105 results about "Lymphatic vessel" patented technology

A contrast agent for imaging lymph nodes or lymphatic vessels with near-infrared light that can selectively image primary lymph nodes relative to secondary or higher lymph nodes. A dose of the composition suitable for imaging lymph nodes or lymphatic vessels.

Some embodiments of the invention advantageously leverage the expansion, dilation or by-pass of the Schlemm's canal using adjustable reversible self-expanding eye stents (SES) or eye tension rings (ETRs) of desired sizes to control and improve aqueous flow throughout the range of the uveolymphatic canal. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the Schlemm's canal wall and is at least partially within the canal and / or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the wall and / or elsewhere in the canal. The partial or complete expansion of the canal can be pre-configured based on pre-operative metrology of the Schlemm's canal to a customized and adjustable fit across the various zones within the uveolymphatic canal and based on the patient specific and evolving needs. Additionally, the SES can utilize entry / exit features for by-pass of fluid, varying control of dilation across its shape that may also allow anchoring, repositioning, and retrieval.

The invention belongs to the technical field of medical data processing, and particularly relates to a bladder cancer vessel tumor embolus assessment method and system based on multi-modal feature fusion, and the optimization method comprises the steps: obtaining and preprocessing the pathological information and image data of a bladder cancer patient, extracting a CT image corresponding to a tumor, and determining a region of interest; image omics features are extracted from the region of interest of the CT image, and deep learning features are extracted from the maximum tumor cross section; carrying out feature selection processing on the obtained radiomics features and deep learning features, and inputting the processed features into a fusion model; and outputting a probability value of'lymphatic vessel invasion 'by the fusion model to obtain an evaluation result. A multi-modal machine learning model is constructed by fusing radiomics features and deep learning features extracted from a CT image, and the objective of the invention is to noninvasively and accurately evaluate the lymphatic vessel infringement state of bladder cancer before an operation, so that a key basis is provided for clinical individualized treatment decision-making.

The invention discloses a modular tumor microenvironment response polypeptide and a preparation method and application thereof. The modular tumor microenvironment response polypeptide is composed of the following functional modules: a targeting and chemotactic module used for targeting tumor cell surface p32 protein and tumor lymphatic vessels and promoting tumor tissue penetration and enrichment; the microenvironment double-response module is used for being cut by MMP-2 / 9 enzyme and broken by high-concentration glutathione GSH in a tumor microenvironment to trigger self-assembly; the self-assembly driving module is used for exposing after the microenvironment responds to activation and driving short peptides to be self-assembled to form a nano structure; a killing module: a pro-apoptotic peptide PAD used for targeting a mitochondrial membrane and inducing tumor cell apoptosis; and the stability optimization module is used for enhancing the degradation resistance of the oligopeptide. By integrating targeted delivery, enzyme digestion response, acid-sensitive release and stabilizing structures, the problems of insufficient targeting property, inaccurate release, poor stability, diagnosis-treatment splitting and the like of the anti-tumor drug and the developing agent are solved.

The invention relates to a gynecological pelvic and abdominal lymphatic cleaning prediction model training method and a lymph node model.The training method comprises the steps that preoperative image data and intraoperative instrument operation parameters of historical patients are subjected to modeling processing, and a dynamic mechanics-fluid coupling lymph node model based on bionic materials is constructed; mechanical deformation and fluid flow of a lymphatic system in various clinical scenes are simulated; performing data acquisition processing on the used lymph node model, and quantifying the dynamic influence of the surgical operation on the lymphatic system; the relevance between historical operation and injury risk is deeply learned, and the lymphatic vessel rupture probability is output; real-time feedback control processing is carried out based on the lymphatic vessel rupture probability, a training correction instruction and a risk thermodynamic diagram are generated, and medical workers are guided to optimize surgical skills. Through fusion analysis of the high-fidelity bionic model and multi-modal data, dynamic simulation of the mechanical-fluid coupling effect in the operation and real-time quantification of the operation risk are achieved, and the accuracy and clinical transformation value of operation training are improved.

The invention belongs to the technical field of biomedical functional dyes and probes, and relates to a fluorescent probe, in particular to a cyclodextrin-based near-infrared fluorescent probe, which is a conjugate formed by coating a fluorescent molecule with cyclodextrin. According to the near-infrared fluorescent probe disclosed by the invention, cyclodextrin is nested on a carbon chain of a fluorescent molecule, so that the water solubility, histocompatibility and safety are improved, the fluorescence lifetime is prolonged, the light stability is improved, and rapid transmission and response of ureters, lymphatic vessels and lymph nodes in vivo are realized; the method can be used for NIR-I and NIR-II imaging; a near-infrared fluorescence probe with targeting property can be formed by marking various tumor targeting molecules, so that accurate targeting fluorescence imaging of different types of tumors such as urogenital tumors, head and neck cancers, breast cancers and cervical cancers and metastatic lymph nodes in NIR-I and NIR-II windows is realized, and the near-infrared fluorescence probe can be applied to fluorescence imaging navigation in clinical operations.

