277 results about "Platycodon grandiflorus" patented technology

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an inhalation type pharmaceutical composition for treating inflammatory respiratory diseases and a preparation method thereof. The inhalation type pharmaceutical composition comprises an active component and a nano-liposome, and mannose is modified on the surface of the nano-liposome; the active ingredients comprise bulbus fritillariae cirrhosae total alkaloids and platycodin D; the nano-liposome is prepared from the following raw materials: phospholipid, cholesterol and cholesterol-polyethylene glycol 1000-mannose ester. The liposome can be specifically recognized by a mannose receptor highly expressed on the surface of alveolar macrophage through a surface-modified mannose ligand, so that the receptor-mediated endocytosis is started, and the wrapped bulbus fritillariae cirrhosae total alkaloids and platycodin D are efficiently introduced into cells. The inhaled pharmaceutical composition of the present invention collectively pushes macrophages from a pro-inflammatory M1 phenotype to a repairable M2 phenotype. Therefore, the overall curative effect of the combination of the two components is far better than that of the independent use of any component.

A traditional Chinese medicine composition for treating pulmonary nodules, wherein the composition is prepared from the following traditional Chinese medicines in parts by weight: a principle drug selected from one or more of 10-45 parts of raw Astragali radix, 10-25 parts of Sargassum, and 10-25 parts of Arisaematis rhizoma preparatum; a minister drug selected from one or more of 10-25 parts of Fritillariae thunbergii bulbus, 10-25 parts of Forsythiae fructus, 10-25 parts of stir-fried Atractylodis macrocephalae rhizoma, 1T0 part of Hirudo, 10-25 parts of Dioscoreae nipponicae rhizoma, 10-35 parts of Adenophorae radix, 10-35 parts of honey-processed Mori cortex, 10-25 parts of Perillae fructus, 10-25 parts of Peucedani radix, 10-35 parts of Phragmitis rhizome, 10-45 parts of raw Coicis semen, 5-25 parts of vinegar-processed Cyperi rhizoma, 10-25 parts of Aurantii fructus, 10-25 parts of Paeoniae radix alba, 10-35 parts of Scutellariae barbatae herba, 10-35 parts of Herba duchesneae indicae, 10-35 parts of Salviae chinensis herba, 5-20 parts of Menispermi rhizoma, 5-20 parts of Momordicae semen, 10-25 parts of Curcumae rhizoma, and 5-20 parts of Gleditsiae spina; an assistant drug selected from one or more of 5-25 parts of vinegar-processed Bupleuri radix, 5-25 parts of Citri reticulatae pericarpium, 10-25 parts of Perillae fructus, 2-12 parts of processed Ephedrae herba, 10-25 parts of Cynanchi stauntonii rhizoma et radix, 5-20 parts of Typhonii rhizoma, 2-12 parts of Zingiberis rhizoma, 10-35 parts of Morindae officinalis radix, 10-35 parts of Scutellariae barbatae herba, 10-45 parts of Radix aconiti lateralis praeparata nigra, and 10-25 parts of Typhonii rhizoma praeparata; and an envoy drug selected from one or more of 5-20 parts of Fagopyri dibotryis rhizoma, 10-25 parts of Platycodonis radix, 10-25 parts of Paeoniae radix alba, and 5-25 parts of Glycyrrhizae radix et rhizoma praeparata cum melle.

The invention provides a traditional Chinese medicine composition for treating acute altitude sickness. The traditional Chinese medicine composition is prepared from ginseng, astragalus membranaceus, acanthopanax, rhodiola rosea, turnip, salvia miltiorrhiza, dogwood, poria cocos, rhizoma cimicifugae, radix bupleuri, platycodon grandiflorum, aster, elecampane, rhizoma anemarrhenae and liquorice. The traditional Chinese medicine composition disclosed by the invention can be used for treating the acute altitude sickness, remarkably prolonging the load-bearing swimming time of rats, remarkably increasing the arterial oxygen partial pressure and the arterial oxygen saturation of acute altitude sickness model rats and relieving physical fatigue, has obvious effects of resisting anoxia, improving acid-base balance and resisting inflammation, and has obvious curative effects on myocardial injury, liver injury, liver injury and the like. And the kidney injury can be protected.

