235 results about "Lymphatic vessel" patented technology

The invention relates to the technical field of drug toxicity evaluation, in particular to an evaluation method for examining toxic and side effects of drugs through a biological organ model. The method comprises the following steps: pretreating a cell line, and carrying out mixed culture with a skeleton structure; connecting an organ model through a biochip; designing a micro-channel network to form a circulation simulation system, and adjusting micro-environment parameters; embedding a biosensor into the biological organ model, and collecting data; adding drugs with different concentrations, and evaluating according to data. According to the method, firstly, the liver, the kidney and the heart are constructed, then the three organ models are connected through the microfluidic technology, microenvironment factors such as micro blood vessels and lymphatic vessels are introduced into the connecting positions, finally, the biosensor technology is introduced, the cell state, metabolites and microenvironment parameters in all the organ models are monitored in real time, and the three organ models are obtained. Through the multi-dimensional biological organ model, the influence of the medicine on different organs can be evaluated more comprehensively.

The invention relates to the technical field of biological medicine, in particular to a lymphatic metastatic breast cancer treatment target and application thereof. The exosome piR-hsa-28212 disclosed by the invention can synergistically enhance VEGFC / VEGFR3 signal transduction, so that lymphatic vessel generation in breast cancer is promoted, and the potential of the exosome piR-hsa-28212 serving as a treatment target of lymphatic metastatic breast cancer is indicated. Besides, piR-hsa-28212 in the serum exosome of the breast cancer patient with lymphatic metastasis is obviously up-regulated, so that the piR-hsa-28212 can be used as a serum marker for predicting the lymphatic metastasis of the breast cancer, and has the advantages of noninvasive property, in-vitro stability, acquisition of samples and the like.

The invention discloses an NIR-II video lymphatic vessel segmentation method based on Frangi and multi-frame accumulation, and belongs to the field of computer vision, and the method comprises the following steps: converting a video into a frame image; preprocessing the frame image by using a contrast limited adaptive histogram equalization algorithm and neighborhood mean filtering; performing top-hat transformation on the preprocessed image to obtain a rough foreground image; taking a mean value of non-zero pixels as a threshold value, and performing adaptive segmentation frame by frame; accumulating the output binary image, and enhancing a tubular structure in the image by using Frangi filtering; and performing certain morphological processing on the image after Frangi filtering to obtain a final lymphatic vessel segmentation result. According to the NIR-II video lymphatic vessel segmentation method based on Frangi and multi-frame accumulation, the detection capability of low-contrast lymphatic vessels with tiny disturbance in the video is improved.

The present invention provides a lipid nanoparticle used for delivering a nucleic acid to a lymphatic endothelial cell, including an ionic lipid represented by the formula (1), cholesterol, and a dimyristoylglycerol PEG with a number average molecular weight of PEG chain of 1,000 to 3,000, wherein an amount of the dimyristoylglycerol PEG is not less than 3 mol % with respect to the total of the ionic lipid represented by the formula (1) and the cholesterol (the symbols in the formula (1) are as defined in the specification).

A contrast agent for imaging lymph nodes or lymphatic vessels with near-infrared light that can selectively image primary lymph nodes relative to secondary or higher lymph nodes. A dose of the composition suitable for imaging lymph nodes or lymphatic vessels.

Some embodiments of the invention advantageously leverage the expansion, dilation or by-pass of the Schlemm's canal using adjustable reversible self-expanding eye stents (SES) or eye tension rings (ETRs) of desired sizes to control and improve aqueous flow throughout the range of the uveolymphatic canal. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the Schlemm's canal wall and is at least partially within the canal and / or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the wall and / or elsewhere in the canal. The partial or complete expansion of the canal can be pre-configured based on pre-operative metrology of the Schlemm's canal to a customized and adjustable fit across the various zones within the uveolymphatic canal and based on the patient specific and evolving needs. Additionally, the SES can utilize entry / exit features for by-pass of fluid, varying control of dilation across its shape that may also allow anchoring, repositioning, and retrieval.

The invention belongs to the technical field of medical data processing, and particularly relates to a bladder cancer vessel tumor embolus assessment method and system based on multi-modal feature fusion, and the optimization method comprises the steps: obtaining and preprocessing the pathological information and image data of a bladder cancer patient, extracting a CT image corresponding to a tumor, and determining a region of interest; image omics features are extracted from the region of interest of the CT image, and deep learning features are extracted from the maximum tumor cross section; carrying out feature selection processing on the obtained radiomics features and deep learning features, and inputting the processed features into a fusion model; and outputting a probability value of'lymphatic vessel invasion 'by the fusion model to obtain an evaluation result. A multi-modal machine learning model is constructed by fusing radiomics features and deep learning features extracted from a CT image, and the objective of the invention is to noninvasively and accurately evaluate the lymphatic vessel infringement state of bladder cancer before an operation, so that a key basis is provided for clinical individualized treatment decision-making.

