107results about How to "Good compressibility" patented technology

The invention discloses a pharmaceutical preparation of a protein kinase inhibitor citrate as well as a preparation method and application of the pharmaceutical preparation. The pharmaceutical preparation comprises citrate of a protein kinase CDK4 / 6 inhibitor and auxiliary materials including a filler, a disintegrating agent, an adhesive, a wetting agent, a glidant and a lubricant. The protein kinase inhibitor citrate pharmaceutical preparation has the advantages of being good in quality, high in stability, high in dissolution rate, simple in preparation method, controllable in quality and the like.

The invention discloses a preparation method and application of biomass-based photo-thermal super-hydrophobic composite aerogel, and belongs to the technical field of oil spill adsorption materials. The method comprises the following steps: (1) mixing sodium alginate, kapok fibers and water to obtain a dispersion; freeze-drying is carried out, such that kapok / sodium alginate composite aerogel is obtained; (2) soaking the kapok / sodium alginate composite aerogel in a CaCl2 aqueous solution for cross-linking, so as to obtain cross-linked composite aerogel; (3) soaking the cross-linked composite aerogel in an aqueous solution containing Tris-HCl and dopamine hydrochloride, so as to obtain a polydopamine composite aerogel; (4) soaking in a pyrrole aqueous solution, and adding anhydrous FeCl3 to obtain photo-thermal composite aerogel; and (5) carrying out hydrophobic modification on the photo-thermal composite aerogel through organosilane vapor deposition to obtain the biomass-based photo-thermal super-hydrophobic composite aerogel. The super-hydrophobic composite aerogel prepared by the method has excellent adsorption performance and photo-thermal performance, and can quickly remove oil stains in water.

The invention relates to a flexible pressure sensor and a preparation method thereof. The preparation method of the flexible pressure sensor comprises the steps of providing a flexible conductive substrate, etching one surface of the flexible conductive substrate by adopting first laser to form a first microstructure with the same height, and then etching the side wall of the first microstructure by adopting second laser to form a hierarchical microstructure with at least one annular groove, a first flexible substrate is obtained; providing a second flexible substrate, wherein the second flexible substrate comprises a second flexible substrate and an electrode arranged on one surface of the second flexible substrate; and arranging a second flexible substrate on the first flexible substrate in a laminated manner, and enabling an electrode to be in contact with the hierarchical microstructure, thereby obtaining the flexible pressure sensor. The flexible pressure sensor prepared by the preparation method not only can maintain high sensitivity, but also has a wide detection range, and can maintain a good linear relation of output signals.

The invention relates to the technical field of medicines, in particular to magnesium oxide particles, a preparation method thereof and magnesium oxide tablets. The magnesium oxide particles comprise the following components in percentage by mass: 50%-85% of magnesium oxide, 3%-10% of protein hydrophilic colloid, 3%-10% of a cross-linking agent and the balance of a filling agent, wherein the cross-linking agent comprises cellulose and / or cellulose derivatives. The preparation method comprises the following steps: S1, adding the protein hydrophilic colloid into water, stirring until the protein hydrophilic colloid is swelled, and heating or adjusting pH to induce hydrogel as slurry; s2, weighing magnesium oxide, a cross-linking agent and a filling agent according to a formula proportion, stirring and mixing, and then adding the slurry under stirring and shearing conditions for granulation and coating; and S3, granulating, drying and sieving the material to obtain the product. When the magnesium oxide particles are used for preparing tablets, the tablets can be effectively prevented from cracking, and meanwhile, the problem of black edges in the tabletting process can be solved.

The invention provides a processing method of a cinnabar dwarf lilyturf tuber decoction piece. The cinnabar dwarf lilyturf tuber decoction piece is obtained by infiltrating dwarf lilyturf tuber, flattening, removing cores, drying, spraying clear water and uniformly mixing with cinnabar fine powder. Wherein the selected infiltrating solution retains the effective components of the radix ophiopogonis to the greatest extent, the anti-sticking layer is prepared for the product in the flattening process, and the cinnabar fine powder is prepared by adopting an ultrahigh-pressure water jet method.

