Chitosan or its derivative as drug carrier for carrying red sage root extract

A chitosan derivative, carrier-loaded technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of limited solubilization, low solubility of cyclodextrin, insoluble in water, etc.

Inactive Publication Date: 2005-11-23
蒋斯扬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tanshinone is a fat-soluble substance, and the biggest obstacle to drug use is that it is insoluble in water and has low bioavailability, which causes difficulties in preparation and application.
In 1978, Qian Mingkun and others sulfonated tanshinone II A and made it into sodium salt, which greatly improved the water solubility of tanshinone, and made it into injection for intravenous injection. However, due to the high water solubility of tanshinone II A sodium sulfonate, injection After the body is quickly excreted with urine and feces, the efficacy of the medicine cannot be exerted as it should
In recent years, how to solve the problem of water solubility of tanshinone drugs has been continuously researched and explored. At present, dozens of patents have been published in our country. However, these solutions are not ideal, and there are still many places to be improved. and improvement, such as Chinese patent CN01141436 through cyclodextrin inclusion solubilization of tanshinone, but the solubility of cyclodextrin itself in water is low, solubilization is limited
In addition, studies have found that in aqueous solution, dissolved cyclodextrins can catalyze drugs or other components in the preparation like enzymes, which will accelerate the decomposition of clathrates (Rainer H Muller et al. System Theory and Practice", People's Military Medical Press, 2004), while tanshinone is a substance with many active sites and strong activity, and is not stable

Method used

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  • Chitosan or its derivative as drug carrier for carrying red sage root extract
  • Chitosan or its derivative as drug carrier for carrying red sage root extract
  • Chitosan or its derivative as drug carrier for carrying red sage root extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Ethanol solution of Danshen extract

[0030] Take 1Kg of Salvia miltiorrhiza produced in Nyingchi region of Tibet, dry and crush it, and use carbon dioxide supercritical extraction to obtain 65g of slurry extract, take 10g of it and add 500mL of 95% ethanol to make ethanol solution of Salvia miltiorrhiza extract, and seal it in a brown glass bottle with a ground glass stopper For standby, according to the literature, the mixed extract contains about 13 natural active ingredients, namely: Tanshinone II A, cryptotanshinone, tanshinone formic acid, tanshinone I, dihydrotanshinone I, danshenxin quinone A, danshenxin quinone B, danshenxin Quinone propane, hydroxyquinone, hypotanshinone, 1,2-dihydrotanshinone, salvianolide, milohanol.

Embodiment 2

[0032] Preparation of Salvia Miltiorrhiza Extract Spherules Loaded with Alkaline Solidified Chitosan

[0033] Get viscosity-average molecular weight and be 100,000, the chitosan 2.0g that the degree of deacetylation is 90% is dissolved in the dilute acetic acid of 600mL2%, add the ethanol solution of the salvia miltiorrhiza extract that 50mL embodiment 1 configures, stir and disperse evenly, use fine nozzle Slowly drop the dropper into 1000mL of 1.5% NaOH solution, carefully stir while adding, filter to obtain the drug-loaded microspheres, freeze-dry, and observe with a scanning electron microscope to obtain 2-10um microspheres.

Embodiment 3

[0035] Sodium tripolyphosphate cross-linked chitosan beads loaded with salvia miltiorrhiza extract

[0036] Get viscosity-average molecular weight and be 100,000, deacetylation degree is 90% chitosan 2.0g is dissolved in the dilute acetic acid of 600mL 2%, add 1.0g gelatin and mix evenly, add the ethanol solution of the salvia miltiorrhiza extract that 50mL embodiment 1 configures , stir and disperse evenly, drop into 1.0% sodium tripolyphosphate cross-linking ion solution through No. After drying, small balls of 15-30um were observed by scanning electron microscope.

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Abstract

The invention relates to a chitosan or its derivative as drug carrier for carrying red sage root extract and the method, wherein the novel carrying agents include chitosan or sodium alginate for the preparation of drug-carrying beads, tanshinone pharmaceutical carrying agents using the carboxymethyl derivative of chitosan and the quaternary ammonium salt of chitosan, and the aquagel as the carrying agent of red sage root active component prepared from chitosan grafted polyethylene glycol.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to the use of chitosan and its derivatives or sodium alginate as a carrier for controlling the release of salvia miltiorrhiza extract, especially the water-soluble polymer glue obtained by grafting hydrophobic chains on chitosan bundle, and then load the salvia miltiorrhiza extract to achieve the purpose of controlling the release of the salvia miltiorrhiza extract. technical background [0002] Salvia miltiorrhiza is a traditional Chinese medicine in my country, which is widely used clinically in the treatment of cardiovascular diseases, stroke, chronic persistent hepatitis, kidney diseases, infectious diseases, etc. The active components of Danshen include fat-soluble diterpene quinones and water-soluble phenolic acids. Diterpene quinone compounds are the main active ingredients of salvia miltiorrhiza in fat-soluble properties, and they ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36
Inventor 蒋斯扬
Owner 蒋斯扬
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