314 results about "Lung function" patented technology

The invention relates to the technical field of medical prediction, in particular to a digital twinborn prediction method for patient lung protective ventilation supported by ECMO, which comprises the following steps: extracting flow velocity change and jump points under the support of ECMO, constructing a ventilation fluctuation trend map, identifying fluctuation sections by combining compliance and pressure value ratio, delimiting lung partitions and analyzing oxygenation ratio trend. And generating an oxygenation capability classification graph, sequencing ventilation path effects, and outputting a pulmonary protective ventilation digital twinborn prediction scheme. According to the method, dynamic response mapping of ventilation behaviors is established on the basis of timing sequence changes of breathing flow velocity jump characteristics and compliance pressure value ratios, the lung regional ventilation state is accurately recognized, lung function zoning division is achieved by combining oxygenation ratio waveform classification, ventilation path utility sorting is completed through oxygenation descending characteristics under path coverage, and the lung function evaluation accuracy is improved. And a path state prediction sequence is constructed by fusing the change relationship between the tensile stress and the ventilation pressure, so that the dynamic adaptability of the ventilation strategy to the lung mechanics and oxygenation state and the region matching precision are improved.

The present disclosure provides methods of treating pulmonary fibrosis, the methods comprising administering taladegib to a subject in need thereof.

The invention belongs to the technical field of lung rehabilitation training, and particularly relates to a lung rehabilitation training effect evaluation system and method based on multi-modal data fusion. According to the method, a dynamic reference model conforming to individual differences is established through three-dimensional pulmonary respiration mobility modeling based on patient CT images, individualized comparative analysis of lung function recovery states of different patients is achieved, and meanwhile external respiration dynamics and internal physiological state parameters are collected and fused; rehabilitation quality is evaluated from the two aspects of exercise performance and physiological response, scientificity and reliability of evaluation are remarkably improved, a patient can visually perceive difference between own breathing actions and an ideal state through AR visual correction prompts, active correction of actions and muscle memory formation are promoted, effectiveness of rehabilitation training is improved, and the rehabilitation training effect is improved. The training difficulty and the resistance threshold value are dynamically adjusted according to the historical evaluation result and the real-time correction effect, it is guaranteed that rehabilitation training is gradually strengthened within the safe and reasonable range, and the rehabilitation efficiency is improved.

The invention discloses a lung function evaluation method for a patient in a pneumonia rehabilitation period, and relates to the technical field of rehabilitation management. Extracting a lung function feature set based on the image data; analyzing based on multi-dimensional parameter association, and establishing a dynamic mapping relationship between the lung function feature set and associated physiological parameters; identifying abnormal associated parameters through a dynamic mapping relation between the lung function feature set and the associated physiological parameters, and when the deviation between the image feature recovery degree and the corresponding physiological parameter recovery degree exceeds a preset threshold value, judging that functional abnormal parameters exist; and matching a potential complication database based on the abnormal parameter type, analyzing the relevance between the abnormal parameter and a preset disease feature model, and outputting secondary disease risk early warning. The method has the advantages that through cross-modal fusion of the lung image features and the dynamic physiological parameters, the early recognition precision of the pneumonia convalescence complication is remarkably improved.

The embodiment of the invention relates to a lung function detection system which comprises a trolley used for bearing all functional modules of the detection system; the ventilation module comprises a valve body and a valve element, and the valve element is switched to be connected or disconnected with a valve body channel through actions so as to form different ventilation paths; the airway resistance module is configured to detect airway resistance parameters in the breathing process; the digital handle comprises a flow velocity tube provided with a total pressure channel, a static pressure channel and a sampling channel, the digital handle is configured to be selectively installed on the ventilation module or the airway resistance module, the breathing pressure is obtained through the total pressure channel and the static pressure channel in the breathing test process, and a corresponding gas sample is collected through the sampling channel; wherein the ventilation module is installed on the trolley through the first mechanical arm, the air channel resistance module is installed on the trolley through the second mechanical arm, and the digital handle is detachably connected to the trolley, the ventilation module or the air channel resistance module.

The present disclosure provides methods of treating pulmonary fibrosis, the methods comprising administering taladegib to a subject in need thereof.

