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Procyanidine-modified carboxymethyl chitosan

A technology of carboxymethyl chitosan and proanthocyanidin, which is applied in the field of preparation of carboxymethyl chitosan to achieve the effects of short production cycle, increased molecular weight and prolonged degradation time

Active Publication Date: 2013-03-13
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] CN1486700A discloses the compound of proanthocyanidin and chitosan, but according to the dynamic viscosity of the compound obtained by the method described in CN1486700A compared with the dynamic viscosity of the used raw material chitosan, there is no obvious change, which can not meet the application in the field of medical materials requirements

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  • Procyanidine-modified carboxymethyl chitosan
  • Procyanidine-modified carboxymethyl chitosan
  • Procyanidine-modified carboxymethyl chitosan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 0.5g of proanthocyanidin (polymerization degree is 3) and dissolve in 100g of purified water, filter; take 20g of carboxymethyl chitosan (weight average molecular weight is 150,000), add into 1000g of purified water to dissolve, filter; stir the proanthocyanidin solution Slowly add carboxymethyl chitosan solution, stir well, and react at 40°C for 2.5 hours. Then, 3000 mL of absolute ethanol was added under stirring to generate a precipitate. Filter, wash the precipitate 3 times with 75% ethanol, then wash 3 times with absolute ethanol, and dry in vacuum at 40°C for 24 hours to obtain 17.7 g of proanthocyanidin-modified carboxymethyl chitosan with a yield of about 86%. According to the second method of the second appendix of the Chinese Pharmacopoeia 2010 edition, the dynamic viscosity of the 1% mass concentration aqueous solution is 1,885mPa.s as measured by a rotor-type rotational viscometer.

Embodiment 2

[0041] Take 1g of proanthocyanidin (polymerization degree is 3) and dissolve in 100g of purified water, filter; take 20g of carboxymethyl chitosan (weight average molecular weight is 150,000), add into 1000g of purified water to dissolve, filter; Add it into the carboxymethyl chitosan solution, stir well, and react at 50°C for 2.5 hours. Then, 3300 mL of 95% ethanol was added under stirring to generate a precipitate. After filtering, the precipitate was washed three times with 75% ethanol, then three times with absolute ethanol, and dried in vacuum at 40°C for 24 hours to obtain 18.2 g of proanthocyanidin-modified carboxymethyl chitosan with a yield of about 87%. According to the second method of the second appendix of the Chinese Pharmacopoeia 2010 edition, the kinetic viscosity of the 1% mass concentration aqueous solution is 3,260mPa.s, measured with a rotor-type rotational viscometer.

Embodiment 3

[0043] Take 1g of proanthocyanidin (polymerization degree is 3) and dissolve in 100g of purified water to make an aqueous solution with a mass concentration of 1%, and filter; take 20g of carboxymethyl chitosan (weight average molecular weight is 150,000), add 1000g of purified water to dissolve, Filtration; slowly add the proanthocyanidin solution into the carboxymethyl chitosan solution under stirring state, fully stir evenly, and react at 50° C. for 1 hour. Then, 3300 mL of 95% ethanol was added under stirring to generate a precipitate. After filtration, the precipitate was washed three times with 75% ethanol, then three times with absolute ethanol, and dried in vacuum at 40°C for 24 hours to obtain 17.8 g of proanthocyanidin-modified carboxymethyl chitosan with a yield of about 85%. According to the second method of the second appendix of the Chinese Pharmacopoeia 2010 edition, the dynamic viscosity of the 1% mass concentration aqueous solution is 2,590mPa.s.

[0044] Tab...

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Abstract

The invention discloses procyanidine-modified carboxymethyl chitosan, a preparation method thereof, and application thereof in the fields of medical materials, health-care foods, cosmetics and the like. The procyanidine-modified carboxymethyl chitosan keeps the characteristics of carboxymethyl chitosan and has high oxidation resistance, antibacterial activity, barrier properties and the like, and is worthy of being applied.

Description

technical field [0001] The present invention relates to a kind of novel modified carboxymethyl chitosan, specifically, the present invention relates to a kind of proanthocyanidin modified carboxymethyl chitosan, the present invention also relates to this proanthocyanidin modified carboxymethyl chitosan Preparation method and use of sugar. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative and an amphoteric polyelectrolyte. It has been widely used in medicine, health products, cosmetics, fresh-keeping, environmental protection, etc., and its stable properties and pharmacological effects such as antibacterial, lipid-lowering and arteriosclerosis prevention are destined to play a role in the daily life of human beings in the future. greater effect. [0003] At present, the preparation of carboxymethyl chitosan needs to be carried out under conditions such as strong alkali or high temperature, so the prepared carboxymethyl chitosan usua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 高明李素哲刘俊英张彪
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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