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Asiatic acid salt tablet and preparation method thereof

A technology of oxalate tablet and oxalate tromethamine, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as unsatisfactory drug efficacy and low bioavailability, and achieve Good bioavailability, easy operation, good particle fluidity and compressibility

Inactive Publication Date: 2012-10-31
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the defects that the existing asiatic acid and its salt tablets have unsatisfactory drug efficacy and extremely low bioavailability, and provide a kind of asiatic acid salt with good bioavailability Tablet and its preparation method

Method used

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  • Asiatic acid salt tablet and preparation method thereof
  • Asiatic acid salt tablet and preparation method thereof
  • Asiatic acid salt tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: according to the above formula, uniformly mix crushed and sieved asiatic acid tromethamine salt, microcrystalline cellulose, pregelatinized starch and cross-linked polyvinylpyrrolidone, then mix with 5% ethanol solution, and granulate , dried, and then mixed with a lubricant and compressed into tablets.

[0028] Wherein, said asiatic acid tromethamine salt is crushed and sieved to pass through a 60-mesh sieve; said microcrystalline cellulose, pregelatinized starch and cross-linked polyvinylpyrrolidone are crushed and sieved to pass through a 80-mesh sieve; The particle size of the granulated particles is 20 mesh; the drying temperature is preferably 90°C to control the water mass percentage within 3%.

[0029] After testing (rat tail vein injection method, see "Journal of Southern Medical University" 2009 06), the bioavailability of asiatic acid tromethamine salt in the obtained tablet is 17.9%.

Embodiment 2

[0031]

[0032] Preparation method: according to the above formula, uniformly mix crushed and sieved asiatic acid tromethamine salt, four-fifths of starch, and hydroxypropyl methylcellulose, then mix with 20% ethanol solution, granulate, Dry it, then mix it with the remaining starch and lubricant, and press it into tablets.

[0033]Wherein, said asiatic acid tromethamine salt is crushed and sieved to pass through a 100 mesh sieve; said starch and hydroxypropyl methylcellulose are crushed and sieved to pass through a 100 mesh sieve; said granulated granules The particle size is 50 mesh; the drying temperature is preferably 50°C to control the water mass percentage within 3%.

Embodiment 3

[0035]

[0036] Preparation method: according to the above formula, uniformly mix crushed and sieved asiatic acid tromethamine salt, microcrystalline cellulose, α-lactose and tragacanth gum, then mix with 20% ethanol solution, granulate, and dry. Afterwards, it is mixed with a lubricant and compressed into tablets.

[0037] Wherein, said asiatic acid tromethamine salt is crushed and sieved to pass through a 60-mesh sieve; said microcrystalline cellulose, α-lactose and tragacanth gum are crushed and sieved to pass through a 80-mesh sieve; The particle size of the granules is 20 mesh; the drying temperature is preferably 50°C to control the water mass percentage within 3%.

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PUM

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Abstract

The invention discloses an asiatic acid salt tablet and a preparation method thereof. A formula of the tablet comprises 1-40 percent of asiatic acid amino butantriol salt, 25-60 percent of a filling agent, 1-10 percent of an adhesive, 0.5-40 percent of a disintegrating agent and 0.1-1.5 percent of a lubricant, wherein the percentage refers to the mass percentage of each component in the total amount of the asiatic acid salt tablet. The method comprises the following steps of: in the terms of the formula, uniformly mixing the smashed and sieved asiatic acid amino butantriol salt, filling agent, adhesive and disintegrating agent; mixing with 5-20 percent by mass of an ethanol solution; pelletizing and drying; mixing with the lubricant; and tableting. The asiatic acid salt tablet disclosed by the invention has high bioavailability.

Description

technical field [0001] The invention relates to a centella asiatica salt tablet and a preparation method thereof. Background technique [0002] It is reported in the prior art that asiatic acid and its salts can prevent and treat fibrosis diseases of some internal organs, but the drug efficacy of the related tablets is not ideal, and the bioavailability is extremely low. In order to maximize the effective utilization of the drug, this The status quo needs to be resolved urgently. Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the defects that the existing asiatic acid and its salt tablets have unsatisfactory drug efficacy and extremely low bioavailability, and provide a kind of asiatic acid salt with good bioavailability Tablets and methods for their preparation. [0004] The formulation of the asiatic acid salt tablet of the present invention contains 1% to 40% asiatic acid tromethamine salt, 25% to 60% fill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K9/20
Inventor 刘英刘全海刘珉宇陈仁海潘绵立杨耀杰虞丽芳孙海燕金立玲邓轶方吴彤
Owner SHANGHAI INST OF PHARMA IND CO LTD
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