The invention provides a breathing mode analysis method and device based on a calm breathing pressure difference waveform and electronic equipment, and relates to the technical field of medical signal processing and artificial intelligence, and the method comprises the following steps: obtaining a calm breathing pressure difference original signal of a target user; preprocessing the calm breathing pressure difference original signal to obtain a target waveform sequence; performing feature extraction based on the target waveform sequence to obtain a plurality of dimension features; combining the at least two dimension features to obtain a multi-modal feature; and inputting the multi-modal features into a trained classification model, and outputting a breathing pattern classification result. According to the method, the whole analysis process is completely based on natural calm breathing, special cooperation or forced breathing actions of the user are not needed, the pain point that traditional lung function examination has a high requirement for the user cooperation degree is solved, and auxiliary decision making of chronic respiratory diseases is achieved.

Provided are methods and systems for measuring lung function, such as shunt and deadspace, using pulmonary gas exchange in management and treatment of pulmonary diseases including COVID-19.

The invention relates to the technical field of biological medicines, in particular to a pharmaceutical composition and application thereof in preparation of a medicine for treating the heart-lung qi deficiency type pulmonary heart disease. The pharmaceutical composition consists of 21-27 parts of astragalus membranaceus, 13-17 parts of semen lepidii, 7-10 parts of cassia twig, 21-27 parts of ligusticum wallichii, 7-10 parts of rhizoma alismatis, 5-7 parts of platycodon grandiflorum and 2-4 parts of Chinese dates. Compared with the prior art, the cassia twig is adopted to replace fructus psoraleae in an original formula, and meanwhile, the medicinal material specifications of the fried semen descurainiae, the raw ligusticum wallichii and the salted rhizoma alismatis are preferably selected. The invention also provides three preparation methods of the pharmaceutical composition, namely a water extraction and alcohol precipitation method, an alcohol extraction and water extraction combined method and a crushing and mixing method. Experimental results show that the pharmaceutical composition has remarkable effects on improving heart functions, lung functions, blood-gas indexes, right ventricular hypertrophy and the like of pulmonary heart disease model animals, meanwhile, the hepatotoxicity risk of fructus psoraleae is avoided, and the pharmaceutical composition has a good clinical application prospect.

The present application belongs to the technical field of medicine preparation, and relates to application of a blood-nourishing oral liquid in preparation of medicine for improving blood oxygen saturation. The blood-nourishing oral liquid can improve blood oxygen saturation, improve hypoxemia, improve lung function, and has a preventive and / or therapeutic effect on lung injury, especially acute lung injury.

The invention provides a traditional Chinese medicine composition for treating or improving asthma, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: inula flower, tabasheer, Japanese ardisia herb, cymbopogon distans, ligusticum, pyrrosia lingua, pawpaw, yam rhizome, rhizoma atractylodis, walnut meat, maltose, citron and liquorice. The monarch, minister, assistant and guide in the traditional Chinese medicine composition make the best responsibility, the traditional Chinese medicine composition aims at the symptoms of phlegm-qi obstruction and adverse rising of lung qi of asthma, also has the effects of strengthening the spleen, tonifying the kidney, soothing the liver and the like to consolidate the root cause, has the effects of dispelling wind and ventilating the lung, eliminating phlegm and lowering adverse qi, tonifying the spleen and eliminating dampness, warming the kidney and absorbing qi, and regulating the liver and regulating qi, and has the effects of purgation and tonification and treatment of both symptoms and root causes. The traditional Chinese medicine composition can effectively inhibit airway inflammation reaction of asthma model mice and improve clinical symptoms of the asthma mice, and is remarkable in treatment effect. The traditional Chinese medicine composition disclosed by the invention has a relatively high total effective rate for treating asthma, and has more advantages in the aspects of relieving clinical symptoms of asthma patients and improving lung functions.

The application relates to kaempferol cerium nanoparticles and a preparation method and application thereof, and belongs to the technical field of biological medicines. The kaempferol cerium nanoparticles are prepared by performing coordination co-assembly on kaempferol and cerium ions in the presence of polyethylene glycol at a specific molar ratio, and the nanoparticles have uniform particle sizes and good dispersity. The nanoparticles have the anti-inflammatory activity of kaempferol and the ROS scavenging capacity of cerium ions, and show a significant synergistic effect in in-vivo and in-vitro experiments, can effectively reduce lung inflammation, inhibit oxidative stress, improve lung function, and have good biological safety, thereby providing a new drug candidate scheme for the treatment of ARDS.

