90 results about "Chitosan derivative" patented technology

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

A hydrogel for treating body cavity injury is derived from a chitosan derivative obtained by bonding aldonic acid to an amino group of a glucosamine unit of chitosan by dehydration condensation. The hydrogel for treating the body cavity injury is granular, can be injected into a body cavity by utilizing an injector, and is used for treating the wound of the body cavity. A body cavity injury treatment kit is provided with a syringe, a tube connected to the syringe, and a granular body cavity injury treatment hydrogel filled into the syringe, the body cavity injury treatment hydrogel being derived from a chitosan derivative, the chitosan derivative is obtained by bonding aldonic acid to an amino group of a glucosamine unit of chitosan through dehydration condensation.

The invention provides a medical absorbable collagen antibacterial suture line and a preparation method thereof. The preparation method comprises the following steps: S1, sequentially carrying out pretreatment, homogenization, digestion, sterilization, salting-out and purification on animal skin to obtain collagen; s2, performing solution blending on collagen and a chitosan derivative to prepare a spinning solution; s3, performing wet spinning on the spinning solution to obtain a wire rod; and S4, crosslinking or weaving the wire rod to prepare the medical antibacterial suture line capable of absorbing collagen. The suture line is high in collagen purity, in a special fiber bundle shape, low in antigenicity, good in spinnability, smooth in surface, soft and smooth in line body and easy to knot, does not need to be soaked before being used, can reduce scar hyperplasia and avoid centipede-shaped suture traces during suture, has antibacterial and hemostatic functions, and is suitable for clinical application. A physical hemostasis barrier can be quickly generated in the suturing process, and an excellent suturing effect is achieved.

The invention belongs to the field of medical materials, and relates to a porous chitosan derivative fiber as well as a preparation method and application thereof. The preparation method provided by the invention comprises the following steps: S1, by taking a chitosan solution as a spinning solution, carrying out wet spinning forming, and preparing porous chitosan fibers with the diameter of 15-25 microns by adopting a programmed heating freeze-drying process; s2, adding the porous chitosan fiber into an organic solvent, and adding an acid solution under a stirring condition for reaction to obtain the porous chitosan derivative fiber. The porous chitosan derivative fiber prepared by the preparation method has relatively high porosity and specific surface area, has excellent hydrophilicity and antibacterial property, and can be widely applied to medical materials.

The invention belongs to the technical field of adhesive materials, and particularly relates to a modified starch-based water-based adhesive as well as a preparation method and application thereof. According to the adhesive, oxidized corn starch is taken as a base material, hydrophobic and weather-resistant modification is realized by introducing a fluorine-silicon-containing functional monomer, and hydroxypropyl quaternized chitosan is compounded to endow antibacterial property and a film-forming enhancement effect; a borax cross-linked polyol system is supplemented to improve the cohesive strength, and a plasticizer, a thickening agent and an emulsifier are matched to optimize the rheological property and wettability. The preparation process comprises the steps of starch gelatinization, fluorosilicone urea grafting, chitosan derivative compounding, auxiliary agent blending and the like, and the process is mild, environment-friendly and non-toxic. The obtained water-based adhesive has the characteristics of strong initial adhesion, good water resistance, moderate flexibility, excellent biocompatibility and the like, and is especially suitable for adhesion and manufacturing of ball products such as basketballs, footballs and the like.

The present application relates to a kind of chitosan derivatives, its preparation method and application, belong to biological medical polymer material technical field.The method includes under the action of first catalyst, N-(2-hydroxypropyl)-3-trimethylammonium chloride chitosan is dissolved in first solvent, second solvent containing n-hexanoic anhydride is added to the first solvent containing N-(2-hydroxypropyl)-3-trimethylammonium chloride chitosan and is reacted, obtains chitosan derivative.The preparation method of the present application is easy to obtain raw material, and reaction condition is mild;And the chitosan derivative obtained carries a large number of positive charge, can be combined to the surface of negative electric tumor cell membrane by electrostatic interaction, promotes the interaction between the hydrophobic part of chitosan derivative and cell membrane phospholipid hydrophobic chain, destroys cell membrane stability and finally causes membrane lysis to make tumor cell necrosis.

