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Hypertension (high blood pressure) is the primary and most important manifesting symptom of hypertensive vascular disease. A diseased vasculature predisposes one to further hypertension, and thus, further vascular disease.
Polynucleotide sequence for simultaneously reducing blood lipid and blood pressure and application thereof
The application discloses a polynucleotide sequence for simultaneously reducing blood fat and blood pressure and application thereof. Cell and mouse experiments show that the application can significantly inhibit the expression levels of multiple blood fat and blood pressure molecular targets such as proprotein convertase subtilisin / kexin type 9 (PCSK9), angiotensinogen (AGT) and beta-hydroxy-beta-methylglutaryl-coenzyme a reductase (HMGCR), thereby reducing the blood fat and blood pressure levels of a related disease model mouse. The application is expected to be applied to treating related cardiovascular and cerebrovascular diseases complicated with high blood fat and high blood pressure symptoms.
Owner:THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV