380 results about "Cyanation" patented technology

The invention belongs to the technical field of solid pollutant treatment, and particularly relates to a method for removing cyanide in cyanidation tailings through metal activated persulfate oxidation. The problems that different cyanide removal mechanisms are different, the removal efficiency is low, the cost is high, secondary pollution is easily caused and the like exist in treatment of the cyanidation tailings. The tailings are subjected to cyanogen reduction treatment by adopting a stage treatment method. The method comprises the following steps: firstly, crushing the tailings to prepare a charcoal-loaded metal composite material Me / BC; when free cyanide in the tailings is smaller than or equal to 50 mg / kg, Me / BC activated persulfate is used for conducting cyanide reduction treatment on the tailings; when the tailings contain free cyanide gt; when the concentration is 50 mg / kg, free cyanides in the tailings are removed through leaching, and then Me / BC is used for activating persulfate to degrade strong complex state cyanides in the tailings. By adopting the method, the problems that complex cyanide is difficult to remove by a single leaching method and persulfate is large in dosage and high in cost in a single oxidation method can be solved, and the cascade cyanogen removal method is efficient, low in cost and free of secondary pollution.

The invention provides a cyanide-containing wastewater resource recovery and cyclic utilization method, and belongs to the technical field of environmental protection and water treatment. According to the method, firstly, copper is collected through sulfuration under the weak acid condition with the pH being 5-6, so that a copper-cyanogen complex ([Cu (CN) 43-]) in wastewater is converted into a mixed material of copper sulfide (CuS) and cuprous cyanide (CuCN), and primary recovery of copper is achieved; and then, adding a pH regulator 2 to control the pH of the reaction system to be 9-11, adding a separation agent to control the ORP of the reaction system to be-400mV to-200mV, and carrying out a separation reaction. In the process, cuprous cyanide reacts with free cyanide (CN <->) to generate a soluble copper-cyanogen complex, and copper sulfide is retained, so that cuprous cyanide is accurately separated from the copper-containing material, the content of cyanide in the material is reduced, and the obtained copper-containing material meets the requirements of industrial product quality standards and pollution control standards; the problems that in the prior art, the cyanide content in the copper-containing material obtained by recycling copper from the cyanide-containing wastewater exceeds the standard, and the environmental risk is high in storage, transportation and comprehensive utilization are solved.

The invention discloses a track kiln for preparing high-strength basalt aggregate from cyanidation tailings, and relates to the technical field of solid waste recycling, the track kiln comprises a base, a track and a kiln car, the track is fixedly mounted at the top of the base, and the kiln car is internally provided with a self-propelled structure and can travel along the track; the device further comprises a side frame fixedly connected to the top of the kiln car, hollow shafts are symmetrically and fixedly connected to the inner side of the side frame, and the sides, close to each other, of the two hollow shafts are fixedly connected with center gears. Raw materials are conveyed in the form of arranging the tunnel kiln, the raw materials are contained in the trays in the conveying process, the materials move in a static mode along with the kiln car, no relative rolling exists between particles, large friction does not exist between the raw materials and between the raw materials and the conveying system, and particle shape damage caused by friction is reduced; the problems that irregular-structure raw material particles outside the raw materials are crushed or rubbed flat due to mutual friction of the raw materials, irregular forms cannot be reserved, and the mechanical property of the aggregate is affected are solved.

The invention relates to a flow battery carbon-based electrode and a preparation method and application thereof, and the preparation method comprises the following steps: respectively dissolving cobalt salt and alkali in a polar organic solvent, and uniformly mixing to form a precursor solution; placing a carbon-based material in the precursor solution, and carrying out a hydrothermal reaction to obtain a carbon-based electrode precursor; and performing high-temperature carbonization on the carbon-based electrode precursor in an inert atmosphere, cooling to room temperature after the reaction is completed, and then cleaning and removing impurities from a product to obtain the carbon-based electrode, the polar organic solvent is at least one of formamide, acetonitrile and N, N-dimethylformamide; after cobalt cyanide is deposited on the surface of the carbon-based material, surface etching and nitrogen doping are carried out on the carbon-based material under the high-temperature condition, surface modification of the carbon-based material is achieved, the contact area of the surface of the carbon-based electrode and electrolyte is increased, and the electrochemical performance of the carbon-based electrode is improved.