The invention relates to a knitted fabric flexible capacitive sensor, which comprises a planar first knitted fabric layer, a planar second knitted fabric layer and a middle layer, the first knitted fabric layer and the second knitted fabric layer are connected with each other by weaving spacing yarns therebetween, and the spacing yarns form a middle layer; the first knitted fabric layer and the second knitted fabric layer are formed by intermeshing conductive yarns; the spacer yarns are insulated elastic yarns and are connected with the first knitted fabric layer and the second knitted fabric layer in a tucking manner. The knitted fabric flexible capacitive sensor is integrally formed, simple in structure, good in stretchability and compressibility, capable of detecting compression loads or stretching loads and outputting specific numerical values of the loads, and capable of being widely applied to the fields of human motion monitoring, human-computer interaction and the like.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an indobufen pharmaceutical composition, a tablet and a preparation method. According to the embodiment of the invention, indobufen, ground lactose and an internally added lubricant are co-crushed, the D90 particle size of the co-crushed material is controlled to be 10-40 [mu] m, then spray-dried lactose, microcrystalline cellulose and an internally added disintegrating agent are added for dry granulation, and finally an externally added disintegrating agent and an externally added lubricant are added for tabletting to prepare the indobufen tablet. Through the process, the prepared material is good in compressibility, the problems of sticking, tablet cracking, low hardness and the like in the tabletting process of indobufen are solved, meanwhile, the dissolution level of the prepared indobufen tablet in an acid medium is remarkably improved, the clinical effect of the product can be better exerted, and therefore replacement of an original product can be achieved; and the preparation is simple in production process, easy to realize large-scale industrial production, and relatively high in popularization and application value.

The invention discloses a long-section peripheral vascular stent which is used for treating diseases such as peripheral vascular stenosis below knees and the like and solves the problems that an existing stent is difficult to introduce into peripheral blood vessels and lacks effective support. The stent has two states of a pressing and holding state and an expansion state with different section radiuses, is implanted into a peripheral vascular affected part in the pressing and holding state, and supports a blood vessel at the affected part in the expansion state. Sufficient radial yield strength is provided through a plurality of supporting rings so as to adapt to the characteristics that the peripheral blood vessel is large in elasticity and thick in outer base layer. And the stent is prepared from a degradable material, so that mechanical support required in the early stage of fusion is met, the stent also has relatively high strength and toughness, and the stent can be degraded in vivo, so that the use safety is greatly improved. Moreover, the pattern of the stent is optimized, so that the circumferential rotation phenomenon of the longer intravascular stent in the expansion process is improved, and the damage to the vascular wall in the implantation process is reduced to the greatest extent.

The invention discloses a heat-conducting powder tabletting method and a sheet obtained by the method. The tabletting method comprises the following steps: dispersing a proper amount of binder and lubricant in a dispersing agent to form a uniformly mixed solvent mixed solution; and mixing heat-conducting powder and the mixed solvent mixed solution, and tabletting. According to the tableting method for the heat-conducting powder, the mixed reagents (the binder and the lubricant) are added, so that compared with the mode that only the binder is added, the friction performance among powder particles is remarkably improved, a sample sheet obtained after tableting is easier to take out, and meanwhile the consistency and uniformity of the sample sheet in the tableting forming process of the powder are remarkably improved. The key problems of poor fluidity among particles, easy dispersion, layering cracking and sticking disintegration during tabletting of the heat-conducting powder are solved, and the phenomena of non-uniform distribution and difficult demolding possibly occurring when a binder is independently added are also avoided.

The invention belongs to the technical field of medicines, and relates to a berberine tannate oral preparation and a preparation method thereof. The oral preparation comprises berberine tannate, a filling agent, a disintegrating agent, an adhesive and a wetting agent, the filling agent is pregelatinized starch, microcrystalline cellulose and colloidal silicon dioxide; the disintegrating agent is one or more of sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone. The auxiliary materials of the berberine tannate oral preparation cooperate with one another, so that the flowability and compressibility of the powder are effectively improved, and the obtained final preparation product is excellent in stability and dissolution property and high in bioavailability; in addition, the oral preparation is simple in preparation process and suitable for large-scale production.

According to the pharmaceutical composition containing iguratimod and the preparation method of the pharmaceutical composition, the microcrystalline cellulose colloidal silicon dioxide co-treatment substance and the anhydrous calcium hydrogen phosphate are adopted as filling agents, the flowability and compressibility of particles can be obviously improved, and the problems that due to the fact that the active ingredients are large in proportion and need to be subjected to micronization treatment, the particle size is large, and the particle size is large are solved. And the traditional Chinese medicine composition has the advantages of being simple in preparation method, rapid and complete in dissolution, stable in quality, high in bioavailability and the like. Polacrilin potassium is used as a disintegrating agent, the tablet can be decomposed into very small particles, and the effective surface area for absorbing active substances is increased, so that the dissolution rate and bioavailability of the active substances are improved. Meanwhile, magnesium silicate is used as a flow aid, so that the flowability of total mixed powder can be greatly improved, and the tablet weight difference during tabletting is small.