The invention discloses a modular tumor microenvironment response polypeptide and a preparation method and application thereof. The modular tumor microenvironment response polypeptide is composed of the following functional modules: a targeting and chemotactic module used for targeting tumor cell surface p32 protein and tumor lymphatic vessels and promoting tumor tissue penetration and enrichment; the microenvironment double-response module is used for being cut by MMP-2 / 9 enzyme and broken by high-concentration glutathione GSH in a tumor microenvironment to trigger self-assembly; the self-assembly driving module is used for exposing after the microenvironment responds to activation and driving short peptides to be self-assembled to form a nano structure; a killing module: a pro-apoptotic peptide PAD used for targeting a mitochondrial membrane and inducing tumor cell apoptosis; and the stability optimization module is used for enhancing the degradation resistance of the oligopeptide. By integrating targeted delivery, enzyme digestion response, acid-sensitive release and stabilizing structures, the problems of insufficient targeting property, inaccurate release, poor stability, diagnosis-treatment splitting and the like of the anti-tumor drug and the developing agent are solved.

The invention relates to a gynecological pelvic and abdominal lymphatic cleaning prediction model training method and a lymph node model.The training method comprises the steps that preoperative image data and intraoperative instrument operation parameters of historical patients are subjected to modeling processing, and a dynamic mechanics-fluid coupling lymph node model based on bionic materials is constructed; mechanical deformation and fluid flow of a lymphatic system in various clinical scenes are simulated; performing data acquisition processing on the used lymph node model, and quantifying the dynamic influence of the surgical operation on the lymphatic system; the relevance between historical operation and injury risk is deeply learned, and the lymphatic vessel rupture probability is output; real-time feedback control processing is carried out based on the lymphatic vessel rupture probability, a training correction instruction and a risk thermodynamic diagram are generated, and medical workers are guided to optimize surgical skills. Through fusion analysis of the high-fidelity bionic model and multi-modal data, dynamic simulation of the mechanical-fluid coupling effect in the operation and real-time quantification of the operation risk are achieved, and the accuracy and clinical transformation value of operation training are improved.

The invention belongs to the technical field of biomedical functional dyes and probes, and relates to a fluorescent probe, in particular to a cyclodextrin-based near-infrared fluorescent probe, which is a conjugate formed by coating a fluorescent molecule with cyclodextrin. According to the near-infrared fluorescent probe disclosed by the invention, cyclodextrin is nested on a carbon chain of a fluorescent molecule, so that the water solubility, histocompatibility and safety are improved, the fluorescence lifetime is prolonged, the light stability is improved, and rapid transmission and response of ureters, lymphatic vessels and lymph nodes in vivo are realized; the method can be used for NIR-I and NIR-II imaging; a near-infrared fluorescence probe with targeting property can be formed by marking various tumor targeting molecules, so that accurate targeting fluorescence imaging of different types of tumors such as urogenital tumors, head and neck cancers, breast cancers and cervical cancers and metastatic lymph nodes in NIR-I and NIR-II windows is realized, and the near-infrared fluorescence probe can be applied to fluorescence imaging navigation in clinical operations.

The invention relates to a model for predicting an early gastric cancer lymph node metastasis risk and a construction method and application thereof. The input variables of the model comprise gender, tumor position, tumor maximum diameter, pathological differentiation degree, pT staging condition, submitted lymph node number and lymphatic vessel invasion condition, and the output value of the model is lymph node metastasis prediction probability. A model for predicting the lymph node metastasis risk of the early gastric cancer is designed, the lymph node metastasis risk of a patient with the early gastric cancer can be accurately evaluated through the model, a model for predicting the number of the lymph node metastasis is further obtained, a corrected pN stage (pNM) is provided based on the predicted number of the lymph node metastasis, and the establishment of the pNM stage can be used for predicting the lymph node metastasis risk of the patient with the early gastric cancer. The method can be applied to diagnosis of early gastric cancer patients who cannot perform sufficient lymph node cleaning due to various reasons, is helpful for clinicians to evaluate and calculate early gastric cancer patients who do not reach the sufficient number of detected lymph nodes, and provides a new way for accurate clinical evaluation.