The present invention provides a method for treating heap leaching cyanide tailings of gold mines, a composite bacterial community, a bacterial agent and a preparation method. The composite bacterial community comprises a TDB-1 strain, a TCD-1 strain and a Z-90 strain, wherein the TDB-1 strain is a Pseudomonas putida strain, and the deposit number is CGMCC No.21602. The TCD-1 strain is a Methylorubrum pseudosasae, and the deposit number is CGMCC NO.24728. The Z-90 strain is a Burkholderia sp., and the deposit number is CGMCC No.9970. The above-mentioned composite bacterial community can effectively remove cyanide, thiocyanide and metal-cyanide complexes. The present method has the advantages of simple operation, high reduction efficiency, stable effect, good impact resistance and low cost.

The invention relates to an efficient copper removal and recycling process for copper-cyanogen complex wastewater, which comprises the following steps: (1) critical acidification-selective crystallization of the copper-cyanogen complex wastewater: directionally recombining a copper-cyanogen complex to generate insoluble CuCN crystals by accurately regulating and controlling the pH value of the wastewater; (2) rotational flow enhanced crystallization: separating CuCN crystals from overflow liquid through a hydrocyclone; (3) gradient activation of a composite vulcanizing agent for deep copper removal: enabling the fine CuCN particles and the dissolved-state low-coordination copper-cyanogen complex to react to generate insoluble CuS crystals by adjusting the pH value and adding the composite vulcanizing agent; and (4) magnetic seed enhanced separation: carrying out magnetic separation by adopting modified magnetic seeds and a low-intensity magnetic separator, separating CuS magnetic flocs from the wastewater, and finally obtaining purified tail liquid. According to the closed-loop process, copper in the copper-cyanogen complex wastewater can be efficiently removed and recovered, the purified tail liquid can be reused for cyanidation leaching operation, the unit consumption of sodium cyanide is remarkably reduced, the leaching rate of gold and silver is increased, and zero discharge of wastewater and full recovery of copper resources are truly achieved.

The invention discloses a method for degrading gold cyanidation tailings through photo-Fenton of an aluminum-based bimetallic catalyst, and belongs to the technical field of cyanidation tailings treatment. Iron salt and zinc salt are loaded on activated aluminum oxide through an impregnation method, the aluminum-based bimetallic catalyst is obtained through the treatment processes of roasting, grinding, drying and the like, and iron oxide and zinc ferrite contained in the synthesized aluminum-based bimetallic catalyst are main active substances for degrading cyanide residues through photo-Fenton catalysis; under the participation of hydrogen peroxide and an ultraviolet light source, the concentration of cyanide in the cyanide residues can be remarkably reduced, toxicity detection on the reacted filter residues shows that the concentration of the cyanide is lower than the national standard, and the cyanide residues can be treated as general solid waste; the cyanide removal rate can reach 95% or above, and the method has a very good application prospect.

The invention relates to the technical field of chemical intermediates, and particularly discloses a preparation method of a givelastat intermediate.According to the preparation method, an initiator compound 5 can be synthesized by adopting cheap 2-hydroxy-6-naphthoic acid (CAS: 16712-64-4, 141 yuan / kg), and the preparation method is different from a method in the prior art. A gemvelastat intermediate compound 4 is synthesized from a compound 5 through a three-step reaction, compared with the prior art, the yield is high, industrial amplification production is more facilitated, in the process of synthesizing a compound 6 from the compound 5, acetonitrile can be adopted as a cyanide source in a reaction system, activated hydroxyl is subjected to a coupling reaction, and the yield is high. In the process of synthesizing a compound 6 from a compound 7 instead of a traditional metal cyanide, or in the process of synthesizing a compound 6 from another compound 5, a cheap cuprous cyanide and cuprous iodide system is adopted for a coupling reaction, and in the process of synthesizing a compound 4 from a compound 7, an acetic acid and sodium triacetoxyborohydride reaction system is adopted, so that the compound 6 is synthesized. And the important intermediate of the givelastat can be obtained with high yield.

