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261 results about "Molecular switch" patented technology

A molecular switch is a molecule that can be reversibly shifted between two or more stable states. The molecules may be shifted between the states in response to environmental stimuli, such as changes in pH, light, temperature, an electric current, microenvironment, or in the presence of ions and other ligands. In some cases, a combination of stimuli is required. The oldest forms of synthetic molecular switches are pH indicators, which display distinct colors as a function of pH. Currently synthetic molecular switches are of interest in the field of nanotechnology for application in molecular computers or responsive drug delivery systems. Molecular switches are also important in biology because many biological functions are based on it, for instance allosteric regulation and vision. They are also one of the simplest examples of molecular machines.

Fabrication of molecular electronic circuit by imprinting

A method of fabricating a molecular electronic device or crossbar memory device is provided. The device comprises at least one pair of crossed wires and a molecular switch film therebetween. The method comprises: (a) forming at least one bottom electrode on a substrate by first forming a first layer on the substrate and patterning the first layer to form the bottom electrode by an imprinting technique; (b) forming the molecular switch film on top of the bottom electrode; (c) optionally forming a protective layer on top of the molecular switch film to avoid damage thereto during further processing; (d) coating a polymer layer on top of the protective layer and patterned the polymer layer by the imprinting method to form openings that expose portions of the protective layer; and (e) forming at least one top electrode on the protective layer through the openings in the polymer layer by first forming a second layer on the polymer layer and patterning the second layer. The imprinting method can be used to fabricate nanoscale patterns over a large area at high speeds acceptable in industrial standards. Consequently, it can be used to fabricate nanoscale molecular devices, e.g., crossbar memory circuits.
Owner:HEWLETT PACKARD DEV CO LP

Compositions, devices, systems, for using a Nanopore

The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Owner:RGT UNIV OF CALIFORNIA

Oligonucleotides comprising a molecular switch

This invention relates to oligonucleotides comprising a molecular switch which may exist in an “open” or “closed” position. The molecular switch portion of the probe is particularly sensitive to the identity of sequences complementary to the molecular switch. Oligonucleotides containing a molecular switch are applicable to all kinds of hybridization processes. Due to the sensitivity of the switch domain of the oligonucleotide, probes containing a molecular switch are particularly useful in the identification of single point mismatches. More specifically, a portion, but not all, of the oligonucleotide becomes unbound from a mismatched target. The invention further relates to methods of using said oligonucleotides for research reagents, and clinical diagnostics. An exemplary oligonucleotide comprises a first hybridizable domain, a second bridging block domain, and a third binding domain.
Owner:GEN PROBE INC

Compositions, devices, systems, and methods for using a nanopore

The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Owner:RGT UNIV OF CALIFORNIA

Configurable molecular switch array

InactiveUS20040041617A1Restore levelMinimal signal degradationResource allocationNanoinformaticsLow voltageEngineering
A computing system for implementing at least one electronic circuit with gain comprises at least one two-dimensional molecular switch array. The molecular switch array is formed by assembling two or more crossed planes of wires into a configuration of devices. Each device comprises a junction formed by a pair of crossed wires and at least one connector species that connects the pair of crossed wires in the junction. The junction has a functional dimension in nanometers, and includes a switching capability provided by both (1) one or more connector species and the pair of crossed wires and (2) a configurable nano-scale wire transistor having a first state that functions as a transistor and a second state that functions as a conducting semiconductor wire. Specific connections are made to interconnect the devices and connect the devices to two structures that provide high and low voltages.
Owner:HEWLETT PACKARD DEV CO LP

Targeted hollow gold nanostructures and methods of use

Provided are novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors and molecular specific photothermal coupling agents. The nanostructures can be used in laser-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The nanostructures are of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. The hollow gold nanospheres have a unique combination of spherical shape, small size, and strong, tunable, and narrow surface plasmon resonance absorption covering the entire visible to near IR region.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Control of DNA movement in a nanopore at one nucleotide precision by a processive enzyme

The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. Of particular note is the stability of the system in a saline medium and to detect individual nucleotide bases in a polynucleotide in real time and which may be used to sequence DNA for many hours without change of reagents. The invention is of particular use in the fields of forensic biology, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Owner:RGT UNIV OF CALIFORNIA

