184 results about "Chitosan derivative" patented technology

The invention belongs to the technical field of biomedical materials, and particularly relates to a multi-layer multifunctional hydrogel microsphere for diabetic wounds as well as a preparation method and application of the multi-layer multifunctional hydrogel microsphere. The preparation method comprises the following steps: firstly, synthesizing a chitosan derivative with proper amino and aldehyde group contents, oxidized macromolecules and modified chitin; then preparing photocuring hydrogel microspheres by utilizing a microfluidic technology, and sequentially immersing the photocuring hydrogel microspheres into an oxidized polymer solution, a modified chitin solution, a tannic acid solution and a metal salt solution, so as to construct the hydrogel microspheres with a multifunctional layer structure. The invention further provides specific application intervals of parameters such as solvents used by various solutions, concentration ranges and soaking time. The preparation method provided by the invention has expansibility and universality, various types of microspheres can be constructed for sequential release of bioactive substances, and the requirements of tissue repair are met.

The present invention relates to the technical field of cosmetics, and discloses a whitening and freckle-removing essence and a preparation method thereof. The whitening and freckle-removing essence is formed by mixing additives such as nicotinamide, EDTA, L-lactic acid, citric acid, baicalein inclusion complex, etc. The baicalein inclusion complex has a coated structure. Since the skin surface carries a negative charge and the coating layer of the baicalein inclusion complex contains chitosan, it can be adsorbed on the skin surface through electrostatic action, producing a sustained-release effect, and then targeted release, so as to improve the whitening effect of the essence. In addition, after being encapsulated, baicalein can have good compatibility with other substances in the formula. Moreover, the linolenic fatty acid chain in the structure of the chitosan derivative has excellent antioxidant, anti-inflammatory and other effects, which can reduce the phenomenon of scar formation on the skin due to inflammation.

The invention relates to the technical field of rice seed germination accelerating systems and methods. Seed selection is conducted, specifically, rice seeds which are full and free of damage are screened, and impurities are removed; the rice seeds are soaked in a plant growth regulator mixed solution to be subjected to oscillation treatment, the mixed solution is composed of gibberellin with the concentration being 20-50 mg / L, pimacol with the concentration being 5-15 mg / L and polyoxyethylene lauryl ether with the concentration being 0.01-0.03%, the liquid temperature is kept at 30 + / -2 DEG C, and the treatment time is 2-4 hours; gradient disinfection: primary disinfection: putting the pretreated seeds into a 0.3-0.5% hydrogen peroxide solution at the temperature of 40-50 DEG C, and stirring for 15-20 minutes; secondary disinfection: transferring to a 0.8-1.2% sodium hypochlorite solution at the temperature of 25-30 DEG C, adding a 0.05-0.1 mol / L phosphate buffer solution to adjust the pH value to 6.8-7.2, and standing for 40-60 minutes; the disinfected seeds are put into magnetized water containing 0.1%-0.3% of chitosan derivatives and 0.05%-0.15% of sodium alginate, the magnetic field intensity ranges from 300 gauss to 500 gauss, and ultrasonic waves of 30 kHz to 50 kHz are adopted for assisting permeation for 1 h to 2 h; the rice seed germination accelerating system and method are high in germination accelerating efficiency.

The invention discloses an antibacterial nanofiber hemodialysis membrane and a preparation method thereof, and relates to the technical field of dialysis membranes, and the preparation method comprises the following steps: mixing a chitosan derivative, heparin, dopamine, an unsaturated monomer and an initiator in a DMF / phosphate buffer mixed solution to obtain a surface treating agent; taking the polyethersulfone nanofiber membrane as a supporting layer, dipping in a surface treating agent, and performing UV irradiation to form a functional layer, thereby obtaining the dialysis membrane. The preparation method comprises the following steps: compounding phenanthroline cerium triacrylate hybridized CeO2 with N-vinyl pyrrolidone, sodium p-styrenesulfonate and lauryl methacrylate to obtain an unsaturated monomer, compounding the unsaturated monomer with a chitosan derivative, heparin and dopamine to prepare a surface treating agent, impregnating a polyether sulfone nanofiber membrane, and carrying out irradiation curing to form a functional layer. The prepared hemodialysis membrane has efficient anticoagulation and broad-spectrum antibacterial properties, high permeability, low protein adsorbability and long-term stability.

