79results about How to "Particles have good fluidity" patented technology

The invention provides a nickel cobalt manganese hydroxide precursor represented by a general formula (I). The hydroxide precursor is an orderly accumulated sphere with a page-like structure composed of a plurality of layers of sheets. The invention further provides a preparation method of the nickel cobalt manganese hydroxide precursor. In the process of preparing the nickel cobalt manganese hydroxide precursor, a sodium hydroxide solution, an ammonia water solution and a mixed solution of nickel salt, cobalt salt and manganese salt are reacted; and the nickel cobalt manganese hydroxide precursor which is the orderly accumulated sphere with the page-like structure is obtained by controlling pH and the amount of the ammonia water solution in the reaction process and adding an additive for adjusting particle morphology in the reaction process at the same time. The experimental results show that the nickel cobalt manganese hydroxide precursor prepared by the invention has better spherical morphology, uniform particle and good particle mobility; therefore, the nickel cobalt manganese hydroxide precursor is beneficial to diffusing lithium ion in the subsequent sintering process.

The invention discloses a polyolefin catalyst adopting carbon nanotubes as carriers and a preparation method thereof. The polyolefin catalyst adopting carbon nanotubes as carriers comprises carbon nanotube catalyst carriers and catalytic activity components, wherein the polyolefin catalyst contains 80.0 to 99.0% by mass of carbon nanotubes and 1.0 to 20.0% by mass of the catalytic activity components. The preparation method of the polyolefin catalyst adopting carbon nanotubes as carriers comprises the following steps of compounding reaction substances and the carbon nanotube catalyst carriers, and carrying out loading of at least one transition metal compound. The polyolefin catalyst adopting carbon nanotubes as carriers has a spherical particle surface appearance, and contains the catalytic activity components which are uniformly distributed on the surface and in the interior of the spherical polyolefin catalyst adopting carbon nanotubes

The invention discloses freshly squeezed spray drying peppermint granular decoction pieces and a preparation process thereof. The process is characterized by harvesting the medicinal material peppermint, then cleaning, selecting and drip-washing peppermint, squeezing peppermint while peppermint is fresh and taking the juice after filtration; adding water to the dregs, stirring the dregs and carrying out filtering and squeezing; mixing the obtained juice and then carrying out vacuum concentration and carrying out spray drying; separating essential oil from concentrated condensate, after inclusion of the essential oil with beta-cyclodextrin, mixing an inclusion compound with a spray-dried product, straightening granules, bagging the granules and carrying out vacuum packaging. The peppermint granular decoction pieces prepared by the method furthest retain the active ingredients in the medicinal material, have good flowability, are easy to store and transport and convenient to regulate, are controllable in quality, have reliable curative effects and have great significance in guaranteeing the clinical effects of traditional Chinese medicines. Popularization and implementation of the method has remarkable social significance and economic benefits.

The invention discloses a preparation method of beta type ammonium tetramolybdate. Three links of acid precipitation, transformation and drying are improved, wherein the beta type ammonium tetramolybdate transformed in the traditional mode is added in the acid precipitation process, then, the traditional low-temperature transformation or drying transformation mode is changed into the high-temperature transformation, and next, the drying is carried out. During the production transformation, the humidity, the temperature and the pressure required during the transformation are considered, the transformation is carried out at a higher temperature, a certain humidity and a certain pressure, the transformation rate of the beta type ammonium tetramolybdate is ensured, the transformation time is also shortened, the transformation rate of the ammonium tetramolybdate reaches more than 95 percent, meanwhile, the beta type ammonium tetramolybdate which has high purity and strong forgeability and drawability on deep-processing molybdenum products through the physical performance such as product appearance, granularity, apparent density and crystal structure is prepared, the quality and the performance of the beta type ammonium tetramolybdate are greatly improved, and reliable raw materials are provided for the subsequent deep processing.

