129 results about "Formylation" patented technology

A process for producing branched aldehyde intermediates from alpha olefins, and further reacting said branched aldehyde intermediates via hydrogenation reactions, surfactant forming reactions and other chemical derivative forming reactions to produce branched alcohols, branched surfactants and other branched derivatives. A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.

A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps:1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine;2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran;3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1;3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.

The invention provides a method for synthesizing a hydroxyl-protected alpha-hydroxy aldehyde compound by electrically reducing aromatic ketone, which comprises the following steps of: adding aromatic ketone, a formylation reagent, an additive and electrolyte into a reaction electrolytic tank, adding a reaction solvent in an inert gas atmosphere, tightly covering a plug with an electrode, and carrying out electrolytic reaction to obtain the hydroxyl-protected alpha-hydroxy aldehyde compound. And separating and purifying to obtain the hydroxyl-protected alpha-hydroxy aldehyde compound. Clean electrons are used as a reducing reagent, no transition metal residues exist, raw materials are simple and easy to obtain, reaction conditions are mild, and the method has wide substrate universality and high operability, is a green and economical synthesis method, has extremely high potential industrial prospects and has high commercial application value.

The invention relates to the technical field of organic catalysis, in particular to a method for preparing glycolaldehyde by catalyzing formaldehyde hydroformylation. The method comprises the following steps: introducing CO and H2 into a mixed solution of paraformaldehyde, a rhodium compound, a ligand and a solvent, and reacting to prepare glycolaldehyde, the ligands comprise a ligand 1 and a ligand 2; the ligand 1 is selected from one or more of compounds as shown in the following L1-L8: # imgabs0 #; the structural formula of the ligand 1 is as shown in the specification, the structural formula of the ligand 2 is as shown in the specification, namely # imgabs1 # or # imgabs2 #, R1 is H, (CH2) ACH3, O-(CH2) ACH3, X or CX3, the value range of A is 0-3, and X is a halogen atom. According to the method disclosed by the invention, different ligands are subjected to dominant combination and cooperate with the rhodium-based catalyst, so that glycolaldehyde is obtained with high conversion rate and high selectivity under relatively mild conditions.

The invention discloses an anti-aging cable for photovoltaic power generation and a preparation method thereof, and relates to the technical field of cables. The anti-aging cable for photovoltaic power generation prepared by the invention comprises a conductor and a protective layer, the protective layer comprises modified polyethylene, modified silicon dioxide and phenylamino-terminated silicone oil, and the modified polyethylene is obtained by grafting polyethylene with N, N-dimethyl-3-buteneamine and then reacting with 3-(tert-butyl)-5-(chloromethyl)-2-hydroxybenzaldehyde; the modified silicon dioxide is obtained by grafting pretreated silicon dioxide with stilbene phosphine oxide and then carrying out formylation; and finally, uniformly mixing and extruding the modified polyethylene, the modified silicon dioxide and the phenylamino-terminated silicon oil to obtain the protective layer. The anti-aging cable for photovoltaic power generation prepared by the invention has good flame retardance, mechanical property and anti-aging property.

A process reacts olefins having 4 to 20 carbon atoms and the feed stream used, containing at least linear olefins and branched olefins, is distilled between two reaction steps and only the high-boiler phase obtained in this distillation is subjected to the second reaction, a heterogeneously catalysed hydroformylation, a homogeneously catalysed hydroformylation or a homogeneously catalysed alkoxycarbonylation.

The invention relates to a method for preparing aldehyde through butene hydroformylation, which comprises the following steps: dissolving a rhodium catalyst, a phosphite ester ligand and a butene raw material in an amide solvent to obtain a premixed solution, and keeping the premixed solution at 0 DEG C or below; adding the premixed liquid into a mixed atmosphere of hydrogen and carbon monoxide; heating the premixed solution to a preset temperature, and reacting for a preset time to obtain a mixed solution; after the mixed liquid is layered, upper liquid is obtained through liquid separation, an aldehyde product is obtained, and the butene raw material comprises at least one of 1-butene and 2-butene. In the reaction process, a ligand does not need to be supplemented, and the problem of more impurities caused by hydrolysis does not exist.