The invention belongs to the technical field of plant fermented beverages, and particularly relates to a synergistically fermented composite plant beverage and a preparation method thereof. The preparation method comprises the following steps: sieving platycodon grandiflorum and liquorice, and then carrying out ultrasonic pretreatment and cold extraction to obtain a platycodon grandiflorum and liquorice cold extraction solution; adding pectinase and beta-glucosidase into the pear juice, and carrying out enzymolysis composite treatment, so as to obtain pear juice after enzymolysis; mixing the platycodon grandiflorum and liquorice cold extraction liquid and the pear juice subjected to enzymolysis to obtain a cold extraction mixed liquid, and then inoculating a combined strain for fermentation to obtain a fermented mixed liquid; and performing molecular distillation and concentration on the fermentation mixed solution, and then performing high-pressure carbon dioxide sterilization and photodynamic sterilization in sequence to obtain the product. According to the preparation method disclosed by the invention, the preparation time is effectively shortened, the energy consumption is reduced, the preparation efficiency is improved, and the prepared composite plant beverage is high in content of active ingredients and nutrient elements such as GABA, platycodin and the like, long in storage time and high in storage stability.

The invention discloses a blood fat reducing composition with homology of medicine and food and a preparation method thereof, and belongs to the technical field of homology of medicine and food. The medicinal and edible blood fat reducing composition comprises the following raw materials in parts by mass: 8-15 parts of peach kernels, 10-20 parts of sea-buckthorn, 6-12 parts of Chinese wolfberry fruits, 3-6 parts of platycodon roots, 4-8 parts of dried orange peel and 5-10 parts of microcapsules. The microcapsule consists of a core material and a wall material, wherein the core material comprises stigma croci, bamboo leaf flavone, earthworm protein peptide powder and natto; the wall material comprises gelatin, sodium carboxymethyl cellulose and Arabic gum-maltodextrin mixed powder. In addition, the invention also provides a preparation method of the blood fat reducing composition. The blood fat reducing composition provided by the invention realizes safe and efficient blood fat reduction.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The invention discloses a method for extracting and preparing an oligosaccharide extract from codonopsis pilosula and application of the oligosaccharide extract in prevention and treatment of neurodegenerative disease Alzheimer's disease, and belongs to the technical field of traditional Chinese medicine pharmacy. According to the present invention, the oligosaccharide extract is enriched and prepared from Codonopsis pilosala (Franch.) Nanf., wherein the Codonopsis pilosala (Franch.) Nanf. Is a plant of the family of Platycodon grandiflorum, and the activity test of the oligosaccharide extract on the improvement of cognitive dysfunction in the animal body is performed; results show that in a mouse cognitive function impairment model caused by sleep deprivation, the high-dose codonopsis pilosula oligosaccharide has a prominent effect on improving the learning and memory ability of a Morris water maze and a neuroprotective effect, the efficacy of the codonopsis pilosula oligosaccharide is equivalent to that of a positive control drug manntranet, and no obvious toxic or side effect is found. The codonopsis pilosula oligosaccharide is expected to be further developed into functional food, health care products and / or medicines with the effect of preventing and / or improving cognitive impairment.