The invention discloses a compound amlodipine and valsartan solid preparation and a preparation method thereof. The preparation can be a tablet or a capsule and contains 2.5-10g of amlodipine or pharmaceutically acceptable salt thereof (calculated according to the amlodipine) and 40-640g of valsartan or pharmaceutically acceptable salt thereof (calculated according to the valsartan). The preparation method of the compound amlodipine and valsartan solid preparation comprises the steps of mixing the two medicines and the corresponding medicinal auxiliary materials according to the proportion, mixing with the corresponding lubricant or glidant after granulating in a wet method, and pressing into a tablet or filling into a capsule so as to obtain the compound amlodipine and valsartan solid preparation. In the invention, the tablet or the capsule is prepared after the two active substances with unequal doses are granulated in the wet method, and the method is simple and convenient, is easy to control the quality and is suitable for the industrialized production. More than 85% of the amlodipine in the preparation is dissolved out within 30 minutes, and the invention has favorable market popularization prospect.

The invention discloses a method for preparing superfine granule special type saltcake, which includes the following technical steps: pumping hot water at 40-70 DEG C, and forming a saltcake solution containing a plurality of impurities; concentrating for crystallization by vacuum evaporation after refining impurities; cutting the saltcake solution at a high rotating speed; drying after centrifugal separation, processing by a fluidized bed, separating coarse granule saltcake and obtaining a superfine granule special type saltcake product. The anhydrous superfine granule special type saltcake product obtained by the process method of the invention after high rotating speed cutting and fluidized bed processing has the advantages of good granule fluidness and low possibility of agglomeration. The product can be widely used for preparing sodium sulfide, sodium silicate and the like, and is also used in industries of paper making, glass, printing and dyeing, synthetic fiber, hide manufacture, food, medicine and the like.

The invention discloses a preparation method of a berberine hydrochloride tablet, and the preparation method is applied to the field of pharmaceutical preparation. The berberine hydrochloride tablet consists of a tablet core and a coating material, wherein the tablet core consists of berberine hydrochloride and auxiliary materials, each tablet contains 300mg of the berberine hydrochloride, and the auxiliary materials contains one or a plurality of a filling agent, a disintegrating agent, a lubricant, a surfactant and a wetting agent; a coating layer consists of the coating material and water; the coating layer further contains a plasticizer or an antiadherent, wherein the filling agent contains one or a random composition of starch, lactose, pregelatinized starch and microcrystalline cellulose; the disintegrating agent contains one or a random composition of crosslinking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, sodium carboxymethyl starch, hydroxypropyl starch and low-substitution hydroxyl propyl cellulose; and the lubricant contains one or a random composition of aerosol, talc powder and magnesium stearate. The method is suitable for the large-scale and long-time production of production departments, and has the advantages of stable technology, no dependence on tablet machines, good particle liquidity and formation, controllable tablet weight difference, stable quality, high tablet core hardness, difficulty in wearing and coating suitability.

The invention disclose an aspirin enteric-coated tablet applied in the technical field of medicine preparations and a preparation technology thereof. The enteric-coated tablet comprises a tablet core and an enteric coating layer. The tablet core comprises aspirin, a filling agent, an adhesive and a glidant. The enteric coating layer comprises an enteric material, a plasticizer, an antiadherent and water. The preparation technology includes mixing blank accessories, granulating the mixed blank accessories and drying to obtain accessory particles, mixing the aspirin and the accessory particles to obtain a totally-mixed particles; subjecting the totally-mixed particles to dry granulation to obtain intermediate particles, tabletting the intermediate particles, coating the tablet core obtained after tabletting to prepare the enteric-coated tablet, and drying the enteric-coated tablet in air. According to the tablet and the preparation technology, aqueous dispersion film is adopted for coating, thus solving latent risks of solvent residue and capability of being flammable and combustible which are produced by coating dissolution by organic solvents. The blank accessories are granulated in a wet method, thus overcoming sticky punch and tablet weight difference over-limit which are caused by tabletting in large batches and for a long time.

The invention provides a preparation method for granulose condensable sugar. The preparation method comprises the following steps: mixing and stirring crystallization agent resistant, overheated and supersaturated cane sugar liquid and powdery condensable sugar seed crystals; after vacuum drying, granulating with a high speed granulator; then forced air drying and dry sieving to obtain a granulose condensable sugar product. The condensable sugar prepared by the preparation method is uniform in grain, high in flow ability and high in yield.