The invention discloses a needle-punched cotton felt containing plant functional fibers and a preparation method of the needle-punched cotton felt, and belongs to the technical field of non-woven materials. The needle-punched cotton felt is composed of jute fibers, polyester staple fibers, auxiliary agent type deodorization fibers and 4080 low-melting-point fibers according to specific mass percent. Wherein the jute fibers are subjected to pretreatment of chemical degumming and soft modification treatment; the assistant type deodorizing fiber is a fiber prepared by blending and spinning a composite deodorizing assistant and a modified polymer matrix; the composite deodorizing auxiliary agent comprises nano zinc oxide, a chitosan derivative and zeolite powder; the modified polymer matrix is a polymer matrix modified by a compatilizer. The needle-punched cotton felt disclosed by the invention has excellent flexibility, high mechanical strength and an efficient and lasting deodorization function.

This invention discloses the application of a fluorinated chitosan derivative in the preparation of anti-neuroinflammatory drugs, belonging to the field of biomedical technology. The fluorinated chitosan derivative is the sole active ingredient in the drug. Its structure is a fluorinated acyl chitosan derivative obtained by N-acylation modification of the primary amine group at the C2 position of the chitosan backbone, with the C2 substituent being -NH-C(O)-Rf, where Rf is selected from -CF3, -C2F5, or -C3F7. The degree of substitution of the fluorinated chitosan derivative is 40%, and the weight-average molecular weight is 2-5 kDa. This fluorinated chitosan derivative is used as the active ingredient in the preparation of anti-neuroinflammatory drugs.

The invention provides a multi-element functional polyacrylamide-chitosan derivative composite flocculant. The structural formula of the multi-element functional polyacrylamide-chitosan derivative composite flocculant is shown in the following formula (I): (I), wherein R1 is an anionic monomer, R2 is a cationic monomer, R3 is acrylamide, and R4 is a coupling monomer; the composite flocculant comprises the following raw materials in parts by weight: 85-92 parts of multi-component copolymerized polyacrylamide dry powder, 1-3 parts of a surface protective agent and 5-15 parts of a chitosan derivative. According to the composite flocculant, the removal rate of various heavy metal ions in high-concentration beneficiation wastewater can reach 95% or above, the removal rate of suspended solids exceeds 98%, and the composite flocculant also has a remarkable adsorption and removal effect on residual flotation reagents; the formed floc is thick, dense and high in settling velocity; the product is wide in application range, can maintain high efficiency performance in a pH value range of 3-10, and is low in dosage and low in cost.

The application relates to the technical field of food packaging, in particular to a degradable food packaging bag and a preparation process thereof. The packaging bag comprises two base films and a functional adhesive layer which is compounded between the two base films. The base film is made of raw materials including the following components in parts by mass: polybutylene adipate terephthalate 50-70 parts; polylactic acid 20-35 parts; corn starch 10-25 parts; and a compatilizer 2-6 parts. The functional adhesive layer is made of raw materials including the following components in parts by mass: water-based polyurethane emulsion 100 parts; hydrophobic silicon dioxide particles 3-15 parts; chitosan derivative modified micron zinc oxide 5-20 parts; and a plasticizer 1-5 parts. The application provides a method which considers the degradation, antibacterial property and mechanical property, and has the effects of being safer and more reliable.

The invention discloses a biological organic leaf fertilizer as well as a preparation method and application thereof, and belongs to the technical field of agricultural planting. Comprising the following raw materials in parts by weight: 40-55 parts of soybean protein fermentation liquor, 8-12 parts of nano silicon dioxide aerogel, 10-15 parts of bacillus subtilis, 13-20 parts of an algal polysaccharide extract, 6-9 parts of fulvic acid, 3-8 parts of trace elements, 3-5 parts of a chitosan derivative and 0.1-2 parts of a film-forming agent. The components in the foliar fertilizer provided by the invention have a synergistic effect, so that the foliar fertilizer not only can effectively provide comprehensive nutrition for soybeans and promote growth and development of the soybeans, but also can enhance the stress resistance of the soybeans, especially has outstanding performance in the aspect of relieving waterlogging damage, and is beneficial to improving the yield and quality of the soybeans. The preparation method provided by the invention is simple and easy for large-scale production, and has remarkable economic benefits.

The invention aims to improve the cleaning performance of washing agents when washing textiles. This was substantially achieved by the use of N-carboxy-sulfoalkylated or N-sulfoalkylated chitosan.

