Traditional chinese medicine composition for treating pulmonary nodules and use thereof

Abstract

A traditional Chinese medicine composition for treating pulmonary nodules, wherein the composition is prepared from the following traditional Chinese medicines in parts by weight: a principle drug selected from one or more of 10-45 parts of raw Astragali radix, 10-25 parts of Sargassum, and 10-25 parts of Arisaematis rhizoma preparatum; a minister drug selected from one or more of 10-25 parts of Fritillariae thunbergii bulbus, 10-25 parts of Forsythiae fructus, 10-25 parts of stir-fried Atractylodis macrocephalae rhizoma, 1T0 part of Hirudo, 10-25 parts of Dioscoreae nipponicae rhizoma, 10-35 parts of Adenophorae radix, 10-35 parts of honey-processed Mori cortex, 10-25 parts of Perillae fructus, 10-25 parts of Peucedani radix, 10-35 parts of Phragmitis rhizome, 10-45 parts of raw Coicis semen, 5-25 parts of vinegar-processed Cyperi rhizoma, 10-25 parts of Aurantii fructus, 10-25 parts of Paeoniae radix alba, 10-35 parts of Scutellariae barbatae herba, 10-35 parts of Herba duchesneae indicae, 10-35 parts of Salviae chinensis herba, 5-20 parts of Menispermi rhizoma, 5-20 parts of Momordicae semen, 10-25 parts of Curcumae rhizoma, and 5-20 parts of Gleditsiae spina; an assistant drug selected from one or more of 5-25 parts of vinegar-processed Bupleuri radix, 5-25 parts of Citri reticulatae pericarpium, 10-25 parts of Perillae fructus, 2-12 parts of processed Ephedrae herba, 10-25 parts of Cynanchi stauntonii rhizoma et radix, 5-20 parts of Typhonii rhizoma, 2-12 parts of Zingiberis rhizoma, 10-35 parts of Morindae officinalis radix, 10-35 parts of Scutellariae barbatae herba, 10-45 parts of Radix aconiti lateralis praeparata nigra, and 10-25 parts of Typhonii rhizoma praeparata; and an envoy drug selected from one or more of 5-20 parts of Fagopyri dibotryis rhizoma, 10-25 parts of Platycodonis radix, 10-25 parts of Paeoniae radix alba, and 5-25 parts of Glycyrrhizae radix et rhizoma praeparata cum melle.

Description

Traditional Chinese medicine composition for treating pulmonary nodule and application thereof TECHNICAL FIELD

[0001] The present application belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating pulmonary nodule and application thereof. BACKGROUND

[0002] Pulmonary nodule refers to a round or irregular lesion in the lung with a diameter of less than or equal to 3 cm, which is shown as a density-increased shadow in imaging, and the lesion boundary can be clear or unclear, without atelectasis, hilar lymph node enlargement and pleural effusion [1] . According to the number of nodules, pulmonary nodules can be divided into solitary nodules and multiple nodules; according to the density of nodules, pulmonary nodules can be divided into solid nodules and sub-solid nodules, and the latter can be further divided into partial solid nodules (or mixed nodules) and ground glass nodules (or ground glass lesions, pure ground glass nodules, non-solid nodules) according to whether they contain solid components. Among them, solid nodules are nodules that completely cover the lung parenchyma on CT imaging, partial solid nodules are nodules that cover part of the lung parenchyma, and non-solid nodules are nodules that do not cover the lung parenchyma, and the bronchi and blood vessels can be identified. Pulmonary nodules have a certain probability of malignancy, and the probability of malignancy of pulmonary nodules with a diameter of 6-8 mm is about 7.39%, and the probability of malignancy of pulmonary nodules with a diameter of >8 mm is about 21.79%. Effective identification and treatment of malignant pulmonary nodules are very critical in clinical diagnosis and treatment. According to the cause, pulmonary nodules can be divided into tumors, inflammations, vascular diseases, congenital diseases and other causes, and tumors include malignant tumors such as primary lung cancer, primary lung lymphoma, carcinoid, solid metastases, etc. and benign tumors including hamartoma, chondroma, etc. GLOBO-CAN 2020 data shows that the incidence and mortality of lung cancer are still high in the world. The prevention and treatment of lung cancer has become an urgent problem.

[0003] In recent years, the rapid development of artificial intelligence, lung cancer autoantibody detection, liquid biopsy and other technologies in the diagnosis of pulmonary nodules has made a great contribution to the evaluation of lung nodule benignity and malignancy. The treatment recommendations of lung nodules in various guidelines at home and abroad mainly include anti-inflammatory treatment, follow-up, surgery, ablation therapy, etc. Studies have shown that traditional Chinese medicine has a certain effect on inhibiting the growth of nodules and preventing lung cancer (Ruan Guangxin. Clinical research and mechanism of Yiqi Yangyin Decoction in delaying the occurrence and development of early lung cancer[D]. Shanghai University of Traditional Chinese Medicine, 2019.). At the same time, traditional Chinese medicine can regulate and treat the constitution of the human body. The so-called relationship between seed and soil can only improve the conditions of the human body, the soil, to fundamentally solve the problem of nodules. Traditional Chinese medicine is a non-invasive treatment with the advantages of high safety and low side effects. Through the dynamic observation, treatment and evaluation of nodules, it can avoid some excessive treatment to some extent, reduce the possibility of surgery for patients, and also reduce the waste of medical resources from a certain angle. Modern medicine has no exact understanding of the cause and mechanism of lung nodules, and lacks effective drug treatment methods. In the period before the nodules reach the indication of surgical resection or other treatment measures, traditional Chinese medicine has a lot to offer. In addition, for elderly patients, patients with multiple primary nodules, patients in the lactation period or pregnancy period and other patients who are unwilling or unsuitable to receive western medicine treatment, traditional Chinese medicine treatment enriches the treatment methods for these special groups (Zhang Xinghan, Zhang Huaixi, Li Shumeng, et al. Three-in-one treatment of lung nodules: clinical experience of constitution differentiation, disease differentiation and syndrome differentiation [J]. Beijing Chinese Medicine, 2022, 41(05): 498-500.). SUMMARY

[0004] The purpose of the present application is to provide a treatment scheme for lung nodules with traditional Chinese medicine, that is, to take "tonifying lung and spleen, resolving phlegm and dampness, regulating qi and promoting blood circulation" as the core principle of treatment, and to provide a traditional Chinese medicine for treating lung nodules. The traditional Chinese medicine has the effect of improving clinical symptoms and can be used as a treatment option for follow-up observation period. At the same time, for some patients who are not suitable for surgery or do not want to undergo surgery, the traditional Chinese medicine of the present application is also a alternative solution.

[0005] In the first aspect, the present application provides a traditional Chinese medicine composition for treating lung nodules, wherein the traditional Chinese medicine composition is made from the following weight parts of traditional Chinese medicines:

[0006] The monarch medicine is selected from one or more of Huangqi 10-45 parts, Haisheng 10-25 parts and Shitian'nanxing 10-25 parts;

[0007] The medicinal ingredients are selected from one or more of the following: Fritillaria thunbergii (10-25 parts), Forsythia suspensa (10-25 parts), stir-fried Atractylodes macrocephala (10-25 parts), Hirudo medicinalis (1-10 parts), Dioscorea nipponica (10-25 parts), Adenophora stricta (10-35 parts), Morus alba (10-35 parts), Perilla frutescens (10-25 parts), Peucedanum praeruptorum (10-25 parts), Phragmites communis (10-35 parts), raw Coix lacryma-jobi (10-45 parts), Cyperus rotundus (5-25 parts), Citrus aurantium (10-25 parts), Paeonia lactiflora (10-25 parts), Scutellaria barbata (10-35 parts), Duchesnea indica (10-35 parts), Hedyotis diffusa (10-35 parts), Sophora tonkinensis (5-20 parts), Momordica cochinchinensis (5-20 parts), Curcuma zedoaria (10-25 parts), and Gleditsia sinensis (5-20 parts).

[0008] The adjuvant herbs are selected from one or more of the following: vinegar-processed Bupleurum chinense (5-25 parts), dried tangerine peel (5-25 parts), perilla seed (10-25 parts), processed ephedra (2-12 parts), Cynanchum paniculatum (10-25 parts), Aconitum carmichaelii (5-20 parts), dried ginger (2-12 parts), Morinda officinalis (10-35 parts), Scutellaria barbata (10-35 parts), processed Aconitum carmichaelii (10-45 parts), and processed Aconitum carmichaelii (10-25 parts).