The invention relates to the technical field of medical care, in particular to an intelligent early warning system for dynamic deterioration of chronic obstructive pulmonary disease, which is used for solving the technical problem of inaccurate evaluation of lung ventilation capability of a user in the prior art. The system comprises a data acquisition unit used for acquiring lung function time sequence data and multi-dimensional physiological time sequence data of a target user in an observation stage; the observation phase comprises a plurality of consecutive dates; the processing unit is used for determining suspected abnormal days according to the lung function time sequence data, determining the deviation degree of the multi-dimensional physiological time sequence data of the suspected abnormal days and the multi-dimensional physiological time sequence data of the reference day and the similarity of the deviation degree of the physiological time sequence data of different dimensions, determining the abnormal days from the suspected abnormal days based on the deviation degree and the similarity, and sending the abnormal days to the user. The chronic obstructive pulmonary disease dynamic deterioration risk level of the target user is determined based on the abnormal days; and performing risk early warning based on the chronic obstructive pulmonary disease dynamic deterioration risk level of the target user.

The invention discloses a voice coil motor-based pulse oscillation lung function instrument, which comprises a rotating bracket, and an IOS gas mixing structure is mounted on the rotating bracket; the pulse oscillation generation module comprises a shell, a motor support is fixedly connected into the shell, a voice coil motor is fixedly connected to the motor support, a motion guide column is installed on the voice coil motor, the voice coil motor is in transmission connection with the motion guide column, the shell is provided with an output port, and a diaphragm structure is fixedly connected to the motion guide column and located at the output port. The output port is communicated with the IOS gas mixing structure, and a sensor module is arranged on the IOS gas mixing structure; and the air tap is mounted on the IOS gas mixing structure. The device is suitable for people who are difficult to complete traditional lung function examination, can detect subtle changes which are difficult to find by a traditional lung function instrument, can distinguish resistance changes of the central airway and the peripheral airway through oscillation signals with different frequencies, and provides richer diagnosis information.

The present application relates to the technical field of health care, in particular to an intelligent early warning system for dynamic exacerbation of chronic obstructive pulmonary disease, which is used to solve the technical problem of inaccurate assessment of lung ventilation capacity of users in the prior art. The system comprises: a data acquisition unit for acquiring lung function time series data and multi-dimensional physiological time series data of a target user in an observation period; the observation period comprises a plurality of consecutive days; a processing unit for determining suspected abnormal days according to the lung function time series data, determining the deviation degree of the multi-dimensional physiological time series data of the suspected abnormal days and the multi-dimensional physiological time series data of the reference days and the similarity of the different dimensional physiological time series data deviation degrees, determining the abnormal days from the suspected abnormal days based on the deviation degree and the similarity, and determining the dynamic exacerbation risk level of the target user's chronic obstructive pulmonary disease based on the abnormal days; and performing risk warning based on the dynamic exacerbation risk level of the target user's chronic obstructive pulmonary disease.

The invention discloses a pitch angle determining device and a pitch angle determining method. The determining device comprises a rotation driving module, a rotatable module, a rotation sensing module, an oscillation measuring module and a control module, the rotation driving module is respectively connected with the rotatable module and the control module, and controls the rotatable module to rotate according to a rotation control signal provided by the control module; the rotation sensing module is used for sensing rotation information of the rotatable module and transmitting the rotation information to the control module; the oscillation measurement module comprises a breathing connection unit and an oscillation measurement unit which are connected; the interface of the breathing connection unit is arranged in the rotatable module; the oscillation measuring unit is electrically connected with the control unit and is used for transmitting the breathing parameters of the sample to be measured to the control unit; the control unit determines the pitching angle of the rotatable module matched with the to-be-tested sample according to the rotation information and the breathing parameters. By adopting the scheme, the pitch angle of the to-be-measured sample is controlled and extracted, accurate measurement of the oscillation lung function is realized, and the problem of measurement errors of different pitch angles is solved.