Photochromic and electrochromic compounds and methods of synthesizing and using same

This invention relates to novel photochromic and electrochromic monomers and polymers based on 1,2-dithienylcyclopentene derivatives and method of using and synthesizing same. The compounds are reversibly interconvertible between different isomeric forms under suitable photochromic or electrochromic conditions. The electrochromic conversion may be catalytic. The application also relates to ultra-high density homopolymers prepared using ring-opening methathesis polymerization (ROMP) where the central ring of the 1,2-bis(3-thienyl)-cyclopentene is incorporated directly into the polymer backbone. The monomer units may be readily functionalized to enable the synthesis of polymers with diverse structural and electronic properties. The compounds have many potential applications including high-density optical information storage systems, photoregulated molecular switches, reversible holographic systems, ophthalmic lenses, actinometry and molecular sensors, photochromic inks, paints and fibers and optoelectronic systems such as optical waveguides, Bragg reflectors and dielectric mirrors.
Owner:SOLUTIA CANADA INC

New E-field-modulated bistable molecular mechanical device

A molecular system is provided for nanometer-scale reversible electronic and optical switches, specifically, electric field-activated molecular switches that have an electric field induced band gap change that occurs via a molecular conformation change or a tautomerization. Changing of extended conjugation via chemical bonding change to change the band gap is accomplished by providing the molecular system with one rotating portion (rotor) and two or more stationary portions (stators), between which the rotor is attached. The molecular system of the present invention has three branches (first, second, and third branches) with one end of each branch connected to a junction unit to form a "Y" configuration. The first and second branches are on one side of the junction unit and the third branch is on the opposite side of the junction unit. The first branch contains a first stator unit in its backbone, the junction unit comprises a second stator unit, and the first branch further contains a rotor unit in its backbone between the first stator unit and the second stator unit. The second branch includes an insulating supporting group in its backbone for providing a length of the second branch substantially equal to that of the first branch, wherein the rotor unit rotates between two states as a function of an externally-applied field.
Owner:SAMSUNG ELECTRONICS CO LTD

Molecular Switches And Methods For Their Use

The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and / or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes. More particularly, the invention relates to compositions allowing self-assembly of active and inactive multicomponent nucleic acid complexes, methods of making such compositions, and methods for use.
Owner:SPEEDX

Targeted hollow gold nanostructures and methods of use

InactiveUS20140012224A1Easy to use detectionMaterial nanotechnologyNanomagnetismDiseasePhotothermal ablation
Provided are novel nanostructures comprising hollow nanospheres (HGNs) and nanotubes for use as chemical sensors, molecular specific photothermal coupling agents, and photothermal ablation compounds. The nanostructures can be used in electromagnetic radiation-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The nanostructures are of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. The hollow gold nanospheres have a unique combination of spherical shape, small size, and strong, tunable, and narrow surface plasmon resonance absorption covering the entire visible to near IR region.
Owner:RGT UNIV OF CALIFORNIA

Methods and compositions to enhance vaccine efficacy by reprogramming regulatory t cells

The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining LNs, where it can potently activate Foxp3 regulatory T cells (Tregs). We now show that IDO functions as a molecular switch in tumor-draining LNs, maintaining Tregs in their normal suppressive phenotype when IDO was active, but allowing inflammation-induced conversion of Tregs to a polyfunctional T-helper phenotype similar to proinflammatory TH17 cells when IDO was blocked. In vitro, conversion of Tregs to the TH17-like phenotype was driven by antigen-activated effector T cells, and required IL-6 produced by activated pDCs. IDO regulated this conversion by dominantly suppressing production of IL-6 in pDCs, in a GCN2-kinase dependent fashion. In vivo, using a model of established B16 melanoma, the combination of an IDO-inhibitor drug plus anti-tumor vaccine caused upregulation of IL-6 in pDCs and in situ conversion of a majority of Tregs to the TH17 phenotype, with marked enhancement of CD8+ T cell activation and anti-tumor efficacy. Thus, Tregs in tumor-draining LNs can be actively re-programmed in vitro and in vivo into T-helper cells, without the need for physical depletion, and IDO serves as a key regulator of this critical conversion.
Owner:GEORGIA HEALTH SCI UNIV RES INST