The invention belongs to the technical field of medical instruments, and particularly relates to a composite material for an anaesthetic laryngoscope and a preparation method thereof. The composite material for the anaesthetic laryngoscope comprises the following raw materials in parts by weight: 50-80 parts of polyvinyl chloride, 45-65 parts of a plasticizer, 0.5-1 part of a lubricant, 0.5-1 part of a stabilizer, 0.5-1 part of a chitosan derivative and 3-8 parts of modified hydroxyapatite. The chitosan derivative, the modified hydroxyapatite and other components are added into the polyvinyl chloride (PVC), so that the composite material is endowed with stable lubricity and antibacterial property, and meanwhile, the mechanical property of the composite material is also improved.

The invention discloses a fluoride-free oil-proof agent for paper pulp molding and a preparation method thereof, and belongs to the technical field of paper pulp molding materials. The fluoride-free oil-proof agent is prepared from the following raw materials in parts by weight: 40 to 60 parts of long-chain alkane, 10 to 20 parts of short-chain alkane, 10 to 15 parts of film-forming agent, 5 to 10 parts of modified polysilazane, 3 to 7 parts of nano material, 1 to 3 parts of chitosan derivative, 0.1 to 3 parts of cross-linking agent, 6 to 10 parts of filler and 60 to 100 parts of solvent. Wherein the modified polysilazane is prepared by reacting polysilazane with methyltriethoxysilane and 3-halogenated propylene under the action of a catalyst and chloroplatinic acid isopropanol. The preparation method comprises the following steps: mixing long-chain alkane, short-chain alkane and a solvent, and heating to react; other components are mixed and subjected to ultrasonic treatment; and mixing the two mixtures under ultrasonic and pressure conditions. The fluoride-free oil-proof agent provided by the invention is environment-friendly and safe, has excellent oil-proof performance, and is suitable for surface treatment of paper pulp molded products.

The present invention provides a natural polymer-based food packaging material, a preparation method, and an application thereof, belonging to the technical field of food packaging materials. The present invention uses a chitosan derivative, chitosan quaternary ammonium salt, as a basis and uses the anions of docusate sodium to perform ion exchange on the chitosan quaternary ammonium salt. On the one hand, the chitosan quaternary ammonium salt takes advantage of its antibacterial and film-forming properties to impart good processing properties to the food packaging material and effectively solve the problem of bacterial growth in food packaging materials. On the other hand, the present invention uses the anions of docusate sodium to modify the chitosan quaternary ammonium salt, partially or completely replacing the chloride ions of the chitosan quaternary ammonium salt with the anions of docusate sodium. This can impart good hydrophobicity to the food packaging material, causing water vapor to accumulate on the surface of the material without penetrating, thereby imparting good water vapor barrier properties.

The invention discloses an extraction process of rape pollen and application of the rape pollen in oral liquid of Kuyuan, and belongs to the technical field of traditional Chinese medicines. The process provided by the invention comprises the following steps: freezing and breaking walls of dried rape pollen, crushing, dipping with ethanol to extract alcohol-soluble substances such as flavone, decocting filter residues with water to extract water-soluble substances such as polysaccharide, concentrating a water extract, adding ethanol and a dual-modified chitosan derivative, settling to remove impurities, and finally combining the alcohol extract and alcohol precipitation supernatant to obtain the full-component extract. Compared with the prior art, the method has the advantages that the alcohol-soluble and water-soluble substances in the rape pollen are synchronously and efficiently extracted, the utilization rate of effective components is increased, the stability and safety of the extract are enhanced, a high-activity, low-cost and high-stability raw material solution is provided for the functional oral liquid, and the requirements of the modern health-care product market are met.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