The utility model provides a blocking valve and a lung function detector, the blocking valve is used for the lung function detector, the blocking valve comprises a valve seat and a blocking device, the valve seat is provided with a hollow cavity, and one end of the valve seat is used for being connected with a collecting device of the lung function detector; the plugging device comprises a fixing seat and a plugging assembly, and the plugging assembly is connected with the fixing seat. The fixed seat is connected with the other end of the valve seat, and the plugging assembly is movably arranged in the hollow cavity; at least part of the fixed seat extends into the hollow cavity; a locking hole is formed in one of the outer wall of the fixing base and the inner wall of the valve seat, an elastic structure is arranged on the other one of the outer wall of the fixing base and the inner wall of the valve seat, and the elastic structure is used for being elastically clamped with the locking hole. According to the blocking valve and the lung function detector provided by the invention, interruption of a lung function test caused by misoperation of a user can be reduced, so that the test efficiency of the lung function detection of the user can be improved.

This invention belongs to the field of biomedical technology, specifically relating to a rapid purification method for umbilical cord MSC exosomes and their application in the preparation of drugs for treating COPD. This invention discloses a method for rapidly purifying umbilical cord mesenchymal stromal cell (MSC) exosomes and a pharmaceutical composition comprising umbilical cord MSC exosomes and yamosaponin. In this pharmaceutical composition, the umbilical cord MSC exosomes and yamosaponin synergistically enhance the dynamic compliance of COPD rats, reduce airway resistance, decrease pulmonary inflammation, and repair pulmonary dysfunction. This invention provides a new technical solution for the preparation of drugs for treating or improving COPD.

The utility model discloses a disposable filter tip for a pulmonary function instrument, and belongs to the technical field of filter tips. The meshing part and the inserting part are connected to the upper end and the lower end of the filtering part respectively, the filtering part comprises two symmetrically-arranged conical shells and a filtering layer arranged between the conical shells, and the two conical shells are connected in a sealed mode; a first sealing piece is arranged in the inserting part and is an annular body made of rubber materials, and an inner ring of the bottom of the first sealing piece is arranged in a fillet mode. According to the disposable filter tip for the pulmonary function instrument, due to the arrangement of the first sealing piece, the insertion part and the connecting pipe of the handheld handle of the pulmonary function instrument can be connected more tightly, so that the sealing effect is achieved, the end of the connecting pipe is blocked through the first step part, the sealing effect is further improved, gas leakage is prevented, and the service life of the filter tip is prolonged. And the detection accuracy is ensured.

The present application relates to the cross technical field of speech signal processing, respiratory physiological monitoring and artificial intelligence, and specifically discloses a respiratory-speech pause signal analysis system and method. The present application synchronously collects speech and respiratory signals, extracts language-adapted pause parameters and physiological indexes, performs time sequence alignment and correlation analysis, and then fuses a prediction model and a true-false recognition model for intelligent analysis, thereby solving the problems that traditional heart-lung function detection relies on professional equipment and cannot be remotely and non-contactly monitored, and that existing speech analysis lacks a physiological coupling mechanism, leading to the inability to identify synthetic speech and insufficient cross-language adaptation, and realizing the dual ability improvement of non-contact respiratory physiological state evaluation and speech fraud recognition.

The invention provides modRNA (Ribonucleic Acid) for treating obliterated bronchitis, and belongs to the technical field of bioengineering. The modRNA for treating obliterated bronchitis provided by the invention is composed of an IL-10 modRNA (Interleukin-10) and an IFN (Interferon)-alpha modRNA (Interferon-alpha) modRNA. The BO treatment effect is achieved by inhibiting bronchial epithelial cell epithelial-mesenchymal transition (EMT), the expression of alpha-SMA and Vimentin in lung tissue can be remarkably reduced, the expression of E-cadherin and Cytokeratin 5 can be up-regulated, microbronchial epithelial injury is repaired, collagen deposition is reduced, and the lung function is improved. The synergistic effect of the two is better than that of single gene therapy, the safety is high, and the controllability is strong.