New system and kit for screening and diagnosing phenylketonuria

The invention discloses a new system for screening and diagnosing phenylketonuria.41 common phenylalanine hydroxylase gene mutation sites and 4 most common 6-pyruvoyl tetrahydrobiopterin synthetase (PTPS) gene (PTS) mutation sites are screened to form the gene mutation detection system of phenylketonuria.The system is low in cost and high in throughput.Compared with the prior art, the system has the advantages that most mutation sites can be detected in one system, and 45 mutation sites can be detected; the comprehensive cost is the lowest, and the total cost of the system is lower than built methods using the DNA chip technology, the 'molecular switch' technology, the high-resolution melting curve method and the SNaPShot technology to detect PAH gene mutation; most mutation sites can be detected, the number of the detected mutation sites is twice as the number of the detected PAH gene mutation sites of the high-resolution melting curve method built by Xiamen University, the number of the detected mutation sites is 4 times as the number of the detected mutation sites of the DNA chip technology and the SNaPShot technology, and the number of the detected mutation sites is 6 times as the number of the detected mutation sites of the 'molecular switch' technology.
Owner:SUZHOU MUNICIPAL HOSPITAL +1

Apparatus and method for fabricating arrays of atomic-scale contacts and gaps between electrodes and applications thereof

A method for forming atomic-scale contacts and atomic-scale gaps between two electrodes is disclosed. The method provides for applying a voltage between two electrodes in a circuit with a resistor. The applied voltage etches metal ions off one electrode and deposits the metal ions onto the second electrode. The metal ions are deposited on the sharpest point of the second electrode, causing the second electrode to grow towards the first electrode until an atomic-scale contact is formed. By increasing the magnitude of the resistor, the etching and deposition process will terminate prior to contact, forming an atomic-scale gap. The atomic-scale contacts and gaps formed according to this method are useful as a variety of nanosensors including chemical sensors, biosensors, hydrogen ion sensors, heavy metal ion sensors, magnetoresistive sensors, and molecular switches.
Owner:ARIZONA STATE UNIVERSITY

Kit for detecting aldehyde dehydrogenase 2 gene polymorphism and amplification method and detection method thereof

The present invention discloses a kit for detecting aldehyde dehydrogenase 2(ALDH2) gene polymorphism by using the single-tube bidirectional allele-specific amplification technology combined with the SNP sensitivity molecular switch technology, and an amplification method and a detection method thereof. The kit genotypes the Glu487Lys(rs671) site on the aldehyde dehydrogenase 2. The kit includes amplification buffer, polymerase, cell lysis buffer and glycerol, and can complete the genotyping for the SNP site in one PCR reaction so as to understand the genotype of the aldehyde dehydrogenase 2 subject and the product activity thereof.
Owner:UNION STEMCELL & GENE ENG +1

1,8-naphthalimide-based light-controlled fluorescent molecular switch compound bonded with bis-spilenpyran unit and synthesis method and application of compound

The invention provides a 1,8-naphthalimide-based light-controlled fluorescent molecular switch compound bonded with a bis-spilenpyran unit and a synthesis method and application of the compound. Firstly, bis-spiropyran is modified to a 1,8-naphthylimide molecule through a covalent bond, the compound shows a good photochromic effect and light-controlled two-color fluorescent molecular switch performance in an organic solvent and a solid medium, the fluorescence resonance energy transfer efficiency of the compound is greatly improved, and the thermodynamic stability and photosensitivity of the compound are also high. The 1,8-naphthalimide-based light-controlled fluorescent molecular switch compound bonded with the bis-spilenpyran unit and the synthesis method and application of the compoundcan be used in the field of ion detection and photochemical imaging of biological systems.
Owner:CHIFENG UNIV

Prodrug activation in cancer cells using molecular switches

The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodrug activating enzyme and a protein that binds a cancer specific marker, polynucleotides encoding the polypeptides, and molecular switches for converting a prodrug into a toxin, comprising the polypeptides. The invention also features methods for converting a prodrug into a toxin, methods for treating cancer, and methods for making the molecular switches, as well as kits.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Diarylethene fluorescent molecular switch and preparation method and application thereof