The utility model provides a foundation pit double-row pile supporting and shock insulation ditch system, which relates to the technical field of foundation pit construction and comprises a row of outer-row cast-in-place piles, a row of inner-row cast-in-place piles are arranged on the inner sides of the row of outer-row cast-in-place piles, and water stop piles are arranged between the adjacent outer-row cast-in-place piles. A shock insulation groove is formed between the inner row of cast-in-place piles and the outer row of cast-in-place piles and filled with shock insulation materials, coping crown beams are arranged at the tops of the inner row of cast-in-place piles and the tops of the outer row of cast-in-place piles, drainage ditches are formed in the inner side portions of the coping crown beams, and prefabricated cover plates are arranged at the tops of the two coping crown beams. And a plurality of temporary inner supports are arranged between the two coping crown beams. According to the utility model, the problems of large requirement on a seismic isolation construction working surface and relatively high construction investment can be solved.

The invention relates to the technical field of mannitol preparation, and particularly discloses a preparation method of medicine auxiliary modified mannitol, the mannitol comprises the following components in parts by mass: 100-120 parts of mannitol, 5-10 parts of polyethylene glycol PEG, 2-5 parts of sodium carboxymethyl cellulose CMC-Na, 3-7 parts of cyclodextrin, 1-3 parts of nano silicon dioxide, 10-20 parts of plant source microcrystalline cellulose, and 1-5 parts of chitosan; through compound modification, the hardness and compressive strength of mannitol in the tablet are remarkably improved, the fragmentation phenomenon in transportation and storage is reduced, the integrity of the tablet is ensured, the powder fluidity is improved by adding nano silicon dioxide, and the plasticity of the preparation in industrial production is better; under the synergistic effect of cyclodextrin and chitosan, the dissolving property of mannitol is improved, so that the medicine disintegration is more uniform, and the preparation method is suitable for different dosage forms such as oral instant tablets and enteric sustained-release tablets; and the adjustability of the disintegration time after modification meets the diversified requirements from quick release to slow release.

The invention discloses an image coding method and system based on a generalized Gaussian model, and the related method comprises a coding part and a decoding part, the coding part comprises transformation, quantization and entropy coding, the decoding part comprises entropy decoding, inverse quantization and inverse transformation, and for image lossy coding, the inverse quantization and inverse transformation are carried out. Introducing a generalized Gaussian model to carry out modeling on probability distribution of the feature map in the encoding process, and carrying out entropy encoding and entropy decoding on the feature map according to generalized Gaussian model parameters obtained through modeling; for image lossless coding, a generalized Gaussian model is introduced to carry out modeling on probability distribution of pixels or lossless transformation coefficients in image lossless compression, and entropy coding and entropy decoding are carried out according to generalized Gaussian model parameters obtained through modeling. According to the scheme provided by the invention, the generalized Gaussian model is introduced into an image coding scheme, so that more accurate probability estimation can be carried out, the code rate required by image compression is saved, the compression performance is improved, and relatively low complexity is maintained.

This utility model relates to the field of photovoltaic module technology, specifically providing a correction device for photovoltaic modules, aiming to solve the problem of how to avoid deviations in correction caused by incoming material errors. To this end, the correction device for photovoltaic modules of this utility model includes a correction wheel, a first transfer mechanism, an elastic structure, and a position detection component. The first transfer mechanism includes a moving part; the moving part is connected to the correction wheel through the elastic structure. The first transfer mechanism is configured to drive the correction wheel to move and abut against the side of the photovoltaic module, thereby forcing the elastic structure to deform. The position detection component is configured to detect the actual position of the correction wheel, so as to determine the deviation size of the photovoltaic module based on the actual position and the preset position of the correction wheel. The correction device of this utility model can determine the deviation size of the photovoltaic module and adjust the correction size according to the deviation size to improve the correction accuracy, and also improve the working accuracy of subsequent processes.

