30 results about "Sodium loxoprofen" patented technology

The invention discloses a sustained-release pill as well as a preparation method and application thereof, and belongs to the technical field of medicines. The sustained-release pill comprises a pill core and a coating layer coated outside the pill core, the pellet core is prepared from the following raw materials in parts by mass: 8 to 14 parts of loxoprofen sodium, 30 to 60 parts of a filling agent, 3 to 10 parts of an adhesive, 2 to 10 parts of a disintegrating agent, 0.1 to 2 parts of a penetration enhancer, 0.05 to 0.2 part of a pH regulator, 0.1 to 0.5 part of a surfactant and 0 to 20 parts of an auxiliary agent; the coating layer is prepared from an aqueous dispersion liquid containing acrylic resin; the coating layer is prepared from an aqueous dispersion liquid containing acrylic resin. Aiming at the drug characteristics of loxoprofen sodium, the loxoprofen sodium sustained-release tablet is composed of specific auxiliary materials, the drug composition is optimized, the drug release rate is accurately controlled, the bioavailability and stability of the drug are effectively improved, and the loxoprofen sodium sustained-release tablet has a good application prospect in preparation of antipyretic and analgesic drugs.

The invention relates to an anti-inflammatory and analgesic external composition, a preparation method and application thereof and a gel preparation, and belongs to the technical field of external pharmaceutical compositions.The anti-inflammatory and analgesic external composition is prepared from, by weight, 3-8 parts of loxoprofen sodium, 500-1000 parts of fried semen brassicae, 300-500 parts of fructus arctii and 10-30 parts of liquorice. The semen brassicae is warm in nature and pungent in taste, belongs to the lung channel, and has the effects of benefiting qi and removing stasis; the fructus arctii is cold in nature, pungent and bitter in taste, belongs to lung and stomach channels and has the effects of detoxifying and promoting eruption, the fructus arctii and the fructus arctii are cold in nature and warm in nature, mutual in medicine property, pungent and divergent in taste and have the effect of transdermal enhancement of the medicine effect, the liquorice is neutral in nature and sweet in taste, belongs to the heart, lung, spleen and stomach channels and has the effects of relieving spasm and pain and harmonizing all the medicines, and the liquorice, the fructus arctii and the liquorice can synergistically play the effects of stimulating menstrual flow and relieving pain. And with the cooperation of loxoprofen sodium, the synergistic interaction effect is achieved in the aspects of diminishing inflammation and relieving pain.

The invention provides a detection method for related substances in loxoprofen sodium oral solution. The adopted ternary mobile phase system solves the interference of auxiliary materials in the low absorption band on the detection of known impurities, thereby avoiding the problem of missed detection and insufficient detection of impurities, effectively solving the interference of auxiliary material methylparaben on the detection of impurities when the related substances are determined, and the types and numbers of impurities to be monitored are large, the separation between various impurities, between impurities and main components, and between impurities and auxiliary materials is good, the related substances in the loxoprofen sodium oral solution can be quickly and accurately monitored, and the method has important significance for the quality evaluation of the loxoprofen sodium oral solution.

The invention discloses a hot-melt loxoprofen sodium patch and a preparation method thereof, the hot-melt loxoprofen sodium patch comprises a backing layer, an adhesion layer and a protective layer, the adhesion layer comprises the following components in percentage by weight: 5-6% of loxoprofen sodium or its hydrate, 19-26% of styrene-isoprene-styrene block copolymer, 5-15% of polyisobutene, 5-15% of hydrogenated rosin glyceride and 40-50% of liquid paraffin; by optimizing the model and dosage of the styrene-isoprene-styrene block copolymer and the polyisobutene, the adhesive force and cohesive force of the loxoprofen sodium patch are improved at the same time through the combined action, and the long-term stability can be kept.

The invention discloses a method for synthesizing loxoprofen sodium by using a resin catalyst, and belongs to the field of medical chemical synthesis. The preparation method comprises the following steps: synthesizing 2-methylene cyclopentanone through methylenation reaction of cyclopentanone, paraformaldehyde and amine; the preparation method comprises the following steps: reacting 4-halogenated phenylacetate with methyl iodide to synthesize 2-(4-halogenated phenyl) propionate; a target intermediate 2-(4-((5-oxocyclopentyl-1-alkenyl) methyl) phenyl) propionate is generated through a Heck coupling reaction; further reducing to 2-(4-((2-oxygen cyclopentyl) methyl) phenyl) propionate through a catalytic hydrogenation reaction; and finally, carrying out a salt forming reaction to obtain loxoprofen sodium. The method adopts the self-made resin catalyst, is efficient and environment-friendly, has good yield and purity, and is suitable for industrial production.