The invention discloses an aggregation-induced emission type diarylethene fluorescent molecular switch and a preparation method and application thereof. The aggregation-induced emission type diarylethene fluorescent molecular switch is characterized in that an AIE radical is introduced to gain solid or aggregation strong emission capacity; two diarylethene can be used for quickly quenching fluorescence of fluorescent radicals which aggregate in the surrounding under the irradiation of ultraviolet rays or visible light, thus achieving the purpose of high fluorescent switch ratio. According to the light control type AIE-effect fluorescent molecular switch, the limitation that traditional fluorescent chromophore leads to fluorescence quenching is broken; in addition, the fluorescent molecularswitch in solid and aggregation state has the advantages of being high in switch ratio and high in fluorescence quenching efficiency by being compared with the fluorescent molecular switch in solution state; the fluorescent molecular switch is applicable to information storage under solid state and photoelectric devices and has potential application in biosensing and fluorescence imaging.
Owner:HUAZHONG UNIV OF SCI & TECH

Library-based methods and compositions for introducing molecular switch functionality into protein affinity reagents

Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target molecule sensitive to an environmental trigger, such as pH, while maintaining binding affinity to the target molecule. Combinatorial libraries created by the method are also disclosed.
Owner:NORTHERN ILLINOIS RES FOUND

Conjugated Organic Molecules for Molecular Electronic Devices

There is provided a conjugated molecule that is useful as a conductive path in an electronic device. The conjugated molecule includes at least one p / n junction so as to provide a direction to electron flow and one end alligator clip group which allows for self-orientation of the molecule during assembly in a device, resulting in an asymmetric structure of the molecule. The conjugated molecule may be used in diodes, molecular switches, transistors, and in the manufacture of memory devices.
Owner:AGENCY FOR SCI TECH & RES +1

CYP2C19 gene detection kit, amplification method and detection method

The present invention discloses a gene detection kit using the multiplex PCR technology combined with the SNP sensitive molecular switch technology for genotyping of cytochrome 4502C19 gene, an amplification method and a detection method. Three common polymorphic sites on the CYP2C19 gene significantly changing the product activity are genotyped by the kit, wherein the three common polymorphic sites include: rs4244285SNP site, rs4986893 site and rs12248560 site. The kit includes a wild-type 2*PCR buffer, a 2*mutant amplification buffer, and a polymerase. The two buffers respectively includes a sequence-specific primer and an internal reference primer corresponding to SNP wild and mutant phenotype, and can complete genotyping for the three SNP sites in two multiplex PCR reactions, and thus the CYP2C19 gene is genotyped, and molecular biological evidence is provided for the gene-expressed enzyme activity prediction.
Owner:UNION STEMCELL & GENE ENG +1

Stabilization of configurable molecular mechanical devices

A route to the fabrication of electronic devices is provided, in which the devices consist of two crossed wires sandwiching an electrically addressable molecular species. The approach is extremely simple and inexpensive to implement, and scales from wire dimensions of several micrometers down to nanometer-scale dimensions. The electronic devices can be used to produce crossbar switch arrays, logic devices, memory devices, and communication and signal routing devices. The construction of molecular electronic devices is achieved on a length scale than can range from micrometers to nanometers via a straightforward and inexpensive chemical assembly procedure. The molecular switchable devices in the cross-bar geometry are configurable while the conformational change is controlled by intramolecular forces that are stronger than hydrogen bonding. The method of the present invention is directed to configuring an ensemble of molecular switches in a prescribed manner in cross-bar geometry and then making such configuration either substantially permanent or stable with respect to temperature fluctuations.
Owner:SAMSUNG ELECTRONICS CO LTD

Two-dimensional Fe(II) complex pressure-caused spin conversion materials, preparation method and application thereof