The invention discloses a method for quantitatively testing the content of organic carbon and disseminated particle size in gold ore, and belongs to the technical field of gold ore detection. The method comprises the steps of sample preparation and quantitative testing, wherein palm wax serves as a cementing agent, barite serves as a standard sample, and a to-be-tested sample is prepared through melting, mixing, consolidation, polishing and carbon spraying; the quantitative test is based on an automatic process mineralogy test system, palm wax backgrounds are removed through backgrounds deduction, an energy spectrum library is established to recognize organic carbon and barite particles, the area ratio of the organic carbon and the barite particles is measured, the mass ratio is converted by combining the density ratio, the organic carbon content of raw ore is inversely calculated, and meanwhile, the particle size distribution of the organic carbon is counted. The method solves the problem that the content and granularity of organic carbon cannot be accurately quantified at the same time in the prior art, has the advantages of high test precision, high efficiency, comprehensive parameters and simplicity and convenience in operation, and can provide key data for optimization of a gold ore cyanidation leaching process.

The invention relates to the technical field of solid-liquid separation devices, and discloses a solid-liquid separation device for recycling and treating rare and precious metals in cyaniding waste liquid, which comprises a support frame body, a separation mechanism, an anti-blocking mechanism, a liquid inlet mechanism and an exhaust mechanism, and the separating mechanism comprises a separating box body, a linear reciprocating driving assembly and a filtering sieve plate, the separating box body is installed on the supporting frame body in a sliding mode, and the driving end of the linear reciprocating driving assembly is connected with one side of the separating box body. The anti-blocking mechanism provided by the invention has two use states, when cyaniding waste liquid is filtered and separated, the anti-blocking mechanism can be used for scraping and cleaning viscous substances adsorbed on the filter sieve plate, the problem that the viscous substances in the cyaniding waste liquid block the filter sieve plate is solved, and after filtration is completed, the viscous substances in the cyaniding waste liquid can be removed by switching the other use state. And the filtering sieve plate can be rotationally cleaned, and the cleaning effect on the filtering sieve plate is improved.

The invention discloses a carbamoyl-substituted diarylethene derivative as well as a preparation method and application thereof, and the preparation method comprises the following steps: reacting R-substituted 3-bromo-2-hydroxybenzaldehyde with an arylmethyl triphenylphosphonium bromide compound or an aryl acetic acid compound to obtain an intermediate A; then the intermediate A and cuprous cyanide are subjected to a heating reaction in N, N-dimethylformamide and nitrogen atmosphere, and an intermediate B is obtained; and finally, heating the intermediate B, acetaldoxime and indium trichloride in toluene for reaction to obtain the carbamoyl-substituted diarylethene derivative. The carbamoyl-substituted diarylethene derivative disclosed by the invention has a remarkable effect in an in-vitro anti-tumor activity test, particularly has excellent anti-proliferation ability to human BRCA mutant tumor cells, and can be used for preparing medicines for treating PARP-1 activity abnormity related diseases. The synthesis route is simple, the cost is low, and large-scale implementation is facilitated.

To provide a thermoplastic resin composition from which a resin molded article excellent in moldability, impact resistance, rigidity, weather resistance and adhesion of a deoxime type silicone-based sealing material cured product is given.SOLUTION: A thermoplastic resin composition contains a graft copolymer obtained by polymerization of a vinyl monomer containing an aromatic vinyl compound and a vinyl cyanide compound in the presence of a rubbery polymer, a vinyl-based copolymer which contains a unit derived from an aromatic vinyl compound and a unit derived from a vinyl cyanide compound, and contains no unit of formula (1), and a modified vinyl-based copolymer containing a unit derived from an aromatic vinyl compound, a unit derived from a vinyl cyanide compound, and a unit of Formula (1), and when the total of the units is 100 mass%, a content ratio of the rubbery polymer is 5 to 25 mass%, and a content ratio of the unit of Formula (1) in the modified vinyl-based copolymer is 1 to 20 mass%.SELECTED DRAWING: None

