Telmisartan composition

Abstract

The invention relates to a telmisartan pharmaceutical composition for treating vascular hypertension, and belongs to the technical field of medicines. The technical scheme of the invention is characterized by adopting a micronization technology: a mixture of a main drug, sodium hydroxide and mannitol is micronized by an air-flow pulverizer, the D90 of the micronized mixture of telmisartan, sodium hydroxide and mannitol is between 3.0 [mu]m and 5.0 [mu]m. According to the technical scheme of the invention, a preparation method of telmisartan tablets is simplified, the preparation period is shortened, the material consumption is reduced, and moreover, the tablets are ensured to have higher dissolution rate; and secondly, through the use of the micronization technology, the drug dissolution rate is improved, the particles prepared by the micronization technology have quite good fluidity and compressibility, sorbitol having quite strong hygroscopicity is not required to be used, and the stability of the sample is improved.

Description

[0001] Technical field: the present invention relates to a kind of telmisartan pharmaceutical composition for the treatment of hypertension, which belongs to the technical field of medicine. Background of the invention: [0002] Hypertension is a common chronic disease. It appears to be an independent disease, but it is actually an important risk factor for cardiovascular, cerebrovascular and renal diseases. If not treated properly, it can lead to severe stroke, The occurrence of hypertensive complications such as myocardial infarction, heart failure or renal failure. [0003] Telmisartan is a non-peptide angiotensin II receptor antagonist with definite curative effect and few side effects, and is clinically used to treat various types of hypertension. [0004] Telmisartan is white or off-white powder at room temperature, insoluble in water. In order to increase the solubility of the tablet, the patent ZL200480011725 first prepares telmisartan into sodium salt, then sprays an...

AI Technical Summary

Problems solved by technology

[0005] The above process is also a common process for preparing telmisartan tablets at present. Its common feature one is that telmisartan is prepared into sodium salt earlier. This process prolongs the production cycle and increases material loss and energy consumption.

The second is that the granules obtained by dissolving telmisartan in sodium hydroxide solution through spray drying or fluidized bed granulation in one step have poor compressibility. sex

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