The invention discloses a preparation and application method of a dual-responsiveness perfume microcapsule for cigarettes, which adopts a simple, low-cost and high-efficiency electron transfer catalytic regeneration atom transfer radical polymerization (ARGET ATPR) method, takes natural plant essential oil as a core material, takes modified chitosan derivatives and polymethylacrylic acid N, N-dimethylaminoethyl ester (PDMAEMA) as wall materials, and adopts a one-step method to prepare the dual-responsiveness perfume microcapsule for the cigarettes. The prepared plant essential oil loaded perfume microcapsule is uniform in shape and size, compact in structure, high in mechanical strength, large in perfume loading amount, high in encapsulation efficiency, high in stability in a normal-temperature environment and long in perfume retention time, and can quickly respond and release weak acid gas generated by cigarette combustion and in a high-temperature environment; the spice microcapsule is added into cigarette tobacco shreds in a spraying or direct mixing mode, the sensory quality of cigarettes can be remarkably improved during combustion, offensive odor is reduced, irritation is reduced, aftertaste is improved, the cigarettes are endowed with unique plant source characteristic aroma, and smoking experience is richer and more diversified.

The application discloses an antibacterial nanofiber hemodialysis membrane and a preparation method thereof, and relates to the technical field of dialysis membranes, and comprises the following process: a surface treatment agent is obtained by mixing a chitosan derivative, heparin, dopamine, an unsaturated monomer and an initiator in a DMF / phosphate buffer mixture; a polyethersulfone nanofiber membrane is taken as a support layer, the surface treatment agent is impregnated, UV irradiation is performed, and a functional layer is formed to obtain a dialysis membrane. The application compounding cerium tris-acrylate phenanthroline hybrid CeO2, N-vinyl pyrrolidone, sodium p-styrene sulfonate and lauryl methacrylate as the unsaturated monomer, compounding the chitosan derivative, heparin and dopamine to prepare the surface treatment agent, impregnating the polyethersulfone nanofiber membrane, and performing irradiation and solidification to form the functional layer, the prepared hemodialysis membrane has high efficient anticoagulation and broad-spectrum antibacterial property, high permeability, low protein adsorption and long-term stability.

The present application relates to a kind of foam type cationic nanoemulsion hair lotion and its preparation method, belong to hair lotion technical field.The preparation method of the present application includes the following steps, S1, surfactant, oil phase material, co-surfactant and bacteriostatic agent are mixed uniformly, drug is added, heating is made to be fully dissolved, and oil phase is obtained;S2, oil phase is added dropwise into aqueous phase, essence is added, and the foam type cationic nanoemulsion hair lotion is obtained;The aqueous phase includes chitosan derivative and water.Utilize the positive electricity of chitosan derivative, make the charge of nanometer emulsion of surface negative charge reverse, make it and epidermal cell better interaction, reduce the amount of drug penetration, improve the amount of drug in skin retention, while chitosan derivative has strong permeability and adhesion, synergistic with foam agent improves the amount of drug in skin retention, prolongs the retention time of drug in vivo, increases the time of drug penetration effect, better play local effect.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The application provides a self-shrinking hydrogel as well as a preparation method and application thereof, wherein the modified chitosan derivative has a structure of formula I. After the chitosan is modified in the application, the solubility of the chitosan is effectively improved, so that the chitosan can be uniformly dispersed in PBS or ultrapure water, the application prospect is widened, and the modified chitosan derivative is more suitable for accelerating wound repair in biochemical functions. The self-shrinking hydrogel containing the modified chitosan derivative is sensitive to temperature in the application, can produce deformation and shrinkage with the increase of temperature, can generate centripetal force on the edge tissue of a wound when applied to the wound, and is beneficial to wound healing.

The invention discloses pranoprofen eye drops and a preparation method thereof. The eye drops comprise pranoprofen, a chitosan derivative, a nonionic thickener, borax, boric acid, a metal ion chelating agent and an osmotic pressure regulator. By adding the chitosan derivative and the nonionic thickening agent, pranoprofen can be continuously and slowly released, so that a longer effective concentration is maintained at an acting part, the administration frequency is reduced, and the medication compliance of a patient is improved.

The invention relates to the field of freeze-dried powder, and discloses collagen composite freeze-dried powder for fading lines as well as preparation and application of the collagen composite freeze-dried powder. The collagen composite freeze-dried powder comprises recombinant XVII type human collagen, a chitosan derivative, superoxide dismutase, mannitol, a plant extract, palmitoyl pentapeptide-4 and water, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are used as cross-linking agents, and carboxymethyl cellulose quaternary ammonium salt and aminated chitosan are subjected to an amidation reaction, so that the chitosan derivative is prepared; the carboxymethyl cellulose quaternary ammonium salt is synthesized by reacting carboxymethyl cellulose and 3-chloro-2-hydroxypropyl trimethyl ammonium chloride in an aqueous solution; the aminated chitosan is prepared by using acryloyl chitosan prepared by reaction of acryloyl chloride and chitosan and further performing thiol-ene click reaction on the acryloyl chitosan and beta-mercaptoethylamine. The collagen composite freeze-dried powder prepared by the preparation method disclosed by the invention has good anti-wrinkle and firming effects and antibacterial performance.