Article of clothing (3, 12) for stimulating lymph flow in a body area (1, 11) of a wearer (2) with having a basic body (4, 13) a multitude of protrusions (8) which are arranged on an inside (9) of the garment (3, 12), wherein the projections (8) are arranged such that they form at least one track (7, 16), wherein at least one pathway (7, 16) runs along at least one lymphatic pathway of a carrier (2), characterized by that the basic body (4, 13) comprises diagonally and / or counter-rotating elastic fiber strands and that the projections (8) are point-shaped and / or have a circular cross-section and form part of a spherical sphere, wherein the projections (8) have a height (H) between 0.5 mm and 2 mm and / or a diameter (D) between 0.5 mm and 3 mm and / or a distance (A) of 0.5 cm to 1.5 cm from each other along the at least one track (7, 16).

The invention discloses a B ultrasonic guided lymphangioma simulated sclerosis injection treatment training model set, which belongs to the technical field of treatment training models, and comprises a sterile bag and a support plate, and the top end of the support plate is provided with a model main body placing groove, a needle cylinder placing groove, a lymphatic simulation liquid bottle placing groove, a capsule body model placing groove and a scalp needle placing groove. A hemispherical silica gel model main body is placed in the model main body placing groove, an elastic clamping block is fixedly connected in the needle cylinder placing groove, a needle cylinder is clamped and connected in the elastic clamping block, bag body models are placed in the bag body model placing grooves, and scalp needles are placed in the scalp needle placing grooves; lymphatic simulation liquid bottles are respectively placed in the lymphatic simulation liquid bottle placing grooves. Through the arrangement of the hemispherical silica gel model main body, the needle cylinder, the lymphatic simulation liquid bottle, the capsule body model and the scalp needle, students can visually learn how to simulate lymphangioma simulation sclerosis injection treatment training operation under the guidance of B ultrasound, observation and learning are facilitated, and rapid mastering is easy.

The invention discloses a human body model, and relates to the technical field of teaching instruments, and the human body model comprises a first model frame which is provided with a plurality of first meshes and is used for simulating a human body skeleton; the second model frame is provided with a cavity, a first connecting part, a second connecting part and a plurality of second meshes, the first model frame is arranged in the cavity and detachably connected with the second model frame, the first connecting part is detachably connected with the second connecting part, the second model frame is used for simulating the outer contour of a human body, and the aperture of at least part of the second meshes is larger than that of the first meshes; each of the first model frame and the second model frame comprises at least one of a head and neck, a thorax, an abdomen, a pelvis and four limbs and is correspondingly arranged; the simulation structure comprises a first simulation piece and a second simulation piece, and the first simulation piece is used for simulating blood vessels, nerves and lymphatic vessels; the second simulation piece is used for simulating human muscles and organs. The problem that in the prior art, a human body model used for teaching is difficult to operate manually while the internal structure is visualized is solved.

The present invention relates to a non-vascular injection formulation comprising nanoparticles, the hydrodynamic diameter of which is adjusted to 2 to 20 nm and the surface charge of which is adjusted to-20 to 0 mV by hydration of hydrophilic functional groups exposed on the surface of the nanoparticles such that the nanoparticles do not permeate into or expel into the capillaries of the administration site, the nanoparticles are only selectively excreted into the peripheral lymphatic vessel, but only selectively excreted into the peripheral lymphatic vessel, wherein the nanoparticles: (i) themselves are therapeutic agents; and / or (ii) a carrier for other drugs, thereby providing a drug form in which the nanoparticles are expelled only into the peripheral lymphatic vessel when injected into a tissue region without intravenous administration, thereby extending the residence time at the injection site. Nanoparticles having adjusted hydrodynamic diameter and surface charge according to the present invention can be excreted from the body within a week after administration without any residue at the site of administration, when designed as contrast agents exhibiting a T1MRI contrast effect and injected into tissues in the vicinity of the blood vessel, the nanoparticles can be used as contrast agents that exhibit a T1MRI contrast effect. Peripheral and / or central lymphatic vessels may be selectively imaged without venous contamination.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The invention discloses an anastomosis instrument for connecting multiple lymphatic vessels and blood vessels. The anastomosis instrument comprises a blood vessel connecting piece and a plurality of lymphatic connecting tubes. According to the integrated anastomosis instrument, the multiple lymphatic vessels can be connected to the lymphatic connecting tubes respectively through the arrangement of the integrated anastomosis instrument with the multiple lymphatic connecting tubes, and the lymphatic vessels are finally guided into the same vein blood vessel through the through holes; therefore, an efficient connection mode of multiple lymphatic vessels and a single blood vessel is realized, the surgical operation is greatly simplified, the surgical time is shortened, the surgical difficulty is greatly reduced, and the risks of postoperative bleeding, inflammation and vascular stenosis are reduced; in addition, due to the establishment of a plurality of drainage channels, the total drainage efficiency of lymph is effectively improved, and the device is more suitable for clinical conditions with large lymphatic load.