[0009] The herb is selected from one or more of the following: 5-20 parts of buckwheat, 10-25 parts of platycodon root, 10-25 parts of white peony root, and 5-25 parts of prepared licorice root.

[0010] Preferably, the traditional Chinese medicine composition for treating pulmonary nodules is made from the following traditional Chinese medicines in parts by weight:

[0011] The principal ingredient is selected from one or more of the following: raw Astragalus membranaceus (10-40 parts), Sargassum (10-20 parts), and processed Arisaema heterophyllum (10-20 parts);

[0012] The herbs used are selected from one or more of the following: Fritillaria thunbergii (10-20 parts), Forsythia suspensa (10-20 parts), stir-fried Atractylodes macrocephala (10-20 parts), Hirudo medicinalis (1-6 parts), Dioscorea nipponica (10-20 parts), Adenophora stricta (10-30 parts), Morus alba (10-30 parts), Perilla frutescens (10-20 parts), Peucedanum praeruptorum (10-20 parts), Phragmites communis (10-30 parts), raw Coix lacryma-jobi (10-40 parts), Cyperus rotundus (5-20 parts), Citrus aurantium (10-20 parts), Paeonia lactiflora (10-20 parts), Scutellaria barbata (10-30 parts), Duchesnea indica (10-30 parts), Hedyotis diffusa (10-30 parts), Sophora flavescens (5-15 parts), Momordica cochinchinensis (5-15 parts), Curcuma zedoaria (10-20 parts), and Gleditsia sinensis (5-15 parts).

[0013] The adjuvant herbs are selected from one or more of the following: vinegar-processed Bupleurum chinense (5-20 parts), dried tangerine peel (5-20 parts), perilla seed (10-20 parts), processed ephedra (2-8 parts), Cynanchum paniculatum (10-20 parts), Aconitum carmichaelii (5-15 parts), dried ginger (2-8 parts), Morinda officinalis (10-30 parts), Scutellaria barbata (10-30 parts), processed Aconitum carmichaelii (10-40 parts), and processed Aconitum carmichaelii (10-20 parts).

[0014] The herb is selected from one or more of the following: 5-15 parts of buckwheat, 10-20 parts of platycodon root, 10-20 parts of white peony root, and 5-20 parts of prepared licorice root.

[0015] More preferably, the traditional Chinese medicine composition for treating lung nodule is made from the following traditional Chinese medicines by weight:

[0016] The monarch drug is selected from one or more of Huangqi 10-35 parts, Haisheng 10-15 parts, and Shitian-nanxing 10-15 parts;

[0017] The minister drug is selected from one or more of Zhebeimu 10-15 parts, Lianqiao 10-15 parts, Chao-baishu 10-15 parts, Shui-chong 1-4 parts, Chuanshenglong 10-15 parts, Nanshenshen 10-25 parts, Mishangbaipi 10-25 parts, Zisu 10-15 parts, Qianhu 10-15 parts, Lugeng 10-25 parts, Shengyiren 10-35 parts, Cixiangfu 5-15 parts, Zhikui 10-15 parts, Baishao 10-15 parts, Ban-zhilian 10-25 parts, Shehe 10-25 parts, Shijianchuang 10-25 parts, Beidougen 5-10 parts, Muhuizi 5-10 parts, E-zhu 10-15 parts, and Zaocai 5-10 parts;

[0018] The assistant drug is selected from one or more of Cichaihu 5-15 parts, Chenpi 5-15 parts, Zisu 10-15 parts, Zhima-huang 2-6 parts, Baiqian 10-15 parts, Bai-fuzi 5-10 parts, Ganjiang 2-6 parts, Bag-tian 10-25 parts, Ban-zhilian 10-25 parts, Hei-shunpian 10-35 parts, and Zhbai-fuzi 10-15 parts;

[0019] The service drug is selected from one or more of Jin-qiao 5-10 parts, Jiegeng 10-15 parts, Baishao 10-15 parts, and Zhigancao 5-15 parts.

[0020] In some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines by weight: Huangqi 10-45 parts, Chao-baishu 10-25 parts, Zhebeimu 10-25 parts, Shitian-nanxing 10-25 parts, E-zhu 10-25 parts, Zaocai 5-20 parts, Lianqiao 10-25 parts, Haisheng 10-25 parts, Zhima-huang 2-12 parts, Cichaihu 5-20 parts, Jin-qiao 10-25 parts, Chenpi 5-25 parts.

[0021] Preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines by weight: Huangqi 10-40 parts, Chao-baishu 10-20 parts, Zhebeimu 10-20 parts, Shitian-nanxing 10-20 parts, E-zhu 10-20 parts, Zaocai 5-15 parts, Lianqiao 10-20 parts, Haisheng 10-20 parts, Zhima-huang 2-8 parts, Cichaihu 5-15 parts, Jin-qiao 10-20 parts, Chenpi 5-20 parts.

[0022] More preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines: Radix Astragali 10-35 parts, Radix Paeoniae Alba 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Dioscoreae 10-15 parts, Curcumae 10-15 parts, Radix Sophorae 5-10 parts, Forsythiae 10-15 parts, Sargassum 10-15 parts, Radix Ephedrae 2-6 parts, Radix Bupleuri 5-10 parts, Fagopyri Cymosi 10-15 parts, Pericarpium Citri Reticulatae 5-15 parts.

[0023] In some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines: Radix Astragali 10-45 parts, Radix Paeoniae Alba 10-25 parts, Fritillariae Thunbergii 10-25 parts, Rhizoma Dioscoreae 10-25 parts, Curcumae 10-25 parts, Radix Sophorae 5-20 parts, Forsythiae 10-25 parts, Sargassum 10-25 parts, Radix Ephedrae 2-12 parts, Radix Bupleuri 5-20 parts, Fagopyri Cymosi 10-25 parts, Pericarpium Citri Reticulatae 5-25 parts, Hirudo 1-6 parts, Dioscoreae 10-20 parts.

[0024] Preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines: Radix Astragali 10-40 parts, Radix Paeoniae Alba 10-20 parts, Fritillariae Thunbergii 10-20 parts, Rhizoma Dioscoreae 10-20 parts, Curcumae 10-20 parts, Radix Sophorae 5-15 parts, Forsythiae 10-20 parts, Sargassum 10-20 parts, Radix Ephedrae 2-8 parts, Radix Bupleuri 5-15 parts, Fagopyri Cymosi 10-20 parts, Pericarpium Citri Reticulatae 5-20 parts, Hirudo 1-6 parts, Dioscoreae 10-20 parts.

[0025] More preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines: Radix Astragali 10-35 parts, Radix Paeoniae Alba 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Dioscoreae 10-15 parts, Curcumae 10-15 parts, Radix Sophorae 5-10 parts, Forsythiae 10-15 parts, Sargassum 10-15 parts, Radix Ephedrae 2-6 parts, Radix Bupleuri 5-10 parts, Fagopyri Cymosi 10-15 parts, Pericarpium Citri Reticulatae 5-15 parts, Hirudo 1-4 parts, Dioscoreae 10-15 parts.

[0026] In some embodiments of the present application, the traditional Chinese medicine composition is made from the following traditional Chinese medicines: Radix Astragali 10-45 parts, Radix Paeoniae Alba 10-25 parts, Fritillariae Thunbergii 10-25 parts, Rhizoma Dioscoreae 10-25 parts, Curcumae 10-25 parts, Radix Sophorae 5-20 parts, Forsythiae 10-25 parts, Sargassum 10-25 parts, Radix Ephedrae 2-12 parts, Radix Bupleuri 5-20 parts, Fagopyri Cymosi 10-25 parts, Pericarpium Citri Reticulatae 5-25 parts, Perilla Frutescens 10-20 parts, Iridis Daturae 10-20 parts, Platycodonis 10-20 parts, Radix Paeoniae Alba 10-20 parts, Radix Glycyrrhizae 5-20 parts.

[0027] Preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-40 parts, Radix Puerariae 10-20 parts, Fritillariae Thunbergii 10-20 parts, Rhizoma Dioscoreae 10-20 parts, Curcuma 10-20 parts, Radix Tramitis 5-15 parts, Forsythia 10-20 parts, Sea Algae 10-20 parts, Radix Sophorae 2-8 parts, Radix Bupleuri 5-15 parts, Fagopyrum 10-20 parts, Pericarpium Citri Reticulatae 5-20 parts, Perilla 10-20 parts, Rehmannia 10-20 parts, Radix Glycyrrhizae 5-20 parts.