The invention discloses a green synthesis process of non-steroidal loxoprofen sodium, and relates to the field of loxoprofen sodium synthesis. A water / organic two-phase free radical bromination and functionalized Pd-Ru / NH2-ZIF-8 catalysis one-step hydrogenation degreasing-tert-butyl ester removal path is adopted. The catalyst is modified by a thiol ligand and cooperates with a chiral inducer to construct a Pd-Ru bimetallic active site, so that the product purity and the product yield are effectively improved, and the catalyst can be repeatedly used. The method is environment-friendly and efficient in process and suitable for industrial application.

The utility model discloses a disinfection device for loxoprofen sodium gel plaster production, which relates to the technical field of disinfection devices for loxoprofen sodium gel plaster production, and comprises a disinfection tank, one end of the disinfection tank is fixedly connected with a second motor, and the other end of the disinfection tank is fixedly connected with a third motor. Through arrangement of a first partition plate, a threaded shaft, a third gear, a third threaded rod, a second partition plate, a first gear, a positioning column, a second gear, a first air pipe, a second air pipe, a sealing ring, a control block and a second rotating block, the disinfection device for loxoprofen sodium gel plaster production has the advantages that operation is simplified, drying is convenient, and the situation that a first valve needs to be closed and then a second valve needs to be opened during drying is avoided; according to the disinfection device for loxoprofen sodium gel plaster production, due to the fact that a disinfection tank, a movable block, a supporting base, a blocking plate, a lifting rod, a first threaded rod, a first gear, a second gear and a first motor are arranged, the disinfection device for loxoprofen sodium gel plaster production can take out medicinal materials, and the situation that the medicinal materials cannot be taken out rapidly is avoided.

The invention discloses a method for determining related substances in a loxoprofen sodium patch in the technical field of drug detection, and aims to solve the technical blank existing in determination of related substances in a loxoprofen sodium patch in the prior art. The method comprises the following steps: respectively weighing a loxoprofen sodium reference substance and an impurity reference substance, and adding a solvent for dilution to prepare a reference substance solution; taking a loxoprofen sodium patch, stripping a protective layer, adding tetrahydrofuran and methanol, shaking to separate the paste from a backing layer, adding water, shaking again, adding a solvent for dilution, uniformly mixing, centrifuging, and taking supernate to obtain a test solution; injecting the prepared reference substance solution and the test solution into a high performance liquid chromatograph for determination to obtain peak areas of the reference substance solution and the test solution; and calculating the content of the related substances in the loxoprofen sodium patch by adopting an HPLC correction factor method according to the peak areas of the reference solution and the test solution. The method is suitable for measuring the content of the related substances in the loxoprofen sodium patch.

The present invention belongs to the technical field of pharmaceutical formulations, specifically relates to a controlled-release tablet of loxoprofen sodium, its preparation method, and use. The controlled-release tablet comprises a drug-containing immediate-release layer, a drug-containing core layer, and a drug-containing sustained-release layer, the drug-containing core layer comprising a plain tablet core, an enteric coating film, and a sealing coating film. The preparation method includes granulating the raw materials for the drug-containing immediate-release layer and the drug-containing sustained-release layer, respectively, wet granulating the raw materials for the plain tablet core and compressing them into tablets, followed by sequentially applying a first sealing coating, a second enteric coating, and a third sealing coating to obtain a drug-containing core, placing the drug-containing core on the drug-containing sustained-release layer granules and pre-compressing them, and then placing the drug-containing immediate-release layer granules on the pre-compressed tablet, compressing them, and coating them to obtain the drug-containing core. The present invention achieves the sustained-release effect of the loxoprofen sodium tablet core by designing the single-layer structure, raw materials, and coating layer components of the dry-coated tablet, thereby achieving 12-hour in vivo efficacy and improving patient compliance.

According to the loxoprofen sodium patch and the preparation method thereof provided by the invention, in the preparation process of the patch, the loxoprofen sodium patch prepared by optimizing the preparation temperature, the coating temperature and an oxygen control mode of vacuumizing and continuously filling nitrogen has the advantages that the increase amplitude of related substances is low under an accelerated test condition; the stability of the patch can be obviously improved, the coating time can be obviously prolonged, and the patch has important significance for increasing the production batch and improving the production capacity.

