43 results about "Merocyanine" patented technology

Disclosed is a polymer film excellent in performance of inducing Rth. The polymer film comprises at least one species of a compound represented by the formula (I) and a compound represented by the formula (I′):

Anthocyanic colorant made of vegetable primary material and process for its production relate to food, cosmetic, pharmaceutical and textile industry and may be used in production of alcoholic and soft drinks, confectionery, products made of sour milk, in coloring of tablet capsules, dying of children's underwear, toys, etc. According to the invention, pelargonidin glycoside was added to the composition of the natural colorant that contained cyanidin glycosides, peonidin glycosides, organic substance and mineral salts. The components percentage shall be as follows, %: cyanidin glycoside 0.1-8.6; peonidin glycoside 0.08-6.45 pelargonidin glycoside 0.005-4.3; organic substance and mineral salts--the rest. Due to the fact that the colorant solution contains pelergonidin glycoside further to cyanidin and peonidin glycosides, the proposed colorant obtained expanded color spectrum. Combination of these three anthocyans in the proposed colorant provides for the most rich spectrum of red colors. At the same time, the ratio of pelargonidin glycoside:peonidine glycoside:cyanidin glycoside must be 1:1.5:2, respectively, and it will provide for production of a colorant with a number of valuable physical properties. Namely, the colorant retains red color when pH of the environment is not more than 7, it is thermostable, photostable and maintains its properties during 2 (two) years, besides, its relative optical density is the highest when it is subjected to the light with wavelength of 505-515 nm. According to the invention, process of the colorant production implies that pre-dried vegetable maize-pulp containing anthocyan is grinded, extracted by a mix of aqueous solutions of hydrochloric and citric acids in the field of ultrasonic vibration. Then the extracted coloring matter is filtered and concentrated in vacuum. The primary material is additionally prepared for extraction by infusion of grinded material in extracting agent during 6-8 hours at the temperature of 35-40.degree. C. Extraction may be performed in three steps. Processing for extraction of each lot shall be 30-40 minutes at the temperature of 35-40.degree. C. The process makes the production technology easier and provides for additional source of primary materials. 2 independent claims, 8 dependent claims, 5 tables.

Cyanine and Indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

Various processes are disclosed for preparing protected epicatechin oligomers having (4β,8)-interflavan linkages. In one process, a tetra-O-protected epicatechin monomer or oligomer is coupled with a protected, C-4 activated epicatechin monomer in the presence of an acidic clay such as a mortmorillonite clay. In another process, a 5,7,3′,4′-benzyl protected or a 3-acetyl-, 5,7,3′,4′-benzyl protected epicatechin or catechin monomer or oligomer is reacted with 3-O-acetyl-4-[(2-benzothiazolyl)thio]-5,7,3′,4′-tetra-O-benzylepicatechin in the presence of silver tetrafluoroborate. In another process, two 5,7,3′,4′-benzyl protected epicatechin monomers activated with 2-(benzothiazolyl)thio groups at the C-4 positions are cross-coupled in the presence of silver tetrofluoroborate. A process is also disclosed for reacting an unprotected epicatechin or catechin monomer with 4-(benzylthio)epicatechin or catechin. The use of naturally-derived and synthetically-prepared procyanidin (4β,8)4-pentamers to treat cancer is also disclosed.

The present invention provides a novel method for assaying OPC contained in natural substances, foods and beverages, pharmaceuticals and / or cosmetics. The present invention is a novel method for assay of OPC which assays anthocyanidin, obtained by hydrolysis of OPC, to determine the total amount of OPC, and elucidates the proportions of the polymerization degrees of OPC by high performance liquid chromatography (HPLC) to determine the contents of the respective polymers in OPC.

The invention discloses a method for extracting and separating procyanidine of hawthorn fruit through low-temperature aqueous two-phase cooling. The method comprises steps as follows: after fresh hawthorn fruit is washed, 30-70 mL of citric acid solutions, 30-70 mL of sodium chloride solutions and 30-70 mL of isopropyl alcohol are added to every 10 g of hawthorn fruit, the mixture is cooled to subzero 18 DEG C in a freezer, taken out and subjected to homogenization treatment for three times by a homogenizer, homogenization treatment is performed for 1-3 min every time, a product is left to stand for 5-15 min, an isopropyl alcohol top phase is separated after complete phase separation, obtained isopropyl alcohol is collected, subjected to vacuum distillation through a rotary evaporator and removed through evaporation, 1-4 ml of ethanol is added, solids are precipitated, the obtained solids are subjected to vacuum drying at the temperature of 20-35 DEG C until the solids are dried, and a procyanidine extract of the hawthorn fruit is obtained. By means of the method, the variety of reagents is reduced, and non-toxic, degradable, green and environment-friendly properties are realized; a homogenizing technology is introduced to the extraction process, mass transfer is effectively improved, the extraction time is greatly shortened, and the purity of the obtained procyanidine of the hawthorn fruit is higher.