[0028] More preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-35 parts, Radix Puerariae 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Dioscoreae 10-15 parts, Curcuma 10-15 parts, Radix Tramitis 5-10 parts, Forsythia 10-15 parts, Sea Algae 10-15 parts, Radix Sophorae 2-6 parts, Radix Bupleuri 5-10 parts, Fagopyrum 10-15 parts, Pericarpium Citri Reticulatae 5-15 parts, Perilla 10-20 parts, Rehmannia 10-20 parts, Radix Glycyrrhizae 5-20 parts.

[0029] In some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-45 parts, Radix Puerariae 10-25 parts, Fritillariae Thunbergii 10-25 parts, Rhizoma Dioscoreae 10-25 parts, Curcuma 10-25 parts, Radix Tramitis 5-20 parts, Forsythia 10-25 parts, Sea Algae 10-25 parts, Radix Sophorae 2-12 parts, Radix Bupleuri 5-20 parts, Fagopyrum 10-25 parts, Pericarpium Citri Reticulatae 5-25 parts, Radix Notoginseng 10-30 parts, Radix Paeoniae Alba 10-30 parts, Perilla 10-20 parts, Peucedanum 10-20 parts, Radix Glycyrrhizae 5-15 parts.

[0030] Preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-40 parts, Radix Puerariae 10-20 parts, Fritillariae Thunbergii 10-20 parts, Rhizoma Dioscoreae 10-20 parts, Curcuma 10-20 parts, Radix Tramitis 5-15 parts, Forsythia 10-20 parts, Sea Algae 10-20 parts, Radix Sophorae 2-8 parts, Radix Bupleuri 5-15 parts, Fagopyrum 10-20 parts, Pericarpium Citri Reticulatae 5-20 parts, Radix Notoginseng 10-30 parts, Radix Paeoniae Alba 10-30 parts, Perilla 10-20 parts, Peucedanum 10-20 parts, Radix Glycyrrhizae 5-15 parts.

[0031] More preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-35 parts, Radix Paeoniae Alba 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Arisaematis 10-15 parts, Curcumae 10-15 parts, Radix Periplocae 5-10 parts, Forsythiae 10-15 parts, Sargassum 10-15 parts, Radix Ephedrae 2-6 parts, Radix Bupleuri 5-10 parts, Fagopyri Cymosi 10-15 parts, Pericarpium Citri Reticulatae 5-15 parts, Radix Adenophorae 10-30 parts, Radix Morini 10-30 parts, Perilla Frutescens 10-20 parts, Radix Peucedani 10-20 parts, Platycodonis 10-20 parts, Radix Glycyrrhizae 5-15 parts.

[0032] In some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-45 parts, Radix Paeoniae Alba 10-25 parts, Fritillariae Thunbergii 10-25 parts, Rhizoma Arisaematis 10-25 parts, Curcumae 10-25 parts, Radix Periplocae 5-20 parts, Forsythiae 10-25 parts, Sargassum 10-25 parts, Radix Ephedrae 2-12 parts, Radix Bupleuri 5-20 parts, Fagopyri Cymosi 10-25 parts, Pericarpium Citri Reticulatae 5-25 parts, Phragmites 10-30 parts, Radix Glycyrrhizae 10-40 parts.

[0033] Preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-40 parts, Radix Paeoniae Alba 10-20 parts, Fritillariae Thunbergii 10-20 parts, Rhizoma Arisaematis 10-20 parts, Curcumae 10-20 parts, Radix Periplocae 5-15 parts, Forsythiae 10-20 parts, Sargassum 10-20 parts, Radix Ephedrae 2-8 parts, Radix Bupleuri 5-15 parts, Fagopyri Cymosi 10-20 parts, Pericarpium Citri Reticulatae 5-20 parts, Phragmites 10-30 parts, Radix Glycyrrhizae 10-40 parts.

[0034] More preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-35 parts, Radix Paeoniae Alba 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Arisaematis 10-15 parts, Curcumae 10-15 parts, Radix Periplocae 5-10 parts, Forsythiae 10-15 parts, Sargassum 10-15 parts, Radix Ephedrae 2-6 parts, Radix Bupleuri 5-10 parts, Fagopyri Cymosi 10-15 parts, Pericarpium Citri Reticulatae 5-15 parts, Phragmites 10-30 parts, Radix Glycyrrhizae 10-40 parts.

[0035] In some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-45 parts, Radix Paeoniae Alba 10-25 parts, Fritillariae Thunbergii 10-25 parts, Rhizoma Arisaematis 10-25 parts, Curcumae 10-25 parts, Radix Periplocae 5-20 parts, Forsythiae 10-25 parts, Sargassum 10-25 parts, Radix Ephedrae 2-12 parts, Radix Bupleuri 5-20 parts, Fagopyri Cymosi 10-25 parts, Pericarpium Citri Reticulatae 5-25 parts, Rhizoma Typhonii 5-15 parts, Rhizoma Zingiberis Recens 2-8 parts, Radix Morini 10-20 parts.

[0036] Preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-40 parts, Radix Paeoniae Alba 10-20 parts, Fritillariae Thunbergii 10-20 parts, Rhizoma Arisaematis 10-20 parts, Curcuma 10-20 parts, Radix Tramitis 5-15 parts, Forsythia 10-20 parts, Sea Algae 10-20 parts, Fried Ephedra 2-8 parts, Vinegar Radix Bupleuri 5-15 parts, Fagopyrum 10-20 parts, Citrus 5-20 parts, Rhizoma Typhonii 5-15 parts, Dried Ginger 2-8 parts, Radix Morindae Officinalis 10-20 parts.

[0037] More preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-35 parts, Radix Paeoniae Alba 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Arisaematis 10-15 parts, Curcuma 10-15 parts, Radix Tramitis 5-10 parts, Forsythia 10-15 parts, Sea Algae 10-15 parts, Fried Ephedra 2-6 parts, Vinegar Radix Bupleuri 5-10 parts, Fagopyrum 10-15 parts, Citrus 5-15 parts, Rhizoma Typhonii 5-15 parts, Dried Ginger 2-8 parts, Radix Morindae Officinalis 10-20 parts.

[0038] In some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-45 parts, Radix Paeoniae Alba 10-25 parts, Fritillariae Thunbergii 10-25 parts, Rhizoma Arisaematis 10-25 parts, Curcuma 10-25 parts, Radix Tramitis 5-20 parts, Forsythia 10-25 parts, Sea Algae 10-25 parts, Fried Ephedra 2-12 parts, Vinegar Radix Bupleuri 5-20 parts, Fagopyrum 10-25 parts, Citrus 5-25 parts, Vinegar Typhonii 5-20 parts, Fructus Aurantii 10-20 parts, Radix Paeoniae Alba 10-20 parts, Perilla 5-15 parts.

[0039] Preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-40 parts, Radix Paeoniae Alba 10-20 parts, Fritillariae Thunbergii 10-20 parts, Rhizoma Arisaematis 10-20 parts, Curcuma 10-20 parts, Radix Tramitis 5-15 parts, Forsythia 10-20 parts, Sea Algae 10-20 parts, Fried Ephedra 2-8 parts, Vinegar Radix Bupleuri 5-15 parts, Fagopyrum 10-20 parts, Citrus 5-20 parts, Vinegar Typhonii 5-20 parts, Fructus Aurantii 10-20 parts, Radix Paeoniae Alba 10-20 parts, Perilla 5-15 parts.

[0040] More preferably, in some embodiments of the present application, the Chinese medicine composition is made of the following Chinese medicines: Radix Astragali 10-35 parts, Radix Paeoniae Alba 10-15 parts, Fritillariae Thunbergii 10-15 parts, Rhizoma Arisaematis 10-15 parts, Curcuma 10-15 parts, Radix Tramitis 5-10 parts, Forsythia 10-15 parts, Sea Algae 10-15 parts, Fried Ephedra 2-6 parts, Vinegar Radix Bupleuri 5-10 parts, Fagopyrum 10-15 parts, Citrus 5-15 parts, Vinegar Typhonii 5-20 parts, Fructus Aurantii 10-20 parts, Radix Paeoniae Alba 10-20 parts, Perilla 5-15 parts.