The invention provides a subdural hematoma targeted drug delivery system, a preparation method thereof and a pharmaceutical preparation, and belongs to the technical field of targeted drugs. The targeted drug delivery system is a drug-loaded liposome, and the drug-loaded liposome comprises a drug active substance and a liposome carrier loaded with the drug active substance; the liposome carrier is prepared from the following components: cholesterol, lecithin, DSPE-PEG (Distearoyl Phosphate Polyethylene-Polyethylene Glycol) and DSPE-PEG-CLTX. The targeted drug delivery system provided by the invention is spherical, small and uniform in particle size, negatively charged on the surface and good in serum stability, can deliver the drug to the subdural hematoma part in a targeted manner, reduces systemic toxicity of the drug, inhibits pyroptosis, relieves inflammatory response, promotes hematoma absorption and meningeal lymphatic vessel drainage, and has a good application prospect. And the purpose of accurate treatment is achieved.

Organ-on-chip system, including a bio-engineered lung region that is functionally connected to a bio-engineered lymphatic region via a functionalized connection region. The bio-engineered lung region includes cultured or transplanted lung cells / tissue, which can mimic in vivo lung function, and the bio-engineered lymphatic region includes lymphatic cells / tissue, which can mimic in vivo lymphatic function. The connection region allows for stimuli and cell secretions to be transported between the lung region and the lymphatic region to confer immune competency to the lung region, as the lymphatic region can generate an immune response based on stimuli received from the lung region, for example, in response to infections or therapeutic agents

The application belongs to the technical field of biological medicine, and provides an application of H151 in preparation of a medicine for treating lymphatic vessel dysfunction, wherein the application uses the STING protein antagonist H151 to treat the lymphatic vessel dysfunction, shows that H151 can significantly inhibit the activation of the cGAS-STING signal path, and then inhibit the secretion of inflammatory factors in the lymphatic endothelial cell, and effectively improve the function of the lymphatic endothelial cell. Therefore, the application uses the STING protein antagonist H151 to treat the lymphatic vessel dysfunction related diseases, opens a new way and method, and effectively solves the problem that the lymphatic vessel dysfunction lacks effective treatment means at present.

The present disclosure relates to systems, devices, and methods for subcutaneously cutting and treating tissue and cellulite with non-invasive acoustic waves. Embodiments of the present disclosure refer to systems, devices, and methods that use unfocused or planar, non-cavitating acoustic waves to induce physical effects in tissue such as dermis, fat, muscle, bone, blood vessels, liver tissue, etc. The physical effects include disruption of the fibrous extracellular matrix of the target tissue. Embodiments of the present disclosure include the application of multiple rapid acoustic pulses (e.g., shockwaves) to cause the breakdown of the fibrous extracellular matrix to reduce the appearance of cellulite or scarring in the treated area. Such unfocused or planar, non-cavitating acoustic waves can induce tissue responses such as reduced fibrosis, induction of angiogenesis or lymphangiogenesis, etc.

The application discloses a marker for depression and application thereof in prevention and treatment of depression. Through the marker, whether an individual is suffering from depression can be detected and diagnosed, so that corresponding treatment strategies can be given in time, and hidden troubles brought by depression to the individual can be reduced. The application also discloses application of the marker in prevention and treatment of depression phenotype. Taking a marker with specific up-regulation as an example, through blocking the function of the marker, prevention and treatment of depression can be realized. Specifically, in addition to specific material markers, it is disclosed that abnormality of meningeal lymphatic vessels is closely related to depression phenotype, and detection of the meningeal lymphatic vessels is expected to be a new marker for early diagnosis and prediction of clinical depression treatment effectiveness. Improvement of the meningeal lymphatic vessels is expected to be applied to treatment of depression and other neurosychiatric diseases related to stress and play an effective treatment role.