1. Name of the product under this design: Pharmaceutical packaging box (Loxoprofen sodium gel patch). 2. Purpose of this design product: This design is used for pharmaceutical packaging. 3. The key design points of this product are the combination of shape, pattern and color. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. The design for which protection is sought includes color.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a loxoprofen sodium preparation and a preparation method thereof. The loxoprofen sodium preparation is composed of a loxoprofen sodium tablet and a tablet outer layer coating, the outer layer coating comprises the following raw materials: L-glutamine, carboxylated chitosan and a coloring agent, the L-glutamine accounts for 24-26% of the mass of the outer layer coating, the carboxylated chitosan accounts for 17-30% of the mass of the outer layer coating, and the coloring agent accounts for 1-2% of the mass of the outer layer coating. The preparation method mainly comprises the following steps: firstly, preparing loxoprofen sodium tablets by a wet granulation process, then preparing a coating solution, and finally, carrying out film coating on the tablets by using the coating solution to obtain the loxoprofen sodium preparation. According to the loxoprofen sodium preparation and the preparation method thereof provided by the invention, the process is simple and convenient, the coating is stable, the release is controllable, the prepared preparation is suitable for being taken by various patient groups, and the medication safety and compliance are further improved while the curative effect is guaranteed.

The invention discloses a hot-melt loxoprofen sodium patch and a preparation method thereof. The hot-melt loxoprofen sodium patch comprises a backing layer, an adhesive layer and a protective layer. The adhesive layer comprises, by weight percentage, 5-6% of loxoprofen sodium or a hydrate thereof, 19-26% of a styrene-isoprene-styrene block copolymer, 5-15% of polyisobutylene, 5-15% of hydrogenated rosin glycerol ester, and 40-50% of liquid paraffin. By optimizing the type and amount of the styrene-isoprene-styrene block copolymer and the polyisobutylene, the adhesive force and cohesive force of the loxoprofen sodium patch are simultaneously improved through their combined action, and the long-term stability of the patch can be maintained.

1. The name of the design product: medicine packaging box (losofil sodium gel paste). 2. The use of the design product: the design is used for the outer packaging of losofil sodium gel paste. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: perspective view. 5. The design claimed contains color.

1. Name of the designed product: packing box (sodium loxoprofen gel plaster). 2. Use of the designed product: for packing products. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The invention provides an ophthalmic preparation containing an aryl propionic acid compound. According to the invention, the active metabolite converted from loxoprofen sodium in vivo, namely the compound as shown in the formula I and the salt thereof, is taken as the effective component and is prepared into various ophthalmic preparations for administration by virtue of a preparation means, so that the problem of low bioavailability due to the fact that only part of prodrugs can be converted into the active metabolite when being directly administered is effectively solved. Compared with the compound shown in the formula I, the salt of the compound has high solubility and good stability, and the ophthalmic preparation prepared by taking the compound as an active component has obviously improved stability and can be stored for a long time. The eye drops are small in side effect, safe, reliable in curative effect and suitable for treating inflammation of external eyes and front eyes, xerophthalmia and eye pain after operation; the raw materials are easy to obtain, the cost is low, industrial large-scale production can be realized, and remarkable economic benefits are achieved.

The application discloses a loxoprofen sodium-containing patch composition, which comprises a backing layer, an adhesive layer and a protective layer, and the adhesive layer comprises, in percentage by weight, 5-6% of loxoprofen sodium or a hydrate thereof, 19-26% of a styrene-isoprene-styrene block copolymer, 5-16% of polyisobutylene, 5-16% of hydrogenated rosin glyceride and 40-50% of liquid paraffin. The loxoprofen sodium patch composition provided by the application can simultaneously improve the adhesive force and cohesion of the loxoprofen sodium patch and maintain long-term stability by optimizing the types of the styrene-isoprene-styrene block copolymer, the polyisobutylene and the liquid paraffin.

1. Name of the product in this design: Packaging Box (Loxoprofen Sodium Gel Patch). 2. Application of this design: This design is intended for use in pharmaceutical packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.

The present invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a loxoprofen sodium controlled-release tablet, and a preparation method and use thereof. The controlled-release tablet includes a drug-containing immediate-release layer, a drug-containing tablet core layer and a drug-containing sustained-release layer. The drug-containing tablet core layer includes a plain tablet core, an enteric coating film and an isolation coating film. The preparation method includes: preparing a granule of a drug-containing immediate-release layer and a granule of drug-containing sustained-release layer respectively from a raw material of the drug-containing immediate-release layer and a raw material of the drug-containing sustained-release layer; subjecting a raw material of a plain tablet core to wet granulation, tableting, and then sequentially coating with a first layer of isolation coating , a second layer of enteric coating, and a third layer of isolation coating to obtain a drug-containing tablet core; and placing the drug-containing tablet core on the granule of the drug-containing sustained-release layer, pre-compressing, and then placing the granule of the drug-containing immediate-release layer on the pre-compressed tablet, tableting, and coating to obtain the tablet. In the present invention, the tablet structure, raw materials, coating and the like components of the core-coated tablet are designed to achieve the effect of sustained-release of the loxoprofen sodium tablet core, so that the tablet can be effective in vivo for 12 h and improve patient compliance.