The invention discloses a chitosan-based zwitterionic membrane as well as a preparation method and application thereof. The film has an interpenetrating network structure composed of a zwitterionic chitosan derivative chemical cross-linked network and a polyvinyl alcohol physical cross-linked network. The zwitterionic chitosan derivative is prepared by carrying out gradient quaternization on a chitosan main chain, carrying out selective oxidation to introduce carboxyl and carrying out secondary quaternization to introduce additional cationic groups. The preparation method comprises the following steps: preparing a chitosan quaternary ammonium salt precursor, respectively carrying out oxidation and secondary quaternization modification, mixing the two modified products, carrying out chemical crosslinking, and carrying out physical crosslinking with polyvinyl alcohol to form the membrane. The film has high ionic conductivity (the room-temperature OH <-> conductivity is 20-150 mS cm <-1 >), high mechanical strength (the elongation at break gt, 120%) and good chemical stability, is low in raw material cost and simple in process, and has wide application prospects in the fields of carbon dioxide electrocatalytic reduction, flow batteries and the like.

The invention discloses an easy-to-clean finishing agent, a preparation method thereof and a functional fabric, and belongs to the technical field of textile treatment. The soil release finishing agent is obtained by mixing ternary composite colloid and citric acid; colloid particles in the ternary composite colloid are of a core-shell structure, and a chitosan-tannic acid polyelectrolyte compound and oxidized nanocellulose are sequentially arranged from inside to outside; the chitosan-tannic acid polyelectrolyte compound is prepared by heating and self-assembling a chitosan derivative aqueous solution and plant polyphenol under the condition that the pH value is 4.5-5.5. The easy-to-clean finishing agent does not contain fluorine and is environment-friendly, and a functional fabric prepared from the easy-to-clean finishing agent has good dirt-removing power and washing resistance.

This invention discloses a hemostatic crystalloid material, its preparation method, and its applications, relating to the field of biomedical materials. The hemostatic crystalloid material of this invention includes a crystalloid carrier and anti-inflammatory molecules, analgesic molecules, and inorganic nanofillers loaded on the crystalloid carrier. The hemostatic crystalloid material exhibits a multilayered, dense porous structure with pore sizes ranging from 10 to 300 μm and an average pore size of 100 to 200 μm. The porosity of the hemostatic crystalloid material is 60-99%, and its density is 0.001-0.1 g / mm³. 3 The surface potential of the hemostatic crystal gel material is -100 to 0 mV. This invention utilizes the reversible dynamic covalent Schiff base formed by the condensation of oxidized hyaluronic acid and chitosan derivatives with aldehyde and amino groups at low temperature, resulting in a shape memory crystal gel with a connected porous structure capable of rapid hemostasis.

The invention belongs to the technical field of cardiovascular repair, and discloses a biodegradable vascular stent material for cardiovascular repair. The material comprises a medical stainless steel intravascular stent body and a composite coating coated on the surface of the medical stainless steel intravascular stent body. The inner layer contains RGD peptide modified chitosan derivatives and polyphenol substances, is used for promoting adhesion and proliferation of endothelial cells and has anti-inflammatory and anti-oxidation effects. The outer layer is a ginsenoside (MPEG)-PLGA microsphere loaded with heparin sodium, and is prepared by carrying out hydrophobic modification on ginsenoside through (2-allyl) succinic anhydride and carrying out co-loading with MPEG-PLGA, so that synergistic controlled release of anticoagulation and vascular repair promoting drugs is realized. The excellent mechanical property of the stainless steel stent is combined with the multifunctional biodegradable coating, and through the synergistic effect of the inner layer and the outer layer, endothelialization can be accelerated, smooth muscle hyperplasia can be inhibited, inflammatory response can be relieved, thrombosis can be prevented, and therefore the risk of restenosis and advanced thrombosis in the stent can be effectively reduced.

The invention relates to the technical field of soil remediation agents, and provides an organic silicon heavy metal soil remediation agent and a preparation method thereof. The organic silicon heavy metal soil remediation agent is prepared from the following raw materials in parts by weight: 40 to 60 parts of modified zeolite, 3 to 6 parts of sodium lignin sulfonate, 6 to 10 parts of potassium fulvate, 8 to 15 parts of chitosan derivative, 1 to 2 parts of organic silicon and 4 to 8 parts of potassium silicate. The modified zeolite is obtained by modifying zeolite with 4-mercaptophenyl acetic acid. According to the technical scheme, the problem that the heavy metal soil remediation agent is insufficient in adsorption and removal capacity on heavy metals in soil in the prior art is solved.