The utility model discloses an improved medical decompression vest, including vest front cloth and the fixed connection of vest back cloth outside the left and right sides of vest front cloth and vest back cloth are equipped with the sleeve, and the upper end of vest front cloth and vest back cloth is equipped with the neck, the outside of vest front cloth is sewed up with needle face magic tape, and needle face magic tape is connected with the bonding of wool face magic tape. The improved medical decompression vest, through the setting of splicing cloth belt and first limit hook, can utilize first limit hook and first connecting buckle of different positions to connect, change the neck pressure of the patient wearing the vest, facilitate the treatment of the cervical lymphatic fistula patient, thereby improve the comfort of the use of the vest, through the control of the buckling of different position second connecting buckle and second limit hook, can adjust the pressure of the clavicle position of the chylous fistula patient, thereby facilitate the stable pressure control of the patient, accelerate the recovery of the patient's condition.

The present invention belongs to the technical field of biomedical functional dyes and probes, and relates to a fluorescent probe, specifically a cyclodextrin-based near-infrared fluorescent probe. The near-infrared fluorescent probe is a conjugate in which a fluorescent molecule is encapsulated by cyclodextrin. In the near-infrared fluorescent probe of the present invention, the cyclodextrin is embedded onto a carbon chain of the fluorescent molecule, which improves the water solubility, histocompatibility and safety, enhances the fluorescence lifetime and photostability, and achieves rapid delivery and response in ureters, lymphatic vessels and lymph nodes in vivo. The near-infrared fluorescent probe can be used for NIR-I and NIR-II imaging. In addition, the near-infrared fluorescent probe can be labeled with various tumor-targeting molecules to form targeted near-infrared fluorescent probes, thereby achieving precise targeted fluorescence imaging in both NIR-I and NIR-II windows for different types of tumors such as genitourinary tumors, head and neck cancer, breast cancer and cervical cancer, and metastatic lymph nodes. The near-infrared fluorescent probe can be used for the navigation of fluorescence imaging during clinical surgeries.

The rapid lymphatic vein communication device comprises an elastic tube body, notches which are symmetrical left and right are formed in the front end of the tube body, the notches are in the shape with the large front portion and the small rear portion, the tube thickness of the notch areas is sequentially decreased from back to front, the section of the tube body is in an oval shape, and the section of the tube body is in an oval shape. The upper end and the lower end of the tube body are provided with sheet-shaped protrusions on the right side of the notch, and lymphatic vessel generation promoting factors are embedded or coated on the tube wall of the tube body. According to the invention, lymphatic tissues and veins can be communicated efficiently and quickly; blood reflux and thrombosis are avoided; sewing operation is not needed or reduced; blood vessel blocking is not needed; specific growth factors contained in the kit can promote the generation of normal lymph lumen, form autologous biological lumen in the later period, and maintain long-term smoothness.

The present invention relates notably to a new isolated splice variant isoform of VEGF having pro-angiogenic and pro-lymphangiogenic activity, said isolated isoform comprising an amino acid sequence having at least 80%, preferably at least 95%, identity to the amino acid sequence of SEQ ID NO:1, preferably is VEGF222 / NF and consists of SEQ ID NO:1.

The application belongs to the technical field of biomedical diagnosis, and provides application of neutrophil extracellular traps in preparation of a lymphangitic inflammation diagnosis kit, wherein the application first discloses high expression of neutrophil extracellular traps in lymphangitic inflammation lesion tissues, and confirms that the expression level is closely related to disease occurrence and development, so that the neutrophil extracellular traps are used as an early diagnosis index to fill the technical blank of lack of early non-invasive screening means for lymphangitic inflammation in the prior art, precise diagnosis and disease monitoring of subclinical stage occult lymphangitic inflammation can be realized, misdiagnosis and missed diagnosis can be effectively avoided, reliable technical support and theoretical basis are provided for early prevention and timely intervention of serious complications such as secondary lymphedema, and thus the incidence of complications is significantly reduced and the prognosis of patients is improved.

In some embodiments herein, implantable scaffolds, their compositions, and methods for modulating lymphatic pathway in the central nervous system and in the vicinity of the central nervous system are presented. Modulating lymphatic pathway, increasing the flow and / or turnover of fluid in the central nervous system, and, in particular, inducing formation of new lymphatic vessels, in accordance with some embodiments, are used to treat, prevent, or ameliorate symptoms of neurodegenerative diseases.