[0041] In some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-45 parts, Rhizoma Atractylodis 10-25 parts, Fritillariae Thunbergii 10-25 parts, Curcumae 10-25 parts, Gleditsiae 5-20 parts, Sea Algae 10-25 parts, Ephedrae 2-12 parts, Citri Reticulatae 5-25 parts, Bartramia 10-35 parts, Duchesnea 10-35 parts, Herba Gnaphii 10-35 parts, Black Order Sheet 5-20 parts, Lycopus 5-20 parts, Prepared White Fuzi 5-20 parts, Fructus Physostegi 5-20 parts, and Radix Glycyrrhizae 5-20 parts.

[0042] Preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-40 parts, Rhizoma Atractylodis 10-20 parts, Fritillariae Thunbergii 10-20 parts, Curcumae 10-20 parts, Gleditsiae 5-15 parts, Sea Algae 10-20 parts, Ephedrae 2-8 parts, Citri Reticulatae 5-20 parts, Bartramia 10-30 parts, Duchesnea 10-30 parts, Herba Gnaphii 10-30 parts, Black Order Sheet 5-15 parts, Lycopus 5-15 parts, Prepared White Fuzi 5-15 parts, Fructus Physostegi 5-15 parts, and Radix Glycyrrhizae 5-15 parts.

[0043] More preferably, in some embodiments of the present application, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: Radix Astragali 10-35 parts, Rhizoma Atractylodis 10-15 parts, Fritillariae Thunbergii 10-15 parts, Curcumae 10-15 parts, Gleditsiae 5-10 parts, Sea Algae 10-15 parts, Ephedrae 2-6 parts, Citri Reticulatae 5-15 parts, Bartramia 10-25 parts, Duchesnea 10-25 parts, Herba Gnaphii 10-25 parts, Black Order Sheet 5-10 parts, Lycopus 5-10 parts, Prepared White Fuzi 5-10 parts, Fructus Physostegi 5-10 parts, and Radix Glycyrrhizae 5-10 parts.

[0044] In a second aspect, the present application provides a traditional Chinese medicine preparation made of the traditional Chinese medicine composition of the first aspect, wherein the traditional Chinese medicine preparation is one or more of the following: paste, pill, bolus, decoction, granule, capsule, powder and / or tablet.

[0045] Further, the traditional Chinese medicine preparation comprises pharmaceutically acceptable excipients required by the corresponding preparation.

[0046] Still further, the excipients are medicinal excipients that have the effect of enhancing the efficacy, reducing the toxicity and / or alleviating the side effects of the main drug.

[0047] In a third aspect, the present application provides a use of the traditional Chinese medicine composition in the preparation of a drug for treating pulmonary nodules.

[0048] Further, the pulmonary nodules include one or more of the following: solid nodules, partially solid nodules, ground glass nodules, pure ground glass nodules and / or non-solid nodules.

[0049] The medicinal properties and effects of each traditional Chinese medicinal material in the present application are as follows:

[0050] Radix Astragali seu Hedysel: sweet, slightly warm, and returns to the lung and spleen meridians. It has the effects of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting water and reducing swelling, generating fluid and nourishing blood, removing stagnation and relieving pain, and promoting pus discharge and healing. It is used for treating qi deficiency and debilitation, poor appetite and loose stool, middle-qi collapse, chronic diarrhea and prolapse, hematochezia and metrorrhagia, exterior deficiency and spontaneous sweating, qi deficiency and edema, internal heat and polydipsia, blood deficiency and emaciation, hemiplegia, arthralgia and numbness, and ulcer and chronic sore.

[0051] Fried Atractylodes: bitter and sweet, warm, and returns to the spleen and stomach meridians. It has the effects of relieving abdominal distension and diarrhea, reducing phlegm and relieving palpitation and edema, and strengthening the spleen and benefiting qi, drying dampness and promoting water, stopping sweating, and preventing miscarriage. It is used for treating spleen deficiency and poor appetite, and fetal movement and instability.

[0052] Fritillariae Thunbergii: bitter, cold, and returns to the lung and heart meridians. It has the effects of clearing heat and reducing phlegm, relieving cough, and detoxifying and resolving and eliminating. It is used for treating wind-heat cough, phlegm-fire cough, lung abscess, mastitis, scrofula, and sore and the like.

[0053] Rhizoma Anemarrhenae: bitter and pungent, warm, and toxic, and returns to the lung, liver, and spleen meridians. It has the effects of drying dampness and reducing phlegm, dispelling wind and stopping convulsion, and resolving and eliminating. It is used for treating stubborn phlegm and cough, wind-phlegm dizziness, wind-phlegm obstruction, mouth and eye deviation, hemiplegia, epilepsy, convulsion, and tetanus; and externally for treating abscess, snake and insect bites, and the like.

[0054] Rhizoma Curcumae: pungent and bitter, warm, and returns to the liver and spleen meridians. It has the effects of removing blood stasis and relieving pain. It is used for treating mass and blockage, blood stasis and amenorrhea, chest pain and heart pain, and food accumulation and abdominal pain.

[0055] Radix Sophorae Tonkinensis: pungent, warm, and returns to the liver and lung meridians. It has the effects of removing wind, removing toxin, reducing swelling, and discharging pus. It is used for treating abscess, sore, scrofula, tinea, and retained placenta and the like.

[0056] Folium Forsythiae: bitter, slightly cold, and returns to the lung, heart, and small intestine meridians. It has the effects of clearing heat and resolving toxin, reducing and eliminating, and dispersing wind-heat. It is used for treating abscess, scrofula, mastitis, erysipelas, wind-heat cold, early stage of warm disease, warm-heat entering the nutrient aspect, high fever and polydipsia, delirium and macula, and heat stranguria and the like.

[0057] Sargassum: bitter and salty, cold, and returns to the liver, stomach, and kidney meridians. It has the effects of reducing phlegm, softening and resolving, and reducing and eliminating. It is used for treating goiter, scrofula, testicular pain, and phlegm edema and the like.

[0058] Radix Ephedrae: pungent and slightly bitter, warm, and returns to the lung and urinary bladder meridians. It has the effects of inducing perspiration and dispelling cold, promoting the lung and relieving asthma, and reducing and eliminating. It is used for treating wind-cold cold, chest stuffiness and cough, and water edema and the like.

[0059] ​Vitex negundo: bitter, acrid, slightly cold, liver, gallbladder, lung meridian. Has the effect of dispersing heat, soothing the liver and relieving depression, lifting yang qi. Used for colds and fever, alternating chills and fever, chest and hypochondrium distending pain, irregular menstruation, uterine prolapse, prolapse of the anus and other symptoms.

[0060] Fagopyrum cymosum: slightly bitter, astringent, cool, lung meridian. Has the effect of clearing heat and resolving toxins, pus and blood stasis. Used for lung abscess, lung heat and cough, tonsillitis and other symptoms.

[0061] Pericarpium citri reticulatae: bitter, acrid, warm, lung, spleen meridian. Has the effect of regulating qi and invigorating the spleen, drying dampness and reducing phlegm. Used for abdominal distension, food retention, vomiting and diarrhea, cough and phlegm and other symptoms.

[0062] Leech: salty, bitter, neutral; small toxic. Liver meridian. Has the effect of breaking blood, unblocking menstruation, removing blood stasis and removing blood stasis. Used for blood stasis, irregular menstruation, mass, stroke, hemiplegia, injury and other symptoms.

[0063] Rhizoma Dispori: sweet, bitter, warm, liver, kidney, lung meridian. Has the effect of dispelling wind and dampness, relaxing the tendons and collaterals, promoting blood circulation and relieving pain, relieving cough and asthma. Used for rheumatism, joint swelling, pain and numbness, injury, lumbar pain, asthma, cough and other symptoms.

[0064] Perilla frutescens: acrid, warm, lung meridian. Has the effect of descending qi and reducing phlegm, relieving cough and asthma, moistening the intestines and relieving constipation. Used for phlegm, cough and asthma, constipation and other symptoms.

[0065] Iris lactea: bitter, acrid, slightly warm, lung meridian. Has the effect of descending qi, reducing phlegm and relieving cough. Used for lung qi stagnation, cough and phlegm, chest fullness and shortness of breath and other symptoms.

