64 results about "Vascular hypertension" patented technology

The invention relates to a pharmaceutical composition used for lowering blood pressure. The pharmaceutical composition with azilsartan medoxomil and another one or two blood pressure lowering substances as active ingredients mainly comprises calcium ion antisticking agent, angiotensin converting enzyme inhibitor (ACEI) and hydrochlorothiazide. The composition provided by the invention can be prepared into an oral preparation and is used for treating vascular hypertension.

The invention relates a pharmaceutical composition comprising a combination of:(i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof; and(ii) a NEP inhibitor or a pharmaceutically acceptable salt thereof and optionally a pharmaceutically acceptable carrier and to a method for the treatment or prevention of a condition or diseaseselected from the group consisting of hypertension, heart failure, such as (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomerular sclerosis, proteinuria of primary renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction, such as Alzheimer's, glaucoma and stroke, comprising administering a therapeutically effective amount of the pharmaceutical composition to a mammal in need thereof.

The invention discloses a compound telmisartan amlodipine besylate medicinal composition. The composite is a tablet which is prepared by the following steps: preparing amlodipine besylate into amlodipine besylate solid dispersion by a solid-state dispersion technology; and preparing the amlodipine besylate solid dispersion and telmisartan into the composite. The tablet improves the dissolubility of primary medicine, promotes the medicament to be quickly disintegrated, prevents dissolution influence of meglumine to the amlodipine besylate, simultaneously improves the absorptivity in blood, and improves the bioavailability of the primary medicine. The tablet has excellent curative effect to hypertension symptoms.

The invention relates to the technical field of sanvitalia procumbens herbal tea and a production method thereof, and relates to the sanvitalia procumbens herbal tea and a preparation method thereof. The sanvitalia procumbens herbal tea is obtained by the steps of extracting sanvitalia procumbens, safflower, radix ophiopogonis, radix polygonati officinalis, liquorice, rhizoma phragmitis, radix asparagi, common lopatherum herb and rhizoma imperatae with water to obtain an extract solution; cooling the extract solution to a room temperature; collating to obtain sanvitalia procumbens crude tea juice; then adding a sweetening agent to the sanvitalia procumbens crude tea juice and blending. The obtained sanvitalia procumbens herbal tea has a red and transparent color, and can effectively play a role of reducing and stabilizing blood fat and blood pressure for patients suffering from hyperlipidemia and hypertension by taking the tea for a long time.

The invention discloses a traditional Chinese medicine oral liquid for lowering blood pressure and regulating blood fat and a preparation method thereof. The oral liquid is prepared from the following active pharmaceutical ingredients in parts by weight: 20-50 parts of gynostemma pentaphyllum, 10-30 parts of lotus leaf, 10-30 parts of chrysanthemum flower, 10-30 parts of hawthorn, 10-30 parts of Flos Buddlejae, 10-20 parts of wolfberry fruit, 5-20 parts of radix salviae miltiorrhizae and 2-10 parts of lophatherum gracile. The oral liquid is strict in prescription, has the effects of lowering blood pressure and blood fat, clearing heat, improving eyesight and the like, and has favorable curative effects on hypertension caused by hyperlipemia, dizziness, palpitation, asthenia, hyperlipemia, obesity and the like. All the active pharmaceutical ingredients except the gynostemma pentaphyllum are medicinal and edible drugs, so the oral liquid is safe to use; and the oral liquid contains abundant nutrient substances and effective components capable of improving human health and treating diseases, and thus, can supplement nutrients required by the human body and enhance the immunity.

A quality control method for the Chinese medicine í‹Antihypertenssive Duzhong medicineíŒ to treat hypertension includes such steps as examining its characteristics, identifying scutellaria root, uncaria stem with hooks and motherwort, and measuring the content of scutelloside.