This utility model provides a pulmonary function rehabilitation and physiotherapy device for respiratory medicine, relating to the field of respiratory medicine. It includes a main body shell and a protective cover. A U-shaped insert is fixedly connected to one side of the protective cover, and the U-shaped insert is inserted into the inner wall of a positioning shell. The positioning shell is fixedly connected to one side of the main body shell. A linkage rod is slidably connected to the inner wall of the positioning shell. One end of the linkage rod is fixedly connected to a limit block, and a first resilient spring is fixedly connected to one side of the limit block. One end of the first resilient spring is fixedly connected to the inner wall of the positioning shell. This application, through the arrangement of the main body shell, protective cover, U-shaped insert, positioning shell, linkage rod, limit block, first resilient spring, and external pull plate, effectively achieves the purpose of protecting the air blowing mask, solving the problem that prolonged exposure of the air blowing mask to air can affect its normal use due to external factors, greatly improving the practicality of the rehabilitation and physiotherapy device.

Described herein are a system and a method for automatically guiding and evaluating a user's performance during structured breathing exercise sessions. The system retrieves predetermined breathing patterns, including sequences of inhales, exhales, and breath-holds across one or more rounds. Each round includes at least two stages: a breath-hold stage and a first full breath stage immediately following the breath-hold. The system provides real-time guidance through sensory cues, receives user-initiated or automatic signals marking stage transitions, records the duration of each stage, and determines ideal or target durations. A longer first full breath duration indicates improved breath-hold performance and reduced stress. The system generates a final score for each round by combining breath-hold and first full breath durations, reflecting performance, relaxation, lung function, tolerance metrics, and the like. Aggregate session scores are computed across rounds, offering insights into exercise suitability, session effectiveness, and physiological adaptation over time.

The invention discloses a deep learning lung segment segmentation and lung function quantitative analysis method and system based on SPECT / CT, and belongs to the field of medical image analysis and nuclear medicine. The method comprises the following steps: firstly, collecting clinical SPECT / CT fusion image data for preprocessing; then, a 3D ResU-Net deep learning network improved by a loss function is utilized to carry out automatic lung segment segmentation on the preprocessed CT structure image, and morphological post-processing is carried out; secondly, performing spatial alignment on the preprocessed SPECT function image and the morphological post-processed CT structure image by adopting multi-strategy registration, and performing multi-dimensional lung function parameter quantification; and finally, carrying out machine learning modeling analysis. The implementation system comprises a data acquisition module, an image preprocessing module, a deep learning segmentation module, an SPECT / CT registration module, a lung function quantization parameter module, a health state evaluation module and a result display module. According to the invention, precise and automatic segmentation of 18 lung segments is realized; the accuracy of function information extraction is ensured; the analysis efficiency and the clinical practicability are improved.

The invention discloses a lung function data prediction method and related equipment. The method comprises the following steps: firstly, acquiring expiratory flow velocity data of a person to be detected, determining the highest point of flow velocity acceleration by calculating the acceleration of each flow velocity sampling point, and intercepting explosion data segments of preset time windows before and after the point; and matching a lung function data prediction sub-model corresponding to the to-be-detected person. The sub-model is obtained by training a plurality of groups of expiratory flow velocity sample data. And finally, inputting the outbreak data segment into the sub-model, and outputting the expiratory flow rate data meeting the quality control standard and predicted lung function data of lung function parameters. The outbreak data segment prediction sub-model is intercepted for prediction, and the to-be-detected person does not need to complete acquisition of complete expiratory flow velocity data meeting the quality control standard.

The utility model discloses a nasal splint fixing device applied to lung function measurement and examination, which comprises a working box, a rectangular groove is arranged on the side wall of the working box, a movable groove is arranged on the top wall of the working box, a clamping component is arranged in the working box, and a motor, a positive and negative screw rod, a sliding seat and a limiting rod are arranged in the clamping component. The side wall of the motor is fixedly connected to the inner side wall of the working box, a positive and negative screw is installed at the output end of the side face of the motor, the side wall of the positive and negative screw is movably connected to the inner side wall of the working box through a bearing, sliding bases are symmetrically connected to the positive and negative screw, supporting rods are fixedly connected to the side walls of the sliding bases, and the side ends of the supporting rods extend outwards through rectangular grooves. Clamping plates are fixedly connected to the opposite side walls of the supporting rods, the buffering pads are arranged, clamping of the limiting blocks is more stable, the limiting plates, the limiting grooves and the movable rods are used, so that the pressing plates move linearly, stability is high, non-slip mats are convenient to disassemble and assemble, cleanliness and sanitation are achieved, practicability is higher, and flexibility is higher.

