Novel blood pressure reducing composition
A composition and a technique for lowering blood pressure, applied in the field of medicine
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Embodiment 1
[0019] Embodiment 1: tablet
[0020] Name of raw material
1
2
3
4
5
Alikren Fumarate
150g
150g
150g
150g
150g
Levoclodipine Besylate
5g
7.5g
10g
----
----
----
25g
----
----
25g
----
----
40g
----
----
----
----
----
25g
12.5g
85g
80g
45g
65g
75g
36g
36g
36g
36g
36g
Sodium carboxymethyl cellulose
10g
10g
10g
10g
10g
55g
55g
55g
55g
55g
1.6g
1.6g
1.6g
1.6g
1.6g
Appropriate amount
Appropriate amount
Appropriate amount
Appropr...
Embodiment 2
[0023] Example 2: chewable tablet
[0024] Name of raw material
1
2
3
4
5
Alikren Fumarate
150g
150g
150g
150g
150g
Levoclodipine Besylate
5g
7.5g
10g
----
----
----
25g
----
----
25g
----
----
40g
----
----
----
----
----
25g
12.5g
205g
195g
160g
185g
175g
105g
105g
105g
105g
105g
Sodium carboxymethyl cellulose
10g
10g
10g
10g
10g
5g
5g
5g
5g
5g
essence
Appropriate amount
Appropriate amount
Appropriate amount
Appropriate amount
Appropriate amount
1.6g
1.6g
1.6g
1.6g ...
Embodiment 3
[0027] Embodiment 3 curative effect verification experiment
[0028] The following is a curative effect evaluation experiment to further illustrate the curative effect advantages of the composition of the present invention.
[0029] 1. Experimental method:
[0030] Take 110 healthy male SD rats, and after one week of adaptive feeding, measure the basic blood pressure with RBP-1 rat blood pressure instrument. They fasted for 12 hours in the night before the operation, and made models the next morning. After 4 weeks of modeling, those whose blood pressure was more than 2.66kPa (3 standard deviations greater than normal blood pressure) and higher than 15.30kPa were determined to form a hypertensive disease model. The rats with successful modeling were randomly divided into: aliskiren (A), levamlodipine (B1), aliskiren + levamlodipine (B2); aliskiren + levamlodipine + hydrochlorothiazide (B3) , Olmesartan medoxomil (C1), Aliskiren + Olmesartan medoxomil (C2), Aliskiren + Olmesa...
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