17results about How to "Prolong degradation time" patented technology

The invention discloses a floating type purification device for a river drain outlet. The floating type purification device comprises a mounting frame, the two sides of the mounting frame are each fixedly provided with two connecting frames, the two connecting frames located on the same side are fixedly provided with the same floating body, the mounting frame is slidably provided with two U-shaped frames, and the two U-shaped frames are provided with sewage purification structures. The invention further comprises a floating type purification method for the river channel sewage draining exit, during operation, the device can be placed at the river channel sewage draining exit, the floating body is utilized to float on the water surface, and the electric pump is utilized to pump water into the purification box, so that the water is purified by the solid microorganism carrier layer and the braid curtain type biological membrane carrier respectively and then is discharged; by arranging the electric pump, water can be promoted to pass through the solid microorganism carrier layer and the braid curtain type biological membrane carrier, then the water purification efficiency is improved, the height of the purification box can be adjusted by rotating a handle, the purification box can adapt to river channels with different depths to be used, and then the applicability and stability of the device are improved.

The invention discloses a composition containing microspheres and cross-linked hyaluronic acid or salt thereof as well as a preparation method and application of the composition. The composition comprises cross-linked hyaluronic acid or salt thereof, microspheres, a phosphate buffer solution and non-cross-linked hyaluronic acid or salt thereof. Mixed hyaluronic acid or salt thereof with high and low molecular weight is used under the condition of large amount of alkali solution to form a loose structure, hyaluronic acid or salt thereof with low molecular weight is used under the condition of small amount of alkali solution to form a compact network structure, and the two are mixed to continue cross-linking reaction to form a cross-linked structure. The preparation method comprises the following steps: firstly, forming gel with a soft elastic embedded structure with loose pores wrapping elastic hard spheres, then mixing the gel with the microspheres, and enabling the composition to have a soft elastic function and a rigid supporting performance due to entry of the rigid microspheres in the gel, so that the composition and the rigid microspheres have a synergistic effect; in addition, the gel can effectively protect the microspheres during moist heat sterilization, reduce degradation of the microspheres and prolong the effect of stimulating collagen regeneration by the microspheres, the gel is suitable for more skin levels and filling parts, and the use safety of the composition is improved.

The invention relates to a biological patch as well as a preparation method and application thereof. The biological patch comprises a base body, the base body comprises a non-crosslinking part and a crosslinking part in the thickness direction of the biological patch, the thickness ratio of the non-crosslinking part to the crosslinking part is 1: 99-99: 1, the porosity of the non-crosslinking part is larger than that of the crosslinking part, and the porosity difference is larger than or equal to 5%. The in-vivo degradation time of the biological patch can be prolonged, the good mechanical property is maintained, meanwhile, the high collagen biological activity is kept, the in-vivo degradation speed is matched with the tissue repair process, and comprehensive repair of injured tissue can be better promoted.

The invention provides a polyethylene glycol derivative. The polyethylene glycol derivative comprises a main chain with a structure as shown in a formula (IIa) and an end group with a structure as shown in a formula (IIb). According to the invention, hydroxyl and carboxyl of polyethylene glycol are directly subjected to esterification reaction to generate a polyethylene glycol derivative of which the end group is provided with o-phthalaldehyde, and finally the polyethylene glycol derivative and polyethylene glycol of which the end group is provided with amino form the chemical crosslinking hydrogel. Due to the introduction of ester bonds, the degradation time of the hydrogel is shortened, the gelling rate of the hydrogel is increased, and meanwhile, the hydrogel is high in adhesion performance, simple in preparation process and suitable for large-scale production.

The invention discloses a high-efficiency degradation method of corn straws containing a low-temperature microbial inoculum for cold regions, which comprises the following steps: crushing corn straws, spraying degrading bacteria onto straw fragments, burying the straw fragments attached with the microbial inoculum under soil through cultivated land, and accelerating the degradation speed of the straws by utilizing the degrading bacteria, so that the degradation rate of the straws is increased; the corn straw degradation efficiency is improved (the corn straw degradation time can be shortened to be within 45 days), the growth environment temperature of bacteria is kept by covering the soil with straw powder, the activity of the bacteria can be improved, the straw degradation speed of the bacteria is further increased, and ultraviolet rays can be isolated by spraying water on the soil and covering the soil with the straw attached with the microbial inoculum, so that the corn straw degradation efficiency is improved. Sunlight is prevented from irradiating the fungicide to kill the fungicide, and the survival rate of microorganisms in the fungicide is increased.

