156 results about "Formylation" patented technology

A process for producing branched aldehyde intermediates from alpha olefins, and further reacting said branched aldehyde intermediates via hydrogenation reactions, surfactant forming reactions and other chemical derivative forming reactions to produce branched alcohols, branched surfactants and other branched derivatives. A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.

A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps:1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine;2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran;3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1;3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.

The invention provides a method for synthesizing a hydroxyl-protected alpha-hydroxy aldehyde compound by electrically reducing aromatic ketone, which comprises the following steps of: adding aromatic ketone, a formylation reagent, an additive and electrolyte into a reaction electrolytic tank, adding a reaction solvent in an inert gas atmosphere, tightly covering a plug with an electrode, and carrying out electrolytic reaction to obtain the hydroxyl-protected alpha-hydroxy aldehyde compound. And separating and purifying to obtain the hydroxyl-protected alpha-hydroxy aldehyde compound. Clean electrons are used as a reducing reagent, no transition metal residues exist, raw materials are simple and easy to obtain, reaction conditions are mild, and the method has wide substrate universality and high operability, is a green and economical synthesis method, has extremely high potential industrial prospects and has high commercial application value.

The invention relates to the technical field of organic catalysis, in particular to a method for preparing glycolaldehyde by catalyzing formaldehyde hydroformylation. The method comprises the following steps: introducing CO and H2 into a mixed solution of paraformaldehyde, a rhodium compound, a ligand and a solvent, and reacting to prepare glycolaldehyde, the ligands comprise a ligand 1 and a ligand 2; the ligand 1 is selected from one or more of compounds as shown in the following L1-L8: # imgabs0 #; the structural formula of the ligand 1 is as shown in the specification, the structural formula of the ligand 2 is as shown in the specification, namely # imgabs1 # or # imgabs2 #, R1 is H, (CH2) ACH3, O-(CH2) ACH3, X or CX3, the value range of A is 0-3, and X is a halogen atom. According to the method disclosed by the invention, different ligands are subjected to dominant combination and cooperate with the rhodium-based catalyst, so that glycolaldehyde is obtained with high conversion rate and high selectivity under relatively mild conditions.

The invention discloses an anti-aging cable for photovoltaic power generation and a preparation method thereof, and relates to the technical field of cables. The anti-aging cable for photovoltaic power generation prepared by the invention comprises a conductor and a protective layer, the protective layer comprises modified polyethylene, modified silicon dioxide and phenylamino-terminated silicone oil, and the modified polyethylene is obtained by grafting polyethylene with N, N-dimethyl-3-buteneamine and then reacting with 3-(tert-butyl)-5-(chloromethyl)-2-hydroxybenzaldehyde; the modified silicon dioxide is obtained by grafting pretreated silicon dioxide with stilbene phosphine oxide and then carrying out formylation; and finally, uniformly mixing and extruding the modified polyethylene, the modified silicon dioxide and the phenylamino-terminated silicon oil to obtain the protective layer. The anti-aging cable for photovoltaic power generation prepared by the invention has good flame retardance, mechanical property and anti-aging property.

The invention discloses a tandem catalysis method for improving the catalytic efficiency of preparing higher alcohol by CO2 hydrogenation, which comprises the following steps: two sections of fixed bed reactors are connected in series, the first section of reactor is filled with a catalyst for preparing olefin by CO2 hydrogenation, and the second section of reactor is sequentially filled with an olefin hydroformylation catalyst and a catalyst for preparing alcohol by aldehyde hydrogenation. According to the invention, segmented catalysis is carried out on the complex process of preparing higher alcohols through CO2 hydrogenation, and a catalyst for preparing olefins through CO2 hydrogenation, a hydroformylation catalyst and an aldehyde hydrogenation catalyst are respectively arranged in an upstream-segment reactor and a downstream-segment reactor, so that the efficiency and selectivity of preparing higher alcohols through CO2 hydrogenation are improved; through tandem catalysis, the selectivity of by-product hydrocarbons can be effectively reduced, the utilization rate of carbon is improved, the selectivity and space-time yield of higher alcohols are remarkably improved, and the separation cost of products is reduced.