This invention relates to the field of solid-state battery technology, and particularly to a composite solid-state electrolyte material, its preparation method, and its application. The composite solid-state electrolyte material contains a crystalline phase substance with the general chemical formula: B%A a RE b X 1 c D g +C%A d M e X 2 f D h Where A represents charge carriers; RE represents rare earth elements; M represents metallic elements; X represents... 1 X 2 D is a halide anion; A is an anion doping element or group; a RE b X 1 c D g and A d M e X 2 f D h It is a crystalline phase substance; B% is A a RE b X 1 c D g The mass fraction of the composite solid electrolyte material; C% is A d M e X 2 f D h The mass fraction of the composite solid electrolyte material is defined as follows: 0 ≤ a ≤ 3, 0 < b ≤ 1, 0.5 < c ≤ 12, 0 < d ≤ 5, 0 < e ≤ 2, 1 < f ≤ 20, 0 ≤ g ≤ 4, 0 ≤ h ≤ 5; 85 < B + C < 98, 10% < B% ≤ 85%; 10% < C% ≤ 85%, 0.2 ≤ C / B ≤ 10. The composite solid electrolyte material of this invention includes crystalline and amorphous phase components, giving it high ionic conductivity. The use of moisture-resistant non-metallic halide components instead of traditional halides and oxyhalides in the raw materials also provides it with good air stability.

An image data encoding / decoding method and a computer readable recording medium are disclosed. The image decoding method includes receiving a bitstream in which an image is encoded, obtaining a plurality of lower blocks from an upper block in a current image by using block partitioning based on a tree structure, generating a prediction image of the current image by referring to syntax information obtained from the bitstream, and obtaining a decoded image by combining the generated prediction image with a residual image obtained by performing inverse quantization and inverse transformation on quantized transform coefficients from the bitstream.

The invention belongs to the technical field of food processing, and particularly relates to an enzymolysis lotus seed tablet for promoting digestion and release of curcumin and a preparation method of the enzymolysis lotus seed tablet. The curcumin-lotus seed based tablet disclosed by the invention is prepared from the following raw materials: curcumin, lotus seed powder and enzyme; the preparation method comprises the following steps: dispersing the lotus seed powder in water, performing high-speed shearing, adding alpha-amylase, and performing enzymolysis to obtain lotus seed slurry; mixing the lotus seed powder with a curcumin solution, drying to prepare curcumin-lotus seed composite powder, and finally tabletting to prepare the curcumin-lotus seed tablet. The tablet disclosed by the invention is simple in ingredients, free of addition of auxiliary materials and capable of meeting the requirements of people on label cleaning; meanwhile, the enzyme modified lotus seed powder is used as an embedding medium of curcumin, can exert the medicinal and edible effects of lotus seeds, such as heart nourishing and blood pressure lowering, while being used as an embedding wall material, and is a natural and safe plant-based delivery carrier. The tablet provided by the invention is safe and green, and is a convenient, healthy and high-quality tablet health product.

The utility model relates to the technical field of wires and cables, in particular to a low-smoke halogen-free flame-retardant special wire and cable, which comprises a wire core and a cable base layer, the outer wall of the wire core is connected with the cable base layer, a protection structure is arranged on the outer side of the cable base layer, and the protection structure comprises a supporting assembly. The inner wall of the supporting assembly is bonded with the cable base layer, and the outer wall of the supporting assembly is bonded with the protection assembly. The supporting assembly is made of butadiene rubber and has good cold resistance, wear resistance and rebound resilience, the outer wall of the supporting assembly is bonded with the protection assembly, the protection assembly is made of a silicon rubber material, the silicon rubber material is a rubber material with excellent elasticity and compressibility, and when extruded by external force, the supporting assembly is not prone to deformation. Through the high elasticity of the protection assembly and the supporting assembly, the mechanical energy of external force is buffered, and the situation that the wire core is damaged and broken is avoided.

This invention discloses a method for evaluating the multi-dimensional coupling aerodynamic performance of a modal selector valve and an engine, belonging to the field of aero-engines. The steps are as follows: establishing a three-dimensional model of the modal selector valve; simulating the model to obtain its flow performance; establishing a computational model of the modal selector valve and calculating the total pressure after the valve; integrating a high-fidelity characteristic calculation model of the component with a zero-dimensional model of the entire engine; inputting the engine's design point performance parameters and performing design point calculations; given the engine control law and the engine's non-design point operating conditions, performing calculations; determining the convergence of the computational model; obtaining the engine characteristic diagram and aerodynamic performance under arbitrary operating conditions, thus obtaining the aerodynamic performance results considering the overall coupling effect of the modal selector valve and the engine. This invention solves the problems in existing technologies where the calculation accuracy of the overall performance calculation code for variable cycle engines cannot meet the design requirements of variable cycle engines, and the coupling of various engine components is poor.