This invention discloses a gellizable, dynamically adhesive, moist wound healing dressing and its preparation method and application. The dressing is constructed from water-soluble cellulose derivatives, chitosan derivatives, and silk fibroin through physical cross-linking and freeze-induced phase separation, achieving dry-state stability without the need for chemical cross-linking agents. Upon contact with wound exudate, a gel layer forms. With prolonged contact, the carboxyl, amino, and hydroxyl functional groups form a dynamic, reversible hydrogen bond and electrostatic interaction network with skin surface proteins, resulting in an adhesion interface strength lower than the external force required for peeling, thus achieving non-damaging peeling. Furthermore, the dressing possesses antibacterial properties and acts as a nutrient substrate to promote cell proliferation and tissue regeneration. This invention's dressing integrates gelation, moisturizing, dynamic adhesion, antibacterial, and nutritional healing functions, making it suitable for moist wound healing treatment of various skin wounds and providing a novel dressing for clinical wound care.

The application belongs to the field of marine biotechnology, and particularly relates to natural polysaccharide-quaternized chitosan nanoparticles with immune stimulation and preparation and application thereof. The nanoparticles formed by natural polysaccharide with negative charge and quaternized chitosan with positive charge are obtained by polyelectrolyte complexation, the particle size is 316.4 nm, and the potential is 31.1 mV; the quaternized chitosan with positive charge and the natural polysaccharide with negative charge are mixed in a mass ratio of 6.25-10:1-4. After immunization of mice, the secretion amount of immunoglobulin IgG and immune factors in the mice is determined, which shows that the nanoparticles have good immune activity, thereby playing an effect in vaccine adjuvant. The application provides a method and guidance for the research on natural polysaccharide and chitosan derivatives as immune adjuvants in recent years.

The invention relates to the technical field of ceramic metallization, in particular to a metallization process of a ceramic material, which comprises the following steps: reacting chitosan with glycidyl methacrylate to obtain a water-soluble vinyl chitosan derivative; the preparation method comprises the following steps: adding a vinyl chitosan derivative, soluble metal salt and a water-based photoinitiator into water to prepare impregnation liquid; impregnating the ceramic material in the impregnation liquid, and curing under ultraviolet light; maintaining ultraviolet light for heat treatment; according to the metallization technology, the tensile strength and the thermal shock resistance of the ceramic metallization layer are remarkably improved, operation is easy, generated waste liquid is little, and the metallization technology is more environmentally friendly.

The present invention relates to a means for dyeing keratinous fibers, in particular human hair, comprising (F-1) at least one colouring compound from the group consisting of pigments and direct dyes, and (F-2) at least one chitosan and / or a chitosan derivative, and (F-3) at least one aliphatic C1-C 22 Monoalcohol, and (F-4) at least one aliphatic C2-C 22 Polyol wherein the weight ratio of the aliphatic C1-C contained in the average 22 -Monoalcohols (F-3) to the aliphatic C2-C contained in the average 22 Polyols (F-4), i.e., the weight ratio (F-3) / (F-4), is at least 1.

The invention belongs to the technical field of cell immobilization, and particularly relates to an acidophilic thiobacillus ferrooxidans immobilization material and application thereof in cell immobilization and desulfurization. According to the acidithiobacillus ferrooxidans immobilized material, Fe3O4 nano-clusters are used as raw materials, a PDA shell layer with a mesoporous structure is formed on the surfaces of the Fe3O4 nano-clusters by means of self-polymerization reaction of dopamine, a nano composite material Fe3O4 (at) mPDA is constructed, meanwhile, biotinylated chitosan derivatives Bio-CS are synthesized by using biotin as raw materials, and the acidithiobacillus ferrooxidans immobilized material is prepared. And combining the Fe3O4 (at) mPDA with a biotinylated chitosan derivative Bio-CS by virtue of an emulsification method, thereby obtaining the Fe3O4 (at) mPDA. The acidithiobacillus ferrooxidans immobilized material provided by the invention can be used for immobilizing acidithiobacillus ferrooxidans. The material provided by the invention not only can effectively maintain the biological activity of the acidithiobacillus ferrooxidans BY3, but also has the advantages of mild reaction conditions, no secondary pollution and capability of maintaining the cyclic utilization of Fe < 3 + >, so that the method meets the manufacturing requirements of a green biotechnology.