The invention discloses immunity-enhancing effervescent tablets. The effervescent tablets comprise the following components in parts by weight: 50-200 parts of vitamin C sodium, 10-30 parts of taurine, 10-30 parts of zinc gluconate and 10-20 parts of fig extract. In order to solve the problems that existing effervescent tablets comprising vitamin C are great in acidity, relatively great in irritation to oval cavity, throat and esophagus and gastric mucosa if being dissolved and not suitable for being taken for a long time, and vitamin C is likely to be oxidized to lose efficacy in the storage process, the effervescent tablets are likely to be affected with damp to absorb moisture and the like, the invention provides the effervescent tablets which have the functions of enhancing the immunity, clearing away heat and toxic materials, tonifying kidneys and spleen, maintaining beauty and keeping young and the like and further can supplement nutrients required by human body, relieve fatigue and delay senescence.

The invention discloses a preparation method of an anode material of lithium-ion power battery lithium vanadium phosphate, comprising the following steps: adding a LiOH.H2O aqueous solution into the white turbid aqueous solution of NH4VO3, and stirring until the solution is clear; then, adding a nodularizer hydrazine hydrate dropwise until the solution becomes yellowish; adding an (NH4)2HPO4 aqueous solution into the above yellowish solution to cause the solution to gradually become brownish black; adding 1,4-butynediol into the above brownish black solution, and stirring; adjusting the pH to10-14; drying the obtained solution in a kettle to obtain precursor powder; and finally, at the temperature of 700-800 DEG C, calcining the precursor powder under the protection of argon to obtain the porous spherical anode material of lithium vanadium phosphate. The lithium-ion battery prepared from the anode material of lithium vanadium phosphate prepared by the method in the invention has the characteristics of high specific capacity, long cycle life, good charging and discharging performances with high multiplying power and the like.

The invention discloses a preparation method of a composite positive pole material of a lithium sulphur battery. The preparation method comprises the following steps of: (1) utilizing activation and nitrogen doping to simultaneously carry out modification on a carbon aerogel to obtain a modified carbon aerogel material; and (2) slowly adding the modified carbon aerogel in an organic sulfur solution, taking a supercritical fluid as an extraction agent to ultrasonically extract in an extraction kettle under room temperature, carrying out pressure reduction and separation, leaching by an ethanol eluting agent, and drying to obtain the modified carbon aerogel-sulfur composite positive pole material. The material prepared by the preparation method provided by the invention has the advantages that the sulfur content is high, the sulfur particles are small, the granularity is uniformly controllable, and the material simultaneously has higher conductibility, specific surface area and porosity. The recovery of the used organic solvent is simple in the preparation process, the extraction agent is circularly used through compression, the extraction efficiency is high, the operation is simple, and the pollution is not generated.

The invention discloses rabdosia rubescens freshly squeezed spray-dried granule slices and a preparation process thereof. The process comprises the following steps: collecting a rabdosia rubescens medicinal material; selecting and washing the rabdosia rubescens medicinal material; squeezing when the rabdosia rubescens medicinal material is still fresh, filtering medicinal material juice; stirring dreg with water, filtering and squeezing; mixing medicinal material juices, condensing at reduced pressure, drying by spraying; and concentrating condensate to separate volatile oil, clathrating with beta-cyclodextrin, mixing with spray-dried material, granulating, packaging in bags and sealing in vacuum. According to the rabdosia rubescens granule slices, effective ingredients in the medicinal material are furthest maintained. The granule slices have the advantages of good liquidity, convenience in storage and transportation, convenience for regulation, controllable quality and reliable curative effect, and has an important meaning to traditional Chinese medicine clinical treatment effect. Popularization and implementation of the granule slices have remarkable social meaning and economic benefit.

