394 results about "Formylation" patented technology

The present invention provides an improved process for the synthesis of α-substituted acroleins from olefins by a tandem hydroformylation and Mannich reaction sequence in the presence of syngas and formaldehyde, wherein the two catalysts are segregated into two different phases thereby preventing deactivation of the catalysts by each other, and yielding a highly selective and active catalyst.

The present invention relates to a catalyst composition for hydroformylation and a method for preparing aldehydes using the same, wherein the catalyst composition for hydroformylation comprises: a triaryl phosphine ligand; a phosphine oxide or phosphine sulfide ligand having a specific chemical formula; and a transition metal catalyst. The catalyst composition provides high catalyst activity and stability and selectivity to normal aldehydes when used in the hydroformylation for preparing aldehydes from olefins.

A method for preparing aldehyde through olefin hydroformylation is characterized in that compositions in portion by weight of 1 to 10 portions of rhodium complex, 10 to 1,000 portions of phosphine ligand, 0.01 to 1 portion of double long chain surface-active agent and 500 to 5,000 portions of deionized water are added in a reaction kettle with an agitator and a thermocouple, and are completely dissolved; synthetic gas in which the volume ratio of hydrogen to carbon monoxide is equal to 1to 1 is used to carry out substitution 3 to 5 times inside the reaction kettle; 100 to 2,000 portions of olefin is added through pressurization and then the pressure of the synthetic gas is increased to 1 to 6MPa so as to carry out reaction at a temperature of between 50 and 150 DEG C for 2 to 8 hours; and finally, reactants are taken out after cooling, and are separated to obtain the product aldehyde.

The present invention concerns a process for preparing 3,5bis(trifluoromethyl)benzylalcohol by formylation in a solvent of an appropriate organo-magnesium derivative with solid paraformaldehyde and optionally its conversion into a 3,5-bis(trifluoromethyl)benzyl halide.

The invention discloses pyrazole amide and pyrazole imine derivatives containing substituted 1, 3, 4-thiadiazole thioether as well as a preparation method and an application of the derivatives. The compounds have the structures as shown in formulae (I) and (II). The preparation method comprises the following steps: by taking substituted hydrazine as an initial raw material, carrying out closed loop, chlorine formylation, oxidation and chloro reaction to obtain pyrazole acyl chloride; carrying out a reaction on 2-amino-5-mercapto-1, 3, 4-thiadiazole and substituted benzyl chloride to obtain 2-amino-5-substituted 1, 3, 4-thiadiazole thioether; and then, carrying out a substitution reaction on 2-amino-5-substituted 1, 3, 4-thiadiazole thioether and substituted pyrazole acyl chloride to obtain the pyrazole amide compound (I) containing substituted 1, 3, 4-thiadiazole thioether; by taking substituted hydrazine as an initial raw material, carrying out closed loop and chlorine formylation to obtain pyrazole aldehyde; carrying out an additive elimination reaction on pyrazole aldehyde and 2-amino-5-mercapto-1, 3, 4-thiadiazole under a backflow condition of anhydrous ethanol to obtain 2-substituted pyrazole imidogen-5-mercapto-1, 3, 4-thiadiazole; and then carrying out a reaction on 2-substituted pyrazole imidogen-5-mercapto-1, 3, 4-thiadiazole and substituted benzyl chloride to generate the pyrazole imine compound (II) containing substituted 1, 3, 4-thiadiazole thioether. The compounds disclosed by the invention have a good inhibiting effect on tobacco mosaic virus and can be used for preparing anti-plant virus drugs.

The process of preparing 3-hydroxy propionic aldehyde and 1, 3-propyelene glycol includes: the hydrogenation and formylation of ethylene oxide and synthetic gas inside the organic solvent with the shown expression and in the presence of carbonyl cobalt catalyst; introducing air or oxygen to oxidize the carbonyl cobalt catalyst into cobalt precipitate; centrifugally separating the cobalt precipitate from the solution, filtering and returning the cobalt precipitate to reactor for next reaction; adding deionized water into the filtrate and vacuum distilling the filtrate to obtain water solution containing 3-hydroxy propionic aldehyde; and final hydrogenating to produce 1, 3-propyelene glycol. The said process has high efficiency and low cost.

Tetraphosphorous ligands are combined with transition metal salts to form catalysts for use in hydroformylation, isomerization-hydroformylation, hydrocarboxylation, hydrocyan-ation, isomerization-formylation, hydroaminomethylation and similar related reactions.

The invention relates to the technical field of biomedical polymer material, and provides an injectable hydrogel material for solving the problems that existing injectable hydrogel is slow in condensation, low in strength, and poor in biocompatibility and biodegradability, and consequently fixed point forming and long-term exercise tolerance of the hydrogel after injection are not facilitated. Theinjectable hydrogel material is generated from a component A and a component B in-situ through isovolumetric injection by adopting dual-linking injection technology; and the component A is carboxymethyl chitosan, and the component B is prepared from reaction of double hydroformylation polysaccharide and an auxiliary cross-linking agent and a formylation contrast agent. According to the injectablehydrogel material, the exercise tolerance is good, the requirements of the biocompatibility and the biodegradability are met, the functions of multimoding development and controlled degradation are further achieved, the effect that the multiple functions of protection, tracing, customized treatment and the like are integrated is achieved, and the wide application prospects in the field of integration of diagnosis and treatment are achieved.

The invention relates to a method for preparing trans-4-amino cyclohexylmethanol hydrochloride, and belongs to the field of medicine. According to the method, 4-aminobenzoic ester is used as a raw material; catalytic hydrogenation, phthaloyl formylation, a conversion reaction, a hydrazinolysis reaction, amino protection, ester group reduction, amino deprotection and hydrogen chloride salification are carried out so as to obtain the trans-4-amino cyclohexylmethanol hydrochloride. The method and trans-4-amino cyclohexylmethanol hydrochloride have the advantages that the initial material is easy to obtain; the operation is simple; column chromatographic purification is not required; the yield and the purity are high; energy is saved; the environment is protected; suitability for industrialized production is realized.