The invention belongs to the field of medicinal chemistry, and particularly relates to a dual-target compound based on multimode analgesia, a composition and application. According to the invention, active metabolite M1, loxoprofen sodium active metabolite (trans-OH body) and amino-acid ester hydrochloride which are generated by CYP2D6 enzyme metabolism of tramadol in the liver are used as raw materials, and esterification, hydrolysis and condensation reactions are carried out to finally prepare the twin drug compound of M1 and loxoprofen sodium active metabolite. The compound overcomes the problem of gastrointestinal irritation after loxoprofen sodium is orally taken and absorbed, and can reduce the problem of inaccurate M1 dosage caused by different CYP2D6 enzyme activity due to individual difference, so as to ensure a good analgesic effect and tolerability.

The present invention addresses the problem of providing a patch that has excellent skin permeability and good adhesiveness. [Solution] A patch provided with a support and an adhesive layer laminated on the support, the adhesive layer containing loxoprofen sodium hydrate, hydrated silica, polyisobutylene, glycerol ester of hydrogenated rosin, a styrene-isoprene-styrene block copolymer, and phosphoric acid. Based on the total mass of the adhesive layer, the content of the silicon dioxide hydrate is preferably 0.3%-1% by mass, the content of the polyisobutene is preferably 5%-15% by mass, the content of the glycerol ester of the hydrogenated rosin is preferably 10%-20% by mass, the content of the styrene-isoprene-styrene block copolymer is preferably 17%-27.5% by mass, and the content of the phosphoric acid is preferably 0.1%-1.5% by mass.

The invention relates to a loxoprofen sodium patch and a preparation method thereof. The loxoprofen sodium patch comprises a backing layer, a drug-containing matrix layer and a stripping layer, the stripping layer is in contact with the drug-containing substrate layer, and the backing layer covers the drug-containing substrate layer; the drug-containing matrix layer comprises loxoprofen sodium, a penetration enhancer and an acrylate pressure-sensitive adhesive, and the tail end of the acrylate pressure-sensitive adhesive only contains a carboxyl group. The loxoprofen sodium patch is stable in performance, simple in component and excellent in adhesion performance, and has a good transdermal release effect.

The invention relates to a loxoprofen sodium dispersible tablet and a preparation method thereof. The dispersible tablet comprises loxoprofen sodium, a disintegrating agent, a filling agent, a flow aid and a lubricating agent. According to the prescription and the prepared product, the dissolution rate is improved, the effect can be quickly achieved, the technological operation is simple and convenient, the product yield is improved, the production cost is saved, and the method is suitable for industrial mass production.

The application belongs to the technical field of pharmaceutical preparations and relates to a loxoprofen sodium-containing tablet and a preparation method thereof. The loxoprofen sodium tablet is composed of the following components in parts by weight: loxoprofen 100 parts, soybean isoflavone 15-45 parts, potamogeton crispus polysaccharide 10-30 parts, lactitol 2-5 parts, microcrystalline cellulose 150-242 parts, low-substitution hydroxypropyl cellulose 12-50 parts, colloidal silicon dioxide 3-20 parts and magnesium stearate 3-8 parts. The preparation process is simple, the dissolution curve of the obtained tablet is consistent with that of a commercial product, the tablet prepared by the application has a low content of related substances, the active substance is stable, the tablet is suitable for clinical use and has high development value.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a controlled-release tablet of sodium loxoprofen, a preparation method and application. The controlled-release tablet comprises a drug-containing immediate-release layer, a drug-containing tablet core layer and a drug-containing sustained-release layer; the drug-containing tablet core layer comprises a blank tablet core, an enteric coating film and an isolation coating film. The preparation method comprises preparing drug-containing immediate-release layer granules from raw materials of the drug-containing immediate-release layer and the drug-containing sustained-release layer; wet granulating raw materials of the blank tablet core, tabletting, and then sequentially performing first isolation coating, second enteric coating and third isolation coating to obtain a drug-containing tablet core; placing the drug-containing tablet core on the drug-containing sustained-release layer granules, pre-compressing, placing the drug-containing immediate-release layer granules on the pre-compressed tablet, tabletting, and coating to obtain the tablet. The tablet core sustained-release effect of the sodium loxoprofen tablet is achieved by designing the tablet type structure of the core tablet and the raw materials, coating and other components, so that the tablet is effective in the body for 12 hours, and the patient compliance is improved.