[0066] Platycodon grandiflorum: bitter, acrid, neutral, lung meridian. Has the effect of promoting lung, benefiting the throat, removing phlegm and pus. Used for cough and phlegm, chest tightness, sore throat and hoarseness, lung abscess and other symptoms.

[0067] Radix Paeoniae Alba: bitter, sour, slightly cold, liver, spleen meridian. Has the effect of nourishing blood and regulating menstruation, astringing yin and stopping sweating, softening the liver and relieving pain, and suppressing liver yang. Used for blood deficiency, irregular menstruation, sweating, night sweating, hypochondriac pain, abdominal pain, limb spasm, headache and dizziness and other symptoms.

[0068] Radix Glycyrrhizae: sweet, neutral, heart, lung, spleen, stomach meridian. Has the effect of tonifying the spleen and stomach, benefiting qi and restoring pulse. Used for spleen and stomach weakness, fatigue, palpitation, pulse and other symptoms.

[0069] Radix Adenophorae: sweet, slightly cold, lung, stomach meridian. Has the effect of nourishing yin and clearing lung, benefiting stomach and producing saliva, reducing phlegm and benefiting qi. Used for lung heat and cough, yin deficiency and cough, phlegm and sticky, stomach yin deficiency, food retention, qi yin deficiency, dry mouth and other symptoms.

[0070] Honey-processed mulberry bark: Sweet in taste and cold in nature. It enters the lung meridian. It has the effects of purging lung heat and relieving asthma, promoting diuresis and reducing swelling. It is used for symptoms such as cough with wheezing due to lung heat, edema with abdominal distension and scanty urine, and facial and skin swelling.

[0071] Peucedanum praeruptorum: Bitter and pungent in taste, slightly cold in nature. It enters the lung meridian. It has the effects of lowering qi and resolving phlegm, dispelling wind and clearing heat. It is used for symptoms such as phlegm-heat wheezing, thick yellow phlegm, and wind-heat cough with excessive phlegm.

[0072] Reed rhizome: Sweet in taste and cold in nature. It enters the lung and stomach meridians. It has the effects of clearing heat and purging fire, promoting body fluid and quenching thirst, relieving irritability, stopping vomiting, and promoting urination. It is used for symptoms such as feverish thirst, cough due to lung heat, lung abscess with purulent sputum, vomiting due to stomach heat, and painful urination due to heat.

[0073] Raw Job's tears: sweet and bland in taste, cool in nature. It enters the spleen, stomach, and lung meridians. It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and stopping diarrhea, relieving numbness, draining pus, detoxifying and dispersing nodules. It is used for edema, beriberi, difficulty urinating, spleen deficiency diarrhea, dampness-induced numbness and contracture, lung abscess, intestinal abscess, warts, and cancer.

[0074] White aconite root: pungent and warm in nature; toxic. It enters the stomach and liver meridians. It has the effects of dispelling wind-phlegm, calming convulsions, detoxifying and dispersing nodules, and relieving pain. It is used for stroke with phlegm obstruction, and symptoms related to mouth and eyes. Symptoms include: slurred speech, infantile convulsions, epilepsy, tetanus, phlegm-induced headache, migraine, scrofula, snake bites, etc.

[0075] Dried ginger: pungent in flavor and hot in nature. It enters the spleen, stomach, kidney, heart, and lung meridians. It has the effects of warming the middle jiao and dispelling cold, restoring yang and unblocking the meridians, and warming the lungs and resolving phlegm. It is used for symptoms such as cold pain in the epigastrium and abdomen, vomiting and diarrhea, cold limbs and weak pulse, and cough with cold phlegm.

[0076] Morinda officinalis: Sweet and pungent in taste, slightly warm in nature. It enters the kidney and liver meridians. It has the effects of tonifying kidney yang, strengthening tendons and bones, and dispelling wind and dampness. It is used for impotence, seminal emission, infertility due to cold uterus, irregular menstruation, lower abdominal pain due to cold, rheumatic pain, and weakness of tendons and bones.

[0077] Vinegar-processed Cyperus: pungent, slightly bitter, and slightly sweet in taste, neutral in nature. It enters the liver, spleen, and triple burner meridians. It has the effects of soothing the liver and relieving depression, regulating qi and relieving chest tightness, regulating menstruation and relieving pain. It is used for liver qi stagnation, chest and rib pain, hernia pain, breast pain, spleen and stomach qi stagnation, abdominal distension and pain, irregular menstruation, amenorrhea, and dysmenorrhea.

[0078] Fructus Aurantii Immaturus: Bitter, pungent, and sour in taste, and slightly cold in nature. It enters the spleen and stomach meridians. It has the effects of regulating qi and relieving chest tightness, promoting circulation and relieving bloating. It is used for symptoms such as qi stagnation in the chest and hypochondrium, abdominal distension and pain, indigestion, phlegm retention, and organ prolapse.

[0079] Scutellaria barbata: pungent and bitter in taste, cold in nature. It enters the lung, liver, and kidney meridians. It has the effects of clearing heat and detoxifying, resolving blood stasis and promoting diuresis. It is used for boils and carbuncles, sore throat, traumatic injuries, edema, jaundice, snake and insect bites, etc.

[0080] Snakeberry: Sweet and bitter in taste, cold in nature, and enters the lung, liver, and large intestine meridians. It has the effects of clearing heat, detoxifying, cooling blood, and reducing swelling. It is used for colds with fever, sore throat, canker sores, dysentery, jaundice, hematemesis, mumps, carbuncles, scrofula, traumatic swelling and pain, burns, etc.

[0081] *Scutellaria baicalensis*: It has a pungent and bitter taste, and is slightly cold in nature. It enters the liver and spleen meridians. It has the effects of promoting blood circulation and removing blood stasis, clearing heat and promoting diuresis, and dispersing nodules and reducing swelling. It is used for irregular menstruation, dysmenorrhea, amenorrhea, metrorrhagia, hematochezia, damp-heat jaundice, heat-toxin dysentery, dysuria, leukorrhea, rheumatic bone pain, scrofula, sores, mastitis, herpes zoster, leprosy, and traumatic injuries with swelling and bruises.

[0082] Black aconite slices: pungent in flavor and warm in nature. Enters the heart, spleen, and kidney meridians. It has the effects of restoring yang and rescuing from collapse, tonifying fire and assisting yang, dispelling cold and relieving pain. Used for restoring yang and rescuing from collapse, tonifying fire and assisting yang, dispelling cold and eliminating dampness. Treats yin excess with yang deficiency, profuse sweating leading to yang collapse, vomiting and diarrhea with cold extremities, cold pain in the heart and abdomen, cold diarrhea, beriberi with edema, infantile convulsions, wind-cold-dampness arthralgia, cramps and contractures, impotence, cold uterus, carbuncles and fistulas, and all chronic cold and stubborn diseases.

[0083] Northern Sophora Root: Bitter in taste, cold in nature; slightly toxic. It enters the lung, stomach, and large intestine meridians. It has the effects of clearing heat and detoxifying, dispelling wind and relieving pain. It is used for sore throat, dysentery due to heat toxicity, and rheumatic pain.

[0084] Prepared Aconitum carmichaelii: pungent and warm in nature; toxic. It enters the stomach and liver meridians. It has the effects of dispelling wind-phlegm, calming convulsions, detoxifying and dispersing nodules, and relieving pain. It is used for stroke with phlegm obstruction, and symptoms related to mouth and eyes. Symptoms include: slurred speech, infantile convulsions, epilepsy, tetanus, phlegm-induced headache, migraine, scrofula, snake bites, etc.

[0085] Momordica cochinchinensis seeds: bitter and slightly sweet in taste, cool in nature; poisonous. It enters the liver, spleen, and stomach meridians. It has the effects of dispersing nodules and reducing swelling, attacking toxins and healing sores. It is used for sores, carbuncles, mastitis, scrofula, hemorrhoids, psoriasis, and tinea capitis.

