164results about How to "Prolong degradation time" patented technology

The invention provides crosslinking sodium hyaluronate gel and a preparation method thereof. The preparation method comprises the following steps: dropwise adding a crosslinking agent in an aqueous alkaline solution of sodium hyaluronate and carrying out crosslinking reaction; after reaction is finished, adjusting pH value of a system to be 7.1-7.5 with acid; stirring for 1-2 hours; and then precipitating with anhydrous ethanol to obtain the crosslinking sodium hyaluronate gel. The shortcoming that the proportion of crosslinking modification degree in a traditional crosslinking technology is lower (about 10%) is overcome effectively, and the proportion of the crosslinking modification degree is increased to be about 60% and is controllable. An ultrasonic crosslinking technology is introduced, the proportion of the crosslinking modification degree in crosslinking hyaluronic acid can be increased effectively, the proportion of suspension modification degree is reduced, and degradation time of a material is prolonged.

The invention relates to a decellularization cornea preparation method, which adopts steps of corneal epithelium layer removing, ultraviolet cross-linking, viral inactivation, decellularization treatment, gradient dehydration, radiation protection and sterilization. According to the present invention, the prepared decellularization cornea has characteristics of complete antigen removing, no excitation of host acquired immunity reaction, good biocompatibility, low damage on nature corneal stroma, maintaining of structure characteristics of the nature corneal, and maintaining of effective components of the nature corneal so as to provide physical and chemical properties similar to the nature corneal; and after the prepared decellularization cornea is transplanted, animal experiment results show that characteristics of transparent transplanted cornea, no scar formation, no melting generation and no neovascularization are provided, the transplanted cornea and the recipient bed are completely integrated after transplanting a month, the transplanted cornea is subjected to complete epithelization after three months, corneal stroma cells migrate toward the decellularization cornea graft so as to prove that the tissue just takes place slow reconstruction, and the transplanted cornea after 6 months does not show significant difference in histology and appearance detection compared with the nature cornea.

The invention relates to a gel hemostatic material and a preparation method thereof. The gel hemostatic material achieves the effect of blocking hemostasis in such a way that a nucleophilic polymer and an amino acid oligomer are in cross-linking reaction with an electrophile polymer to generate a three-dimensional polymer in situ. A gel hemostatic material composition and a preparation method thereof have the advantages that the raw material ratio is controlled accurately, the reasonable gel forming time can be achieved, the gel forming time is less than 10 seconds, the expected strength is relatively high, and the testing result shows that the elongation at break of the biologic gel hemostatic material is 300-600 percent, and the compression strength of the biologic gel hemostatic material is larger than 3 Mpa; the requirement of surgical operation can be met well.

A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.

The invention relates to a bionic nerve graft used for peripheral nervous recovery and a preparation method and application thereof. The bionic nerve graft comprises a chitosan film conduit and a fibrous protein hydrogel beam positioned in the chitosan film conduit, wherein the fibrous protein hydrogel beam is prepared from fibrous protein through an electrospinning technique. The bionic nerve graft prepared by the preparation method is formed by the filling of the chitosan film conduit and the fibrous protein hydrogel beam of a multi-stage orientation structure, wherein a nerve regrowth space is effectively supported by a chitosan film, the orientational regeneration of a nerve axon is effectively guided by the fibrous protein hydrogel beam of multi-stage orientation, the cell affinity and the mechanical property of whole materials are good, and in addition, degrading speed and the repairing speed of peripheral nervous tissues are matched.

The invention discloses a temporary plugging agent with tassel-shaped two ends as well as a preparation method and application thereof. The preparation method comprises the following steps: doubling and compounding water-swelling deformed fibers and high-strength rigid fibers to form a temporary plugging fiber bundle; knotting the temporary plugging fiber bundle to form a temporary plugging fiberbundle of which the middle is provided with a tassel knot main body and the two ends are in a tassel shape; and carrying out dipping treatment on the temporary plugging fiber bundle with the tassel-shaped two ends by using polyester resin to obtain the temporary plugging agent with the tassel-shaped two ends. The pressure bearing strength of the temporary plugging agent with the tassel-shaped twoends is as high as 70 MPa, the temporary plugging agent can plug shot holes and even deformed shot holes, can reduce the using amount of bridge plugs and the temporary plugging agent, or even replacethe bridge plugs to form more effective plugging, and the cost is reduced; the degradation performance is flexible and controllable, the time for drilling a bridge plug can be saved by selecting a degradable material, the construction cost is reduced, the construction safety is ensured, and the purpose of temporary plugging steering can be achieved by adding a small amount of tassel-shaped temporary plugging agent into a fracturing fluid.