The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and / or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

The invention belongs to the technical field of biology, and discloses a biological tissue transparentizing kit, an imaging method and application, the biological tissue transparentizing kit comprises a biological tissue transparentizing agent and an antibody incubation agent, and the antibody incubation agent comprises a first incubation agent and a second incubation agent; according to the tissue transparentizing reagent disclosed by the invention, the permeability of antibodies in tissues is optimized, the antibodies are uniformly distributed in the tissues, and the efficiency and effect of tissue transparentizing treatment and subsequent immunolabeling are greatly improved; the tissue transparentizing imaging method can enhance the tissue transparentizing efficiency and degree, is especially suitable for integrated visual detection of multiple tissues such as blood vessels, nerves, lymphatic vessels, muscles, osteochondral tissues and the like of a motor system, and has a better detection effect on proteins with low expression quantity and unstable properties.

A hyaluronic acid based three dimensional bioengineered vessel includes living biological cells, and norbornene functionalized hyaluronic acid (Nor-HA) comprising a hyaluronic acid derivative and a plurality of norbornene moieties covalently linked to the hyaluronic acid derivative, at least a portion of the plurality of norbornene moieties being crosslinked via a thiol linkage, respectively, to each of a thiol functionalized metalloproteinase (MMP) sensitive peptide, and a thiol functionalized RGD peptide to provide an HA-crosslinked hydrogel matrix that comprises HA- norbornene-MMP sensitive peptide-norbornene-HA linkages and HA-norbornene- cell adhesive peptide-biological cell linkages, the matrix maintained in a culture medium comprising MV2 culture media and at least VEGF-C and Ang2. The three dimensional bioengineered vessel comprises one or more of individual tubes, branched tubes, lymphatic capillaries with button like junction, and lymphatic valve with zipper like junction, and can transport lymph fluid and immune cells.

A lymphangiogenesis inducing device includes: a puncture member comprising a distal end portion configured to puncture living tissue, and a through hole penetrating the puncture member along a central axis and extending from the distal end portion toward a proximal end; and a rod-shaped body inserted into the through hole and configured to be moved so as to protrude from the distal end portion. The rod-shaped body comprises a shaft portion, and a wound imparting structure comprising at least one protrusion located on the shaft portion and configured to impart a wound to the living tissue. The at least one protrusion has a protruding height from the shaft portion that increases when the at least one protrusion transitions from a state in which the at least one protrusion is located in the through hole to a state in which the at least one protrusion is located outside the through hole.

Article of clothing (3, 12) for stimulating lymph flow in a body area (1, 11) of a wearer (2) with having a basic body (4, 13) a multitude of protrusions (8) which are arranged on an inside (9) of the garment (3, 12), wherein the projections (8) are arranged such that they form at least one track (7, 16), wherein at least one pathway (7, 16) runs along at least one lymphatic pathway of a carrier (2), characterized by that the basic body (4, 13) comprises diagonally and / or counter-rotating elastic fiber strands and that the projections (8) are point-shaped and / or have a circular cross-section and form part of a spherical sphere, wherein the projections (8) have a height (H) between 0.5 mm and 2 mm and / or a diameter (D) between 0.5 mm and 3 mm and / or a distance (A) of 0.5 cm to 1.5 cm from each other along the at least one track (7, 16).

The invention relates to a medical access system for providing access to a hollow body of a patient, the access system having at least one catheter with a tubular catheter intermediate tube, the catheter being configured to, after a puncture of a sheath of the hollow body to be punctured, provide access to the hollow body to be punctured. Through an opening through the sheath of the hollow body by means of a puncture needle or otherwise implemented, the catheter is pushed over at least a portion of the length of the catheter intermediate tube and is retained there for a period of time. Such a hollow body of a patient may be, for example, a tubular tube, in particular a blood vessel, such as a vein or artery or lymphatic vessel, or other hollow organ.

Provided is an effective agent for the treatment of intractable lymphangiopathy and intractable vascular disease. A therapeutic agent for intractable lymphatic diseases and intractable vascular diseases, which contains sirolimus as an active ingredient, and which is administered orally or via a tube at an administration amount that is determined on the basis of parameters associated with the in-vivo dynamics of sirolimus in a patient suffering from the diseases and the body weight and month age of the patient.