[0086] The treatment principle in this invention:

[0087] Qi deficiency is the underlying cause of pulmonary nodules. Qi deficiency leads to insufficient propulsion and warming functions, while Qi stagnation results in impaired Qi function. Yang deficiency represents the extreme of Qi deficiency, manifesting as even greater weakness in propulsion and warming functions. Metabolic disorders of Qi lead to the abnormal metabolism of body fluids, resulting in the accumulation of pathological products within the body. The pathological changes in body fluids, in turn, exacerbate Qi stagnation, creating a vicious cycle. The interplay of factors such as phlegm-dampness, blood stasis, and Qi dysfunction contributes to the formation and gradual development of nodules, potentially leading to precancerous lesions or even malignant tumors. Therefore, disordered Qi and body fluids lead to the formation of masses. Based on the theory of Qi and body fluids, treatment combines tonifying Qi, regulating Qi, and transforming Qi, while also addressing phlegm-resolving, dampness-removing, blood-activating, swelling-reducing, cancer-fighting, and detoxifying effects.

[0088] The Chinese medicine composition of the present application has the following effects: the sea algae and rhizoma arisaematis can soften and resolve phlegm and nodus, radix astragali can tonify lung qi and spleen qi, and they are the monarch drugs; fritillariae thunbergii and forsythia can clear heat, resolve phlegm and nodus, atractylodes can tonify spleen qi, zedoary and soapwort can activate blood and resolve swelling, and they are the minister drugs. The monarch drugs and the minister drugs are matched and complemented each other, and they can clear heat, resolve phlegm and nodus; radix bupleuri and pericarpium citri reticulatae can soothe liver and regulate qi, and ephedra can activate yang and regulate qi, and they are the assistant drugs; and radix junci can enter lung meridian, clear lung and resolve swelling, and they are the ministerial drugs.

[0089] For the patients with obvious blood stasis, further add leech and rhizoma dioscoreae nipponicae to activate blood and resolve swelling; for the patients with severe lung qi disorder, further add perilla, radix bisolae, and platycodon to promote lung qi, radix paeoniae alba to soothe liver and activate blood, and radix glycyrrhizae preparata to harmonize all drugs; for the patients with lung heat and adverse qi, further add radix adenosmae, mulberry bark, perilla, radix angelicae sinensis, and platycodon to clear lung and descend qi, and radix glycyrrhizae preparata to harmonize all drugs; for the patients with phlegm-heat accumulation, add radix rhizomatis alismatis and semen euryales to clear lung and resolve phlegm; for the patients with yang qi deficiency, further add radix aconiti lateralis preparata, zingiber officinale, and radix morindae officinalis to warm yang and activate qi; for the patients with qi stagnation, add vinegar-fried atractylodes rhizome to soothe liver and regulate qi, perilla to open stagnation and descend qi, and fructus aurantii and radix paeoniae alba to regulate qi and activate blood; for the patients with possible malignancy, take radix scutellariae barbatae, rubus coreanus, herba rubi parvifolii, radix astragali complanati, and semen phaselis to attack cancer and detoxify, and take radix aconiti lateralis preparata to warm yang and activate qi to help cancer and toxin to dissipate, and to prevent the harm of cold and cool detoxification drugs to yang. Beneficial effects

[0090] 1. The present application is a pure Chinese medicine prescription, which has mild drug nature, high safety, fast effect, good curative effect, wide drug source, and is suitable for clinical popularization and application.

[0091] 2. According to the curative effect determination of lung nodule diameter change, the effective rate of the Chinese medicine composition in the present application is 26.4%, and oral Chinese medicine treatment can reduce the medium and high risk lung nodule lesions.

[0092] 3. According to the determination of TCM symptom score, the Chinese medicine composition in the present application can effectively improve the TCM symptoms such as cough, chest tightness, fatigue, loss of appetite, irritability, and insomnia, and the effective rate of the Chinese medicine composition is 72.2%.

[0093] 4. The treatment effective rate of the patients with nodules found within half a year is increased compared with the patients with nodules not found within half a year, which indicates that the patients with nodules found within half a year are more likely to benefit from the Chinese medicine treatment. BRIEF DESCRIPTION OF DRAWINGS

[0094] Figure 1 is a histogram of baseline TCM symptom score. DETAILED DESCRIPTION

[0095] The specific embodiments of the present application are further described below. It should be noted that the description of the embodiments is used to help understand the present application, but does not constitute a limitation on the present application. In addition, the technical features involved in the following described embodiments can be combined with each other as long as they do not conflict with each other.

[0096] The experimental methods in the following examples are all conventional methods unless otherwise specified. The experimental materials used in the following examples are all commercially available unless otherwise specified.

[0097] Terminology

[0098] Follow-up of pulmonary nodules: refers to the process of dynamically monitoring, evaluating and making real-time optimal intervention plan for nodules.

[0099] Differentiation of body is based on the concept of TCM holism. Although pulmonary nodules grow in a local part, it is a systemic disease from the beginning. Differentiation of body and regulation of body constitution reflect the TCM thought of "preventing disease".

[0100] ST: In the early study of electrocardiogram, Einthoven used English letters to represent each wave of electrocardiogram: P represents atrial depolarization wave; Q, R, S all represent ventricular depolarization wave, collectively known as QRS wave group; T wave reflects the potential change during the repolarization of left and right ventricles. The part between S wave and T wave is called ST segment. The time when ventricular muscle is completely depolarized and repolarization has not yet begun. At this time, the ventricular muscle of each part is in the state of depolarization, and there is no potential difference between cells. Therefore, under normal circumstances, the ST segment should be on the isoelectric line. When some parts of the myocardium show ischemia or necrosis, there is still a potential difference in the ventricle after depolarization. At this time, it shows that the ST segment of electrocardiogram has deviated.

[0101] Neuron specific enolase: (neuron specific enolase, NSE) is a kind of enolase, which is an acid protease secreted by neurons and neuroendocrine cells. It has high specificity in neuroendocrine tumors. About 70% of patients with small cell lung cancer will have elevated NSE. Therefore, it has been applied to the differential diagnosis of tumor pathological types, disease monitoring, efficacy evaluation and recurrence prediction.

[0102] Cytokeratin 19 fragment (abbreviated as Cyfra 21-1) is a lung cancer-related tumor marker, belonging to the intermediate filament protein family, with a molecular weight of about 40 kD, mainly existing in the cytoplasm of tumor cells of epithelial cell origin such as esophageal cancer and lung cancer. After squamous epithelial (complex epithelial) cells deteriorate, the intermediate filaments that constitute the main intracellular cytoskeleton will be broken and degraded. Intermediate filaments are one of the cytoskeletal components that support eukaryotic cells, and are filaments with a diameter of about 10 nm. The main subunit of intermediate filaments is cytokeratin, which is divided into 1 to 20 subtypes due to sequence differences. Among them, the content of keratin 19 is relatively rich, and during the lysis process, water-soluble fragments are produced and released into the circulatory system, which is Cyfra 21-1. Therefore, in clinical detection, Cyfra 21-1 is often considered as an effective detection fragment of cytokeratin 19.

[0103] Carcinoembryonic antigen: (carcinoembryonic antigen, CEA) with a molecular weight of 180,000 is a glycoprotein produced during embryonic development. It is a carcinoembryonic antigen. It exists in the intestinal tube, pancreas and liver of the fetus during the first two months of pregnancy. When CEA is too high, it often indicates a digestive tract cancer, commonly seen in colorectal cancer, pancreatic cancer, gastric cancer, breast cancer, lung cancer, medullary thyroid cancer, etc. CEA is a broad-spectrum tumor marker. About 15% to 53% of patients with benign diseases such as benign breast tumors, severe alcoholic cirrhosis, emphysema, collagen disease, cardiovascular disease, diabetes, and non-specific colitis also have elevated serum CEA. Therefore, CEA is not a specific marker for malignant tumors. It mainly has auxiliary value in diagnosis and has great clinical value for prognosis and efficacy observation.

[0104] Traditional Chinese medicine composition in Example 1

[0105] 1. Yiqi Huatan Sanjie Decoction: Radix Astragali 30g, Radix Pini 15g, Fritillariae Thunbergii 15g, Rhizoma Dioscoreae 15g, Curcuma 15g, Radix Sophorae Tonkinensis 10g, Forsythia Suspensa 15g, Sargassum 15g, Radix Sophorae 6g, Radix Bupleuri 10g, Fagopyrum 15g, Citri Reticulatae 12g.

[0106] 2. Yiqi Huatan Sanjie Decoction with modifications (combined with blood stasis): Radix Astragali 30g, Radix Pini 15g, Fritillariae Thunbergii 15g, Rhizoma Dioscoreae 15g, Curcuma 15g, Radix Sophorae Tonkinensis 10g, Forsythia Suspensa 15g, Sargassum 15g, Radix Sophorae 6g, Radix Bupleuri 10g, Fagopyrum 15g, Citri Reticulatae 12g, Hirudo 3g, Rhizoma Dispori 15g.

