9results about How to "Prolong degradation time" patented technology

The invention discloses a composition containing microspheres and cross-linked hyaluronic acid or salt thereof as well as a preparation method and application of the composition. The composition comprises cross-linked hyaluronic acid or salt thereof, microspheres, a phosphate buffer solution and non-cross-linked hyaluronic acid or salt thereof. Mixed hyaluronic acid or salt thereof with high and low molecular weight is used under the condition of large amount of alkali solution to form a loose structure, hyaluronic acid or salt thereof with low molecular weight is used under the condition of small amount of alkali solution to form a compact network structure, and the two are mixed to continue cross-linking reaction to form a cross-linked structure. The preparation method comprises the following steps: firstly, forming gel with a soft elastic embedded structure with loose pores wrapping elastic hard spheres, then mixing the gel with the microspheres, and enabling the composition to have a soft elastic function and a rigid supporting performance due to entry of the rigid microspheres in the gel, so that the composition and the rigid microspheres have a synergistic effect; in addition, the gel can effectively protect the microspheres during moist heat sterilization, reduce degradation of the microspheres and prolong the effect of stimulating collagen regeneration by the microspheres, the gel is suitable for more skin levels and filling parts, and the use safety of the composition is improved.

The invention relates to a biological patch as well as a preparation method and application thereof. The biological patch comprises a base body, the base body comprises a non-crosslinking part and a crosslinking part in the thickness direction of the biological patch, the thickness ratio of the non-crosslinking part to the crosslinking part is 1: 99-99: 1, the porosity of the non-crosslinking part is larger than that of the crosslinking part, and the porosity difference is larger than or equal to 5%. The in-vivo degradation time of the biological patch can be prolonged, the good mechanical property is maintained, meanwhile, the high collagen biological activity is kept, the in-vivo degradation speed is matched with the tissue repair process, and comprehensive repair of injured tissue can be better promoted.

The invention discloses a high-efficiency degradation method of corn straws containing a low-temperature microbial inoculum for cold regions, which comprises the following steps: crushing corn straws, spraying degrading bacteria onto straw fragments, burying the straw fragments attached with the microbial inoculum under soil through cultivated land, and accelerating the degradation speed of the straws by utilizing the degrading bacteria, so that the degradation rate of the straws is increased; the corn straw degradation efficiency is improved (the corn straw degradation time can be shortened to be within 45 days), the growth environment temperature of bacteria is kept by covering the soil with straw powder, the activity of the bacteria can be improved, the straw degradation speed of the bacteria is further increased, and ultraviolet rays can be isolated by spraying water on the soil and covering the soil with the straw attached with the microbial inoculum, so that the corn straw degradation efficiency is improved. Sunlight is prevented from irradiating the fungicide to kill the fungicide, and the survival rate of microorganisms in the fungicide is increased.

The application discloses a bovine type I alpha interferon-ferritin fusion protein, a mutant thereof, and a preparation method and application thereof. The bovine type I alpha interferon is fused with a ferritin subunit, the self-assembly characteristics of the ferritin are utilized, the interferon molecules are highly repeated and orderly displayed on the surface of the ferritin nanocage, and the expression level, structural stability and antiviral activity of the interferon are significantly improved. The fusion protein is further subjected to rational design mutation at a unit point or multiple points, and a mutant with significantly improved antiviral activity and stability is obtained. The fusion protein or the mutant thereof is expressed by using a silkworm or insect cell eukaryotic expression system, the expression system is safe in operation, simple in procedure, low in cost, and extremely beneficial to large-scale industrial production, and the prepared fusion protein or mutant nanometer particle has application prospects in the preparation of medicines or reagents for preventing or treating bovine viral diseases.

The invention relates to the technical field of medical materials, in particular to hydrogel for biological tissue bonding and a preparation method and application thereof. The hydrogel for biological tissue adhesion comprises a first component, a second component, a third component and a fourth component, the first component and the second component form electrostatic interaction, and the third component and the fourth component form a covalent cross-linked structure; the first component, the second component, the third component and the fourth component are all biocompatible components. The hydrogel for biological tissue adhesion provided by the invention has excellent biocompatibility, relatively high adhesion strength and relatively low swelling property.

The utility model discloses a microbial degradation environment-friendly toilet, which relates to the field of sanitary equipment, and comprises a toilet main body, a flush toilet is fixedly arranged in the toilet main body, the bottom of the flush toilet is communicated with a degradation box through a water pipe, and a stirring roller and two support discs arranged side by side are arranged in the degradation box. The exteriors of rotating shafts at the two ends of the stirring roller are rotationally connected with two supporting discs respectively; according to the microbial degradation environment-friendly toilet, the stirring roller is driven by the first driving mechanism to revolve around the central axis of the supporting disc and rotate around the axis of the stirring roller at the same time, so that the stirring effect of the stirring roller on excrement in the degradation box is better, and stirring plates on the stirring roller rotate under the driving of the second driving mechanism; the stirring plates can also turn over and stir the surrounding excrement when rotating, so that the stirring disturbance effect on the excrement is further improved, the excrement is stirred more uniformly, the degradation efficiency is improved, and the degradation effect is better.

The present invention relates to a biological polysaccharide hydrogel, a preparation method therefor and an application thereof. The biological polysaccharide hydrogel of the present invention is formed by means of the mixing and reaction of two solutions; the first solution is a polysaccharide derivative solution having an aldehyde on a side chain; the second solution is a polysaccharide derivative solution having a primary amine on a main chain or a side chain, or a small molecule compound solution having two or more primary amines. The preparation method of the present invention comprises preparing the first solution and the second solution, and then mixing the first solution and the second solution to form a transparent biological polysaccharide hydrogel. The biological polysaccharide hydrogel of the present invention can be applied as a vitreous substitute.

The invention relates to the technical field of blood products, in particular to a wound dressing and a preparation method thereof. According to the preparation method provided by the invention, the plasma matrix is jointly treated by using a freeze drying technology and collagen, so that the three-dimensional protein fiber network density of the plasma matrix can be improved, meanwhile, the mechanical strength of a plasma matrix product is improved, the degradation time is prolonged, and the prepared wound dressing has a better effect in a clinical application scene.

The application discloses injectable long-acting collagen and a preparation method and application thereof, and belongs to the technical field of collagen preparation. The application solves the problems of rapid degradation and insufficient mechanical property of collagen after injection into the body, and the problem of inability to have biological safety, good biological activity and injectability. The long-acting collagen is prepared by taking methoxypolyethylene glycol active ester and collagen as raw materials. Amide reaction is caused between the methoxypolyethylene glycol active ester and lysine residues on the collagen, hydrophilic PEG is introduced on the surface of the collagen, a hydration layer is formed, biological enzymes are hindered from contacting the collagen, collagen degradation is delayed, and the single-arm structure of the methoxypolyethylene glycol active ester can avoid product agglomeration and abnormal viscosity caused by excessive cross-linking. The long-acting collagen has a long retention time in the body, has no obvious cytotoxicity, has high biological safety, and maintains cell proliferation, migration and adhesion activity and biological repair functions.