69 results about "Methyl derivative" patented technology

The invention relates to a chitosan or its derivative as drug carrier for carrying red sage root extract and the method, wherein the novel carrying agents include chitosan or sodium alginate for the preparation of drug-carrying beads, tanshinone pharmaceutical carrying agents using the carboxymethyl derivative of chitosan and the quaternary ammonium salt of chitosan, and the aquagel as the carrying agent of red sage root active component prepared from chitosan grafted polyethylene glycol.

The invention discloses a polybenzimidazole material and midbody organic diacid thereof as well as preparation methods thereof. The preparation methods comprise the following steps of: condensing fluorine-containing halide and 3,5-dimethyl phenol under the action of basic catalyst to generate fluorine-containing side-chain-substituted m-dimethyl benzene derivatives then oxidizing the obtained fluorine-containing side-substituted m-dimethyl benzene derivatives by potassium permanganate or nitric acid to obtain side-chain fluorine-containing organic diacid monomer and derivatives thereof; and carrying out polycondensation on the side-chain fluorine-containing organic diacid monomer, compound diacid monomer and tetramine monomer in polyphosphoric acid to generate the side-chain fluorine-containing soluble polybenzimidazole material . The prepared polybenzimidazole material has favorable heat resistance performance and solubility performance and can be used as high-temperature proton exchange membranes, separation membranes, sensors, heat resistance materials, composite materials, caking agents and other functional materials for fuel cells.

There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO₂F₂) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.

The invention provides a process for fermenting rapamycin with high yield, and belongs to a method for preparing antibiotics by utilizing fermentation of microorganism in the technical field of biology. According to the method, enzymolytic cotton seed powder, dextrin, glycerinum, yeast extract, L-lysine, KH2PO4, K2HPO4, (NH4)2SO4 and trace elements as culture media, wherein the trace elements contain Co<2+>, glycerinum and phosphate buffer are fed in the early phase of the fermenting culture process, and L-pipecolic acid and shikimic acid are fed in the synthesizing phase. By adopting the method, the methyl derivative can be reduced in the growing phase, and the content of rapamycin is increased; intermediate products can be reduced, and rapamycin can generate key enzyme activity; the beneficial effect of high yield of rapamycin can be achieved.

The total synthesis and evaluation of key analogs of vancomycin containing single atom changes in the binding pocket are disclosed as well as their peripherally modified, N-(hydrophobe-substituted) derivatives exemplified by a N-4-(4′-chlorob-phenyl)-methyl derivative and their pharmaceutically acceptable salts are disclosed. Their evaluation indicates the combined pocket and peripherally modified analogs exhibit a remarkable spectrum of antimicrobial activity and truly impressive potencies against both vancomycin-sensitive and -resistant bacteria, and likely benefit from two independent and synergistic mechanisms of action. A pharmaceutical composition containing a contemplated compound or its pharmaceutically acceptable salt is disclosed, as is a method of treating a bacterial infection in a mammal by administering an antibacterial amount of a contemplated compound or its salt as above to an infected mammal in need of treatment.

The invention provides a method for synthesizing 7-Acetyleno quinone methide compounds that is safe and inexpensive. The method avoids the need for extremely cold reaction temperatures and unlike the prior art does not require any highly explosive materials. The method comprises the steps of

• • a) performing a condensation reaction between 3,5-di-tert-butyl-4-hydroxybenzaldehyde and a secondary amine thereby forming a secondary amine quinone methide intermediate;
  • b) removing water from the secondary amine quinone methide intermediate by azeotropic distillation;
  • c) adding the dehydrated secondary amine quinone methide intermediate to an organic medium containing a metal acetylide to form a Mannich base intermediate; and
  • d) adding a release agent to the Mannich base intermediate to yield a 7-Acetyleno quinone methide.