The utility model belongs to the technical field of sewage treatment, and particularly relates to a carbon fiber production wastewater treatment device. Comprising a plate heat exchanger, a polymer sedimentation tank, an air flotation machine, a hydrolysis acidification tank, an anoxic tank, an aerobic tank and a secondary sedimentation tank which are sequentially connected, an inlet of the plate heat exchanger is connected with a carbon fiber production device, and an outlet of the secondary sedimentation tank is connected to a sewage treatment plant; the system further comprises a decyanation pool, an inlet of the decyanation pool is connected with the high-concentration cyano compound wastewater collecting tank, and an outlet of the decyanation pool is connected to the hydrolysis acidification pool; an inlet of the neutralization tank is connected with the acrylic acid production device, and an outlet of the neutralization tank is connected to the hydrolysis acidification tank. By using the acrylic acid production wastewater as the composite carbon source and recovering the dry powder, the outsourcing cost of the carbon source and the sludge treatment cost are remarkably reduced; by combining the synergistic effect of physical pretreatment, chemical decyanation and biodegradation processes, cyanides, suspended solids and organic pollutants are efficiently removed, and it is ensured that the effluent index stably reaches the standard.

The present invention provides a paroxysmal hemoglobinuria indication drug ipropam key intermediate synthesis method, and relates to the technical field of ipropam, the method comprises: taking p-bromobenzaldehyde as an initial raw material, adopting an S-configuration catalyst to obtain an intermediate 03, carrying out protection group removal on the intermediate 03, carrying out automatic ring closing to obtain an intermediate 04, and carrying out post-treatment to obtain the paroxysmal hemoglobinuria indication drug ipropam key intermediate. Reducing the intermediate 04 with sodium borohydride to obtain a single cis-configuration intermediate 05, then carrying out a chiral flip reaction and hydrolysis to remove p-nitrobenzoic acid, then carrying out an etherification reaction with diethyl sulfate to obtain an intermediate 08, reducing amide of the intermediate 08 with sodium borohydride and boron trifluoride diethyl etherate to obtain an intermediate 09, then carrying out an acetylation reaction to protect amino, and finally carrying out a reaction to obtain the chiral cis-configuration intermediate 03. Cuprous cyanide is subjected to a cyanation reaction and a hydrolytic esterification reaction to obtain the ipropam key intermediate TM. The method is low in raw material price, high in chiral control selectivity, easy in reaction condition control and low in equipment requirement, avoids column chromatography and other operations, and is more suitable for industrial production.

The invention provides a process for removing cyanide from a cyanide-bearing aqueous fluid, the process comprising: (i) adding a solid composition comprising a first mixed-metal cyanide complex comprising copper and iron to a cyanide-bearing aqueous fluid comprising free cyanide and metal-complexed cyanide, wherein at least a portion of the first mixed-metal cyanide complex dissolves, with complexation of the copper by the free cyanide, to produce an aqueous solution comprising cyanometallates, the cyanometallates comprising copper cyanide and iron cyanide complexes derived from the first mixed-metal cyanide complex; (ii) contacting the aqueous solution with an anion-exchange absorbent to absorb the cyanometallates, thereby producing a cyanide-lean aqueous fluid; (iii) extracting the anion-exchange absorbent comprising the absorbed cyanometallates with at least one non-acidic aqueous extractant to produce an aqueous extract comprising the copper cyanide and iron cyanide complexes; and (iv) acidifying the aqueous extract to produce a precipitate comprising a second mixed-metal cyanide complex comprising copper and iron.

This invention discloses a method for recycling and reusing cyanide silver plating wastewater. The method includes four steps: separation of silver ions and cyanide, concentration of the silver-containing solution, cyanide concentration, electrolysis and residual liquid recycling, and reuse of reclaimed water. This method achieves the separate recycling and reuse of silver, cyanide, and water. The silver-containing solution is electrolyzed to obtain metallic silver, the cyanide concentrate's main component is sodium cyanide or potassium cyanide solution, and the reclaimed water with a conductivity below 20 μS / cm is reused in the production line. This method not only maximizes resource utilization and reduces wastewater discharge, but also separates most of the cyanide from the silver-containing solution during electrolysis, making the electrolysis process safer. Furthermore, the residual liquid after electrolysis can be recycled multiple times for the separation and concentration of silver ions and cyanide.