This invention discloses a traditional Chinese medicine composition for improving fever in wind-heat common cold, belonging to the field of traditional Chinese medicine preparation technology. Addressing the shortcomings of existing Western medicines that suppress fever through central nervous system suppression, easily damaging organs and inhibiting microcirculation, and the limitations of traditional Chinese medicine preparations such as bitter and cold properties that astringe pathogens, causing low-grade fever rebound, damaging yin and spleen, and insufficient ability to resolve phlegm and strengthen the body, this invention innovatively combines the principles of monarch, minister, assistant, and guide herbs in a synergistic formulation based on the core microscopic pathogenesis of wind-heat common cold: "constriction of visceral microvessels, stagnation of heat pathogens, high fever depleting body fluids, fluid deficiency and blood stasis, and phlegm production due to stagnation." This invention is prepared using gardenia, platycodon, angelica, peppermint, ophiopogon, dandelion, lily, coix seed, and rehmannia as core raw materials. It utilizes pungent and dispersing herbs to open up the microcirculation of the body surface and lungs, dispersing stagnant heat and replacing the traditional bitter and cold heat-suppressing mechanism. Combined with heat-clearing and anti-inflammatory components, it targets and inhibits the release of inflammatory factors, resulting in stable fever reduction. Small doses of yin-nourishing herbs repair the damage to body fluids and blood caused by high fever, reversing the pathology of fluid deficiency and blood stasis. Spleen-strengthening and dampness-removing herbs harmonize the medicinal properties and strengthen the spleen. This invention achieves a balance of hot and cold properties, and addresses both tonification and purgation, providing a one-stop solution for complex symptoms such as fever, sore throat, nasal congestion, yellow phlegm, dry mouth, weakness, and fatigue caused by dampness in wind-heat colds. It provides stable fever reduction without rebound, and avoids the side effects of Western medicine and bitter and cold Chinese patent medicines. It addresses both the symptoms and the root cause, effectively avoiding post-cold sequelae and reducing the recurrence rate. Furthermore, the preparation process is simple, allowing for processing into various dosage forms, suitable for industrial mass production and widespread clinical application, possessing extremely high medical value and market potential.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for promoting blood circulation, excreting dampness and reducing blood pressure and a preparation method and application thereof. The active ingredient of the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3-10 parts of prepared radix aconiti lateralis preparata, 5-15 parts of rhizoma zingiberis, 5-15 parts of honey-fried licorice root, 5-15 parts of wine-processed radix cyathulae, 10-30 parts of radix salviae miltiorrhizae, 10-30 parts of radix paeoniae rubra, 10-30 parts of radix puerariae, 10-30 parts of rhizoma alismatis and 5-15 parts of radix platycodonis. The traditional Chinese medicine has the effects of tonifying deficiency, dispelling excess, promoting blood circulation, excreting dampness, reducing blood pressure and strengthening the body resistance, not only strengthens healthy qi to treat root causes, but also promotes blood circulation, excretes dampness to treat symptoms, and achieves the effect of treating both symptoms and root causes. Clinical research shows that the traditional Chinese medicine composition can promote blood circulation, excrete dampness and support healthy qi, so that the blood pressure level of a hypertensive patient is reduced, and the purpose of effectively treating hypertension is achieved.

The invention discloses a traditional Chinese medicine composition for treating cough. The invention belongs to the field of traditional Chinese medicine for treating cough. The traditional Chinese medicine composition is prepared from 17 traditional Chinese medicines including thunberg fritillary bulb, semen lepidii, platycodon grandiflorum, perilla leaf, almond, polygala tenuifolia, schisandra chinensis and the like. The cough is not injured by lung and cough, not injured by spleen and not coughed for a long time, and not injured by kidney and not cough and asthma, and the cough is not cured for a long time and is mostly caused by lung yin deficiency and kidney deficiency. Years of research finds that the fundamental cause of cough is lung qi upflow and phlegm obstructing lung regardless of external infection, internal injury and deficiency and excess symptoms, and the basic thought of treatment is to reduce phlegm and expel fluid retention; the lung qi is reduced; and tonifying spleen and kidney. According to the theory, the traditional Chinese medicines are screened according to the principle of syndrome differentiation and treatment of traditional Chinese medicine, and the prescription is an empirical prescription which is continuously explored and gradually formed in the practice process. The traditional Chinese medicine composition has a treatment effect on cough.

According to the traditional Chinese medicine prescription, radix scrophulariae, wild buckwheat rhizome, platycodon grandiflorum and radix angelicae have the effects of detoxifying and expelling pus and are used as monarch drugs, radix angelicae sinensis, radix paeoniae rubra, cowherb seed and beautiful sweetgum fruit have the effects of activating blood and dredging orifices as auxiliary drugs, radix astragali, radix saposhnikoviae, pericarpium citri reticulatae and honey-fried licorice root have the effects of tonifying qi and regulating the spleen and stomach as guide drugs, periostracum cicada and stiff silkworm have the effects of dredging collaterals as assistant drugs, and through clinical observation of thousands of cases, the traditional Chinese medicine prescription has the advantages of quick curative effect, no toxic or side effect and the like. The effective rate can reach 100%, and the clinical cure rate is 70% or above.

The invention discloses a highland barley wine composition with a liver protection effect as well as a preparation method and application of the highland barley wine composition, and relates to the technical field of traditional Chinese medicine compositions. The highland barley wine comprises the following raw materials in parts by weight: 30-600 parts of highland barley wine, 2-10 parts of dandelion, 3-10 parts of dried lalang grass rhizome, 2-15 parts of orange peel, 6-15 parts of cinnamon, 5-15 parts of poria cocos, 2-10 parts of platycodon grandiflorum, 3-10 parts of liquorice, 3-10 parts of kudzu vine root and 3-15 parts of hawthorn. According to the highland barley wine composition, the problem that heat-sensitive liver protection components are easy to degrade due to high temperature in a traditional process is solved through a stepped heating sterilization mode, high-activity components are reserved, and it is ensured that effective components play a synergistic effect in key links such as hepatic cell oxidative stress inhibition and detoxification enzyme activity adjustment; a plurality of traditional Chinese medicine raw material components and the highland barley wine form an anti-oxidation-anti-inflammatory-regeneration-promoting triple synergistic protection network, so that the liver protection function of the highland barley wine is enhanced.