The invention discloses a pre-lithiated silicon-oxygen negative electrode material as well as a preparation method and application thereof. The method comprises the steps of (1) mixing a biphenyl methyl derivative with a first organic solvent to obtain a biphenyl methyl derivative solution; (2) mixing metal lithium with the biphenyl methyl derivative solution to obtain a Li-biphenyl methyl derivative compound; and (3) mixing silicon monoxide particles with the Li-biphenylmethyl derivative compound, carrying out pre-lithiation, and carrying out solid-liquid separation so as to obtain the pre-lithiated silicon-oxygen negative electrode material. Micron-sized silicon-based negative electrode particles are soaked in a solution with the Li-biphenylmethyl derivative compound as a chemical pre-lithiation reagent, lithium ions in the compound make contact with the silicon-oxygen negative electrode particles, and the pre-lithiated silicon-oxygen negative electrode material with the surface coated with an artificial SEI film and lithium embedded inside is formed.

The invention discloses a preparation method of a formaldehyde adsorbent, and belongs to the technical field of adsorbing materials. According to the preparation method, Tofu is taken as a raw material; natural mildewing of Tofu is realized, and then mildewed Tofu is mixed with fresh milk for fermentation; under the action of mucor, proteins in Tofu and milk are degraded into amino acids; diatomite is taken as a raw material, citric acid is adopted for impurity removing so as to increase the specific surface area and the porosity of diatomite; diatomite is loaded with guanidine sulfamate via acylation and esterification of guanidine sulfamate, so that crosslinking reaction of guanidine groups and hydroxy groups with formaldehyde is realized, bridged bonds are formed, and immobilization of formaldehyde is realized; and at last, modified diatomite and amino acids are subjected to immersion together so as to load diatomite with the amino acids via adsorption, reaction of amino groups and guanidine groups in the amino acids with formaldehyde is realized so as to form hydroxymethyl derivatives, and removing of formaldehyde is realized. The formaldehyde adsorbent possesses excellent adsorption effect; indoor air secondary pollution is avoided; service life is long; and the formaldehyde adsorbent is worthy of popularization and application.

The invention relates to an acidity water base fracturing fluid which is prepared by an acidity multiple-effect thickening agent for fracturing, wherein the acidity multiple-effect thickening agent is obtained by carrying out chemical stem grafting reaction on carboxymethyl derivatives of vegetable gelatins such as guar gum, sesbania glue, tonka-bean glue and the like. The acidity water base fracturing fluid prepared by using the acidity multiple-effect thickening agent can meet the using requirement without the addition of a bactericide, a clay stabilizing agent, a surface active agent, a demulsifying agent and a foaming agent. Under the condition that each performance index of the fracturing fluid is comparative to that of the traditional fracturing liquid, the method has the advantages of enabling operating working procedures to be simplified, being beneficial to the increasing of the quality of fluid and reducing conditions needed for monitoring and the construction procedure and time.

The invention discloses an application of a fullerene methylene derivative I in perovskite solar cells and a perovskite solar cell. The perovskite solar cell includes a conductive layer, an electron transport layer, a perovskite layer doped with the fullerene methylene derivative I, a hole transport layer and electrodes, which are arranged in sequence into a layered structure. The photovoltaic performance of the solar cell is improved by applying the fullerene methylene derivative I to the solar cell.

A process for the production of 4-thiazolylmethyl derivatives are provided. A process for the production of the compound represented by the formula (I):wherein R1 is hydrogen or halogen and Hal is halogen, which comprises reacting 4-methylthiazole with N-halosuccinimide in a solvent in the presence of a radical initiator.