The invention discloses an olaquindox slow release particle and a preparing method and application thereof. The olaquindox slow release particle is prepared by an olaquindox raw material, a dispersing agent and a release retardant. The preparing method includes the steps of weighing the dispersing agent according to formula proportion, and heating and fusing the dispersing agent to be evenly mixed; adding olaquindox to be evenly stirred; adding the release retardant to be evenly stirred; and conducting fluidized-bed spray granulation nodulizing, cooling, screening and collecting through a scientific process. By means of the olaquindox slow release particle, absorption of olaquindox in the intestinal tract of a target animal can be reduced, the bioavailability of the olaquindox is reduced by about 10%-50%; after the animal eats the olaquindox slow release particle, the olaquindox slow release particle can be released in the intestinal tract in the whole process, and the action concentration and the action time of the olaquindox in the intestinal tract are prolonged. According to the preparing method, in the production process, dust and static electricity are not generated, and cross contamination of feed production is effectively avoided; the slow release particle is good in mobility and dispersibility, feed and drugs can be conveniently mixed, and drug application is convenient.

The invention discloses a method for preparing coarse granule special type saltcake, which includes the following technical steps: pumping hot water at 40-70 DEG C by a pump, and forming a saltcake solution containing a plurality of impurities; concentrating for crystallization by vacuum evaporation after refining impurities; obtaining a supersaturated solution containing saltcake crystals, keeping the temperature at 10-120 DEG C, and aging for 0.5-3.0 hours; drying after centrifugal separation, processing by a fluidized bed, separating fine granule saltcake and obtaining coarse granule special type saltcake. The anhydrous coarse granule special type saltcake product obtained by the process method of the invention has the advantages of good granule fluidness and low possibility of agglomeration. The product can be widely used for preparing sodium sulfide, sodium silicate and the like, and is also used in industries of paper making, glass, printing and dyeing, synthetic fiber, hide manufacture, food, medicine and the like.

The invention discloses an asiatic acid salt tablet and a preparation method thereof. A formula of the tablet comprises 1-40 percent of asiatic acid amino butantriol salt, 25-60 percent of a filling agent, 1-10 percent of an adhesive, 0.5-40 percent of a disintegrating agent and 0.1-1.5 percent of a lubricant, wherein the percentage refers to the mass percentage of each component in the total amount of the asiatic acid salt tablet. The method comprises the following steps of: in the terms of the formula, uniformly mixing the smashed and sieved asiatic acid amino butantriol salt, filling agent, adhesive and disintegrating agent; mixing with 5-20 percent by mass of an ethanol solution; pelletizing and drying; mixing with the lubricant; and tableting. The asiatic acid salt tablet disclosed by the invention has high bioavailability.

The invention provides a Levetiracetam medicinal composition and a preparation method thereof. The composition mainly comprises Levetiracetam, polyethylene glycol 6,000 serving as a melting agent and other excipients. The preparation method mainly comprises: preparing medicine particles through a hot melting granulation technique; and pressing into tablets or filling into capsules.

The invention discloses a composition for protecting eyesight. The composition is prepared from, by weight, 30-100 parts of sodium ascorbate, 0.1-1 part of vitamin A, 1-10 parts of xanthophyll, 10-20 parts of taurine and 10-30 parts of flower and fruit tea extract. Aiming at the problems that existing lozenges containing vitamin C are high in acidity after being dissolved, causing serious irritation to the oral cavity, the throat, the esophagus and the gastric mucosa, thus not suitable for long-term use, besides, vitamin C is prone to oxidization and invalidation during storage, and lozenges is liable to absorb moisture, the invention provides the composition which can improve immunity, clear heat, improve eyesight, whiten and nourish skin, and remarkably improve blurred vision, eye dryness, eye distension, ophthalmodynia and phengophobia.

The invention discloses freshly squeezed honeysuckle spray-dried granular decoction pieces and a preparation process thereof. The process comprises the following steps: harvesting honeysuckle medicinal materials, cleaning and leaching the honeysuckle medicinal materials, squeezing the honeysuckle medicinal materials when the honeysuckle medicinal materials are fresh, and filtering to obtain medicinal liquor; adding water into residues, stirring, and performing filtering and squeezing; combining the medicinal liquor obtained twice, and performing vacuum concentration and spray drying; separating volatile oil from concentrated condensate, performing inclusion through beta-cyclodextrin, mixing the product with a spray-dried object, and performing granulation, bagging and vacuum packaging. The honeysuckle granular decoction pieces prepared by the preparation process retain the effective components in the medicinal materials to the maximum extent. The granular decoction pieces are high in flowability, convenient for storage, transportation and brewing, controllable in quality, and reliable in treating effect, and have great significance for guaranteeing the traditional Chinese medicinal clinical treating effect. The preparation process has outstanding social and economical benefits for popularization and implementation.

