed in one side of each medicine storage plate, a label groove is formed in each medicine containing bag, and a sealing piece is arranged at an opening of each medicine containing bag. The reminding module is installed on the outer surface of the first shell. According to the storage book, the medicine storage mechanisms can be added or removed at any time according to requirements, and the constantly changing medicine use requirements are met.

The invention provides a stable pharmaceutical preparation which comprises 60 g / L of an anti-alpha4beta7 antibody, 112 g / L of trehalose, 26.34 g / L of arginine hydrochloride, 0.6 g / L of Tween 80 and 50 mM of a histidine-histidine hydrochloric acid buffer solution, the PH value of the pharmaceutical preparation is 6.3, and the anti-alpha4beta7 antibody is videlizumab.