The invention relates to a branched polymer for selective water control of an oil well and a preparation method thereof, and belongs to the technical field of oilfield chemistry. The preparation method comprises the following steps: firstly, carrying out formylation modification on nano-cellulose by using an oxidizing agent, then carrying out Schiff base reaction on the formylated nano-cellulose and polyethylene polyamine to realize amination modification, and then reducing the nano-cellulose by using a reducing agent to improve the dispersity and reaction activity of the nano-cellulose. On the basis, through an oxidation-reduction reaction between the aminated nanocellulose and Ce < 4 + >, a nonionic water-soluble monomer, an anionic water-soluble monomer, a hydrophobic monomer and the like are used as raw materials, and a polymer with a branched structure is prepared through aqueous solution polymerization. The branched polymer has high molecular rigidity, and the temperature resistance, salt resistance and retention capacity of the branched polymer are remarkably improved. Tests show that the branched polymer still keeps an excellent selective water control effect under long-term scouring of a large amount of liquid.

A process reacts olefins having 4 to 20 carbon atoms and the feed stream used, containing at least linear olefins and branched olefins, is distilled between two reaction steps and only the high-boiler phase obtained in this distillation is subjected to the second reaction, a heterogeneously catalysed hydroformylation, a homogeneously catalysed hydroformylation or a homogeneously catalysed alkoxycarbonylation.

The invention relates to a method for preparing aldehyde through butene hydroformylation, which comprises the following steps: dissolving a rhodium catalyst, a phosphite ester ligand and a butene raw material in an amide solvent to obtain a premixed solution, and keeping the premixed solution at 0 DEG C or below; adding the premixed liquid into a mixed atmosphere of hydrogen and carbon monoxide; heating the premixed solution to a preset temperature, and reacting for a preset time to obtain a mixed solution; after the mixed liquid is layered, upper liquid is obtained through liquid separation, an aldehyde product is obtained, and the butene raw material comprises at least one of 1-butene and 2-butene. In the reaction process, a ligand does not need to be supplemented, and the problem of more impurities caused by hydrolysis does not exist.

The present invention provides an iridium-based catalyst, a preparation method thereof, and a method for catalytic hydroformylation of propylene. The structural formula of the iridium-based catalyst is where Ph is a phenyl group, x is any one of 0, 1, and 2, and X is any one of Cl, NO<subgt;3< / subgt;, BF<subgt;4< / subgt;, PF<subgt;6< / subgt;, and acac. The iridium-based catalyst disclosed in the present invention has good catalytic effect and high activity, and can still maintain high catalytic performance after being used multiple times.

A process for producing branched aldehyde intermediates from alpha olefins, and further reacting said branched aldehyde intermediates via hydrogenation reactions, surfactant forming reactions and other chemical derivative forming reactions to produce branched alcohols, branched surfactants and other branched derivatives. A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.

Provided is a method for synthesis of carbon-14 radioisotope-labeled flonicamid. Carbon-14 radioisotope is labeled on a pyridine ring in a flonicamid molecule. Carbon-14-labeled barium carbonate is adopted as a radioisotope raw material and then subjected to a reaction with concentrated sulfuric acid to release carbon-14-labeled carbon dioxide, and the carbon-14-labeled carbon dioxide is then subjected to reactions such as reduction, formylation, dehydration, substitution, cyclization, and amide condensation to synthesize a target product.

The invention provides an olefin hydroformylation method. The method comprises the following steps: mixing CO, H2, an olefin raw material and a complex catalyst to obtain a mixed raw material, and carrying out a hydroformylation reaction to obtain an aldehyde product; the complex catalyst comprises a transition metal raw material and a phosphite ester type bidentate phosphine ligand containing an aryl ether structure, and the phosphite ester type bidentate phosphine ligand containing the aryl ether structure has a structure as shown in a general formula (1). By optimizing the structure of the phosphine ligand of the catalyst, the hydroformylation reaction can realize higher conversion rate, higher selectivity and higher normal / isomeric ratio under the conditions of low reaction pressure and low reaction temperature; in the industrial application process, the method disclosed by the invention has the advantages of low metal loss and low ligand loss, and the operation cost of the device can be remarkably reduced; the production efficiency of a target product can be remarkably improved through the high normal-different ratio, the production cost is reduced, the product performance is more stable, and market popularization is facilitated.