The invention provides a dyeing composition, a preparation method and a dyeing technology. The dyeing composition is solid particles and is prepared from, by weight, 3%-75% of pigments, 1%-3% of a dispersing agent, 5%-10% of a high-molecular polymer and 12%-91% of a low-molecular polymer, wherein a resin polymer is adopted as the high-molecular polymer, and a wax substance is adopted as the low-molecular polymer. The pigment content of the dyeing composition can reach up to 75%, the dispersity is good, and equipment and an environment are easy to clean when the dyeing composition is used.

The invention relates to a hydrogen storage alloy particle and a preparation method thereof and belongs to the technical field of hydrogen storage. The hydrogen storage alloy particle is characterized in that the surface of the hydrogen storage alloy particle is covered with a hardening resistant agent; and the hardening resistant agent is methylsilicone oil. The preparation method of the hydrogen storage alloy particle is characterized in that a hydrogen storage alloy block body material and the hardening resistant agent are stored in an airtight reactor, and after hydrogen is pumped in the reactor, hydrogenation crushing occurs in the hydrogen storage alloy block body material, so that the surface of the obtained hydrogen storage alloy particle is covered with the hardening resistant agent. The hydrogen storage alloy particle and the preparation method thereof have the advantages that particle flowability is good, particle hardening is avoided in the hydrogen absorption and desorption processes, the hydrogen storage alloy particle is stable in the air environment, the preparation technique is simple, manufacturing cost is low, and product performance is stable and can be widely applied to metal hydride hydrogen storage containers for storing the hydrogen.

The present invention discloses a choline particle and a preparation method and an application thereof. The preparation method comprises the following preparation steps: step one, crushing choline topass a 20-100 mesh sieve; step two: dissolving a first binder in water to obtain a binder solution; and step three: after mixing the choline processed in the step one with a second binder, putting themixture into a granulator, and adding the binder solution obtained in the step two for granulation to obtain the choline particle. The binder is dissolved in water, then the choline is granulated, the prepared granule is uniform and moderate in size, good in fluidity, and not easy to absorb moisture; and a prepared pressed tablet is smooth on surface, small in difference in tablet weight, good inhardness (good in friability), and good in disintegration.

The invention discloses a preparation method of high-purity cefoperazone sodium micro powder, and belongs to the technical field of medicines. Cefoperazone acid is taken as a raw material, a cefoperazone sodium solution is prepared first, decolorizing treatment is then conducted, the decolorized cefoperazone sodium solution is added to a reaction kettle to which a super-critical fluid is added, and the cefoperazone sodium micro powder is obtained through crystallization. The preparation method has the advantages that the process is stable, the micro powder is green and environmentally friendly, the oxidation of a product can be avoided, the prepared cefoperazone sodium micro powder has the advantages of high purity and less impurity, the particle fluidity of the product is good, and the granularity is controllable.

The invention discloses a polyolefin catalyst adopting carbon nanotubes as carriers and a preparation method thereof. The polyolefin catalyst adopting carbon nanotubes as carriers comprises carbon nanotube catalyst carriers and catalytic activity components, wherein the polyolefin catalyst contains 80.0 to 99.0% by mass of carbon nanotubes and 1.0 to 20.0% by mass of the catalytic activity components. The preparation method of the polyolefin catalyst adopting carbon nanotubes as carriers comprises the following steps of compounding reaction substances and the carbon nanotube catalyst carriers, and carrying out loading of at least one transition metal compound. The polyolefin catalyst adopting carbon nanotubes as carriers has a spherical particle surface appearance, and contains the catalytic activity components which are uniformly distributed on the surface and in the interior of the spherical polyolefin catalyst adopting carbon nanotubes