[0107] 3. Yiqi Huatan Sanjie Decoction (combined with lung qi dysfunction): Radix Astragali seu Hedysari 30g, Rhizoma Atractylodis Macrocephalae 15g, Fritillariae Thunbergii 15g, Rhizoma Anemarrhenae 15g, Curcuma 15g, Radix Tramitis 10g, Forsythia suspensa 15g, Sargassum 15g, Radix Glycyrrhizae 6g, Radix Bupleuri 10g, Fagopyrum cymosum 15g, Pericarpium Citri Reticulatae 12g, Perilla frutescens 15g, Radix Bistortae 15g, Platycodonis 15g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 12g.

[0108] 4. Yiqi Huatan Sanjie Decoction (combined with lung heat and adverse qi): Radix Astragali seu Hedysari 30g, Rhizoma Atractylodis Macrocephalae 15g, Fritillariae Thunbergii 15g, Rhizoma Anemarrhenae 15g, Curcuma 15g, Radix Tramitis 10g, Forsythia suspensa 15g, Sargassum 15g, Radix Glycyrrhizae 6g, Radix Bupleuri 10g, Fagopyrum cymosum 15g, Pericarpium Citri Reticulatae 12g, Radix Notoginseng 20g, Radix Morae 20g, Perilla frutescens 15g, Radix Peucedani 15g, Platycodonis 15g, Radix Glycyrrhizae 10g.

[0109] 5. Yiqi Huatan Sanjie Decoction (combined with phlegm heat): Radix Astragali seu Hedysari 30g, Rhizoma Atractylodis Macrocephalae 15g, Fritillariae Thunbergii 15g, Rhizoma Anemarrhenae 15g, Curcuma 15g, Radix Tramitis 10g, Forsythia suspensa 15g, Sargassum 15g, Radix Glycyrrhizae 6g, Radix Bupleuri 10g, Fagopyrum cymosum 15g, Pericarpium Citri Reticulatae 12g, Phragmites communis 20g, Semen Oryzae 30g.

[0110] 6. Yiqi Huatan Sanjie Decoction (combined with yang qi deficiency): Radix Astragali seu Hedysari 30g, Rhizoma Atractylodis Macrocephalae 15g, Fritillariae Thunbergii 15g, Rhizoma Anemarrhenae 15g, Curcuma 15g, Radix Tramitis 10g, Forsythia suspensa 15g, Sargassum 15g, Radix Glycyrrhizae 6g, Radix Bupleuri 10g, Fagopyrum cymosum 15g, Pericarpium Citri Reticulatae 12g, Radix Aconiti 10g, Radix Zingiberis 6g, Radix Morindae Officinalis 15g.

[0111] 7. Yiqi Huatan Sanjie Decoction (combined with qi stagnation, with visible swelling and pain on the body): Radix Astragali seu Hedysari 30g, Rhizoma Atractylodis Macrocephalae 15g, Fritillariae Thunbergii 15g, Rhizoma Anemarrhenae 15g, Curcuma 15g, Radix Tramitis 10g, Forsythia suspensa 15g, Sargassum 15g, Radix Glycyrrhizae 6g, Radix Bupleuri 10g, Fagopyrum cymosum 15g, Pericarpium Citri Reticulatae 12g, Radix Aconiti 12g, Fructus Aurantii 15g, Radix Paeoniae Alba 15g, Perilla frutescens 10g.

[0112] 8. Yiqi Huatan Sanjie Decoction (for possible malignancy): Radix Astragali seu Hedysari 30g, Rhizoma Atractylodis Macrocephalae 15g, Fritillariae Thunbergii 15g, Curcuma 15g, Radix Tramitis 10g, Sargassum 15g, Radix Glycyrrhizae 10g, Radix Glycyrrhizae 6g, Pericarpium Citri Reticulatae 12g, Hedyotis diffusa 20g, Duchesnea indica 20g, Herba Potentillae Discoloris 20g, Radix et Rhizoma Polygoni Multiflori 10g, Radix Lycii 9g, Rhizoma Anemarrhenae 9g, Semen Pharbitidis 10g.

[0113] Preparation method: the above medicinal materials are put into a decocting pot, soaked with appropriate amount of water for 30-60 min, with the water level being 2-5 cm higher than the medicinal materials, the first decoction is boiled with strong fire and then decocted with gentle fire for 20-25 min, the second time, appropriate amount of water is added, with the water level being 1-2 cm higher than the medicinal materials, boiled with strong fire and then decocted with gentle fire for 15-20 min, and then combined and filtered to obtain.

[0114] Example 2 clinical study

[0115] 1. Study plan

[0116] The present application collects general information of patients, lung nodule image, symptoms and other clinical data, collects efficacy evaluation related information after oral traditional Chinese medicine intervention, evaluates the overall efficacy of oral traditional Chinese medicine intervention for lung nodule treatment, and explores the efficacy related factors of oral traditional Chinese medicine intervention for lung nodule.

[0117] 2. Case source

[0118] The present application collects lung nodule patients who visit the outpatient department of the oncology department of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University from September 30, 2022 to May 30, 2024 for the treatment of lung nodule with traditional Chinese medicine. The present application has passed the approval of the ethics committee of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University (ethics number: 2022BL02-079)

[0119] 3. Disease diagnosis standard

[0120] The currently recognized lung nodule diagnosis standard is a circular or irregular lesion with a diameter less than or equal to 3 cm in the lung, which is a shadow with increased density in imaging, and can be single or multiple, with clear or unclear boundary. The lung nodule risk classification in the 2024 Expert Consensus on Lung Nodule Management in Combination with Traditional Chinese and Western Medicine is selected as the method for clinical classification of lung nodule in this study, and the diagnosis standard is shown in Table 1:

[0121] Table 1 Lung nodule risk classification

[0122]

[0123] 4. Inclusion and exclusion criteria

[0124] 4.1 Inclusion criteria:

[0125] (1) Patients who visit the hospital due to lung nodule and require traditional Chinese medicine treatment;

[0126] (2) Imaging shows at least one measurable lung nodule, which meets the definition of medium-high risk nodule.

[0127] (3) Age 18-75 years old;

[0128] (4) Voluntarily participate and sign the informed consent form.

[0129] 4.2 Exclusion criteria:

[0130] (1) Patients with confirmed sarcoidosis, infectious diseases caused by known pathogens;

[0131] (2) History of malignant tumor, diagnosed by clinical or pathological diagnosis or not excluded recurrence or metastasis;

[0132] (3) Highly suspected to be malignant by multidisciplinary team and suitable for surgical treatment;

[0133] (4) No review after anti-inflammatory treatment;

[0134] (5) Patients taking glucocorticoids or other immunosuppressive agents within the past month;

[0135] (6) Patients with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney, blood, etc;

[0136] (7) With mental diseases such as mania, schizophrenia and other reasons cannot cooperate with observation and research;

[0137] (8) Women planning to get pregnant, pregnant or lactating;

[0138] (9) Allergic to known research drugs;

[0139] (10) Currently participating in other drug clinical trials;

[0140] (11) Missing case information affecting data analysis.

[0141] 4.3 Withdrawal of subjects

[0142] (1) Patients lost to follow-up;

[0143] (2) Subjects voluntarily withdraw from the trial for any reason;

[0144] (3) Poor compliance, affecting safety and effectiveness evaluation during the study;

[0145] (4) Combination therapy, especially with drugs that have a greater impact on the study drug, affecting effectiveness and safety evaluation.

[0146] 5 Intervention program

[0147] The intervention program uses Professor Yang Guowang's lung nodule team to combine disease differentiation and syndrome differentiation with traditional Chinese medicine compound decoction treatment, 200ml twice a day, and taking medicine not less than 5 days a week.

[0148] 6 Observation indicators and observation time points

[0149] 6.1 Observation indicators

[0150] 6.1.1 Primary Outcome Measures:

[0151] (1) Average diameter of pulmonary nodules (the sum of the largest long diameter and the longest short diameter perpendicular to the largest long diameter (the largest short diameter) of the nodule divided by 2; the measurement method of the solid component of a partial solid nodule is the same);

[0152] (2) Volume of pulmonary nodules (measured by volume determination software in volume rendering image reconstruction by an artificial intelligence pulmonary nodule auxiliary diagnosis system; for CT images from other hospitals, the DICOM images of the chest CT are imported into the artificial intelligence pulmonary nodule auxiliary diagnosis system to calculate the volume of the pulmonary nodules);

[0153] (3) Complete reporting of the location, density, size, position, and shape (presence or absence of lobulation, spiculation, traction, and vacuoles) of pulmonary nodules.

