10 results about "Vascular hypertension" patented technology

The invention relates to the technical field of medicines, and particularly discloses a compound antihypertensive pharmaceutical composition. The pharmaceutical composition provided by the invention selects sacubitril valsartan sodium and indapamide as active ingredients, and within a prescription dosage range limited by the application, the two medicines can fully realize an antihypertensive effect through a synergistic effect, and the renal function of a patient is effectively improved. Through cooperation of the two components, the hypertension symptom of a patient can be effectively controlled, the adverse reaction is not obvious, and the compliance of the patient can be improved by adopting the compound preparation, so that the control on the blood pressure of the patient is enhanced.

The invention discloses a traditional Chinese medicine composition for hypertension reversal and a preparation method thereof, and relates to the technical field of medicines, although chemical medicines take effect quickly, blood pressure fluctuation is large and side effects are large in the blood pressure reduction process, and metabolism of water, electrolyte, blood fat, blood sugar and the like can be obviously influenced; the organs such as heart, brain and kidney are directly injured. The invention provides a traditional Chinese medicine composition for hypertension reversal and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 15g of polygala tenuifolia, 15g of rhizoma acori graminei, 20g of rhizoma smilacis glabrae, 12g of dens draconis, 6g of rhizoma atractylodis macrocephalae, 9g of rhizoma pinellinae praeparata, 15g of gastrodia elata, 12g of exocarpium citri grandis, 12g of radix ophiopogonis, 9g of fructus lycii, 12g of angelica sinensis, 20g of rehmannia, 12g of radix paeoniae alba, 9g of ligusticum wallichii, 6g of liquorice tablets, 20g of codonopsis pilosula tablets, 9g of bupleurum chinense, 9g of fructus viticis, 12g of immature bitter orange, 15g of gypsum, 6g of wine-treated rhubarb and 12g of euonymus alatus. The life quality of the patient is improved, and the curative effect of traditional Chinese medicine syndromes is improved.

The present invention relates to activin receptor IIB type variants and methods of use thereof. The present invention features a polypeptide comprising an extracellular ActRIIB variant. In some embodiments, the polypeptides of the invention comprise extracellular ActRIIB variants fused to an Fc domain monomer or part. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving myasthenia and atrophy, bone injury, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.

The present invention relates to activin receptor IIB type variants and methods of use thereof. The present invention features a polypeptide comprising an extracellular ActRIIB variant. In some embodiments, the polypeptides of the invention comprise extracellular ActRIIB variants fused to an Fc domain monomer or part. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving myasthenia and atrophy, bone injury, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.

The utility model relates to the technical field of medicine boxes, and discloses a portable hypertension medicine box which comprises a medicine box body, a sliding strip is fixedly connected to the top of the medicine box body, a cover is connected to the outer side of the sliding strip in a sliding mode, a bouncing mechanism is connected to the inner side of the medicine box body in a sliding mode, and the bouncing mechanism comprises a first-aid box. A fixing plate is fixedly connected to the inner bottom side of the medicine box, a rotating shaft is fixedly connected to the outer side of the upper portion of the fixing plate, a rotating limiting plate is rotatably connected to the outer side of the rotating shaft, a triangular block protruding out of the bottom of the rotating limiting plate is slidably connected with a first sliding plate, and a driving assembly is slidably connected to the outer side of the first sliding plate. According to the utility model, when a hypertension symptom suddenly occurs, the first-aid box can be quickly popped out of the medicine box by pressing the pushing column, so that the quick response mechanism gains precious first-aid time, ensures that a patient can obtain medicines in a short time, and enhances the self-rescue capability of the patient in an emergency.

The application discloses a polynucleotide sequence for simultaneously reducing blood fat and blood pressure and application thereof. Cell and mouse experiments show that the application can significantly inhibit the expression levels of multiple blood fat and blood pressure molecular targets such as proprotein convertase subtilisin / kexin type 9 (PCSK9), angiotensinogen (AGT) and beta-hydroxy-beta-methylglutaryl-coenzyme a reductase (HMGCR), thereby reducing the blood fat and blood pressure levels of a related disease model mouse. The application is expected to be applied to treating related cardiovascular and cerebrovascular diseases complicated with high blood fat and high blood pressure symptoms.