The invention relates to a vonoprazan fumarate-containing tablet and a determination method for a dissolution rate thereof. The vonoprazan fumarate-containing tablet provided by the invention is composed of the following components in parts by weight: 10-15 parts of vonoprazan fumarate, 65-75 parts of mannitol, 2-5 parts of organic acid, 2-4 parts of hydroxy propyl cellulose, 8-12 parts of microcrystalline cellulose, 2-6 parts of croscarmellose sodium, 0.5-2 parts of magnesium stearate, 3-4 parts of coating powder and 0.2-1.0 part of polyethylene glycol. According to the tablet prepared by using the method, a damp-heat process is avoided; the granules of the tablet are good in flowability and compressibility, and the tablet is free of sticking, smooth in surface, qualified in friability and stable in tablet weight; after coating is completed, an aqueous polyethylene glycol solution is used for polishing treatment, so the appearance of the tablet is more glossy, a better moisture insulation effect is achieved on the tablet, and the dissolution behavior of the tablet is not influenced.

The invention relates to the technical field of health foods, and in particular relates to vitamin CE effervescent tablets. The vitamin CE effervescent tablets are prepared from the following components in parts by weight: 50-150 parts of vitamin C, 10-50 parts of vitamin E, 800-1600 parts of lactose, 600-1500 parts of sodium bicarbonate, 500-1200 parts of tartaric acid, 60-120 parts of a lubricant, 40-100 parts of a sweetening agent and 15-50 parts of a flavoring agent. The vitamin CE effervescent tablets provided by the invention are finely prepared by a scientific formula, can be consumed as a nutritional supplement for a long term, and has the functions of oxidation resistance and immunity enhancement; and the preparation of the vitamin CE effervescent tablets is simple, the prepared tablets have smooth surfaces and uniform effervescent gas production, the solution after disintegration is clear, transparent and fragrant and sweet in mouthfeel, and the tablets have the characteristics of a solid preparation as well as a liquid preparation, and are convenient to carry and safe and effective in use.

The invention provides a tildipirosin 1,4-dioxane solvate and a preparation method thereof. Characteristic peaks occur in an X-ray powder diffraction pattern represented by 2theta when 2theta is equal to 6.06+ / -0.2, 8.42+ / -0.2, 9.34+ / -0.2, 9.94+ / -0.2, 10.28+ / -0.2, 12.34+ / -0.2, 13.44+ / -0.2, 13.74+ / -0.2, 14.66+ / -0.2, 15.58+ / -0.2, 15.78+ / -0.2, 16.40+ / -0.2, 17.00+ / -0.2, 17.90+ / -0.2, 18.60+ / -0.2, 19.32+ / -0.2, 20.10+ / -0.2, 21.40+ / -0.2, 22.34+ / -0.2, 22.68+ / -0.2, 23.34+ / -0.2 and 24.18+ / -0.2. The preparation method employs a constant-temperature suspended crystal transformation process and is simple in process and low in energy consumption. The tildipirosin 1,4-dioxane solvate is in a rod shape and crystal is of a regular shape.

The invention provides a nickel cobalt manganese hydroxide precursor represented by a general formula (I). The hydroxide precursor is an orderly accumulated sphere with a page-like structure composed of a plurality of layers of sheets. The invention further provides a preparation method of the nickel cobalt manganese hydroxide precursor. In the process of preparing the nickel cobalt manganese hydroxide precursor, a sodium hydroxide solution, an ammonia water solution and a mixed solution of nickel salt, cobalt salt and manganese salt are reacted; and the nickel cobalt manganese hydroxide precursor which is the orderly accumulated sphere with the page-like structure is obtained by controlling pH and the amount of the ammonia water solution in the reaction process and adding an additive for adjusting particle morphology in the reaction process at the same time. The experimental results show that the nickel cobalt manganese hydroxide precursor prepared by the invention has better spherical morphology, uniform particle and good particle mobility; therefore, the nickel cobalt manganese hydroxide precursor is beneficial to diffusing lithium ion in the subsequent sintering process.