The application belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating abdominal distension and diarrhea of cold-heat complex type and a preparation method thereof. The technical scheme points of the traditional Chinese medicine composition are as follows: the traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 3-6 parts of perilla, 3-10 parts of dried ginger, 3-12 parts of eucommia, 3-10 parts of scrophularia, 2-6 parts of coptis, 10-20 parts of fried coix seed, 6-10 parts of clear pinellia, 3-10 parts of dried tangerine or orange peel, 10-15 parts of poria, 6-10 parts of wheat-cooked atractylodes, 6-10 parts of vinegar-cured corydalis, 6-10 parts of vinegar-cured bupleurum, 6-10 parts of pericarpium zephyritae, 6-10 parts of chuanxiong, 6-10 parts of magnolia officinalis, 6-10 parts of fried hawthorn fruit, 3-6 parts of platycodon, and 3-10 parts of fried licorice. The traditional Chinese medicine composition and the traditional Chinese medicine water pill prepared from the traditional Chinese medicine composition have the effect of treating abdominal distension and diarrhea of cold-heat complex type.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a more low-irritation analgesic ancient prescription microemulsion gel and application thereof in anti-arthritis drugs. The application finds that after water-soluble and fat-soluble components of black plaster prepared from raw frankincense, myrrh, eaglewood, dragon's blood, Strychnos nux-vomica, Panax notoginseng, Oldenlandia diffusa, Venenum Bufonis, bovine bezoar, Stachys jamaicensis, Platycodon grandiflorum, Hirudo nipponia, Tinea, Solenopsis geminata, Scorpio, scorpio, red lead and sesame oil are extracted, a more low-irritation analgesic ancient prescription microemulsion gel is prepared; compared with the black plaster itself, the analgesic effect of the microemulsion gel is significantly improved, and the microemulsion gel has good anti-inflammatory effect and can be used for preparing anti-arthritis drugs; and the microemulsion gel has reduced toxicity and is more convenient to use.

The invention relates to platycodon grandiflorum polysaccharide as well as a preparation method and application thereof. The structural formula of the platycodon grandiflorum polysaccharide is shown in the specification. The preparation method of the platycodon grandiflorum polysaccharide comprises the following steps: extracting platycodon grandiflorum crude polysaccharide from degreased platycodon grandiflorum by adopting a water extraction and alcohol precipitation method, and then decoloring, deproteinizing and purifying to obtain the platycodon grandiflorum polysaccharide PGP. And further preparing a platycodon grandiflorum polysaccharide calcium chelate and a platycodon grandiflorum polysaccharide zinc chelate by utilizing the platycodon grandiflorum polysaccharide PGP. Experiments prove that the prepared platycodon grandiflorum polysaccharide calcium chelate has an anti-osteoporosis effect, and the platycodon grandiflorum polysaccharide zinc chelate has immunoregulatory activity and a probiotic effect of synchronously regulating intestinal microecology. The platycodon grandiflorum polysaccharide calcium / zinc chelate provided by the invention is beneficial to development and application of novel calcium / zinc supplementation agents.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof, active ingredients of the traditional Chinese medicine composition including a fermentation product prepared by subjecting traditional Chinese medicine raw materials to anaerobic solid-state fermentation in combination with Lactobacillus helveticus and enzyme preparation; the traditional Chinese medicine raw materials include ginseng, poria cocos, Chinese yam, white lentil, lotus seed, yiyi seed, amomum villosum, platycodon grandiflorum, licorice and dried tangerine or orange peel; and the enzyme preparation includes cellulase and / or cellobiase. The application effectively promotes dissolution of effective ingredients of Shenlingbaizhu powder, significantly enriches antioxidant active ingredients in the fermentation product, relieves inhibition of oxidative stress on immune cells, and greatly improves survival rate and phagocytic efficacy of macrophages, so that the application shows a significant antibacterial pneumonia effect and has an excellent application prospect.

