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Pellet medicine combination containing valsartan, amlodipine and hydrochlorothiazide

A technology of hydrochlorothiazide and amlodipine, which is applied in the field of medicine and can solve problems such as increased absorption, prolonged residence time, and incompleteness

Active Publication Date: 2012-08-01
BEIJING MEDISAN TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral absorption of hydrochlorothiazide is rapid but incomplete, and eating can increase the absorption, which may be related to the prolonged residence time of the drug in the small intestine

Method used

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  • Pellet medicine combination containing valsartan, amlodipine and hydrochlorothiazide
  • Pellet medicine combination containing valsartan, amlodipine and hydrochlorothiazide
  • Pellet medicine combination containing valsartan, amlodipine and hydrochlorothiazide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Embodiment 1: Valsartan amlodipine hydrochlorothiazide pellet capsule (160 / 5 / 12.5mg)

[0091]

[0092] Preparation:

[0093] Valsartan pellets: Pass valsartan, microcrystalline cellulose, and crospovidone through an 80-mesh sieve, mix well, make a soft material with 3% PVP-K30 aqueous solution, and put the soft material in an extrusion-spheronizer Prepare drug-containing micropills, pass the drug-containing micropills through a 16-40 mesh sieve, place in a fluidized bed and coat with Opadry until the weight of the micropills increases by 1.5-3%, dry until the water content is less than 1%, pass through 16 -40 mesh sieves, get valsartan pellets, standby;

[0094] Amlodipine pellets: Weigh the prescribed amount of amlodipine and polyvinyl alcohol and disperse them in water, stir until the solution becomes a uniform suspension; put the blank pill core in the fluidized bed, spray the suspension to apply the medicine, spray After the solution is completed, spray Opadry ...

Embodiment 2

[0098]Embodiment 2: Valsartan, levamlodipine, hydrochlorothiazide pellet capsules (160 / 2.5 / 12.5mg)

[0099]

[0100] Preparation:

[0101] Valsartan pellets: Pass valsartan, microcrystalline cellulose, and crospovidone through an 80-mesh sieve, mix well, make a soft material with 3% PVP-K30 aqueous solution, and put the soft material in an extrusion-spheronizer Prepare drug-containing micropills, pass the drug-containing micropills through a 16-40 mesh sieve, place in a fluidized bed and coat with Opadry until the weight of the micropills increases by 1.5-3%, dry until the water content is less than 1%, pass through 16 -40 mesh sieves, get valsartan pellets, standby;

[0102] Levoamlodipine pellets: Weigh the prescribed amount of Levoamlodipine and polyvinyl alcohol and disperse them in water, stir until the solution becomes a uniform suspension; put the blank pill core in the fluidized bed, spray the suspension on the drug , after the liquid spraying is completed, spray ...

Embodiment 3

[0106] Embodiment 3: Valsartan amlodipine hydrochlorothiazide pellet capsules (160 / 5 / 12.5mg)

[0107]

[0108]

[0109] Preparation:

[0110] Valsartan pellets: pass valsartan, microcrystalline cellulose, and crospovidone through an 80-mesh sieve, mix well, use 3% PVP-K30 aqueous solution to make a soft material, pass through a 18-mesh sieve to granulate, and release immediately Roll into a coating pan to prepare drug-containing pellets, pass the drug-containing pellets through a 16-40 mesh sieve, dry in a fluidized bed, and coat with Opadry until the weight of the pellets increases by 1.5-3%, dry When the water content is less than 1%, pass through a 16-40 mesh sieve to obtain valsartan pellets for subsequent use;

[0111] Amlodipine pellets: Weigh the prescribed amount of amlodipine and polyvinyl alcohol and disperse them in water, stir until the solution becomes a uniform suspension; put the blank pill core in the fluidized bed, spray the suspension to apply the medi...

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Abstract

The invention relates to a pellet medicine combination containing valsartan, amlodipine and hydrochlorothiazide, which is characterized by simultaneously containing three active ingredients, namely valsartan, amlodipine and hydrochlorothiazide. The active ingredients of valsartan, amlodipine and hydrochlorothiazide and medicine acceptable additives are together prepared into pellets, and the pellets containing medicines are coated with coating layers with different colors. Each pallet is composed of a pellet core and a coating layer, and the pellet combination can be further made into pellet capsules. The pellet medicine combination has the advantages that the medicine can be scattered in gastrointestinal tract fast, has low thrill on the gastrointestinal tract and is even and complete in absorption and high in bioavailability, a pellet capsule casing is free of bitter taste and the like. The obtained preparation can be controlled in quality easily and is good in stability and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and more precisely relates to a drug combination of pellets containing active ingredients valsartan, amlodipine and hydrochlorothiazide. Background technique [0002] According to statistics, about 25% of the world's population suffers from hypertensive disorders, and the control rate of blood pressure is not ideal, and the rate of achieving blood pressure control with unilateral drugs is less than 50%. Years of clinical practice have proved that 50% of hypertensive patients need combined medication or compound prescription. The US Health and Nutrition Examination and Review Board reported that only 27% of patients diagnosed with hypertension can control their blood pressure below 140 / 90mmHg. At present, guidelines from all over the world recommend the use of multi-drug combination regimens, and combined drug use has become a common clinical antihypertensive strategy. Most hypertensive patien...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61K9/48A61P9/12A61K31/41A61K31/4422
Inventor 刘津爱刘颖慧王明新王爱玲
Owner BEIJING MEDISAN TECH
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