The medical collagen material is made through the processes of chondroitin sulfate crosslinking, high temperature vacuum drying and ethylene oxide. Is has stable molecule structure and better anti-seepage and anti-stick performance, and is used in repairing cerebral dura mater, spinal dura mater and peripheral nerve.

The invention discloses a degradable seedling culture cup, which comprises the following components in parts by weight: 10-20% of waste paper pulp, 50-75% of plant fiber and 5-10% of adhesive, wherein the waste paper pulp is formed by directly pulping recycled waste paper without deinking and disinfecting processing, production cost is low, the plant fiber is formed by smashing straws, and the adhesive is vegetable gelatin. According to the degradable seedling culture cup disclosed by the invention, the recycled waste paper and straws are used as main raw materials to make waste profitable, and cost is lowered. After the waste paper pulp and the adhesive are used, the toughness of the degradable seedling culture cup is improved, and the usability is improved. In addition, the seedling culture cup degrading time is prolonged by the adhesive, more time is obtained for the market sale of a new seedling growth and culture mechanism, and therefore, the degradable seedling culture cup is worth popularizing.

The invention discloses a porous bladder acellular matrix retaining bioactive factors and a preparation method thereof. A bladder of a pig, a rabbit, a dog or cattle is handled by digestive juice, hypotonic buffer solution, hypertonic buffer solution with surfactants, buffer solution with nuclease, and deionized water. An abacterial bladder acellular matrix is obtained by cooling, freezing out and sterilizing. The bladder acellular matrix is not provided with cells, an urinary tract epithelial layer, a submucous layer or a blood circulatory system, thus having good biocompatibility and appropriate ultrastructural structure. Bioactive factors are retained, including cell adhesive factors, growth factors and chemokines. Therefore, the bladder acellular matrix is an ideal scaffold material for a bladder in tissue engineering.

The invention provides a degradable metal composite plate for the cranio-maxillofacial bone restoration and a preparation method thereof. The metal composite plate comprises a layer of magnesium-basedor iron-based metal plate and two layers of zinc-based metal plates, wherein the two layers of zinc-based metal plates are respectively compounded onto the two surfaces of the magnesium-based or iron-based metal plate to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate. The degradable metal composite plate for the cranio-maxillofacial bone restoration of the structure can solve the problems of poor biocompatibility, undegradability and requirement of secondary operation for taking out of a cranio-maxillofacial bone restorationmaterial in clinics. Through controlling the thickness ratio of the magnesium-based or iron-based metal plate and the zinc-based metal plate, the regulation on the metal composite degradation time canbe achieved, so that the degradation speed can better correspond to the human body restoration speed; the human body restoration speed is accelerated. By the coating lamination rolling preparation method, the zinc-based metal plate is compounded onto the surface of the magnesium-based or iron-based metal plate to form the degradable cranio-maxillofacial bone restoration material; the process treatment method is simple; the control is easy; the manufacturing cost is low.