The invention relates to the technical field of blood products, in particular to a modified plasma matrix and a preparation method and application thereof. According to the preparation method, the calcium phosphate modifier is combined with the plasma matrix, so that the mechanical strength of the plasma matrix can be effectively enhanced, and the degradation time of the plasma matrix can be prolonged; and meanwhile, the defect of weak osteogenic inductivity of a calcium phosphate biological material is overcome by utilizing good biocompatibility and strong growth factor release capability of the plasma matrix. In addition, the plasma matrix is concentrated by using a freeze-drying technology, so that a fibrin network in the plasma matrix is formed more compactly, the mechanical strength of a plasma matrix product is further improved, and the degradation time is prolonged; and a calcium phosphate modifier and plasma matrix mixture is prepared into a product which is easy to store and use by a freeze-drying technology, so that the product can meet wider clinical application scenes, and a better treatment effect is obtained.

The application discloses a bovine type I alpha interferon-ferritin fusion protein, a mutant thereof, and a preparation method and application thereof. The bovine type I alpha interferon is fused with a ferritin subunit, the self-assembly characteristics of the ferritin are utilized, the interferon molecules are highly repeated and orderly displayed on the surface of the ferritin nanocage, and the expression level, structural stability and antiviral activity of the interferon are significantly improved. The fusion protein is further subjected to rational design mutation at a unit point or multiple points, and a mutant with significantly improved antiviral activity and stability is obtained. The fusion protein or the mutant thereof is expressed by using a silkworm or insect cell eukaryotic expression system, the expression system is safe in operation, simple in procedure, low in cost, and extremely beneficial to large-scale industrial production, and the prepared fusion protein or mutant nanometer particle has application prospects in the preparation of medicines or reagents for preventing or treating bovine viral diseases.

The invention relates to the technical field of medical materials, in particular to hydrogel for biological tissue bonding and a preparation method and application thereof. The hydrogel for biological tissue adhesion comprises a first component, a second component, a third component and a fourth component, the first component and the second component form electrostatic interaction, and the third component and the fourth component form a covalent cross-linked structure; the first component, the second component, the third component and the fourth component are all biocompatible components. The hydrogel for biological tissue adhesion provided by the invention has excellent biocompatibility, relatively high adhesion strength and relatively low swelling property.

The utility model discloses a microbial degradation environment-friendly toilet, which relates to the field of sanitary equipment, and comprises a toilet main body, a flush toilet is fixedly arranged in the toilet main body, the bottom of the flush toilet is communicated with a degradation box through a water pipe, and a stirring roller and two support discs arranged side by side are arranged in the degradation box. The exteriors of rotating shafts at the two ends of the stirring roller are rotationally connected with two supporting discs respectively; according to the microbial degradation environment-friendly toilet, the stirring roller is driven by the first driving mechanism to revolve around the central axis of the supporting disc and rotate around the axis of the stirring roller at the same time, so that the stirring effect of the stirring roller on excrement in the degradation box is better, and stirring plates on the stirring roller rotate under the driving of the second driving mechanism; the stirring plates can also turn over and stir the surrounding excrement when rotating, so that the stirring disturbance effect on the excrement is further improved, the excrement is stirred more uniformly, the degradation efficiency is improved, and the degradation effect is better.

The present invention relates to a biological polysaccharide hydrogel, a preparation method therefor and an application thereof. The biological polysaccharide hydrogel of the present invention is formed by means of the mixing and reaction of two solutions; the first solution is a polysaccharide derivative solution having an aldehyde on a side chain; the second solution is a polysaccharide derivative solution having a primary amine on a main chain or a side chain, or a small molecule compound solution having two or more primary amines. The preparation method of the present invention comprises preparing the first solution and the second solution, and then mixing the first solution and the second solution to form a transparent biological polysaccharide hydrogel. The biological polysaccharide hydrogel of the present invention can be applied as a vitreous substitute.

The invention relates to the technical field of blood products, in particular to a wound dressing and a preparation method thereof. According to the preparation method provided by the invention, the plasma matrix is jointly treated by using a freeze drying technology and collagen, so that the three-dimensional protein fiber network density of the plasma matrix can be improved, meanwhile, the mechanical strength of a plasma matrix product is improved, the degradation time is prolonged, and the prepared wound dressing has a better effect in a clinical application scene.

The invention relates to the technical field of biological medicine, in particular to porous microsphere composite sodium hyaluronate gel and a preparation method thereof. The preparation method comprises the following steps: preparing porous hydroxyapatite microspheres by using a spray drying method, physically mixing the porous hydroxyapatite microspheres with a sodium hyaluronate solution, adding the mixture into polysaccharide polymer gel, uniformly dispersing the porous microspheres in the gel, performing vacuum filling in a pre-filling syringe, and performing high-pressure steam sterilization to obtain the porous hydroxyapatite hydrogel. The composite sodium hyaluronate gel containing the porous microspheres is obtained. The sodium hyaluronate is of a non-crosslinking type, the safety problem caused by residues of a chemical crosslinking agent is avoided, and the effects of immediate filling and collagen regeneration promoting are achieved by introducing the active material porous microspheres. The filling effect of the prepared gel can last for 12-18 months, and the gel can be safely degraded, can be prepared on a large scale and is suitable for industrial production.