A method employing pattern recognition techniques for identifying the functional status of patients with Pulmonary Hypertension is described. This method describes a process by which sets of cardiopulmonary exercise gas exchange variables are measured during rest, exercise and recovery and stored as unique data sets. The data sets are then analyzed by a series of feature extraction steps, yielding a multi-parametric index (MPIPH) which reflects the current functional status of a patient. The method also employs a description scheme that provides a graphical image that juxtaposes the measured value of MPI to a reference classification system. An additional description scheme provides a trend plot of MPI values measured on a patient over time to provide feedback to the physician on the efficacy of therapy provided to the patient. The method will enable physicians to gather, view, and track complicated data using well-understood visualization techniques to better understand the consequences of their therapeutic actions.

The invention discloses a Chinese herbal compound preparation used for treating alcoholism and gout, mainly comprising the following components in parts by weight: 10-40 parts of kudzuvine root, 15-40 parts of hovenia acerba, 3-10 parts of pseudo-ginseng, 3-15 parts of phyllanthus emblica, 3-10 parts of fructus amomi, 35-10 parts of myristica fragrans, 3-15 parts of dchisandra chinensis, 4-15 parts of American olive, 10-20 parts of honeysuckle, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of coix seed, 10-30 parts of poria cocos, 10-20 parts of zaocys dhumnade, 10-20 parts of lucid ganoderma, 10-20 parts of American ginseng and 10-20 parts of turmeric. No hepatorenal dysfunction is caused when the compound preparation disclosed by the invention is used for treating hyperuricosuria, which shows that the preparation has no obvious toxic or side effect and mild medicine property, thus the preparation is beneficial to long-term administration. The inventor also knows that medicine taking compliance of patients and tolerance are good from some follow-up visited patients, annual attack frequency is reduced, and the preparation disclosed by the invention has obvious treatment effect on combined diabetes mellitus, hyperlipidemia and vascular hypertension, thus the preparation disclosed by the invention can be regarded as a safe Chinese herbal compound preparation which can be taken by a patient who is repeatedly attacked by acute gouty arthritis for a long time and can control symptoms and reduce attack frequency.

The invention discloses a pharmaceutical composition of amrinone and application of the pharmaceutical composition in hypertension treatment. Amrinone and a novel-structure natural product compound (I) separated out of dried rhizomes of blackberry lily are contained in the pharmaceutical composition of amrinone, and when amrinone and the natural product compound (I) act independently, the treatment effect on renal vascular hypertension is achieved; when amrinone and the natural product compound (I) act jointly, the treatment effect on renal vascular hypertension is further improved, the pharmaceutical composition can be developed into medicine for treating renal vascular hypertension, and compared with the prior art, prominent substantive features and remarkable progress are achieved.

The present invention discloses microparticles comprising iloprost. In some embodiments, the microparticles are used to treat pulmonary hypertension. Also disclosed are devices comprising microparticles. Conjugation therapy using microparticles is also provided.

The invention relates to a depressurization chewing gum and a preparation method thereof, belonging to the technical field of gum. 2-40 percent by weight of Eucommia ulmoides depressurization active component or Eucommia ulmoides component depressurization active component, 50-97 percent of sugar alcohol and 1-10 percent of food additive are added into chewing gum so that the chewing gum becomes a health care food which is beneficial to the crowd with hypertension symptoms. The invention changes the characteristic of single function of the traditional chewing gum, endows the chewing gum with multiple functions of prevention and treatment of light and moderate hypertension diseases, adjuvant therapy of a severe hypertension disease, and the like and achieves the effect of promoting body health.

A method employing pattern recognition techniques for identifying the functional status of patients with Pulmonary Hypertension is described. This method describes a process by which sets of cardiopulmonary exercise gas exchange variables are measured during rest, exercise and recovery and stored as unique data sets. The data sets are then analyzed by a series of feature extraction steps, yielding a multi-parametric index (MPIPH) which reflects the current functional status of a patient. The method also employs a description scheme that provides a graphical image that juxtaposes the measured value of MPI to a reference classification system. An additional description scheme provides a trend plot of MPI values measured on a patient over time to provide feedback to the physician on the efficacy of therapy provided to the patient. The method will enable physicians to gather, view, and track complicated data using well-understood visualization techniques to better understand the consequences of their therapeutic actions.

