1results about How to "Stimulation" patented technology

This invention relates to the field of tumor immunotherapy technology, and more particularly to HLA-restricted neoantigen peptides based on malignant ascites tumor cells and their applications. This invention provides a cholangiocarcinoma neoantigen peptide, the amino acid sequence of which is shown in SEQ ID NO.3. This invention isolates and screens tumor neoantigen peptides from malignant ascites of cholangiocarcinoma patients. These neoantigen peptides have a high affinity for HLA molecules, can stimulate the production of tumor-specific T cells, and thus generate an immune response targeting tumor cells. They can serve as targets for clinical treatment or diagnosis of tumors and have promising applications in tumor immunotherapy.