The invention relates to a gold oxide ore carbon slurry cyaniding smelting extraction method which comprises the following steps: 1) pretreating ore pulp: adding lime milk into gold oxide ore powder, adjusting the pH value to be greater than 10.5 to obtain ore pulp, then adding a pretreating agent, and fully and uniformly mixing to obtain pretreated ore pulp; (2) synchronous cyaniding leaching and adsorption are conducted, specifically, the pretreated ore pulp is subjected to synchronous leaching and adsorption, in the process, the concentration of free cyanogen is controlled to be 0.04%-0.06%, the PH value is controlled to be larger than 10.5, the concentration of a carbon adsorbent is controlled to be 18-22 g / L, and a gold loading material is obtained; the gold loading material is desorbed till the gold concentration in a desorption solution is smaller than or equal to 0.2 mg / L, desorption is stopped, a pregnant solution is obtained and then electrolyzed, when the gold concentration is smaller than or equal to 0.2 mg / L, electrolysis is stopped, scraping is conducted, and gold mud is obtained, and (4) smelting and aftertreatment are conducted, the gold mud is smelted and subjected to aftertreatment, and gold is obtained.The process has the advantages of being small in cyanide consumption and the like.

This invention discloses a catalyst for the production of p-cyanobenzoic acid and its preparation method, belonging to the field of catalyst technology. The method includes the following steps: adding an organic ligand solution dropwise to a cobalt source, stirring, aging, centrifuging, collecting the solid phase and washing to obtain a cobalt-based MOF framework; dispersing the cobalt-based MOF framework in a copper source, stirring, filtering, and collecting the solid phase to obtain copper-cobalt doped particles; dispersing reduced graphene oxide in deionized water, adding sodium alginate, stirring evenly, adding copper-cobalt doped particles and ammonium dihydrogen phosphate, continuing stirring, standing, centrifuging, collecting the lower gel precipitate, washing, and vacuum freeze-drying to obtain an aerogel precursor; carbonizing the aerogel precursor in a hydrogen-argon mixed atmosphere, cooling, and grinding to obtain the catalyst. The catalyst prepared by this invention can efficiently catalyze the cyanation reaction of p-bromobenzoic acid, improving the yield and purity of the target product, while also possessing excellent recycling performance.

The application provides a method for recovering valuable metals and cyanide in cyanide tail liquid based on pulse current diaphragm electrolysis, and belongs to the field of wastewater treatment, wherein a diaphragm electrolysis device is assembled to separate an anode chamber and a cathode chamber by an ion exchange membrane; an alkaline electrolyte solution is added into the anode chamber, and a cyanide tail liquid to be treated is added into the cathode chamber; a single pulse current is used for electrolysis reaction, and the cathode chamber is continuously aerated; after the reaction is completed, the cathode electrolyte is determined to calculate the cyanide recovery rate and the valuable metal recovery rate. The application can efficiently, lowly and selectively recover valuable metals in the cyanide tail liquid under alkaline conditions, and can effectively recover cyanide at the same time, overcomes the limitations of the traditional electrolysis method, and has important economic and environmental significance.

The invention discloses a method for preparing substituted imidazole by taking acyl chloride as a raw material, belongs to the technical field of synthesis of fine chemicals, and aims to solve the problems that the raw material structure is complicated, the source is limited, the raw material needs to be prepared in advance and the cost is low in the existing method for synthesizing substituted imidazole. The reaction conditions are harsh, the reaction time is long, and a transition metal catalyst needs to be used. The method comprises the following steps: synthesizing 2-substituted-4-dimethylamino-5-cyano imidazole from acyl chloride, tetramethylguanidine and a cyaniding reagent at a certain temperature and under an alkaline condition; according to the method disclosed by the invention, the 2-substituted-4-dimethylamino-5-cyano imidazole is synthesized in one step by taking the acyl chloride as the substrate, the reaction rate is greatly accelerated by selecting various acyl chlorides and alkali and synergistically and reasonably controlling the ratio of various substances, efficient synthesis of the 2-substituted-4-dimethylamino-5-cyano imidazole is realized, and the substrate is good in adaptability and high in yield. The method has wide application prospects in the fields of chemistry, biology, medicine and the like.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of topiromilast. The preparation method comprises the following steps: taking a compound 1, namely 4-(1H-1, 2, 4-triazole-5-yl)-pyridine, and a compound 2, namely 2-cyanopyridine-4-formaldehyde as raw materials, and reacting under the action of a free radical initiator and a catalyst; and performing post-treatment to obtain the target compound topiromilast. According to the invention, the problems of low yield, use of a highly toxic cyaniding reagent and the like caused by construction of a triazole ring or introduction of a cyano group are avoided; the yield and the purity of the product are improved, the post-treatment operation is simple, and the method is suitable for industrial production.