The invention discloses a herb tea for lowering blood pressure. The herb tea comprises the following active pharmaceutical ingredients in the mass ratio: 15-20 of folium mori, 14-18 of salvia miltiorrhiza, 9-12 of herba portulacae, 8-12 of fructus crataegi, 3-7 of folium ginkgo and 8-15 of catsia tora linn. The herb tea is prepared by selecting, cleaning, drying and grinding the active pharmaceutical ingredients, and evenly mixing in the mass ratio so as to obtain the mixed medicinal powder; bagging by using a conventional preparing method. A method for taking the herb tea is as follows: the herb tea is brewed in warm water to be taken and is taken three times a day, and one bag of the herb tea is taken each time, is brewed in 200ml of warm water to be taken and is repeatedly brewed to form tea for being drunk. The herb tea for lowering blood pressure is prepared from natural traditional Chinese medicinal materials, can lower the blood pressure and relieves the hypertension symptom; the herb tea for lowering blood pressure has an obvious effect and can prevent hypertension; and the herb tea for lowering blood pressure is suitable for people suffering from hypertension.

The invention discloses an oral medicinal preparation of hairy holly root total aglycon, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total glycosides extracted from hairy holly roots are hydrolyzed to obtain total aglycon which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the hairy holly root total aglycon. The preparation has significant curative effects in the treatment of coronary arteriosclerotic cardiopathy, acute myocardial infarction, thromboangitis obliterans, central retinitis, tonsillitis, pharyngolaryngitis, child pneumonia, chilblain, burn and scald, hypertension, hyperlipemia, hyperglycemia and other diseases.

An excellent medicine for the treatment or prevention of hypertension or the like is provided. A specific acid addition salt of (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3- yl)ester 5-isopropyl ester is useful as a medicine for the treatment or prevention of hypertension or the like.

A novel carbazole derivative which has the excellent functions of reducing the weight of fat tissues and lowering the blood sugar level and the blood lipid level. It is useful as a preventive / therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral fat, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver, or non-alcoholic steatohepatitis. It is a carbazole derivative represented by the following general formula (I). (In the formula (I), ring A represents phenyl, etc.; X represents -O-, etc.; Y represents =N-, etc.; a and b each represents methylene, etc.; V and Z each represents -O-, etc.; W represents C1-10 alkylene in which one or two hydrogen atoms may be replaced with phenyl or C1-5 alkyl, or represents 1,2-phenylene, 1,3-cyclohexyl, etc.; R<1> represents methyl, etc.; R<2> represents methoxy, etc.; and R<3> represents carboxy, etc.

The invention relates to a pu-er tea ferment soft capsule which is capable of regulating yin-yang, sedating, and lowering blood pressure and is used for various vascular hypertensions and various complicating diseases of heart, brain and kidney caused by vascular hypertension. The medicament comprises pu-er tea extract, aweto, lumbricus, black-snakes, monascus purpureus, rhizoma dioscorea, wolfberry fruit, cassia seeds, tortoise shells, fleece-flower roots, roots of red rooted salvia, round cardamom, angelica dahurica, tangerine peels, spine date seeds, ginkgo biloba, safflower, hawthorn, and the like. The production method comprises the following steps: hydrolyzing pu-er tea to prepare pu-er tea extract by using the purification and zymohydrolysis method, mixing the sundried powders such as aweto, lumbricus, tortoise shells, fleece-flower roots, roots of red rooted salvia, and the like to make soft capsules. In the invention, effective components are largely reserved due to the adoption of the purification and zymohydrolysis method, the medical value of the soft capsule can be fully improved; the preparation can improve blood oxygen saturation, is suitable for the diseases such as vexation, chest distress, short breath, hypertension, hyperlipidemia, arteriosclerosis, arrhythmia, myocardial ischemia, angina pectoris, coronary heart diseases, strokes, and the like.