The utility model provides a spherical tablet, and belongs to the field of pharmaceutical preparations. The spherical tablet comprises an upper hemisphere, a lower hemisphere and a middle belt, and the middle belt is located in the middle of the spherical tablet and is in a belt shape with the same thickness. The upper hemisphere and the lower hemisphere are located on the two end faces of the middle belt, and the two hemispheres are the same in size and shape. The diameter of the middle zone is larger than the diameter of the hemisphere, the diameter of the hemisphere of an upper stamping die and the diameter of the hemisphere of a lower stamping die of a tablet pressing die adopted when the spherical tablet is pressed ranges from 6.5 mm to 10 mm, and the ratio of the arc depth to the diameter of the hemisphere is (0.2-0.4): 1. The spherical tablet is small in size, easy to swallow, high in drug loading capacity and less in taking quantity; and the tablet has the advantages of good compressibility, good hardness, strong shock resistance and wear resistance, small tablet weight difference, facilitation of later coating and other operations, and good uniformity and reproducibility.

The invention provides a motion information list construction method, device and equipment in video coding and decoding, and relates to the technical field of video coding and decoding. The method comprises the steps that a spatial motion information list is constructed, the spatial motion information list comprises motion information of a spatial adjacent block of a current coding and decoding block, and the spatial adjacent block at least comprises an ISC block; and under the condition that the motion information in the candidate motion information list is insufficient, acquiring at least one piece of motion information from the airspace motion information list, and filling the candidate motion information list with the at least one piece of motion information. According to the method, when the motion information contained in the candidate motion information list is insufficient, the motion information close to the airspace is adopted for filling, content expansion of the candidate motion information list is achieved, more and more effective displacement vectors are provided in the candidate motion information list, a better displacement vector prediction effect is achieved, and the prediction accuracy of the displacement vectors is improved. And the video compression performance is improved.

The application provides a composite material for sludge dewatering, a preparation method thereof and a sludge dewatering conditioner. The composite material for sludge dewatering comprises magnetic porous carbon and molybdenum disulfide loaded on the magnetic porous carbon, wherein the magnetic porous carbon comprises porous carbon and ferroferric oxide loaded on the porous carbon. The preparation method comprises the following steps: mixing the magnetic porous carbon with a molybdenum source and a sulfur source, and performing a hydrothermal reaction to make the molybdenum source and the sulfur source react to generate molybdenum disulfide; after the reaction is completed, performing solid-liquid separation, collecting the solid product, and calcining the solid product under an inert atmosphere at 350-450 DEG C to obtain the molybdenum disulfide magnetic porous carbon composite material; wherein the magnetic porous carbon comprises porous carbon and ferroferric oxide loaded on the porous carbon; and the composite material for sludge dewatering can construct a molybdenum disulfide magnetic carbon-based composite material with a large specific surface area, high catalytic activity and high universality, and the composite material can improve the sludge dewatering performance.

The invention discloses an oxidized kitchen waste grease composite coal flotation agent and a preparation method thereof. The oxidized kitchen waste grease composite coal flotation agent consists of the following components in parts by weight: 30-40 parts of oxidized kitchen waste grease, 20-30 parts of kerosene, 3 parts of oleic acid, 3 parts of sodium oleate, 4 parts of methyl octanoate, 5 parts of dodecyl polyoxyethylene ether and 15-35 parts of water. The preparation process is simple, and the defect of poor stability of the existing composite agent is overcome. The composite agent can maintain long-term stability without stratification at room temperature, does not require additional dispersing and emulsifying equipment, is simple and flexible to use, has a small amount of use, and has obvious effect.

