Pharmaceutical composition used for lowering blood pressure

A composition, technology of blood pressure, applied in the field of medicine

Inactive Publication Date: 2011-10-26
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Method used

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  • Pharmaceutical composition used for lowering blood pressure
  • Pharmaceutical composition used for lowering blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 tablet

[0029] Name of raw material

[0030] water

[0031] Process: Take the above-mentioned raw materials, grind them through 80-mesh sieves respectively, and set aside; each auxiliary material respectively pass through 60-mesh sieves, and set aside; except magnesium stearate, take each raw and auxiliary materials respectively, mix them evenly according to the method of equal increase, and add an appropriate amount of Water-based soft material, 18 mesh granulation, 60 degree fluidized bed drying, 24 mesh granulation, adding magnesium stearate, mixing evenly, tableting.

Embodiment 2

[0032] Example 2 tablet

[0033]

[0034] Process: Take the above-mentioned raw materials, pulverize them through 80-mesh sieves respectively, and set aside; each auxiliary material is respectively passed through 60-mesh sieves,

[0035] Standby; except for magnesium stearate, take each raw and auxiliary material separately, mix them evenly according to the method of equal increase, add appropriate amount of water to make soft material, granulate with 24 mesh, dry in a 60-degree oven, granulate with 40 mesh, add magnesium stearate , mix evenly, and press into tablets.

Embodiment 3

[0036] Embodiment 3 capsules

[0037] Name of raw material

[0038] Delapril

[0039] Process: Take the above-mentioned raw materials, grind them through 80-mesh sieves respectively, and set aside; each auxiliary material respectively pass through 60-mesh sieves, and set aside; except magnesium stearate, take each raw and auxiliary materials respectively, mix them evenly according to the method of equal increase, and add an appropriate amount of Water-based soft material, granulated with 18 mesh, dried in a fluidized bed at 60 degrees, granulated with 24 mesh, added with magnesium stearate, mixed evenly, filled into empty capsule shells, and obtained.

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Abstract

The invention relates to a pharmaceutical composition used for lowering blood pressure. The pharmaceutical composition with azilsartan medoxomil and another one or two blood pressure lowering substances as active ingredients mainly comprises calcium ion antisticking agent, angiotensin converting enzyme inhibitor (ACEI) and hydrochlorothiazide. The composition provided by the invention can be prepared into an oral preparation and is used for treating vascular hypertension.

Description

technical field [0001] The invention relates to a medicinal composition for lowering blood pressure, which belongs to the technical field of medicine. Background technique [0002] Hypertension is the most prevalent cardiovascular disease in the world today, and it is also an important risk factor for coronary heart disease, stroke and renal failure. Patients with hypertension not only have increased blood pressure and abnormal hemodynamics, but also often accompanied by It is a systemic disease with sugar and lipid metabolism disorders and damage to target organs such as the heart, brain, and kidneys. There are many antihypertensive drugs clinically, including diuretics, β-blockers, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II (AT II) receptor antagonists, calcium antagonists and alpha-blockers. However, they all have certain limitations and side effects in use. Therefore, antihypertensive drugs with small side effects, good tolerance, and stable effi...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/4245A61K38/05A61P9/12A61K31/4422A61K31/549
Inventor 不公告发明人
Owner FUKANGREN BIO PHARMA
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