The invention discloses a medicinal and edible traditional Chinese medicine composition with the effects of regulating immunity, relieving fatigue and relieving sore throat and a preparation method of the medicinal and edible traditional Chinese medicine composition, and belongs to the technical field of medicinal and edible traditional Chinese medicine compositions.The medicinal and edible traditional Chinese medicine composition is prepared from 100 parts of phyllanthus emblica, 30-70 parts of astragalus membranaceus, 30-70 parts of fructus lycii, 1-20 parts of platycodon grandiflorum and 1-20 parts of mint. The preparation method comprises the following steps: crushing the phyllanthus emblica, the astragalus membranaceus, the platycodon grandiflorum and the mint into coarse powder, adding an ethanol aqueous solution with the concentration of 50wt% or above, carrying out ultrasonic treatment and heating treatment, and adding water into the fructus lycii for ultrasonic treatment. According to the traditional Chinese medicine composition, radix astragali, fructus lycii, radix platycodonis and herba menthae which can synergistically regulate immunity and relieve sore-throat and moisten throat are compounded, and through an optimized extraction process, the traditional Chinese medicine composition can have good sensory quality, regulate immunity, relieve fatigue and relieve sore-throat and moisten throat.

The invention discloses a traditional Chinese medicine composition for treating acute pharyngitis as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The technical problems to be solved are that the traditional Chinese medicine composition for treating acute pharyngitis is not suitable for long-term administration, is not suitable for sensitive people and is easy to damage spleen and stomach. The invention provides a traditional Chinese medicine composition for treating acute pharyngitis. The traditional Chinese medicine composition is prepared from the following raw materials: honeysuckle flower, fructus forsythiae, radix isatidis, herba menthae, radix bupleuri, fructus arctii, schizonepeta spike, gypsum, radix scutellariae, fructus gardeniae, radix platycodonis, radix paeoniae rubra, rhizoma phragmitis, semen armeniacae amarae, herba lophatheri, fructus aurantii, radix saposhnikoviae, medicated leaven, stiff silkworm and liquorice root. The traditional Chinese medicine composition disclosed by the invention can inhibit inflammatory reaction by inhibiting phosphorylation levels of PI3K / AKT and RAS / MAPK signal pathways AKT and MAPK, so that acute pharyngitis is improved.

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

A traditional Chinese medicine composition for treating acute and chronic inflammation of the ear, nose, and throat, and its preparation method, characterized in that, by weight, it is made from the following traditional Chinese medicinal materials: 10-30 parts of Lycium chinense root bark, 8-30 parts of Gardenia jasminoides, 10-30 parts of Sanguisorba officinalis root bark, 8-25 parts of Schizonepeta tenuifolia root bark, 6-16 parts of Angelica dahurica root bark, 10-35 parts of Asparagus cochinchinensis root bark, 11-35 parts of Platycodon grandiflorus root bark, 7-46 parts of Paeonia lactiflora root bark, 8-46 parts of Rehmannia glutinosa root bark, and 5-10 parts of Oroxylum indicum root bark. 14 parts of the following ingredients are used: Astragalus membranaceus 12-50 parts, Magnolia biondii 10-30 parts, Trichosanthes kirilowii 10-35 parts, Stellaria dichotoma 5-20 parts, Imperata cylindrica 7-30 parts, Fagopyrum dibotrys 10-35 parts, Coix lacryma-jobi 13-60 parts, Lepidium apetalum 5-15 parts, Gypsum fibrosum 14-50 parts, Sophora tonkinensis 3-20 parts, Lonicera japonica 12-50 parts, Xanthium sibiricum 6-35 parts, Ephedra sinica 6-30 parts, and Styrax benzoin 1-3 parts. After grinding into powder, the mixture is steamed with rice wine to obtain pills. The principle of treating all three (ear, nose, and throat) simultaneously, considering the anatomical structure and physiological function of the ear, nose, and throat, aims to reduce cross-infection, promote recovery, and achieve ideal medicinal properties.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic refractory cough and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following fifteen traditional Chinese medicines in specific parts by weight: blackberry lily, roasted ephedra, asarum, bamboo juice pinellia ternate, raw liquorice, radix bupleuri, fried scutellaria baicalensis, fructus aurantii, platycodon grandiflorum, roasted perillaseed, almond, wild buckwheat, Japanese metaplexis pericarp, calyx seu fructus physalis and pericarpium trichosanthis. Aiming at the core pathogenesis of the chronic refractory cough, such as residual evil and turbidity and lung-qi obstruction, evil and turbidity are separately eliminated by a method of separately eliminating and discharging, and the lung-qi is diffused and restored. The traditional Chinese medicine composition is reasonable in component and remarkable in curative effect, clinical data shows that the traditional Chinese medicine composition can effectively improve core symptoms such as cough, expectoration and throat itching, no obvious adverse reaction is found, and safety is high.