The present invention provides an iridium-based catalyst, a preparation method thereof, and a method for catalytic hydroformylation of propylene. The structural formula of the iridium-based catalyst is where Ph is a phenyl group, x is any one of 0, 1, and 2, and X is any one of Cl, NO<subgt;3< / subgt;, BF<subgt;4< / subgt;, PF<subgt;6< / subgt;, and acac. The iridium-based catalyst disclosed in the present invention has good catalytic effect and high activity, and can still maintain high catalytic performance after being used multiple times.

A process for producing branched aldehyde intermediates from alpha olefins, and further reacting said branched aldehyde intermediates via hydrogenation reactions, surfactant forming reactions and other chemical derivative forming reactions to produce branched alcohols, branched surfactants and other branched derivatives. A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.

Provided is a method for synthesis of carbon-14 radioisotope-labeled flonicamid. Carbon-14 radioisotope is labeled on a pyridine ring in a flonicamid molecule. Carbon-14-labeled barium carbonate is adopted as a radioisotope raw material and then subjected to a reaction with concentrated sulfuric acid to release carbon-14-labeled carbon dioxide, and the carbon-14-labeled carbon dioxide is then subjected to reactions such as reduction, formylation, dehydration, substitution, cyclization, and amide condensation to synthesize a target product.

A process for producing branched aldehyde intermediates from alpha olefins, and further reacting said branched aldehyde intermediates via hydrogenation reactions, surfactant forming reactions and other chemical derivative forming reactions to produce branched alcohols, branched surfactants and other branched derivatives. A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.

The invention discloses an isolongifolanone-based fluorescent probe for detecting hydrazine as well as a preparation method and application of the isolongifolanone-based fluorescent probe. Isolongifolanone is used as a raw material and is subjected to condensation with 2-amino-4 '-bromobenzophenone, the condensation product and 4-hydroxyphenylboronic acid are subjected to Suzuki coupling, the coupling product and urotropine are subjected to formylation, the formylation product and 1-bromobutane are etherified, and the isolongifolanone derivative is obtained. The preparation method comprises the following steps: reacting 2-(2-(4-butoxy-4 '-(1, 1, 5, 5-tetramethyl-1, 3, 4, 5, 6, 12b-hexahydro-2H-2, 4a-arbor methyl benzacridine-7-yl)-[1, 1'-biphenyl]-3-yl) vinyl)-3-ethyl-benzothiazole-3-onium (abbreviated as ABP-BBT) by using 2-(2-(4-butoxy-4 '-(1, 1, 5, 5-tetramethyl-1, 3, 4, 5, 6, 12b-hexahydro-2H-2, 4a-arbor methyl benzacridine-7-yl)-1, 1'-biphenyl)-1, 2, 4, 5-tetramethyl-1, 3, 4, 5 The compound ABP-BBT can specifically recognize hydrazine, the detection limit of hydrazine reaches 7.5 nM, and the compound ABP-BBT has a good application prospect.

A method for producing a higher alcohol from a waste plastic feedstock is disclosed, comprising: (a) providing a hydrocarbon feed stream comprising a pyrolysis oil feed obtained from pyrolysis of plastic waste, wherein the pyrolysis oil comprises at least 20 wt % higher olefins with a carbon number in the range C5-C20, based on its total hydrocarbon content; (b) contacting the hydrocarbon feed stream with synthesis gas under hydroformylation conditions in the presence of a hydroformylation catalyst and recovering a hydroformylation product; (c) subjecting the hydroformylation product to hydrogenation and / or a distillation to recover a higher alcohol product.