The invention discloses a synbiotic compound preparation conducive to alleviation of hypertension symptoms without solid lesions. A formula of the synbiotic compound preparation comprises 8%-12% of bifidobacterium infantis, 8%-12% of bifidobacterium longum, 8%-12% of bifidobacterium breve, 3%-6% of lactobacillus acidophilus, 3%-6% of lactobacillus casei, 3%-6% of lactobacillus rhamnosus, 3%-6% oflactobacillus plantarum, 3%-6% of lactobacillus paracasei, 3%-6% of lactobacillus bulgaricus, 12%-18% of streptococcus thermophilus, 0.2%-0.8% of sodium acetate, 0.4-0.8% of sodium butyrate, 1.2%-1.5%of fructo-oligosaccharide, 0.5%-0.9% of lactulose, 0.1%-0.5% of barley malt powder, 1.4%-1.8% of skim sheep milk powder, 1.3%-1.8% of active hexose correlated compound, 0.8%-1.4% of inulin and 0.2%-0.5% of plantago ovate shell. The invention further discloses a preparation method of the synbiotic compound preparation conducive to alleviation of hypertension symptoms without solid lesions. The preparation method includes steps of quantitative weighing, probiotic culture, probiotic fermentation, skim sheep milk resuspension and mixing for capsule preparation.

The invention discloses an oral medicine composition for treating obesity or vascular hypertension, and belongs to the field of medicine. The medicine composition comprises Orlistat or Cetilista and active ingredients of dipine medicine. In the medicine composition, the use amount of Orlistat or Cetilista and dipine medicine is greatly reduced; particularly, a sustained-release capsule prepared from the medicinal composition can achieve the treatment effect after being taken once a day only, so that the benefit / cost is increased, the patient compliance is improved, and the social value is higher.

The invention relates to a telmisartan pharmaceutical composition for treating vascular hypertension, and belongs to the technical field of medicines. The technical scheme of the invention is characterized by adopting a micronization technology: a mixture of a main drug, sodium hydroxide and mannitol is micronized by an air-flow pulverizer, the D90 of the micronized mixture of telmisartan, sodium hydroxide and mannitol is between 3.0 [mu]m and 5.0 [mu]m. According to the technical scheme of the invention, a preparation method of telmisartan tablets is simplified, the preparation period is shortened, the material consumption is reduced, and moreover, the tablets are ensured to have higher dissolution rate; and secondly, through the use of the micronization technology, the drug dissolution rate is improved, the particles prepared by the micronization technology have quite good fluidity and compressibility, sorbitol having quite strong hygroscopicity is not required to be used, and the stability of the sample is improved.

The invention discloses a traditional Chinese medicine oral liquid for lowering blood pressure, preventing dizziness and regulating blood fat and a preparation method thereof. The oral liquid is prepared from the following active pharmaceutical ingredients in parts by weight: 20-50 parts of gynostemma pentaphyllum, 10-30 parts of honeysuckle flower, 10-30 parts of chrysanthemum flower, 10-30 parts of hawthorn, 10-30 parts of fructus momordicae, 10-20 parts of wolfberry fruit, 5-20 parts of radix salviae miltiorrhizae, 2-10 parts of lophatherum gracile and 2-10 parts of purslane. The oral liquid is strict in prescription, has the effects of lowering blood pressure and blood fat, clearing heat, improving eyesight and the like, and has favorable curative effects on hypertension caused by hyperlipemia, dizziness, palpitation, asthenia, hyperlipemia, obesity and the like. All the active pharmaceutical ingredients except the gynostemma pentaphyllum are medicinal and edible drugs, so the oral liquid is safe to use; and the oral liquid contains abundant nutrient substances and effective components capable of improving human health and treating diseases, and thus, can supplement nutrients required by the human body and enhance the immunity.

The invention discloses a plantain seed tea beverage for preventing and treating vascular hypertension. The plantain seed tea beverage is characterized by adopting the following raw materials in parts by weight: 100 to 120 parts of plantain seed, 60 to 80 parts of semen cassiae, 15 to 25 parts of semen celosiae, 8 to 16 parts of salvia miltiorrhiza and 15 to 20 parts of mint. A preparation method of the plantain seed tea beverage comprises the following steps that raw materials are made into drinking tablets, and the package is carried out after the mixing. A drinking method comprises the following steps that 2 to 4g of drinking tablets are taken each time and are placed into a cup to be soaked by boiling water, and the liquor can be drunk after 3 minutes. After the liquor is drunk to 2 / 3, the boiling water is added again for brewing, and the drinking tablets can be generally brewed for 4 to 6 times. The plantain seed tea beverage has the effects of dispelling wind and heat, reducing lipid, brightening the eyes, alleviating water retention and relaxing the bowels, and has the obvious effects when being used for the prevention and the auxiliary treatment on vascular hypertension.