The invention provides a hydrogel composition as well as a preparation method and application thereof. The hydrogel composition comprises the following components: a temperature-sensitive chitosan derivative solution and a blood sample, the volume ratio of the temperature-sensitive chitosan derivative solution to the blood sample is 1: (0.5-8), and the concentration of solute in the temperature-sensitive chitosan derivative solution is 3wt%-10wt%. The temperature-sensitive chitosan derivative solution with the specific concentration and the blood sample are matched for use according to the specific volume ratio, the obtained hydrogel composition has the phase transition temperature close to the physiological temperature of a human body, the volume shrinkage rate of a blood clot is low, the compressive strength is high, and the biological safety is good; when used for repairing cartilage injury, the cartilage injury repairing material can reduce the shifting and falling risks of blood clots, and then the cartilage injury repairing effect is improved.

A hydrogel for treating body cavity injury is derived from a chitosan derivative obtained by bonding aldonic acid to an amino group of a glucosamine unit of chitosan by dehydration condensation. The hydrogel for treating the body cavity injury is granular, can be injected into a body cavity by utilizing an injector, and is used for treating the wound of the body cavity. A body cavity injury treatment kit is provided with a syringe, a tube connected to the syringe, and a granular body cavity injury treatment hydrogel filled into the syringe, the body cavity injury treatment hydrogel being derived from a chitosan derivative, the chitosan derivative is obtained by bonding aldonic acid to an amino group of a glucosamine unit of chitosan through dehydration condensation.

The invention provides a medical absorbable collagen antibacterial suture line and a preparation method thereof. The preparation method comprises the following steps: S1, sequentially carrying out pretreatment, homogenization, digestion, sterilization, salting-out and purification on animal skin to obtain collagen; s2, performing solution blending on collagen and a chitosan derivative to prepare a spinning solution; s3, performing wet spinning on the spinning solution to obtain a wire rod; and S4, crosslinking or weaving the wire rod to prepare the medical antibacterial suture line capable of absorbing collagen. The suture line is high in collagen purity, in a special fiber bundle shape, low in antigenicity, good in spinnability, smooth in surface, soft and smooth in line body and easy to knot, does not need to be soaked before being used, can reduce scar hyperplasia and avoid centipede-shaped suture traces during suture, has antibacterial and hemostatic functions, and is suitable for clinical application. A physical hemostasis barrier can be quickly generated in the suturing process, and an excellent suturing effect is achieved.

The invention belongs to the field of medical materials, and relates to a porous chitosan derivative fiber as well as a preparation method and application thereof. The preparation method provided by the invention comprises the following steps: S1, by taking a chitosan solution as a spinning solution, carrying out wet spinning forming, and preparing porous chitosan fibers with the diameter of 15-25 microns by adopting a programmed heating freeze-drying process; s2, adding the porous chitosan fiber into an organic solvent, and adding an acid solution under a stirring condition for reaction to obtain the porous chitosan derivative fiber. The porous chitosan derivative fiber prepared by the preparation method has relatively high porosity and specific surface area, has excellent hydrophilicity and antibacterial property, and can be widely applied to medical materials.

The invention relates to an agent (F) for dyeing keratin fibers, in particular human hair, containing (F-1) at least one pigment and (F-2) at least one chitosan and / or chitosan derivative, characterized in that the weight ratio of all pigments (F-1) contained in the agent to all chitosan (derivatives) (F-2) contained in the agent, i.e. the weight ratio (F-1) / (F-2), is in the range of 1.00:1.05 to 1.00:2.45.

