4 results about "Methyl derivative" patented technology

This invention discloses a method for synthesizing medroxyprogesterone acetate intermediates based on a metal-organic synergistic catalysis. The method uses 17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecano-1H-cyclopenta[a]phenanthrene-17-yl acetate as a starting material. Under the synergistic catalytic system composed of a chiral α-amino acid (such as L-proline) and a Lewis acid metal salt (such as zinc acetate), it reacts with a secondary amine and a formaldehyde source to selectively prepare a 6-methylene derivative. This invention utilizes the regio-directing effect of amino acids and the activating and stabilizing effect of metal ions to significantly suppress C2-position side reactions and dimer formation, resulting in a product yield exceeding 93% and a purity exceeding 99%. Column chromatography is not required, making it suitable for large-scale industrial production.

The present application relates to a kind of 2-oxazolidinone-3-carbamimidate-5-methylene derivatives and preparation method thereof, belong to organic synthesis technical field.The structure of 2-oxazolidinone-3-carbamimidate-5-methylene derivatives provided in the present application is as shown in formula (I)-(III).2-Oxazolidinone-3-carbamimidate-5-methylene derivatives of the present application can be applied to the synthesis and activity screening of novel oxazolidinone antibiotics, can provide technical support for the further derivatization and biological activity research of 2-oxazolidinone-3-carbamimidate derivative compound, with wide application prospect.