The invention relates to a natural lipopeptide composite with biological activity extracted from conch, preparation and application in pharmaceutical fields of the same, which pertains to biological and pharmaceutical technical fields. The invention protects a lipopeptide composite with biological activity, preparation and application thereof. The lipopeptide is produced from marine organisms, can be used in treatment and improving hypertension and congestive heart failure.

The invention discloses a tibetan medicine for treating hypertension, which is composed of active ingredients or active ingredients and pharmaceutically acceptable additives, wherein the active ingredients are prepared from agilawood, lagotisglauca, corydalis pygmaea, radix onosmatis, tinospora sinensis merr, elecampane, pleurospermum hookeri, flos pyrethri tatsienensis, caragana sinica, shellac,rubia wallichiana decne, gastrodia elata, fructus choerospondiatis, fruit of emblic leafflower and corydalis impatiens according to a weight ratio. The tibetan medicine can be prepared to any common oral medication dosage form. The tibetan medicine disclosed by the invention has the functions of soothing the nerves, quieting the heart and decreasing the blood pressure. The tibetan medicine is suitable for headache, dizziness, limb numbness, palpitation, dismay, tinnitus, insomnia and hypertension.

The invention discloses carboxyl group-containing benzothiadiazide derivatives, a preparation method thereof, a medicine composition containing the compound and an application thereof in treatment or prevention for complications of vascular hypertension and serum hyperuricemia and / or hypercholesteremia. The benzothiadiazide derivative compounds meet a general formula (I) specified in the description. The carboxyl group-containing benzothiadiazide derivatives are synthesised by a one-step method, as well as are simple in synthesis process, simple in separation and purification methods, high in yield, good in repeatability, free of strong acid-resistant special equipment, and suitable for large-batch production.

Disclosed is a dripping pill for treating hypertension. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, easy administration, low price, and causing no pollution during production. The drop pill is prepared from powdered wild chrysanthemum flower, pearl powder, clonidine hydrochloride, hydrochlorothiazidum, globularicitrin as raw material, and medicinal carrying agent as the base material.

The invention relates a pharmaceutical composition comprising a combination of:(i) the AT 1-antagonist vaisertan or a pharmaceutically acceptable salt thereof; and(ii) a NEP inhibitor or a pharmaceutically acceptable salt thereof and optionally a pharmaceutically acceptable carrier and to a method for the treatment or prevention of a condition or diseaseselected from the group consisting of hypertension, heart failure, such as (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomerular sclerosis, proteinuria of primary renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction, such as Alzheimer's, glaucoma and stroke, comprising administering a therapeutically effective amount of the pharmaceutical composition to a mammal in need thereof.

The invention discloses a pharmaceutical composition of ambroxol hydrochloride and application thereof in biological medicines. The pharmaceutical composition of ambroxol hydrochloride provided by the invention comprises ambroxol hydrochloride, and a natural product compound (I) which has a novel structure and is separated from dried roots and rhizomes of Notopterygium incisum. The composition of ambroxol hydrochloride and the compound (I) provided by the invention can significantly reduce the concentration of angiotensin II and the activity of renin in a hypertensive rat model; meanwhile, the effects of the composition are superior to the independent effects of ambroxol hydrochloride or the compound (I). The composition of ambroxol hydrochloride and the compound (I) can be developed into drugs used for treating renal vascular hypertension; and compared with the prior art, the composition has excellent substantial characteristics and significant advancement.

A composite Chinese medicine in the form of dripping pill and soft capsule for treating hypertension, dizziness, palpitation, dreamfull sleep, etc, and its preparing process are disclosed.