This invention discloses an instrument for connecting lymphatic vessels and blood vessels, comprising a vascular connecting tube, a connecting lumbar tube, and at least one connecting branch tube. The connecting branch tube includes interconnected primary and secondary branches, through which lymph fluid can enter the bloodstream. This instrument enables a stable connection between lymphatic vessels and blood vessels via the instrument itself, rather than relying solely on surgical sutures. This simplifies the surgical procedure, reduces the stringent requirements on the surgeon's skills, significantly reduces the difficulty and risk of the surgery, decreases the incidence of postoperative complications, improves patient recovery speed and treatment effectiveness, and provides a more convenient and reliable connection method, greatly enhancing the convenience, safety, and effectiveness of connecting lymphatic vessels and blood vessels.

A method of inducing lymphangiogenesis in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of inducing lymphangiogenesis in a tumor in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of treating a cancer of the brain or central nervous system is also provided in which an effective amount of a lymphangiogenesis inducer is administered. An example of a lymphangiogenesis inducer is VEGFC. The lymphangiogenesis inducer can be in the form of a protein or a polynucleotide encoding the protein, such as an mRNA or AAV. The lymphangiogenesis inducer can be administered to the cistema magna or directly into the lymphatic system. An immunotherapeutic agent, such as a checkpoint inhibitor, may also be administered.

Some embodiments of the invention advantageously leverage the expansion, dilation or by-pass of the Schlemm's canal using adjustable reversible self-expanding eye stents (SES) or eye tension rings (ETRs) of desired sizes to control and improve aqueous flow throughout the range of the uveolymphatic canal. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the Schlemm's canal wall and is at least partially within the canal and / or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the wall and / or elsewhere in the canal. The partial or complete expansion of the canal can be pre-configured based on pre-operative metrology of the Schlemm's canal to a customized and adjustable fit across the various zones within the uveolymphatic canal and based on the patient specific and evolving needs. Additionally, the SES can utilize entry / exit features for by-pass of fluid, varying control of dilation across its shape that may also allow anchoring, repositioning, and retrieval.

The present invention relates to a human implant for inducing regeneration of body vessels and a method for treating lymphedema or ischemic diseases using the same. The structure of the present invention not only provides appropriate physical strength and mechanical support to prevent re-injury of body vessels such as lymphatic vessels or blood vessels during regeneration, but also structurally and functionally mimics in vivo body vessel tissue by promoting the flow of body fluids through capillary action using a simple rod structure with irregularities (e.g., H-beams) or lumens (e.g., tubular). Furthermore, the structure of the present invention is implanted into the lesion and decomposes at an appropriate time after the completion of body vessel regeneration, making it useful as an efficient treatment for various pathological conditions caused by blocked lymphatic flow or reduced blood flow.

The invention discloses a contact structure for in-vivo targeted therapy, and belongs to the technical field of medical instruments, the structure is flexible, degradable and free of rigid support, can be conveyed to an in-vivo target position in an interventional minimally invasive mode, and is in contact with at least one surface and inside of a blood vessel wall, a lymphatic vessel wall and visceral organ tissues, and the contact structure is used for in-vivo targeted therapy. Blood vessel walls, lymphatic vessel walls and surfaces and interiors of visceral organ tissues can be contacted at the same time; the structure contains a drug and releases the drug at a target position; the flexible, degradable and rigid-support-free structural design is adopted, and the drug delivery system can be safely conveyed to the in-vivo target position in a minimally invasive intervention mode and can be stably attached to the surfaces and the interiors of blood vessel walls, lymphatic vessel walls and visceral organ tissues, so that accurate release of the drug in a focus area is achieved, the treatment targeting is remarkably improved, and the side effect of systemic medication is reduced.

The invention provides a composite hydrogel for lymphatic tissue repair, which is formed by photo-crosslinking a gelatin-dopamine hydrogel capable of being subjected to methacrylic acid esterification, a lymph node acellular matrix and a photo-crosslinking initiator. The invention also provides a preparation method of the composite hydrogel, a re-cellularized hydrogel and application of the composite hydrogel and the re-cellularized hydrogel in preparation of a material for treating lymphatic tissue defects. By compounding the lymph node acellular matrix and the photo-crosslinkable gelatin dopamine hydrogel, a stent carrier which has natural biological signals, is suitable for a three-dimensional microenvironment and has good mechanical properties and in-situ forming characteristics is constructed, and an ideal platform is provided for field planting, growth and function exertion of ADSCs at a lymphatic tissue defect part; the ADSCs are assisted to play a repairing role in promoting lymphatic vessel regeneration and regulating a local microenvironment, and a novel composite hydrogel stent system adaptive to a cell repairing function is provided for treatment of related diseases such as lymphedema.