The invention relates to a method for catalyzing olefin hydroformylation by using a molecular sieve confinement monatomic catalyst, which comprises the following steps: performing hydroformylation on olefin with an R1R2C = CH2 structure and synthesis gas CO / H2 at the temperature of 80-120 DEG C to obtain a product R1R2CH-CH2CHO or R1R2CH (CHO)-CH3. According to the method, Rh1-coated zeolite is used as a catalyst, and an active site monatomic rhodium metal of the catalyst is confined in a molecular sieve frame structure. The catalyst for catalyzing hydroformylation of styrene has the advantages of high conversion rate, high selectivity and high catalytic efficiency. And the catalyst has selective hydroformylation catalysis performance, and realizes accurate selective catalysis of reactant olefin molecules smaller than molecular sieve pore size # imgabs0 #.

A method for preparing a 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1 H-benzo[d]imidazol-2-yl]butyric acid alkyl ester, wherein 1 mol of 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester is reacted with 2.0 to 2.2 mol of chloromethylenedimethyliminium chloride or with >2.2 to 5 mol of chloromethylenedimethyliminium chloride to prepare a by-product in the form of a 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1 H-benzo[d]imidazol-2-yl]butyric acid alkyl ester. The alkyl ester can be hydrolyzed to form 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H benzo[d]imidazol-2-yl]butyric acid that is usable in the field of medicine.

The application discloses a rhodium-catalyzed desymmetrization hydroformylation method for constructing polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides comprises the following steps: under the condition of an inert atmosphere, an acetylacetone dicarbonyl rhodium metal precursor and a chiral ligand are added into an organic solvent to prepare a catalyst solution, the catalyst solution is mixed with a substrate, and a reaction is carried out under the condition of a hydrogen atmosphere and a carbon monoxide atmosphere; after the reaction is completed, filtration and purification are carried out, and polychiral center cycloalkyl aldehyde is obtained; and the aldehyde group is converted to obtain the polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides has the advantages of high selectivity, wide substrate compatibility, high reaction efficiency, easy conversion of products, and the like. The whole reaction process can obtain polychiral center cycloalkyl aldehyde in one step with extremely high enantioselectivity and diastereoselectivity, the aldehyde group is converted, polychiral center carbon rings can be obtained with high yield, high dr value and high ee value, and the method is simple and easy to operate.

A Method for the synthesis of ω-amino acids or derivatives thereof, includes the following steps synthesis of an ω-oxoester / linear acid by hydroformylation by CO / H2 mixture of at least one monounsaturated acid / ester, the monounsaturated acid / ester preferably resulting from a reaction of metathesis of oils / fats from renewable sources; synthesis of a linear ω-amino acid / ester and / or ω-aminoamide, subjecting the aforementioned ω-oxoester / linear acid to reductive amination; and possible synthesis of a linear ω-amino acid, subjecting the aforementioned linear ω-aminoester and / or ω-aminoamide to hydrolysis.

The invention discloses a preparation method of methoxy imidazo [1, 5-a] pyridine, which comprises the following steps: firstly, taking a compound P1, specifically 1-methylamino-3-methoxypyridine, as an initial raw material, and carrying out carbamylation reaction in a formylation reagent to prepare a compound P2, specifically N-[(5-methoxypyridine-2-yl) methyl]; further carrying out intramolecular ring closing reaction on the compound P2 to obtain a compound P3 which is specifically 7-methoxy imidazo [1, 5-a] pyridine; then, a selective bromination experiment at the C3 position is carried out by taking a compound P3 as a parent skeleton and cyanogen bromide (CNBr) as a bromination reagent, and finally, specific bromination of the C3 site of the imidazo [1, 5-a] pyridine with the selectivity of 100% is realized. A solid theoretical basis is laid for efficient specific modification of the low-reaction-activity C3 site, and an efficient synthesis path is provided for rapid construction of the imidazopyridine derivative, so that the imidazopyridine derivative has a wide application prospect.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