A method of forming a wound for inducing lymphangiogenesis includes: providing a lymphangiogenesis inducing device that includes: a puncture member including a distal end portion configured to puncture living tissue, and a through hole penetrating the puncture member along a central axis and extending from the distal end portion toward a proximal end, and a rod-shaped body inserted into the through hole and configured to be moved so as to protrude from the distal end portion, where the rod-shaped body includes a shaft portion, and a wound imparting structure; puncturing the living tissue with the lymphangiogenesis inducing device while the rod-shaped body is located in the through hole; passing the lymphangiogenesis inducing device through a regeneration route; pulling back the puncture member while the rod-shaped body is left in the living tissue; and pulling back the rod-shaped body.

The invention discloses a B ultrasonic guided lymphangioma simulated sclerosis injection treatment training model set, which belongs to the technical field of treatment training models, and comprises a sterile bag and a support plate, and the top end of the support plate is provided with a model main body placing groove, a needle cylinder placing groove, a lymphatic simulation liquid bottle placing groove, a capsule body model placing groove and a scalp needle placing groove. A hemispherical silica gel model main body is placed in the model main body placing groove, an elastic clamping block is fixedly connected in the needle cylinder placing groove, a needle cylinder is clamped and connected in the elastic clamping block, bag body models are placed in the bag body model placing grooves, and scalp needles are placed in the scalp needle placing grooves; lymphatic simulation liquid bottles are respectively placed in the lymphatic simulation liquid bottle placing grooves. Through the arrangement of the hemispherical silica gel model main body, the needle cylinder, the lymphatic simulation liquid bottle, the capsule body model and the scalp needle, students can visually learn how to simulate lymphangioma simulation sclerosis injection treatment training operation under the guidance of B ultrasound, observation and learning are facilitated, and rapid mastering is easy.

The present invention relates to the application of CircRAB3IP in the preparation of drugs for treating heart failure, belonging to the field of biomedical technology. The present invention provides the application of CircRAB3IP in the preparation of drugs for preventing or treating heart failure, myocardial fibrosis, myocarditis or promoting lymphangiogenesis; provides the application of CircRAB3IP in the preparation of a prognostic diagnostic kit for heart failure. Through the present invention, it is disclosed that CircRAB3IP is involved in the regulation of lymphangiogenesis and has a protective effect on the heart in hypertensive cardiac remodeling; through the present invention, the cardiac dysfunction caused by hypertensive mechanical stress can be effectively improved, cardiac remodeling and myocardial fibrosis can be slowed down, and cardiac inflammation can be reduced; a new target for the treatment of hypertensive cardiac remodeling is provided.

The invention discloses a decellularized artificial lymph drainage tube and a preparation method and application thereof, and the preparation method of the decellularized artificial lymph drainage tube comprises the following steps: taking an animal blood vessel as a raw material, and performing decellularization treatment, cleaning treatment, enhancement treatment, hole forming treatment and drying treatment on the raw material. The decellularized artificial lymph drainage tube prepared by the preparation method can solve the problems of long consumed time and difficult operation of the existing lymphatic vessel-vein anastomosis operation, can drain the lymph at the swelling part of a patient to the vein system in time after implantation, and can quickly relieve the swelling symptom. The decellularized artificial lymph drainage tube supports ingrowth, migration and proliferation of autologous cells and is good in biocompatibility, the degradation time can be adjusted to be matched with the reconstruction time of an autologous lymphatic reflux system, and long-term patency is guaranteed.

The invention provides an iopromide-ethanol composition as well as a preparation method and application thereof, and relates to the technical field of medicines. The iopromide-ethanol composition provided by the invention is an injection and consists of iopromide, ethanol and water for injection, the liquid medicine can be used for treating vascular deformity, lymphatic vessel deformity, mixed deformity and the like, tedious operation caused by two-step injection of treatment and radiography is reduced, treatment and development can be completed only through one-step injection, the purpose of dynamic monitoring in the treatment process is achieved, and compared with suspension liquid, the liquid medicine has the advantages of higher treatment precision, smaller side effect, smaller irritation and lower cost. The stability is higher, and the clinical safety can be effectively ensured.

The invention discloses a human body model, and relates to the technical field of teaching instruments, and the human body model comprises a first model frame which is provided with a plurality of first meshes and is used for simulating a human body skeleton; the second model frame is provided with a cavity, a first connecting part, a second connecting part and a plurality of second meshes, the first model frame is arranged in the cavity and detachably connected with the second model frame, the first connecting part is detachably connected with the second connecting part, the second model frame is used for simulating the outer contour of a human body, and the aperture of at least part of the second meshes is larger than that of the first meshes; each of the first model frame and the second model frame comprises at least one of a head and neck, a thorax, an abdomen, a pelvis and four limbs and is correspondingly arranged; the simulation structure comprises a first simulation piece and a second simulation piece, and the first simulation piece is used for simulating blood vessels, nerves and lymphatic vessels; the second simulation piece is used for simulating human muscles and organs. The problem that in the prior art, a human body model used for teaching is difficult to operate manually while the internal structure is visualized is solved.