A process for producing branched aldehyde intermediates from alpha olefins, and further reacting said branched aldehyde intermediates via hydrogenation reactions, surfactant forming reactions and other chemical derivative forming reactions to produce branched alcohols, branched surfactants and other branched derivatives. A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.

The present invention discloses a method for producing aldehydes. The method comprises: hydroformylating olefins to form aldehydes using a hydroformylation catalyst; recovering an effluent stream comprising the aldehyde, hydrogen and the hydroformylation catalyst; conveying the effluent stream to a stripping column; contacting the effluent stream with a stripping gas in the stripping column to produce a stripped effluent stream having a lower hydrogen concentration than the effluent stream; and recovering the stripped effluent stream.

The invention relates to a composite catalyst and a preparation method thereof. The composite catalyst can be used for promoting long-chain alpha-olefin and a synthesis gas raw material to be subjected to continuous hydroformylation-hydrogenation reaction in one step to obtain a high-carbon alcohol product. Derived cobalt and graphite-phase carbon nitride in different proportions are compounded, the electronic effect is regulated and controlled, a high-dispersion and high-activity catalytic center is formed, and the composition of a product is effectively changed. The scheme provided by the invention has the advantages of simple preparation, controllable product, high alcohol selectivity and the like, and has a large-scale application and popularization prospect.

The invention discloses an isolongifolanone-based fluorescent probe for detecting hydrazine as well as a preparation method and application of the isolongifolanone-based fluorescent probe. Isolongifolanone is used as a raw material and is subjected to condensation with 2-amino-4 '-bromobenzophenone, the condensation product and 4-hydroxyphenylboronic acid are subjected to Suzuki coupling, the coupling product and urotropine are subjected to formylation, the formylation product and 1-bromobutane are etherified, and the isolongifolanone derivative is obtained. The preparation method comprises the following steps: reacting 2-(2-(4-butoxy-4 '-(1, 1, 5, 5-tetramethyl-1, 3, 4, 5, 6, 12b-hexahydro-2H-2, 4a-arbor methyl benzacridine-7-yl)-[1, 1'-biphenyl]-3-yl) vinyl)-3-ethyl-benzothiazole-3-onium (abbreviated as ABP-BBT) by using 2-(2-(4-butoxy-4 '-(1, 1, 5, 5-tetramethyl-1, 3, 4, 5, 6, 12b-hexahydro-2H-2, 4a-arbor methyl benzacridine-7-yl)-1, 1'-biphenyl)-1, 2, 4, 5-tetramethyl-1, 3, 4, 5 The compound ABP-BBT can specifically recognize hydrazine, the detection limit of hydrazine reaches 7.5 nM, and the compound ABP-BBT has a good application prospect.

A method for producing a higher alcohol from a waste plastic feedstock is disclosed, comprising: (a) providing a hydrocarbon feed stream comprising a pyrolysis oil feed obtained from pyrolysis of plastic waste, wherein the pyrolysis oil comprises at least 20 wt % higher olefins with a carbon number in the range C5-C20, based on its total hydrocarbon content; (b) contacting the hydrocarbon feed stream with synthesis gas under hydroformylation conditions in the presence of a hydroformylation catalyst and recovering a hydroformylation product; (c) subjecting the hydroformylation product to hydrogenation and / or a distillation to recover a higher alcohol product.

The invention relates to a method for catalyzing olefin hydroformylation by using a molecular sieve confinement monatomic catalyst, which comprises the following steps: performing hydroformylation on olefin with an R1R2C = CH2 structure and synthesis gas CO / H2 at the temperature of 80-120 DEG C to obtain a product R1R2CH-CH2CHO or R1R2CH (CHO)-CH3. According to the method, Rh1-coated zeolite is used as a catalyst, and an active site monatomic rhodium metal of the catalyst is confined in a molecular sieve frame structure. The catalyst for catalyzing hydroformylation of styrene has the advantages of high conversion rate, high selectivity and high catalytic efficiency. And the catalyst has selective hydroformylation catalysis performance, and realizes accurate selective catalysis of reactant olefin molecules smaller than molecular sieve pore size # imgabs0 #.