PCT No. PCT/JP97/03536 Sec. 371 Date Mar. 26, 1999 Sec. 102(e) Date Mar. 26, 1999 PCT Filed Oct. 3, 1997 PCT Pub. No. WO98/14423 PCT Pub. Date Apr. 6, 1998The present invention provides an aminomethylene derivative represented by general formula (I): wherein A is a cyclic oxo group selected from the group consisting of following general formulae (a), (b), (c), (d) and (e): wherein R1, R2, R3, R4 and R5 each independently represent H, an alkyl group or the like; R6, R7 and R8 each independently represent an alkyl group or the like; R1 and R2 or R7 and R8 may combine with each other to form a tetramethylene group or the like; R represents an alkyl group optionally containing OH or O; and n is an integer of 0 to 4, a process for the same, and the use thereof. The derivatives have an excellent ultraviolet absorption ability and a high optical stability.

The invention relates to the technical field of a synthesis method of 1-oxacephalosporin-3-epoxymethylene derivatives as a synthetic intermediate of 1-oxacephalosporin for resisting microbes and especially relates to a preparation method of 1-oxacephalosporin-3-epoxymethylene derivatives shown in the formula (I). The preparation method is characterized in that a 1-oxacephalosporin-3-methylene derivative shown in the formula (II) is efficiently and selectively epoxidized into a 1-oxacephalosporin-3-epoxymethylene derivative by hydrogen peroxide in the presence of a catalyst. The 1-oxacephalosporin-3-epoxymethylene derivative and a derivative of a mercaptotetrazole alkali metal salt shown in the formula (III) undergo a reaction and the reaction products are dehydrated under acidic conditions to form a corresponding 1-oxacephalosporin intermediate shown in the formula (IV). The preparation method has the advantages that a halogen addition reaction is avoided; the easily available catalyst is used; a clean and environmentally friendly oxygen source is used; a reaction process is not carried out at a low temperature; equipment corrosion caused by halogens in industrial production is avoided; an investment of expensive special-purpose equipment is reduced; a risk generation rate is greatly reduced; and 1-oxacephalosporin preparation processes are simple and can be operated easily. Therefore, the preparation method has large competitiveness in industrial production.

The invention provides a boron-dipyrromethene derivative and a nano-particle, preparation methods thereof, and applications of the nano-particle. The derivative is a 2,6-bis(triphenylamino)-1,3,5,7-tetramethyl-8-triphenylamino-boron-dipyrromethene derivative, and has a structure represented by formula I. The invention also provides the preparation method of the boron-dipyrromethene derivative. Theinvention further provides the nano-particle formed by packaging the boron-dipyrromethene derivative in an amphiphilic polymer distearoyl phosphoethanolamine-polyethylene glycol. The nano-particle has the characteristics of good water dispersibility, excellent stability and excellent biocompatibility, can rapidly enter HeLa cells and emit red fluorescence in the cells in several seconds, and canbe used in noninvasive cell tracking and long-term imaging of tumors in vivo as a long-term cell tracer to realize intracellular ultrafast imaging and long-term bioimaging.

The invention provides a pre-lithiation method, a pre-lithiation negative plate and a lithium ion battery. The pre-lithiation method comprises the following steps: 1) carrying out stirring pre-lithiation treatment on a to-be-pre-lithiated negative electrode plate by utilizing a pre-lithiation reagent to obtain an intermediate pre-lithiated negative electrode plate; and (2) sequentially carrying out stirring cleaning treatment and drying treatment on the intermediate pre-lithiated negative electrode plate to obtain a pre-lithiated negative electrode plate, wherein the stirring speed of the stirring pre-lithiation treatment and the stirring cleaning treatment is 5-200r/min, and the pre-lithiation reagent comprises a Li-polycyclic aromatic hydrocarbon methyl derivative. In the pre-lithiation method disclosed by the invention, the pre-lithiation process can be accelerated by stirring and pre-lithiation treatment, and the pre-lithiation reagent remained on the pole piece can be removed by stirring and cleaning treatment; through stirring pre-lithiation treatment and stirring cleaning treatment, the pre-lithiation process of the silicon-oxygen negative electrode plate with high surface density and high compaction density can be completed under the condition of shortening the pre-lithiation time, and the volume expansion of the negative electrode plate to be pre-lithiated in the pre-lithiation process can be inhibited.