The invention discloses a composition containing an astragalus extract as well as a preparation method and application of the composition. The composition comprises a carrier layer, a core functional layer, an assistant functional layer, a functional powder layer and a probiotic layer from inside to outside. According to the invention, monarch and ministerial drugs (astragalus membranaceus, codonopsis pilosula, bighead atractylodes rhizome and poria cocos) are taken as a core layer through a fluidized bed, adjuvant and conductant drugs (isatis root, dandelion and platycodon grandiflorum) are taken as a secondary layer, sequence batch layering is realized, and directional release can be realized.

The composition is prepared from humifuse euphorbia herb, exocarpium benincasae, herba asari, radix platycodonis, radix sophorae flavescentis, radix rehmanniae, leech, lumbricus, radix salviae miltiorrhizae, semen pharbitidis and radix glycyrrhizae, all the raw materials are natural medicinal raw materials, and chemical synthesis anti-hepatic fibrosis components are not contained. Through the synergistic effect of multiple components, the composition inhibits the liver fibrosis process at the molecule, cell and tissue levels, improves the liver structure and function, and can be used for preparing drugs for treating liver fibrosis caused by various causes. The invention has the advantages of naturalness, safety, multiple targets and integral regulation, and is suitable for long-term intervention of chronic liver diseases.

The application discloses a traditional Chinese medicine composition for preventing and treating chicken Bordetella, a preparation method and application thereof. The traditional Chinese medicine composition for preventing and treating chicken Bordetella comprises the following raw medicinal materials in parts by weight: one red 15-20 parts, Tianwen grass 15-20 parts, goldenrod 10-15 parts, Jixiang grass 10-15 parts, white yam 5-12 parts, Buddha's hand 5-12 parts and platycodon 5-10 parts. The traditional Chinese medicine composition adopts one red, Tianwen grass, goldenrod, Jixiang grass, white yam, Buddha's hand and platycodon for reasonable compounding, has the effects of clearing heat and cooling blood, relieving cough and asthma, and can effectively treat chicken Bordetella disease. The seven kinds of medicines are mixed to prepare an oral liquid, the seven kinds of medicines have a synergistic effect in the preparation process, the effects of the medicines are effectively exerted, and the effects of clearing heat and detoxifying, clearing heat and cooling blood, relieving cough and asthma are further enhanced. The composition is scientifically matched, has no obvious toxic side reaction and drug tolerance, and can provide a train of thought for solving the problem of antibiotic resistance.

The invention relates to the technical field of traditional Chinese medicines, in particular to a combustion type chronic obstructive pulmonary disease traditional Chinese medicine fumigant for targeted phlegm clearing, which is characterized in that the traditional Chinese medicine formula of the fumigant comprises platycodon grandiflorum, bulbus fritillariae cirrhosae, fructus perillae, flos farfarae, almond, radix stemonae and liquorice. The medicine effect is lasting and stable, the bulbus fritillariae cirrhosae or the green fritillary bulb is selected as a bulbus fritillariae cirrhosae source, the bulbus fritillariae cirrhosae and the green fritillary bulb have no obvious difference in phlegm clearing effect, but the bulbus fritillariae cirrhosae is slightly excellent in medicine effect durability, the medicine action time is prolonged, and the treatment effect is improved.

The invention discloses a traditional Chinese medicine composition for chronic obstructive pulmonary disease and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: main medicines: 15-30 parts of radix rehmanniae preparata and 3-9 parts of semen allii tuberosi; auxiliary medicines: 10-30 parts of ginseng, 15-30 parts of astragalus membranaceus, 6-12 parts of ganoderma sinense, 6-12 parts of bighead atractylodes rhizome and 3-6 parts of schisandra chinensis; adjuvant drugs: 6-12 parts of radix ophiopogonis, 6-10 parts of rhizoma anemarrhenae, 6-10 parts of radix cyathulae and 6-10 parts of platycodon grandiflorum; and conductant drugs: 3-6 parts of radix bupleuri and 3-6 parts of rhizoma cimicifugae. The composition directly refers to the core pathogenesis of lung-kidney deficiency, the adjuvants reinforce lung and kidney tonifying, spleen strengthening and superficies consolidating, the adjuvants have the effects of nourishing yin, moistening dryness, reducing phlegm and activating blood, and the medicines prevent tonifying and stagnation, are orderly in lifting and descending and promote synergistic efficacy.