A method for preparing a 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1 H-benzo[d]imidazol-2-yl]butyric acid alkyl ester, wherein 1 mol of 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester is reacted with 2.0 to 2.2 mol of chloromethylenedimethyliminium chloride or with >2.2 to 5 mol of chloromethylenedimethyliminium chloride to prepare a by-product in the form of a 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1 H-benzo[d]imidazol-2-yl]butyric acid alkyl ester. The alkyl ester can be hydrolyzed to form 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H benzo[d]imidazol-2-yl]butyric acid that is usable in the field of medicine.

The application discloses a rhodium-catalyzed desymmetrization hydroformylation method for constructing polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides comprises the following steps: under the condition of an inert atmosphere, an acetylacetone dicarbonyl rhodium metal precursor and a chiral ligand are added into an organic solvent to prepare a catalyst solution, the catalyst solution is mixed with a substrate, and a reaction is carried out under the condition of a hydrogen atmosphere and a carbon monoxide atmosphere; after the reaction is completed, filtration and purification are carried out, and polychiral center cycloalkyl aldehyde is obtained; and the aldehyde group is converted to obtain the polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides has the advantages of high selectivity, wide substrate compatibility, high reaction efficiency, easy conversion of products, and the like. The whole reaction process can obtain polychiral center cycloalkyl aldehyde in one step with extremely high enantioselectivity and diastereoselectivity, the aldehyde group is converted, polychiral center carbon rings can be obtained with high yield, high dr value and high ee value, and the method is simple and easy to operate.

A Method for the synthesis of ω-amino acids or derivatives thereof, includes the following steps synthesis of an ω-oxoester / linear acid by hydroformylation by CO / H2 mixture of at least one monounsaturated acid / ester, the monounsaturated acid / ester preferably resulting from a reaction of metathesis of oils / fats from renewable sources; synthesis of a linear ω-amino acid / ester and / or ω-aminoamide, subjecting the aforementioned ω-oxoester / linear acid to reductive amination; and possible synthesis of a linear ω-amino acid, subjecting the aforementioned linear ω-aminoester and / or ω-aminoamide to hydrolysis.

The invention discloses a preparation method of methoxy imidazo [1, 5-a] pyridine, which comprises the following steps: firstly, taking a compound P1, specifically 1-methylamino-3-methoxypyridine, as an initial raw material, and carrying out carbamylation reaction in a formylation reagent to prepare a compound P2, specifically N-[(5-methoxypyridine-2-yl) methyl]; further carrying out intramolecular ring closing reaction on the compound P2 to obtain a compound P3 which is specifically 7-methoxy imidazo [1, 5-a] pyridine; then, a selective bromination experiment at the C3 position is carried out by taking a compound P3 as a parent skeleton and cyanogen bromide (CNBr) as a bromination reagent, and finally, specific bromination of the C3 site of the imidazo [1, 5-a] pyridine with the selectivity of 100% is realized. A solid theoretical basis is laid for efficient specific modification of the low-reaction-activity C3 site, and an efficient synthesis path is provided for rapid construction of the imidazopyridine derivative, so that the imidazopyridine derivative has a wide application prospect.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

This invention belongs to the field of heterogeneous Rh-based catalyst technology, and discloses a method for preparing a heterogeneous rh-based catalyst and its application. This invention prepares a heterogeneous rh-based catalyst using a one-pot method. By employing a reduction-reoxidation process, the content of different valence states of rhino in the rhino species on the surface of the heterogeneous rh-based catalyst is simply and precisely controlled, increasing the content of the most favorable δ+ valence state from 7.31% to 44.78%, thereby giving the catalyst higher hydroformylation activity. Under reaction conditions of 120℃ and a mixed gas pressure of 2 MPa, the styrene conversion rate reaches 73.9% and the aldehyde selectivity reaches 95.9% within 4 hours, which is superior to most heterogeneous rhino-based catalysts and close to that of homogeneous rhino catalysts. The heterogeneous rhino-based catalyst is prepared by the sol-gel method, which is simple in preparation and control. The prepared catalyst has a uniform rhino distribution, stable performance, and is beneficial for industrial applications.