The invention discloses an oral cancer diagnosis model construction method, which is based on DeepLabv3 +, increases an auxiliary branch to provide position information for a diagnosis model and increases SCConv attention so as to realize segmentation processing of oral cancer multi-tissue category pathological images. The method comprises the following steps: acquiring sample set labeling data sets ORA-TCGA and ORA-Nine for training a diagnosis model, classifying data set tissues into tumors, epithelium, interstitial substances, lymphatic vessels, skeletal muscles and vessels, and performing diagnosis model training and prediction by using OCMS-Net. The diagnosis model is based on OCMS-Net and comprises a main branch A and an auxiliary branch B, the input of the main branch A is an oral cancer pathological image, the output of the main branch A is a segmentation mask, and the segmentation mask represents different tissue types with different colors; the input of the auxiliary branch B is an oral cancer pathological image, and the output of the auxiliary branch B is a binary segmentation map and a nuclear pixel distance map of a cell nucleus.

In some embodiments herein, methods, compositions, and uses for countering the effects of aberrant meningeal lymphatic drainage and / or modulating lymphatic vessels of the central nervous system are described. In some embodiments, methods, compositions, or uses for treating, preventing, or ameliorating symptoms of a neurodegenerative disease associated with aberrant meningeal lymphatic drainage are described. Modulating lymphatic vessels, or countering the effects of aberrant meningeal lymphatic drainage, in accordance with some embodiments, are used to diagnose, treat, prevent, or ameliorate symptoms of neurodegenerative diseases such as Alzheimer's disease (AD) and dementia. Methods of diagnosing and monitoring the progression of neurological diseases are also provided.

The present invention relates to a non-vascular injection formulation comprising nanoparticles, the hydrodynamic diameter of which is adjusted to 2 to 20 nm and the surface charge of which is adjusted to-20 to 0 mV by hydration of hydrophilic functional groups exposed on the surface of the nanoparticles such that the nanoparticles do not permeate into or expel into the capillaries of the administration site, the nanoparticles are only selectively excreted into the peripheral lymphatic vessel, but only selectively excreted into the peripheral lymphatic vessel, wherein the nanoparticles: (i) themselves are therapeutic agents; and / or (ii) a carrier for other drugs, thereby providing a drug form in which the nanoparticles are expelled only into the peripheral lymphatic vessel when injected into a tissue region without intravenous administration, thereby extending the residence time at the injection site. Nanoparticles having adjusted hydrodynamic diameter and surface charge according to the present invention can be excreted from the body within a week after administration without any residue at the site of administration, when designed as contrast agents exhibiting a T1MRI contrast effect and injected into tissues in the vicinity of the blood vessel, the nanoparticles can be used as contrast agents that exhibit a T1MRI contrast effect. Peripheral and / or central lymphatic vessels may be selectively imaged without venous contamination.

The invention belongs to the technical field of organ cores, and provides a brain lymphatic circulation reflux system multi-organ cascade chip model construction method and a model, and the method comprises the following steps: adjusting the size of a channel inlet and outlet of a brain lymphatic chip to be consistent with the size of a middle channel inlet of a meningeal lymphatic chip; the size of an outlet of a middle channel of the meningeal lymphatic vessel chip is adjusted to be consistent with the size of an inlet of a channel of the deep cervical lymph node chip; corresponding outlets and inlets of the brain lymphatic chip, the meningeal lymphatic vessel chip and the deep cervical lymph node chip are communicated through catheters, series connection of the three chips is achieved, the flowing process is consistent with the cerebrospinal fluid lymphatic circulation backflow process, and the blank that the cerebrospinal fluid lymphatic circulation backflow process cannot be achieved in vitro before is filled up. Moreover, the brain lymphatic chip, the meningeal lymphatic vessel chip and the deep cervical lymph node chip are cascaded to one substrate, so that the actual sizes of the three chips are reduced, and the cascade operation of multiple chips is more convenient.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The invention relates to application of polypeptide in preparation of drugs for preventing, inhibiting and / or treating angiogenesis diseases and lymphangiogenesis diseases, in particular to diseases such as cancer, ophthalmic diseases, arteriosclerosis, heart, brain and kidney vascular diseases, Alzheimer's disease, aging diseases and scar formation.