The invention belongs to the technical field of adhesive materials, and particularly relates to a modified starch-based water-based adhesive as well as a preparation method and application thereof. According to the adhesive, oxidized corn starch is taken as a base material, hydrophobic and weather-resistant modification is realized by introducing a fluorine-silicon-containing functional monomer, and hydroxypropyl quaternized chitosan is compounded to endow antibacterial property and a film-forming enhancement effect; a borax cross-linked polyol system is supplemented to improve the cohesive strength, and a plasticizer, a thickening agent and an emulsifier are matched to optimize the rheological property and wettability. The preparation process comprises the steps of starch gelatinization, fluorosilicone urea grafting, chitosan derivative compounding, auxiliary agent blending and the like, and the process is mild, environment-friendly and non-toxic. The obtained water-based adhesive has the characteristics of strong initial adhesion, good water resistance, moderate flexibility, excellent biocompatibility and the like, and is especially suitable for adhesion and manufacturing of ball products such as basketballs, footballs and the like.

The present application relates to a kind of chitosan derivatives, its preparation method and application, belong to biological medical polymer material technical field.The method includes under the action of first catalyst, N-(2-hydroxypropyl)-3-trimethylammonium chloride chitosan is dissolved in first solvent, second solvent containing n-hexanoic anhydride is added to the first solvent containing N-(2-hydroxypropyl)-3-trimethylammonium chloride chitosan and is reacted, obtains chitosan derivative.The preparation method of the present application is easy to obtain raw material, and reaction condition is mild;And the chitosan derivative obtained carries a large number of positive charge, can be combined to the surface of negative electric tumor cell membrane by electrostatic interaction, promotes the interaction between the hydrophobic part of chitosan derivative and cell membrane phospholipid hydrophobic chain, destroys cell membrane stability and finally causes membrane lysis to make tumor cell necrosis.

The invention discloses a needle-punched cotton felt containing plant functional fibers and a preparation method of the needle-punched cotton felt, and belongs to the technical field of non-woven materials. The needle-punched cotton felt is composed of jute fibers, polyester staple fibers, auxiliary agent type deodorization fibers and 4080 low-melting-point fibers according to specific mass percent. Wherein the jute fibers are subjected to pretreatment of chemical degumming and soft modification treatment; the assistant type deodorizing fiber is a fiber prepared by blending and spinning a composite deodorizing assistant and a modified polymer matrix; the composite deodorizing auxiliary agent comprises nano zinc oxide, a chitosan derivative and zeolite powder; the modified polymer matrix is a polymer matrix modified by a compatilizer. The needle-punched cotton felt disclosed by the invention has excellent flexibility, high mechanical strength and an efficient and lasting deodorization function.

The present invention relates to the field of electroless copper plating materials, and provides an environment-friendly electroless copper plating agent and a preparation method thereof. The electroless copper plating agent comprises a quaternized chitosan complexing agent, a chitosan-cysteine derivative, a chitosan-glutathione derivative, tea polyphenols, dopamine, potassium citrate trihydrate, ascorbic acid, glucose, sodium alginate, sodium citrate and an ethanol-water mixed solvent. The preparation method includes the synthesis of chitosan derivatives, the preparation of complexing agents and the preparation of electroless copper plating agents. By optimizing the stability of complexing agents, the copper ion complexing ability and the deposition uniformity, the adhesion and uniformity of the deposited layer are improved. The obtained electroless copper plating agent solution has a stable conductivity and a controllable copper deposition rate, and is suitable for electronic circuit manufacturing and metal surface treatment. The present invention uses natural polymer complexing agents to replace traditional harmful complexing agents, realizes high-efficiency and environment-friendly electroless copper plating, reduces environmental pollution, and has good industrial application value.