InactiveCN101712695ANo spin conversionIron organic compoundsMagnetic susceptibilitySpins
The invention provides two-dimensional Fe(II) complex pressure-caused spin conversion materials, a preparation method and application thereof. The invention relates to the field of spin conversion materials science, in particular to pressure-caused spin conversion materials, a preparation method and application thereof. The chemical formula of the two-dimensional Fe(II) complex pressure-caused spin conversion materials is [Fe(L)2(SCN)2]n, wherein L is 1,3-Bis (1H-1,2,4-triazol-1-ylmethyl)-2,4,6-trimethylbenzene ligand. The preparation method chooses L as the ligand to synthesize the two-dimensional Fe(II) complex pressure-caused spin conversion materials. The materials are free from the phenomenon of spin conversion under normal pressure; the results of temperature-change magnetic susceptibility show that antiferromagnetic interaction exists between Fe and Fe; and after pressure is increased, the results of temperature-change magnetic susceptibility show that the phenomenon of spin conversion appears, and the temperature of spin conversion changes from low to high with the increase in pressure, so the temperature of spin conversion can be regulated by regulating external pressure. Therefore, the materials have good application prospects in the fields of nanometer devices, molecular memory, molecular switches and molecule display, as well as industry.
Owner:NANKAI UNIV

Chimeric antigen receptors with integrated controllable functions

The present invention relates to the field of cell immunotherapy and more particularly to a new generation of chimeric antigen receptors (CAR), allowing the control of immune cells endowed with such CARs through the interaction with small molecules. More particularly, the present invention relates to chimeric antigen receptor which comprise in at least one ectodomain a molecular switch turning the antigen binding function of the receptor from an off to on state, and vice versa. The present invention thus provides more controlled and potentially safer engineered CAR endowed immune cells, such as T-lymphocytes.
Owner:CELLECTIS SA

DNA binding compound-mediated molecular switch system

The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.
Owner:GENELABS TECH INC

Photo-Swichable Surfaces with Controllable Physico-Chemical Properties

Photochromic materials, such as spiropyran dyes, are disclosed that can be used for high-density optical storage and molecular switches. According to the disclosure these compounds can be used as transducers in optical sensors. When the spiropyran dye absorbs UV light it switches to the merocyanine form, and this structure has an active binding site for cations. When cations bind to the site, the resulting colored complex has a new absorption band in the visible spectrum. By shining white or green light on the colored complex, the dye is reverted to the closed spiropyran form, and the cation is released. The disclosure optimizes the immobilization of the spiropyran dye onto a polymer substrate via long chain alkyl groups. These long chain alkyl linkers enable the dye to reversibly form the preferred merocyanine (2):(1) cation sandwich complex.
Owner:DUBLIN CITY UNIVERSITY

Dithiophene ethene functional material, and its preparing method and use

The invention belongs to the technical field of diarylethylene photic color-changing material, relating to a diarylethylene photic color-changing monomer or polymer whose main chain contains a single or plural alkyl fluorenes, which remarkably raise closed loop quantum efficiency of the material; and the long chain alkyl makes the polymer possess very good solubility, beneficial to polymer rotary coating to form film. The fluorescence of the polymer changes obviously before and after photic changing color, and thus the polymer has very good fluorescent ON and OFF performances. The synthesizing route is convenient and compact, and the polymerization degree is high. The material can be applied to the fields of high density information storage, molecular switches, molecular lead wires, etc.
Owner:FUDAN UNIV

E-field-modulated bistable molecular mechanical device

A molecular system is provided for nanometer-scale reversible electronic and optical switches, specifically, electric field-activated molecular switches that have an electric field induced band gap change that occurs via a molecular conformation change or a tautomerization. Changing of extended conjugation via chemical bonding change to change the band gap is accomplished by providing the molecular system with one rotating portion (rotor) and two or more stationary portions (stators), between which the rotor is attached. The molecular system of the present invention has three branches (first, second, and third branches) with one end of each branch connected to a junction unit to form a "Y" configuration. The first and second branches are on one side of the junction unit and the third branch is on the opposite side of the junction unit. The first branch contains a first stator unit in its backbone, the junction unit comprises a second stator unit, and the first branch further contains a rotor unit in its backbone between the first stator unit and the second stator unit. The second branch includes an insulating supporting group in its backbone for providing a length of the second branch substantially equal to that of the first branch, wherein the rotor unit rotates between two states as a function of an externally-applied field.
Owner:SAMSUNG ELECTRONICS CO LTD
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