The invention discloses a traditional Chinese medicine compound with lipid-lowering and blood-pressure-lowering effects, and relates to the field of traditional Chinese medicine preparations. The traditional Chinese medicine compound comprises the following raw materials in parts by weight: monarch drugs: 12-30g of raw red yeast rice and 9-20g of gynostemma pentaphylla; ministerial drugs: one or more of 12-30 g of clean hawthorn, 15-60 g of astragalus membranaceus, 12-30 g of salvia miltiorrhiza and 12-30 g of rhizoma alismatis; assistant and guide drugs: one or more of 9-20 g of corn stigma, 12-30 g of selfheal, 12-30 g of prepared rhizoma polygonati, 20-60 g of semen coicis, 12-30 g of prepared polygonum multiflorum, 9-20 g of polygonum cuspidatum and 9-20 g of semen cassiae; the traditional Chinese medicine compound with the lipid-lowering and blood-pressure-lowering effects is reasonable in formula, can effectively improve the symptoms of hyperlipidemia and hypertension, and has no damage to liver and kidney functions and muscle functions.

The invention discloses a shark source single-domain antibody targeting LRP6 and application of the shark source single-domain antibody. The single-domain antibody has an amino acid sequence as shown in SEQ ID NO: 1, shows nanomole-level high affinity to LRP6 protein, has an affinity constant KD value of 1.8 * 10 <-9 > M, shows excellent physical and chemical stability, has a thermal denaturation temperature as high as 75.6 DEG C, and can still retain 92% or more of binding activity after being incubated for 2 hours under a strong acidic condition. Meanwhile, the antibody has high specificity, and the cross reaction rate of the antibody with homologous protein LRP5 and homologous protein LDLR is lower than 4%. The invention also provides a composition for reducing hypertension, hyperglycemia and hyperlipidemia, which contains the single-domain antibody and a specific natural plant extract composite component. Experiments show that the composition can synergistically act on a plurality of pathological links of the metabolic syndrome, the symptoms of hyperglycemia, hyperlipidemia and hypertension are remarkably improved in an animal model, the effect is better than that of a single component and a traditional control drug, and a brand new multi-target treatment scheme is provided for prevention and treatment of the metabolic syndrome.

The invention relates to a compound and a composition and application thereof, and the compound can be used for preparing a GLP-1 receptor agonist and can also be used for preventing or treating diseases related to agonizing a GLP-1 receptor. Comprising but not limited to diseases such as diabetes, diabetic complications, metabolic syndrome, obesity, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, Parkinson's disease, Alzheimer's disease, hypertension, hyperlipidemia, atherosclerosis, cardiovascular risk, coronary heart disease or cerebral apoplexy. Compound with following structural formula: # imgabs0 #

The invention discloses a health-care shoe, and relates to the technical field of health-care shoes. The shoe comprises a sole, the top of the sole is fixedly connected with a plurality of elastic pieces, the tops of the elastic pieces are connected with an insole, the bottom of the insole is provided with a first electrode, and the top of the sole is provided with a second electrode. The health-care shoe can massage specific acupuncture points of the sole, magnet therapy can be carried out through the generated magnetic field, and in the process of lifting and falling of the foot, due to the existence of the multiple elastic pieces between the sole and the insole, the first electrode and the second electrode arranged on the surface of the sole and the lower layer of the insole can make contact with each other and be separated from each other; therefore, a vertical contact separation type nanometer generator is formed, tiny current is generated and input into the massage stick, the massage stick performs current stimulation while massaging foot acupoints of a user, and the effect of improving hypertension symptoms is integrally achieved in combination with massage generated by the magnetic massage piece and traditional Chinese medicine released from the insole.