The utility model relates to the technical field of oral solution leakage-proof packaging, and discloses a loxoprofen sodium oral solution leakage-proof packaging structure which comprises a packaging box outer shell, the front side and the rear side of the inner wall of the packaging box outer shell are both fixedly connected with limiting blocks, and the outer walls of the limiting blocks are connected with a packaging box inner shell in a sliding mode. Sliding grooves are formed in the front side and the rear side of the outer wall of the packaging box inner shell correspondingly, the inner walls of the sliding grooves are matched with the outer walls of the limiting blocks, and a damping plate is arranged at the top end of the inner wall of the packaging box inner shell. According to the utility model, the damping plate is placed above the interior of the inner shell of the packaging box, the upper side of the outer wall of the damping plate is attached to the inner wall of the outer shell, the lower side of the damping plate is attached to the solution bottle body, and the concave groove in the sponge strip is attached to the rear end of the solution bottle body, so that when the sealing cover is loosened to cause solution leakage, leaked liquid can be sucked in time, and the solution bottle body is clamped on the clamping soft plate; the top is attached to the damping plate, all-directional wrapping of a solution bottle body is achieved, and the solution is prevented from leaking due to extrusion and impact during transportation.

The invention discloses a synthesis method of high-purity loxoprofen sodium, and relates to the technical field of loxoprofen sodium synthesis. According to the method, dimethyl adipate is adopted as a cheap initiator, processes such as Deckmann condensation, hydrolysis decarboxylation and alkalization salt preparation are adopted for optimizing routes, precise temperature, time and pH control is assisted, and solvent recovery and activated carbon decoloration treatment are combined, so that the impurity content is effectively reduced. The HPLC purity of the final product reaches 99.95% or above, the content of single impurities is smaller than or equal to 0.05%, the content of total impurities is smaller than or equal to 0.5%, and excellent industrial expandability and economic benefits are shown.

1. Name of the product of this design: pharmaceutical packaging box (loxoprofen sodium). 2. Purpose of this design product: This design is used for the packaging of medicines. 3. The design key points of this appearance design product are: the combination of shape, pattern and color. 4. The picture or photo that best illustrates the key points of the design: Reference diagram of the design 1 in use. 5. The design for which protection is sought includes color. 6. Designate Design 1 as the base design.

The invention discloses a loxoprofen sodium patch and a particle size control method of a special raw material medicine of the loxoprofen sodium patch, and aims to solve the problems that in the prior art, the dispersibility of raw material medicines in a matrix is poor, and the in-vitro permeation rate difference of patches among batches is large. The method comprises the following steps: screening raw material medicines; pre-treating the screened crude product of the raw material medicine; carrying out crushing treatment on the pretreated raw material medicines by adopting a low-temperature jet mill; carrying out grading treatment on the crushed raw material medicines by adopting an airflow grader according to a preset condition; putting the graded raw material medicines into a constant-temperature and constant-humidity box, and carrying out crystal form stabilizing treatment; carrying out particle size detection on the raw material medicine subjected to crystal form stabilization treatment, and carrying out post-treatment on the raw material medicine of which the particle size detection reaches a preset standard, so as to obtain the special raw material medicine for the loxoprofen sodium patch. The loxoprofen sodium patch preparation method is suitable for loxoprofen sodium patch preparation, and the effects that the particle size distribution of the raw material medicine is narrow, the patch matrix is adapted, and the dispersion uniformity of the medicine in the matrix is guaranteed can be achieved.

The invention belongs to the technical field of pharmaceutical preparations, and relates to loxoprofen sodium-containing tablets and a preparation method thereof. The loxoprofen sodium tablet is prepared from the following components in parts by weight: 100 parts of loxoprofen, 15 to 45 parts of soy isoflavone, 10 to 30 parts of brasenia schreberi polysaccharide, 2 to 5 parts of lacrotitol, 150 to 242 parts of microcrystalline cellulose, 12 to 50 parts of low-substituted hydroxypropyl cellulose, 3 to 20 parts of colloidal silicon dioxide and 3 to 8 parts of magnesium stearate. The preparation process is simple, the dissolution curve of the obtained tablet is consistent with that of a commercially available product, and an acceleration test shows that the loxoprofen sodium tablet prepared by the preparation method disclosed by the invention is relatively low in content of related substances and relatively stable in active substances, is suitable for clinical use, and has a development value.