The invention relates to the technical field of traditional Chinese medicine and health food processing, and discloses a preparation process and application of a black ginseng extract lozenge, and the preparation process comprises the following steps: crushing starch, powdered sugar and polyethylene glycol in parts by weight, and sieving for later use; performing ultrasonic extraction and vacuum concentration on the black ginseng to obtain a black ginseng concentrated solution; slowly adding a pre-prepared black ginseng concentrated solution into the sieved starch and powdered sugar, and stirring to prepare a soft material; granulating, drying and finishing the soft material to obtain dry granules; and adding sieved polyethylene glycol into the dry particles, uniformly mixing, tabletting, forming, and sterilizing by ultraviolet radiation to obtain the buccal tablets. According to the method, ultrasonic-assisted extraction is adopted, so that degradation of heat-sensitive rare saponin is avoided; the concentrated solution is directly granulated, so that the difficulty that the extract absorbs moisture and is sticky is overcome, and the forming rate is increased; the prepared lozenge can activate a PI3K-Akt signal channel and regulate release of 5-HT, and can be used for preparing products for relieving chronic fatigue syndrome and improving spatial cognitive impairment.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a carbocisteine tablet and a preparation method thereof. The granule core containing carbocisteine is prepared from the main medicine components and the auxiliary materials by adopting a fluidized bed granulation process, so that the influence of too fast addition of a wetting agent on the granule state is avoided, and the compressibility and dissolution of the material are ensured; finally, the hydroxypropyl methylcellulose aqueous dispersion is used for coating, the taste of main medicine components is masked, meanwhile, the aqueous dispersion coating liquid replaces an organic solvent coating liquid, energy consumption is low, safe production and environmental protection are facilitated, and the production and development direction of modern preparations is met; meanwhile, the influence of air and heat on the active ingredients is isolated through the coating. According to the invention, the formability and the dissolution rate of the preparation are improved through a fluidized bed granulation technology, and meanwhile, the stability of medicinal components is improved through a coating technology.

The invention relates to a piribedil sustained-release tablet, the sustained-release tablet comprises piribedil, talcum powder, a sustained-release material, an adhesive and a lubricant, the sustained-release material is hydroxypropyl methylcellulose, and the dissolution similar factor f2 of the sustained-release tablet and an original reference preparation Tesuda # imgabs0 # is greater than or equal to 50. According to the piribedil sustained-release tablet disclosed by the invention, on the basis that a sugar-coating layer is not coated, by optimizing a prescription and adding a hydroxypropyl methylcellulose sustained-release material, the technical effect of in-vivo bioequivalence with that of an original reference preparation Tesuda # imgabs1 # is obtained.

The invention discloses a preparation method of inositol nicotinate tablets, and belongs to the technical field of pharmaceutical preparations. By optimizing the existing process and coating components, stable dissolution of drugs is realized, and the method comprises the following steps: dispersing inositol nicotinate in mixed oil to prepare an oil phase, mixing and emulsifying the oil phase and a water phase, performing spray drying to obtain drug milk powder, coating the drug milk powder with modified chitosan, and directly tabletting the coated drug milk powder and auxiliary materials. The preparation method comprises the following steps: uniformly dispersing inositol nicotinate in mixed oil to promote the inositol nicotinate to maintain the uniformity of the drug content in the subsequent process, and adsorbing solid particles on the surfaces of drug-containing oil drops through an emulsification technology to protect the drug components; coating components are reasonably designed, so that fixed-point release of the medicine is realized, the medicine is endowed with anti-pressure ability, and the medicine can be directly tableted; and the coated medicine particles are mixed with auxiliary materials and then are directly tableted, so that the process is simplified, and the coating structure of the medicine particles is protected at the same time. The preparation method can prepare the inositol nicotinate tablet with stable drug dissolution, and the inositol nicotinate tablet is good in taste and small in stimulation to gastric mucosa.

The invention relates to a lamidetan tablet and a preparation process thereof, the prepared lamidetan tablet is good in powder flowability and compressibility, the dissolution meets the requirements, and the preparation process can effectively avoid or reduce the risk of crystal transfer in preparation of a preparation.

The invention relates to a Nicodil tablet and a preparation method thereof. The Nicodil tablet comprises the following components in percentage by mass: 5-15% of Nicodil, 70-90% of a filler, 2-10% of a disintegrating agent, 0.5-5% of an adhesive and 0.2-10% of a lubricant, and the filling agent is micronized mannitol. During preparation, the mannitol, the adhesive and the internally added disintegrating agent are prepared into blank dry particles, and then the blank dry particles are mixed with the nicodil, the externally added disintegrating agent and the lubricant step by step. According to the invention, the stability of the Nicodil tablet is improved, the granulation process is improved, the obtained Nicodil tablet is superior to a reference preparation in related substance level under the influence factor condition, meets the long-term stability requirement, and is stable in product quality, free of obvious change in content and small in impurity growth under the condition of accelerating at 40 DEG C for 3 months, and is suitable for large-scale industrial production.