Semi-bionic preparation method for Xinkeshu preparations

Abstract

The invention discloses a semi-bionic preparation method for Xinkeshu preparations. The preparation method comprises steps as follows: (1), costus roots are taken, ground, mixed with water, heated and subjected to reflux distillation, preliminary distillate is collected, redistillation is performed, volatile oil is extracted and the distillate is filtered; (2), other raw materials are taken and combined with medicine residues in the step (1), water with the pH (potential of hydrogen) value being 2.0-2.5 is added, and the mixture is heated, extracted and filtered; (3), water with the pH being 6.5-7.0 is added to medicine residues obtained in the step (2), and the mixture is heated, extracted and filtered; (4), water with the pH value being 7.8-8.5 is added to medicine dregs obtained in the step (3), and the mixture is heated, extracted and filtered; (5), filtrate obtained in the steps (2), (3) and (4) is combined and concentrated until an ointment is obtained, the ointment is granulated, dried and mixed with the volatile oil obtained in the step (1), a carrier or an auxiliary material acceptable in pharmaceutics is added, and medicine preparations are prepared. The content of effective ingredients of the Xinkeshu preparations prepared with the method is substantially increased, and the Xinkeshu preparations have higher bioavailability and are better absorbed by human bodies.

Description

technical field [0001] The invention relates to a semi-bionic preparation method of Xinkeshu preparations, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Cardiovascular and cerebrovascular diseases are serious diseases that endanger human health and life, and are called "the number one killer of human beings" by the World Health Organization. In my country, there are about 1.95 million new cardiovascular patients every year, and nearly 1.56 million people die of cardiovascular diseases. The mortality rate of cardiovascular and cerebrovascular diseases has reached 35%, ranking first in the mortality rate of various diseases. [0003] Xinkeshu preparation is composed of salvia miltiorrhiza, notoginseng, kudzu root, hawthorn, and woody fragrance. It is a traditional Chinese medicine prescription for promoting blood circulation, removing blood stasis, promoting qi and relieving pain. It is used for chest tightness, di...

AI Technical Summary

Problems solved by technology

However, in the preparation method of Xinkeshu preparation in the prior art, the preparation process is that part of the medicinal materials are crushed into the original drug powder, and some of the medicinal materials are subjected to water extraction and alcohol extraction to produce crude products, which have low content of active ingredients, large dosage, and incomplete absorption. , low bioavailability, slow drug effect, inconvenient to carry, etc.

With the continuous development of science and technology and the continuous improvement of the level of new drug research and development, the continuous application of new theories, new technologies, new processes, and new equipment, its traditional preparation process does not fully meet the requirements of modernization of traditional Chinese medicine.

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