To provide a method for synthesizing a cyanide that is a precursor to a β-amino acid derivative having bulky optical activity, intended for peptide synthesis including a β-amino acid having bulky optical activity.SOLUTION: The present invention provides a method for synthesizing a cyanation product having a bulky tertiary alkylated structure and having optical activity, by reacting an α-haloamide having a bulky tertiary alkylated structure and having optical activity with a cyanohydrin in the presence of a copper catalyst.SELECTED DRAWING: None

The application discloses a method for improving recovery rate of extremely fine-grained gold ore by multi-process cooperation and belongs to the field of gold leaching by a wet method.According to different occurrence states of the extremely fine-grained gold ore, the application sequentially carries out phased and targeted recovery in the order of flotation, magnetic separation, alkali leaching pretreatment and cyanide leaching, or sequentially carries out phased and targeted recovery in the order of alkali leaching pretreatment, cyanide leaching, cyanide breaking, flotation and magnetic separation.Through the multi-process cooperative process, the application realizes phased and accurate recovery of gold in different occurrence states in the extremely fine-grained gold ore, significantly improves the total recovery rate of gold, and has the advantages of mild process, controllable cost and good environmental protection, thereby providing a new technical scheme for efficient recovery of extremely fine-grained refractory gold ore and having a wide industrial application prospect.

The invention belongs to the technical field of medicine synthesis, and discloses a preparation method of a sodium nitroprusside raw material medicine. According to the method, weak acid is adopted for catalysis, the effect of remarkably reducing generation of toxic substances such as cyanide and nitrogen dioxide is achieved by controlling the material dripping speed and the dripping pH, the reaction is mild, the technological operation is safe and controllable, and industrial production of the sodium nitroprusside raw material medicine is facilitated. According to the preparation method of some examples, silica gel filtration is used for post-treatment, the residual risk of impurities such as sodium ferricyanide, ferric ferrocyanide and ferric ferricyanide is reduced, and the purity of the raw material medicine is larger than or equal to 99.9% and is far superior to the requirements of pharmacopoeia of various countries.

Carbon is one of the most common elements in bioactive organic compounds. Theoretically, nearly all carbon-based organic functional groups can be labeled with 11C if an appropriate 11C-synthon is developed and utilized. Although there are various reports on developing PET agents based on alkyl [11C]nitriles, efficient and facile cyanation of arenes with radioisotope-containing reagents, particularly electron-rich arenes, still requires further improvements. The organic photoredox-catalyzed cyanation method reported herein introduces a [11C]nitrile quickly with high radiochemical conversion (RCC) in a metal-free manner, which can also be further diversified to other functional groups such as [11C]carboxylic acids, [11C]amides, and [11C]alkyl amines.

The application belongs to the field of fuel cells, and particularly relates to a preparation method of a single-iron atom catalyst. A solution containing component A, component B and component C is subjected to a coprecipitation reaction to obtain a precipitate; the precipitate is aged in a component D solution to obtain an aged product; and the aged product is subjected to gradient calcination to obtain the single-iron atom catalyst. The component A contains a compound of formula 1; the component B contains at least one of iron cyanide, dopamine and a salt thereof; the component C contains an iron source and a zinc source; and the component D contains a water-soluble compound having a fragment of formula 3. The application also discloses a material prepared by the method and an application of the material in ORR and fuel cells. Research shows that the material prepared by the method has excellent catalytic activity and stability in ORR, and a metal-air battery assembled by using the material can have excellent limiting current density, peak power and discharge specific capacity.