The application discloses injectable long-acting collagen and a preparation method and application thereof, and belongs to the technical field of collagen preparation. The application solves the problems of rapid degradation and insufficient mechanical property of collagen after injection into the body, and the problem of inability to have biological safety, good biological activity and injectability. The long-acting collagen is prepared by taking methoxypolyethylene glycol active ester and collagen as raw materials. Amide reaction is caused between the methoxypolyethylene glycol active ester and lysine residues on the collagen, hydrophilic PEG is introduced on the surface of the collagen, a hydration layer is formed, biological enzymes are hindered from contacting the collagen, collagen degradation is delayed, and the single-arm structure of the methoxypolyethylene glycol active ester can avoid product agglomeration and abnormal viscosity caused by excessive cross-linking. The long-acting collagen has a long retention time in the body, has no obvious cytotoxicity, has high biological safety, and maintains cell proliferation, migration and adhesion activity and biological repair functions.

The invention relates to a bio-crosslinked solid plasma matrix as well as a preparation method and application thereof. The preparation method is selected from any one of the following modes: mode I: placing a first volume of blood in a blood collection tube, centrifuging and stripping to obtain a solid plasma matrix; soaking the solid plasma matrix in a solution containing metal ions, and then washing to obtain a bio-crosslinked solid plasma matrix; mode II: spraying or adding the solution containing the metal ions into the blood collection tube to obtain the blood collection tube containing the metal ions; placing a second volume of blood in a blood collection tube containing metal ions, centrifuging and stripping to obtain a bio-crosslinked solid plasma matrix; the metal ions comprise magnesium ions and / or strontium ions. The bio-crosslinked solid plasma matrix obtained by the preparation method disclosed by the embodiment of the invention has the characteristics of higher strength, longer degradation time, more lasting capability of releasing active factors and optimized anti-inflammatory capability.

The invention discloses a sewing thread structure with a lifting effect, which comprises a thread body with a thread diameter; the hooks are arranged on one surface of the line body, and each hook is provided with at least one plane; the plurality of grooves are adjacently arranged on one side of the hook thorn, the hook thorn has a hook thorn height and a hook thorn width, each groove has a groove length and a groove depth, the hook thorn height is between 0.2 time and 0.35 time of the line diameter, the hook thorn width is between 0.35 time and 0.5 time of the line diameter, and the groove length is between 0.2 time and 0.35 time of the line diameter. The length of the groove is between 0.5 time and 0.8 time of the wire diameter, and the depth of the groove is between 0.3 time and 0.5 time of the wire diameter. Due to the facts that the barbs are arranged on the surface of the line body, and the depth of the groove is 0.33 times of the line diameter, the structural strength is relatively high, and the line is not prone to breakage. Furthermore, the hook thorn is provided with at least one plane, so that the hook thorn is in a non-sharp shape, and the chance of stabbing is effectively reduced.

The invention relates to the technical field of high polymer materials, in particular to a high-strength PBS biodegradable plastic and a preparation method thereof.The high-strength PBS biodegradable plastic is prepared from 4000-5000 parts of succinic acid, 5000-6000 parts of 1, 4-butanediol, 0.9-22 parts of a first catalyst and 4.5-550 parts of a functional additive; wherein the functional aids comprise a first functional aid and a second functional aid; the first functional additive comprises at least one of polyethylene wax, polypropylene wax and oxidized polyethylene wax; the second functional additive is selected from one of a formula (I) or a formula (II); the weight ratio of the first functional additive to the second functional additive is (0.5-3): 1; according to the high-strength PBS biodegradable plastic prepared by selecting a specific functional aid and a catalyst to be matched with the raw materials, the crystallization temperature of the PBS plastic is increased, the crystallization speed is increased, meanwhile, the tensile strength and the high-temperature resistance of the PBS plastic are improved, the hydrophobicity of the PBS plastic is enhanced, and therefore the degradation time of the PBS plastic is prolonged.

The invention discloses a high-density artificial bone repair material and a preparation method thereof. A preparation method of an artificial bone repair material comprises the following steps: A, obtaining a mixed solution of collagen and a first acid solution, and heating or irradiating the mixed solution to activate collagen molecules; b, dissolving the activated collagen in a second acid solution to obtain a collagen acid solution, adding calcium phosphate powder, uniformly mixing, and adding a cross-linking agent to obtain slurry; and C, injecting the slurry into a mold, carrying out a cross-linking reaction, and demolding. The artificial bone repair material disclosed by the invention is relatively high in density, the degradation time of the artificial bone repair material implanted into a human body is prolonged, and the growth rate of a new bone is favorably matched.