This invention belongs to the field of heterogeneous Rh-based catalyst technology, and discloses a method for preparing a heterogeneous rh-based catalyst and its application. This invention prepares a heterogeneous rh-based catalyst using a one-pot method. By employing a reduction-reoxidation process, the content of different valence states of rhino in the rhino species on the surface of the heterogeneous rh-based catalyst is simply and precisely controlled, increasing the content of the most favorable δ+ valence state from 7.31% to 44.78%, thereby giving the catalyst higher hydroformylation activity. Under reaction conditions of 120℃ and a mixed gas pressure of 2 MPa, the styrene conversion rate reaches 73.9% and the aldehyde selectivity reaches 95.9% within 4 hours, which is superior to most heterogeneous rhino-based catalysts and close to that of homogeneous rhino catalysts. The heterogeneous rhino-based catalyst is prepared by the sol-gel method, which is simple in preparation and control. The prepared catalyst has a uniform rhino distribution, stable performance, and is beneficial for industrial applications.

A catalytic one-pot process for the preparation of an alcohol is provided. The process comprises decomposition of methanol into synthesis gas, the hydroformylation of an optionally substituted alkene using said synthesis gas and hydrogenation to the corresponding alcohol. The catalyst system combines a hydroformylation catalyst and a transition metal complex catalyst.

The application provides a preparation method of 3-aryl / alkyl-beta-naphthyl ether compounds, and the preparation method comprises the following steps: reacting trimethyl orthoformate with 1,3-diaromatic propyl ketone compounds or 1-aryl-3-alkyl ketone compounds to obtain 3-aryl-beta-naphthyl ether compounds or 3-alkyl-beta-naphthyl ether compounds. The reaction condition of the application is mild, trimethyl orthoformate is cheap and easy to obtain, can be used as a methylation reagent and a carbon source for extending a carbon chain at the same time, the range of reaction substrates is wide, and the functional group tolerance is good; the reaction is efficient, the selectivity is high, the post-treatment is simple, the operation is simple, and the application is suitable for large-scale industrial production; the complex substrate prepared in advance in the traditional reaction is avoided, the metal catalyst necessary for the traditional reaction is not needed, the binaftyl alcohol precursor compounds can be prepared with high chemical selectivity, and a more simple and efficient route is provided for the olefin hydroformylation / hydroformyl esterification reaction for synthesizing bidentate ligands.

A process for preparing 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester, in which 1 mole of 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester is reacted with 2.0 to 2.2 moles of chloromethylenedimethyliminium chloride or more than 2.2 to 5 moles of chloromethylenedimethyliminium chloride to prepare a by-product in the form of 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester. The alkyl ester can be hydrolyzed to form 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid, which can be used in the pharmaceutical field.

The invention discloses a synthesis method of 2, 4-dichlorobenzaldehyde, and belongs to the technical field of unsaturated halogenated hydrocarbons, the method comprises the following steps: diazotization, formylation, quenching and purification; the diazotization method comprises the following steps: dissolving 2, 4-dichloroaniline in an HCl solution, placing the solution in an ice salt bath, cooling to 0 DEG C, dropwise adding a NaNO2 solution through a constant-pressure funnel, controlling the dripping speed to be 1-2 drops per second, controlling the system temperature to be 0-2 DEG C, adding urea after dropwise adding is finished, and carrying out heat preservation and stirring for 25-35 minutes to form a diazonium salt suspension; the method for preparing the 2, 4-dichlorobenzaldehyde has the advantages of high yield, high purity and few byproducts, the total yield can reach 82.7-84.9%, the purity is 98.72-99.03%, and the content of the byproduct 3, 5-dichlorobenzaldehyde in a crude product is 1t; and 2%.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a single-molecule fluorescent probe based on a phenothiazine structure as well as a preparation method and application of the single-molecule fluorescent probe. The preparation method comprises the following steps: firstly introducing an alkyl chain to a nitrogen atom of a raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then carrying out regioselective formylation on the raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then treating the raw material by adopting aluminum trichloride to realize O-demethylation, and finally carrying out intramolecular cyclization reaction on the raw material and 1H-benzimidazole-2-acetonitrile to obtain the phenothiazine structure-based single-molecule fluorescent probe. The single-molecule fluorescent probe based on the phenothiazine structure prepared by the invention is compatible with orthogonal chemical reaction activity and maintains controllable electron transfer, so that different chemical events are converted into specific optical signals, and selective and mechanism specific fluorescent response to phosgene, copper ions and hypochlorite is realized.