This invention provides a method for synthesizing the anti-AIDS drug enovirine. This invention belongs to the field of pharmaceutical preparation technology. The synthesis method includes the following steps: (1) SM1 compound reacts with Grignard reagent and then reacts with SM2 compound to obtain compound III; (2) Compound III undergoes oxidation reaction to obtain compound II; (3) Compound II undergoes demethylation reaction under the action of demethylation reagent to obtain compound I; (4) Compound I undergoes ethylation reaction to obtain enovirine. The synthesis route of this invention effectively avoids the use of highly toxic cyanide reagents and expensive heavy metal catalysts. At the same time, the reaction conditions of this route are simple and mild, with high yield, and have excellent industrialization prospects.

Disclosed in the present invention are a method for synthesizing deucravacitinib and intermediates thereof. An intermediate 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is prepared by subjecting 2,3-dichloronitrobenzene to an etherification reaction and a cyanation reaction to prepare 2-methoxy-3-nitrobenzonitrile; then reacting 2-methoxy-3-nitrobenzonitrile with ammonium chloride under the action of an alkali to generate 3-(2-methoxy-3-nitrophenyl)-1-methyl-1H-1,2,4-triazole; and finally, carrying out a catalytic reduction reaction to obtain the target product. Another intermediate N-(5-bromo-6-cyanopyrazin-3-yl)cyclopropanecarboxamide is prepared by subjecting 3-amino-6-chloropyridazine to a bromination reaction to prepare 3-amino-4-bromo-6-chloropyridazine, then reacting 3-amino-4-bromo-6-chloropyridazine with sodium nitrite under low-temperature condition and in the presence of an acid to generate a diazonium salt, and then adding a cyanate reagent to generate 4-bromo-6-chloro-3-cyanopyridazine; and finally carrying out a substitution reaction to obtain a target product (I). Deucravacitinib is obtained by subjecting these intermediates to a Buchwald-Hartwig coupling reaction, carrying out nitrile hydrolysis, and carrying out condensation.

The utility model belongs to the technical field of separation devices, and relates to a cyanidation tailing secondary gold recovery device which comprises a reaction barrel, a gear ring is arranged at the upper end of the reaction barrel, first equal-row sawtooth grooves are formed in the inner side of the gear ring, and a limiting block is located on the inner side of the reaction barrel and rotationally connected with the reaction barrel. A first equal-column sawtooth block is slidably clamped to the inner side of the limiting block, the lower end of the first equal-column sawtooth block is fixedly connected with a secondary filtering barrel, a second equal-column sawtooth groove is formed in the inner side of the first equal-column sawtooth block, and a second equal-column sawtooth block is slidably connected to the inner side of the second equal-column sawtooth groove; the lower end of the second equal-row sawtooth block is fixedly connected with a first-stage filtering barrel, and a driving assembly is arranged on the inner side of the reaction barrel. According to the utility model, tailings with larger particles are recovered through the primary filter vat, and finer and purer tailings components are recovered from the secondary filter vat, so that cyanidation tailings on the inner sides of the primary filter vat and the secondary filter vat are subsequently recovered with different precisions.

The invention relates to the field of polyacrylate photoresists, in particular to a photoresist film-forming resin raw material and a preparation method thereof.The preparation method comprises the steps that cyclopentadiene is dropwise added into a mixed solution of alpha-bromomethyl acrylate and a solvent, the temperature is controlled, a reaction is conducted for 4 h, and 5-bromodicyclohept-2-ene-5-carboxylic acid methyl ester is prepared; the preparation method comprises the following steps: adding alkali into 5-bromo dicycloheptyl-2-ene-5-carboxylic acid methyl ester, and hydrolyzing at 20-30 DEG C for 2 hours to obtain a hydrolysis product; the hydrolysis product is subjected to epoxidation and hydrolysis with hydrogen peroxide under the condition of glacial acetic acid, and 1-bromine-5-hydroxy-3-oxa-tricyclic nonyl-2-ketone is obtained; according to the method, 1-bromo-5-hydroxy-3-oxa-tricyclic nonyl-2-ketone is cyanided by cuprous cyanide to prepare the 1-cyano-5-hydroxy-3-oxa-tricyclic nonyl-2-ketone monomer, and the method has the advantages that the raw materials are convenient and easy to obtain, the route is short, the reaction conditions are relatively mild, the operation safety is relatively high, the total yield is remarkably improved, and the like.