The invention provides berberine hydrochloride oral pill dried gel as well as a preparation method and applications of the berberine hydrochloride oral pill dried gel. According to the berberine hydrochloride oral pill dried gel as well as the preparation method and the applications of the berberine hydrochloride oral pill dried gel, firstly, the applications of berberine hydrochloride in preparing the medicines for treating heart diseases are defined, and secondly, the condition that the berberine hydrochloride oral pill dried gel comprises berberine hydrochloride pills uniformly distributed in gel matrix is defined, and the gel matrix comprises a gel forming agent, a curing agent, a corrigent, an aromatic, a preservative and a pH regulator. The berberine hydrochloride provided by the invention can be used for preparing the medicines for treating heart diseases, the treatment effects are obvious, and the side effects can be effectively reduced; for the berberine hydrochloride, through the pill coating technology, the stability of the medicine is improved, the bad smell of the medicine is masked, and the side effects are reduced; meanwhile, after the pill is added into the gel matrix, the slow release effect can be effectively achieved, so that the medicine taking times is reduced, the irritation to the gastrointestinal tract is reduced, the mouthfeel of the preparation is completely improved, the fearful mental state generated when children patients take the medicine is overcome, and the compliance is improved.