The present disclosure provides a method. In one embodiment, the method includes providing a purge stream comprising octene isomers. The method includes subjecting the purge stream to hydroformylation conditions and forming a reaction product comprising nonanal.

The invention discloses a method for synthesizing formanilide and derivatives thereof by catalyzing nitro-aromatic hydrocarbon, a mixture of o-aniline, ferric chloride hexahydrate and silicon dioxide sol is used as a precursor, high-temperature pyrolysis is performed, silicon dioxide is removed by etching with an ammonium bifluoride solution, and a nitrogen-doped mesoporous carbon-loaded iron catalyst is obtained. The raw materials are easily available and low in cost. And by taking nitro-aromatic hydrocarbon as a reaction substrate, adding the prepared nitrogen-doped mesoporous carbon loaded iron catalyst, and reacting for 24 hours at the temperature of 60-80 DEG C in a nitrogen atmosphere by taking tetrahydrofuran as a solvent and formic acid as a reducing agent and a formylation reagent to obtain formanilide and derivatives thereof. The reaction conditions are relatively mild, high temperature and high pressure are not needed, additional additives are not needed, resources are saved, the synthesis yield is excellent, and the method is suitable for industrial production.

This invention discloses a system and method for preparing 4-acetoxybutyraldehyde by hydroformylation of allyl acetate. The system includes a reaction unit, a separation unit, and a product tank connected in sequence, as well as a dynamic dehydration unit that forms a loop with the reaction unit through pipelines and pumps, a catalyst regeneration unit connected to the organic phase outlet of the heating unit, and a circulating dehydration unit connected between the catalyst regeneration unit and the reaction unit. The method employs a carbonyl metal catalytic system, using a bypass molecular sieve to dynamically adsorb the self-condensing water of the reaction. After separating the aldehyde product, the remaining organic phase is deeply dehydrated by the molecular sieve and recycled. This invention reduces the water content in the reaction system by setting up a closed-loop dehydration system throughout the entire process. Through the combined strategy of "dynamic adsorption by molecular sieve + deep dehydration of the circulating phase," it achieves multiple benefits, including "reduced corrosion, reduced highly toxic byproducts, and increased yield."

The present invention relates to a process for preparing and processing of synthesis gas, the process particularly comprising the steps of preparing a first gas stream comprises H2 and CO2; feeding said gas stream into a first reactor comprising a reverse water gas shift catalyst, wherein said gas stream is fed into the first reactor at a gas hourly space velocity (GHSV) in the range of from 1,000 to 100,000 h-1, wherein the reverse water gas shift reaction is conducted at a temperature in the range of from 650 to 1,000 °C, wherein in a time interval Δt, wherein Δt is in the range of from 1 to 60 minutes, the GHSV of said gas stream displays a gradient in the range of from 2,000 to 60,000 h-1, obtaining a second gas stream; feeding the second gas stream into a second reactor, wherein the second reactor comprises one or more of a methanol synthesis catalyst, a dimethyl ether synthesis catalyst, an oxo synthesis or hydroformylation catalyst, a Fischer-Tropsch synthesis catalyst, a formic acid synthesis catalyst, and a phosgene synthesis catalyst, obtaining a product stream.

This invention discloses a highly selective synthesis method for isovlandrin, comprising the following steps: Step S1, reacting guaiacol with a benzylating agent in the presence of an alkaline catalyst and an organic solvent to generate o-benzyloxyanisole; Step S2, reacting the o-benzyloxyanisole with a Vilsmeier-Haack reagent for formylation to obtain 3-benzyloxy-4-methoxybenzaldehyde; Step S3, mixing 3-benzyloxy-4-methoxybenzaldehyde with a 65wt%-70wt% aqueous sulfuric acid solution to perform an acid debenzylation reaction to obtain crude isovlandrin; Compared with the prior art, the yield of isovlandrin can reach up to 70% or more, and the selectivity is greatly improved.