This invention discloses the application of a fluorinated chitosan derivative in the preparation of anti-neuroinflammatory drugs, belonging to the field of biomedical technology. The fluorinated chitosan derivative is the sole active ingredient in the drug. Its structure is a fluorinated acyl chitosan derivative obtained by N-acylation modification of the primary amine group at the C2 position of the chitosan backbone, with the C2 substituent being -NH-C(O)-Rf, where Rf is selected from -CF3, -C2F5, or -C3F7. The degree of substitution of the fluorinated chitosan derivative is 40%, and the weight-average molecular weight is 2-5 kDa. This fluorinated chitosan derivative is used as the active ingredient in the preparation of anti-neuroinflammatory drugs.

The present invention provides a composite disinfectant containing chlorine dioxide and its preparation process, belonging to the technical field of composite disinfectant preparation; the preparation process includes the following steps: preparation of a carrier stabilizer; preparation of modified carboxymethyl chitosan; preparation of slow-release gel microspheres; preparation of modified chitosan derivatives; preparation of a chlorine dioxide composite disinfectant. The chlorine dioxide composite disinfectant prepared by the present invention can avoid the initial burst release of the slow-release gel microspheres, enable the slow and stable release of the chlorine dioxide component, play a lasting and efficient disinfection and antibacterial role, and can reduce the corrosion of chlorine dioxide to metals.

The present invention belongs to the fields of medicine and agriculture, and particularly relates to an N-carboxymethyl chitosan quinolone derivative, a preparation method thereof, and an application thereof. The derivative is a compound shown in Formula I. The preparation method is to prepare N-carboxymethyl chitosan and perform ion exchange with a protonated quinolone compound derivative to obtain the derivative shown in Formula I. The raw materials of this method are cheap and easily available, and the preparation is simple. The chitosan derivative prepared by this method has higher antibacterial activity than chitosan, the reaction conditions are green and harmless, the yield is high, and it can be widely applied in the fields of medicine, agriculture, etc. Formula I.

The invention provides a multi-element functional polyacrylamide-chitosan derivative composite flocculant. The structural formula of the multi-element functional polyacrylamide-chitosan derivative composite flocculant is shown in the following formula (I): (I), wherein R1 is an anionic monomer, R2 is a cationic monomer, R3 is acrylamide, and R4 is a coupling monomer; the composite flocculant comprises the following raw materials in parts by weight: 85-92 parts of multi-component copolymerized polyacrylamide dry powder, 1-3 parts of a surface protective agent and 5-15 parts of a chitosan derivative. According to the composite flocculant, the removal rate of various heavy metal ions in high-concentration beneficiation wastewater can reach 95% or above, the removal rate of suspended solids exceeds 98%, and the composite flocculant also has a remarkable adsorption and removal effect on residual flotation reagents; the formed floc is thick, dense and high in settling velocity; the product is wide in application range, can maintain high efficiency performance in a pH value range of 3-10, and is low in dosage and low in cost.

The present invention discloses a degradable wound dressing and a preparation method thereof. The degradable wound dressing is made from the following raw materials, calculated by weight: 70-80 parts starch; 10-20 parts chitosan derivative; 10-30 parts water; 1-10 parts plasticizer; 1-5 parts cross-linking agent; and 5-10 parts nano-titanium dioxide. By using starch as the main film-forming substance, adding chitosan derivatives to improve water solubility and thus increase degradation speed, and adding nano-titanium dioxide, which can generate hydroxyl radicals from water molecules when exposed to sunlight, further promoting starch oxidation and increasing degradation speed, and the nano-titanium dioxide generates active oxygen species under sunlight that can destroy bacterial structures and accelerate wound healing. Therefore, the degradable wound dressing has a fast degradation rate and good wound healing effect.

The invention belongs to the field of medicine and agriculture, and particularly relates to an N-carboxymethyl chitosan quinolone derivative as well as a preparation method and application thereof. The derivative is a compound as shown in a formula I. The preparation method comprises the following steps: preparing N-carboxymethyl chitosan, and carrying out ion exchange on the N-carboxymethyl chitosan and a protonated quinolone compound derivative to obtain the derivative as shown in the formula I. The method has the advantages of cheap and easily available raw materials and simple preparation. The antibacterial activity of the chitosan derivative prepared by the method is higher than that of chitosan, the reaction conditions are green and harmless, the yield is high, and the chitosan derivative can be widely applied to the fields of medicines, agriculture and the like. And the # imgabs0 # is shown in the formula 1.