This invention relates to the field of data monitoring, and more particularly to a data monitoring system for Traditional Chinese Medicine (TCM) pulmonary rehabilitation training. The system includes: a multi-source monitoring data kernel function construction module, used to construct a linear kernel function based on the BODE index of lung function, an RBF kernel function based on TCM syndrome scores obtained from a TCM questionnaire, and a periodic similarity kernel function based on pulse oximeter data; an SVM parameter optimization module, used to optimize SVM parameters using a soft-margin algorithm; a kernel function combination weight optimization module, used to determine the optimal solution of initial weighting coefficients using a grid search algorithm to generate an optimized SVM pulmonary rehabilitation level judgment model; and an SVM training suggestion output module, which generates pulmonary rehabilitation levels and determines the corresponding TCM pulmonary rehabilitation training suggestions displayed to the user by the rehabilitation training data monitoring platform. This invention meets the needs of TCM pulmonary rehabilitation data monitoring and achieves intelligent pulmonary rehabilitation training guidance.

The invention discloses an airway clearance auxiliary system based on aged airway clearance parameters, and belongs to the technical field of medical auxiliary equipment. The airway clearance auxiliary system based on the aged airway clearance parameters comprises a multi-modal parameter acquisition module, an efficiency evaluation module, an intelligent adjustment module and a risk evaluation module. The problem that in the prior art, sputum excretion and respiratory support parameters cannot be dynamically and iteratively adjusted according to long-term monitoring data of a single elderly patient is solved. According to the method, full-process dynamic optimization of intervention parameters is achieved through a two-dimensional adjustment mechanism, the pertinence and effectiveness of airway clearance are improved, the method is particularly suitable for old users with large lung function fluctuation, timely risk management and control are achieved by comprehensively evaluating the clearance requirement level and potential risks of the users, and the risk management efficiency of the users is improved. Therefore, the whole-process safety control of airway clearance assistance is realized, the occurrence risk of adverse events is reduced, and a powerful guarantee is provided for safe use of elderly users.

The application discloses a kind of application system of sitting eight-sections in COPD mechanical ventilation patient, including nurse hierarchical intervention module, man-machine synchronization module, multi-dimensional monitoring early warning module and continuity management module.The advantages of the present application: improve self-care ability of daily life, improve the critical level of patient course, reduce the hospitalization time of patient, promote the early rehabilitation of COPD mechanical ventilation patient, enhance lung function after exercise this project after discharge, avoid repeated attacks, improve the quality of life, reduce the admission rate, improve patient and family satisfaction, shorten the hospitalization time of COPD patient, reduce hospitalization expenses, reduce the readmission rate, also reduce the economic burden for society.

A respiratory function exercise device effectively solves the problems that an existing weight lifting device is prone to falling and has safety risks, and when training intensity is adjusted, a balance weight needs to be found, and operation is troublesome. Comprising an H-shaped mounting frame, mounting plates are fixed to the left side and the right side of the upper end of the mounting frame correspondingly, a plurality of mounting holes are formed in the mounting plates, moving grooves are formed in the left side and the right side of the mounting frame correspondingly, moving blocks are slidably connected into the moving grooves, and T-shaped vertical grooves with downward openings are formed in the two moving blocks correspondingly; a U-shaped weight lifting rod is slidably connected into the two vertical grooves, the rear sides of the two moving grooves are communicated through a transverse groove, the left side and the right side of the transverse groove are each slidably connected with a transverse rod, and friction blocks are fixed to the opposite ends of the two transverse rods respectively; the weight lifting rod is ingenious in structure, the initial state of the weight lifting rod can be adjusted according to the height of a patient, the comfort degree of the patient during weight lifting training is increased, upper limb muscles and respiratory muscles can be trained, the lung function is enhanced, disease recovery of the patient is facilitated, and practicability is high.