The invention discloses a polymorphic medicinal and edible stasis removing composition based on AI optimization and a classic famous prescription as well as a preparation method and application thereof, and relates to the technical field of medicinal and edible homology. The food is prepared from the following raw materials in parts by weight through artificial intelligence algorithm optimization determination: 6-12 parts of kelp, 6-12 parts of hawthorn, 3-6 parts of platycodon grandiflorum, 3-6 parts of pericarpium citri reticulatae, 6-12 parts of poria cocos and 3-6 parts of liquorice. The composition is prepared from kelp, hawthorn, platycodon grandiflorum, pericarpium citri reticulatae, poria cocos and liquorice according to a specific proportion, and is obtained by cutting and optimizing'seaweed jade pot soup 'and'cassia twig and poria cocos pills' through a deep learning algorithm. The traditional Chinese medicine theory is combined with the modern artificial intelligence and food engineering technology, a series of products with the remarkable auxiliary stasis removing effect and excellent taste and convenience are created, and the problems that traditional Chinese medicine is poor in taste and not portable, and modern functional food is unclear in effect are solved; an innovative solution is provided for daily prevention and conditioning of the nodular diseases.

The invention belongs to the technical field of medicine quality control, and particularly relates to a platycodon grandiflorum extract and a preparation and quality control detection method thereof. The method for detecting platycodin D in the platycodon grandiflorum extract comprises the following steps: dissolving the platycodon grandiflorum extract in a solvent, and filtering to prepare a test solution; performing high performance liquid chromatography pre-separation on the test solution, and collecting fractions with the retention time of 9-11 minutes to prepare a target fraction collection solution; filtering the target fraction collection liquid, and then carrying out ultra-high performance liquid chromatography analysis; and calculating the content of platycodin D in the platycodon grandiflorum extract according to the standard curve. According to the method disclosed by the invention, the platycodin D in the platycodon grandiflorum extract is detected by firstly using the liquid chromatography (HPLC) and then using the ultra-high performance liquid chromatography (UPLC), so that the high-capacity sample treatment capacity of the HPLC and the ultra-high separation efficiency of the UPLC are fully exerted, the interference of a complex matrix is effectively overcome through fractional separation, the sample pretreatment time is remarkably shortened, and meanwhile, the loss of a chromatographic column and the consumption of a solvent are greatly reduced.

The invention provides a traditional Chinese medicine composition, a preparation method and application thereof and a pharmaceutical composition. The traditional Chinese medicine composition comprises radix pseudostellariae, astragalus membranaceus, sculellaria barbata, houttuynia cordata, radix bupleuri, semen coicis, rhizoma polygonati, platycodon grandiflorum and liquorice. The traditional Chinese medicine composition provided by the invention is high in safety, long in application period, outstanding in immune regulation function, low in drug resistance risk, remarkable in comprehensive curative effect, wide in adaptation disease range and flexible in clinical application, and multiple mechanisms are cooperated.

The invention discloses a preparation method of a negundo chastetree fruit and prevention mixture, which belongs to the field of medicine and sequentially comprises the steps of pretreatment, water extraction, alcohol extraction, clear paste preparation and preparation. Wherein during water extraction, herba schizonepetae, radix saposhnikoviae, notopterygium root, radix angelicae pubescentis and radix peucedani are combined to extract volatile oil A; adding water into extracted medicine residues, radix bupleuri, platycodon grandiflorum and liquorice, decocting, filtering and concentrating to obtain a concentrated solution A, and extracting volatile oil B from ligusticum wallichii and fructus aurantii; percolating the extracted medicine residues and poria cocos by using ethanol as a solvent, concentrating the percolate to obtain a concentrated solution B, combining the concentrated solution A and the concentrated solution B, and adding ethanol to obtain a clear paste; the preparation method disclosed by the invention can save labor force, shorten the production cycle, reduce the use quantity of extraction tanks, reduce the risk of pollution, improve the transfer rate of effective components, remarkably improve the properties of the product and ensure the quality and curative effect of the product.