The present invention belongs to the field of slow-release fertilizers, and specifically discloses a melon high-efficiency slow-release fertilizer with degerming insecticidal effects, the melon high-efficiency slow-release fertilizer with degerming insecticidal effects is characterized by comprising the following components in parts by weight: garlic polysaccharide sulfide derivative, attapulgite, polyvinyl alcohol, a crosslinking agent, polyglutamate hydrogel, mesoporous silica nanoparticles, salicylic acid, toosendanin, pyrethrum, tea polyphenols, composite microbial agents, sodium selenite, compound sodium nitrophenolate, viscous konjac flour, residue of furfural, brown sugar residue, and amino acids and the like. The garlic polysaccharide sulfide derivative and the attapulgite are used as basic coating materials, the micron size composite hydrogel prepared from the polyglutamate hydrogel and different sizes of mesoporous silica nanoparticle matters are added into the coating materials, the pore size of the coating materials are enriched, the dynamic slow-release performance and nutrient use efficiency of the fertilizer are improved, the fertilizer efficiency regulation property is ensured, the melon high-efficiency slow-release fertilizer promotes the melon to absorb and utilize different nutrients, and promotes the efficient cultivation.

The invention discloses procyanidine-modified carboxymethyl chitosan, a preparation method thereof, and application thereof in the fields of medical materials, health-care foods, cosmetics and the like. The procyanidine-modified carboxymethyl chitosan keeps the characteristics of carboxymethyl chitosan and has high oxidation resistance, antibacterial activity, barrier properties and the like, and is worthy of being applied.

A starch-based hydrogel for the controlled delivery of a biologically active agent is described. The hydrogel comprises a dispersed phase, and a dispersion medium consisting substantially of water. The dispersed phase includes a polymeric network comprising a hydrolyzable polymeric substance derived from starch, and a cross-linker. In various embodiments, the polymeric starch-derived network includes amylose, amylopectin, or a combination thereof, or soluble starch. The cross-linker is a molecule having at least two carboxyl moieties. The hyrogel is biocompatible and biodegradable, and suitable for loading with biologically active agents ranging from small molecule therapeutics to macromolecules such as proteins, polysaccharides and nucleic acids. Upon administration to a host animal, the hydrogel biodegrades, releasing as degradation products only naturally-occurring sugar molecules that are non-toxic and non-immunogenic to the host.

The invention relates to the technical field of contraceptive drugs, in particular to a biodegradation type long-acting subdermal contraceptive implant containing gestodene which uses the biodegradable polymer materials as the carrier for preparation and the preparation. The invention consists of the drug gestodene and the polymer biodegradable materials which are taken as a carrier (such as, trimethylene carbonate/p-Dioxanone copolymer (P(TMC-co-PDO))), a bar-shaped drug core is prepared by mixing the drug and the carrier, then the carrier materials are prepared into a drug delivery tube, then the drug core is arranged in the drug delivery tube, and the both ends are blocked by adhesives. The average daily drug delivery amount of the drug gestodene in the body is 10 to 30 micrograms. The implantation of one implant can be contraceptive for 1 to 2 years. The carrier materials can be degraded into small molecules after the release of the drug, the invention does not need to be taken out by the operation method, and the using cost is greatly reduced.

The invention relates to the field of biological material, and particularly relates to an acellular matrix tendon anti-adhesion film and a preparation method thereof. The method disclosed by the invention is characterized in that mammalian tendons are used, and an acellular matrix tendon anti-adhesion film is prepared by a process of raw material treatment, decellularization, matrix dissolution, low-temperature drying film formation, neutralization water washing, and the like. The acellular matrix tendon anti-adhesion film provided by the invention eliminates the immunogenicity of heterologousand foreign tissues, retains the active components of the tendon extracellular matrix, directly wraps a tendon injury part, provides a good microenvironment for tendon repair, prevents adhesion of tendons to surrounding tissues, and promotes tendon repair. In addition, the method for preparing the tendon anti-adhesion film has low cost.

The invention provides a degradation inhibitor of a gamma-polyglutamic acid and a gamma-polyglutamic acid water-retaining agent and an application method thereof, wherein after the gamma-polyglutamic acid or the gamma-polyglutamic acid water-retaining agent product is dried and ground, edetic acid disodium salt or tartaric acid and other degradation inhibitors are added, the mixture is added intoa light-proof and airtight composite material wrapper, is vacuum sealed and is stored at a drying low temperature position, the degradation time of the gamma-polyglutamic acid or the derivatives thereof is prolonged from 5 days to 6 months in the solution state, the degradation time is prolonged above 35 times, and the quality guarantee period of the product can reach above 24 months.