The application provides a chromium-contaminated laterite soil repairing agent and a repairing method thereof, and the method realizes effective repair of the laterite soil through the steps of pretreating the soil, applying the repairing agent I and applying an electric field, adding the repairing agent II for maintenance, and finally connecting biological strains.The method comprises the following steps: removing sundries, plowing the soil, applying the repairing agent I containing a reducing agent, citric acid and other components, and treating under specific electric field conditions.Subsequently, the repairing agent II, such as organic fertilizer, iron oxide, nano zeolite and chitosan derivative, is added.Finally, specific proportions of aspergillus, citrobacter freundii and psychrobacter are connected for biological repair.The method comprehensively considers physical, chemical and biological repair means, aims to efficiently remove chromium pollution in the soil, improve the soil organic carbon content of the laterite soil, and restore the ecological function of the soil.

The application relates to the technical field of food packaging, in particular to a degradable food packaging bag and a preparation process thereof. The packaging bag comprises two base films and a functional adhesive layer which is compounded between the two base films. The base film is made of raw materials including the following components in parts by mass: polybutylene adipate terephthalate 50-70 parts; polylactic acid 20-35 parts; corn starch 10-25 parts; and a compatilizer 2-6 parts. The functional adhesive layer is made of raw materials including the following components in parts by mass: water-based polyurethane emulsion 100 parts; hydrophobic silicon dioxide particles 3-15 parts; chitosan derivative modified micron zinc oxide 5-20 parts; and a plasticizer 1-5 parts. The application provides a method which considers the degradation, antibacterial property and mechanical property, and has the effects of being safer and more reliable.

The invention discloses a biological organic leaf fertilizer as well as a preparation method and application thereof, and belongs to the technical field of agricultural planting. Comprising the following raw materials in parts by weight: 40-55 parts of soybean protein fermentation liquor, 8-12 parts of nano silicon dioxide aerogel, 10-15 parts of bacillus subtilis, 13-20 parts of an algal polysaccharide extract, 6-9 parts of fulvic acid, 3-8 parts of trace elements, 3-5 parts of a chitosan derivative and 0.1-2 parts of a film-forming agent. The components in the foliar fertilizer provided by the invention have a synergistic effect, so that the foliar fertilizer not only can effectively provide comprehensive nutrition for soybeans and promote growth and development of the soybeans, but also can enhance the stress resistance of the soybeans, especially has outstanding performance in the aspect of relieving waterlogging damage, and is beneficial to improving the yield and quality of the soybeans. The preparation method provided by the invention is simple and easy for large-scale production, and has remarkable economic benefits.

The invention discloses a weather-resistant, anti-impact and antibacterial ABS composite material and a preparation process thereof.The prepared ABS composite material is simple in process, the antibacterial effect of the ABS composite material is improved through chitosan derivatives, meanwhile, the original tensile strength and bending performance of the ABS composite material are kept, the ABS composite material has excellent mechanical performance, a specific stabilizer compounding system is adopted, and the ABS composite material is environmentally friendly. And a coating system is established and is uniformly dispersed in the ABS composite material, so that the weather aging resistance and the yellowing resistance are remarkably improved.

The present invention relates to a means (F) for dyeing keratinous fibers, in particular human hair, comprising (F-1) at least one pigment, and (F-2) at least one chitosan and / or a chitosan derivative, characterized in that the weight ratio of all pigments (F-1) contained in the average to all chitosan (derivatives) (F-2) contained in the average, i.e. the weight ratio (F-1) / (F-2), is in the range of 1.00:1.05 to 1.00:2.45.