The invention discloses a C3 aryl formyloxylated 4H-pyrido [1, 2-a] pyrimidine-4-ketone derivative and a synthesis method thereof, and belongs to the technical field of organic photocatalytic synthesis. Aiming at the problems that a noble metal catalyst, a strong oxidant, a photosensitizer which pollutes the environment, a toxic solvent and the like exist in the current C3-H functionalization of a 4H-pyrido [1, 2-a] pyrimidine-4-ketone derivative and the aryl formyloxylation of a heterocyclic compound, the method disclosed by the invention is characterized in that the 4H-pyrido [1, 2-a] pyrimidine-4-ketone derivative is synthesized under the condition of room-temperature air and the irradiation of 410-415nm purple light. The preparation method comprises the following steps: reacting 4H-pyridino [1, 2-a] pyrimidine-4-ketone with a peroxide aryl formyl compound in a dimethyl carbonate solvent to generate a C3 aryl formyloxylated 4H-pyridino [1, 2-a] pyrimidine-4-ketone derivative; the method does not need to add any oxidant or photocatalyst, and has the advantages of simplicity and convenience in operation, mild conditions, easily available raw materials, environmental friendliness, excellent compatibility of substrate functional groups, high reaction yield and the like.

A catalytic one-pot process for the preparation of an alcohol is provided. The process comprises decomposition of methanol into synthesis gas, the hydroformylation of an optionally substituted alkene using said synthesis gas and hydrogenation to the corresponding alcohol. The catalyst system combines a hydroformylation catalyst and a transition metal complex catalyst.

The application provides a preparation method of 3-aryl / alkyl-beta-naphthyl ether compounds, and the preparation method comprises the following steps: reacting trimethyl orthoformate with 1,3-diaromatic propyl ketone compounds or 1-aryl-3-alkyl ketone compounds to obtain 3-aryl-beta-naphthyl ether compounds or 3-alkyl-beta-naphthyl ether compounds. The reaction condition of the application is mild, trimethyl orthoformate is cheap and easy to obtain, can be used as a methylation reagent and a carbon source for extending a carbon chain at the same time, the range of reaction substrates is wide, and the functional group tolerance is good; the reaction is efficient, the selectivity is high, the post-treatment is simple, the operation is simple, and the application is suitable for large-scale industrial production; the complex substrate prepared in advance in the traditional reaction is avoided, the metal catalyst necessary for the traditional reaction is not needed, the binaftyl alcohol precursor compounds can be prepared with high chemical selectivity, and a more simple and efficient route is provided for the olefin hydroformylation / hydroformyl esterification reaction for synthesizing bidentate ligands.

A process for preparing 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester, in which 1 mole of 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester is reacted with 2.0 to 2.2 moles of chloromethylenedimethyliminium chloride or more than 2.2 to 5 moles of chloromethylenedimethyliminium chloride to prepare a by-product in the form of 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester. The alkyl ester can be hydrolyzed to form 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid, which can be used in the pharmaceutical field.

The present scheme provides a method for synthesizing radioactive isotope carbon-14 labeled flonicamid, in which the radioactive isotope carbon-14 is labeled on the pyridine ring in the flonicamid molecule, and carbon-14 labeled barium carbonate is used as a radioactive isotope raw material, and carbon-14 carbon dioxide is released by reacting with concentrated sulfuric acid, and the target product is synthesized through reduction, formylation, dehydration, substitution, cyclization, amide condensation and other reactions. The pyridine ring carbon-14 labeled flonicamid prepared by the present invention can be used as a tracer for tracing and other research on the plant antiviral agent flonicamid in plants, animals, soil and water bodies; at the same time, the method of the present invention provides a reference for the preparation of carbon-14-containing synthetic building blocks.