[0154] (4) Evaluation method:

[0155] ① Volume: complete remission: chest CT shows that the pulmonary nodules have disappeared; partial remission: chest CT shows that the pulmonary nodules have shrunk, with a maximum volume reduction rate of ≥50%; improvement: chest CT shows that the pulmonary nodules have shrunk, with a maximum volume reduction rate of ≥25% and <50%; stable: chest CT shows that the pulmonary nodules have shrunk by <25% or increased by <25%; progression: chest CT shows that the pulmonary nodules have increased by ≥25%. Efficiency = (number of cases of complete remission + number of cases of partial remission + number of cases of improvement) / total number of cases x 100%.

[0156] ② Average diameter: complete remission: chest CT shows that the pulmonary nodules have disappeared; partial remission: chest CT shows that the pulmonary nodules have shrunk, with an average diameter reduction of ≥1.5 mm; stable: chest CT shows that the pulmonary nodules have changed by <1.5 mm; progression: chest CT shows that the pulmonary nodules have increased, with an average diameter increase of ≥1.5 mm. Efficiency = (number of cases of complete remission + number of cases of partial remission) / total number of cases x 100%.

[0157] 6.1.2 Secondary Outcome Measures

[0158] (1) TCM symptom score: observe the improvement of clinical symptoms such as cough, expectoration, chest tightness, shortness of breath, fatigue, loss of appetite, and other TCM symptoms after treatment, and evaluate them according to the symptom grading and quantification standards for lung cancer in the "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine".

[0159] Evaluation method: TCM symptoms were divided into 4 levels according to clinical observation: (0) no symptoms, (1) mild, (2) moderate, (3) severe. Evaluation method: Comparison of total symptom scores before and after treatment (pre-treatment / post-treatment) Marked effect: symptoms disappeared, or symptom score decreased by ≥2 / 3; Effective: symptoms were relieved, and the score decreased by ≥1 / 3 and ≤2 / 3; Ineffective: symptoms were not relieved or relieved by <1 / 3. 6.1.3 Safety index: detection of blood, urine routine, liver and kidney function, electrocardiogram, etc., and recording of adverse reactions during treatment.

[0160] 7 Statistical methods

[0161] SPSS 26.0 statistical software was used to analyze and process the data. For measurement data conforming to normal distribution, mean ± standard deviation (±s) was used, and for non-normal distribution, non-parametric test was used, with median (first quartile-third quartile) used. For measurement data conforming to normal distribution, independent sample t-test was used, and for non-normal distribution, non-parametric test was used. For self-paired measurement data before and after treatment, paired sample t-test was used for data conforming to normal distribution. For count data, Pearson's chi-square test / continuity correction chi-square test / Fisher's exact probability method was used, and Bonferroni correction was used for post-hoc test. Logistics regression analysis was used to explore factors that may affect efficacy. Bilateral test P<0.05 indicates that the difference is statistically significant, and P<0.01 indicates that the difference is significantly statistically significant.

[0162] 8 Research results

[0163] 8.1 General information

[0164] A total of 90 patients were included, of which 30 were male, accounting for 33.3%, and 60 were female, accounting for 66.7%. The age interval was 25-73 years old, with an age of 56 (43, 64.25) years old. There were 22 cases of elderly people (age ≥65 years old) (24.4%), and 68 cases of non-elderly people (75.6%). There were 42 cases with tumor family history (46.7%), and 48 cases without tumor family history (53.3%). There were 17 cases with smoking history (18.9%), and 73 cases without smoking history (81.1%). There were 53 cases with exposure history (58.9%), and 37 cases without exposure history (41.1%). There were 12 cases with a history of lung cancer (13.3%), and 78 cases without a history of lung cancer (86.7%). There were 2 cases with a history of other tumors (3.3%), and 88 cases without a history of other tumors (96.7%), as shown in Table 2.

[0165] Table 2 General information and medical history

[0166] 8.2 Baseline image data

[0167] 8.2.1 Lung nodule diameter

[0168] The baseline diameter of lung nodules of the enrolled patients was 9.27 ± 3.68 mm, with the maximum of 23.5 mm and the minimum of 4.75 mm, as shown in Table 3.

[0169] 8.2.2 Lung nodule volume

[0170] The baseline volume of lung nodules of the enrolled patients was 665.24 ± 758.38 mm 3 , with the maximum of 2272.20 mm 3 and the minimum of 59.60 mm 3 , as shown in Table 3.

[0171] Table 3 Diameter and volume of lung nodules

[0172]

[0173] 8.2.3 Lung nodule type (classified by density)

[0174] As shown in Table 4, according to the density classification of the most important lung nodules of each patient, the non-solid nodules (59 cases, 65.6%) > partial solid nodules (23 cases, 25.6%) > solid nodules (8 cases, 8.9%) in the enrolled population.

[0175] Table 4 Baseline imaging characteristics of lung nodules

[0176] 8.2.4 Lung nodule location

[0177] The most important lung nodules of the patients were located in the upper lobe of the lung in 60 cases (66.7%), of which in the right upper lobe (40 cases, 44.4%) and in the left upper lobe (20 cases, 22.2%), as shown in Table 4.

[0178] 8.2.5 Malignant CT signs of lung nodules

[0179] The common malignant CT signs included lobulation, pleural indentation, short and thin spicules, multiple cystic bright shadows, bronchovascular bundle sign, and spicular protrusion, etc. As shown in Table 4, there were 25 cases (27.8%) of the most important nodules with malignant CT signs and 65 cases (82.2%) without malignant CT signs in the enrolled population. As shown in Table 4, there were 8 cases (8.89%) of nodules with lobulation, 6 cases (6.67%) with pleural indentation, 6 cases (6.67%) with spicules, 4 cases (4.4%) with vascular bundle sign, and 10 cases (11.1%) with vacuoles.

[0180] 8.2.6 Risk classification of lung nodules

[0181] As shown in Table 4, the study included a high-risk population of pulmonary nodules, 69 cases of medium-risk nodules (76.7%), and 21 cases of high-risk nodules (23.3%).

[0182] 8.2.7 Whether the pulmonary nodule is new within half a year

[0183] As shown in Table 4, the time from the initial TCM treatment to the initial detection of pulmonary nodules was less than half a year, and the population included 48 cases (53.3%) with less than half a year from the initial detection of pulmonary nodules, and 42 cases (46.7%) with more than half a year from the initial detection of pulmonary nodules.

[0184] 8.3 Baseline data of clinical symptoms

[0185] 8.3.1 Baseline total score of TCM symptoms

[0186] There were 11 cases (12.2%) with a baseline TCM symptom score of 0, and 79 cases (87.8%) with a baseline TCM symptom score of >0. The distribution of different symptom scores is shown in Figure 1.

[0187] 8.3.2 Baseline data of different TCM symptoms

[0188] The baseline data of different TCM symptoms is shown in Table 5. The symptoms with the highest frequency from high to low were irritability, insomnia, fatigue, cough, chest tightness, loss of appetite, chest pain, shortness of breath, nausea and vomiting.

[0189] Table 5 Baseline data of TCM symptoms

[0190]

[0191] 8.4 Time of TCM intervention

[0192] As shown in Table 6, 69 cases (76.7%) in the included population took TCM for more than 3 months, and 21 cases took TCM for less than 3 months.

[0193] Table 6 Table of medication time

[0194]

[0195] 8.5 Imaging efficacy evaluation

[0196] 8.5.1 According to the diameter of the nodule

[0197] As shown in Table 7, according to the diameter of the nodule, the therapeutic effect was determined, 7 cases (7.8%) of complete remission, 14 cases (15.6%) of partial remission, 64 cases (71.1%) of stability, and 5 cases (5.6%) of progression were included in the population. According to the effective rate calculation formula, the effective rate was 26.4%. The diameter before treatment was 8 (6.5, 11.03) mm, and the diameter after treatment was 7.025 (6, 10) mm. The difference between the diameter after treatment and the diameter before treatment was statistically significant (P<0.01). Among the included population, 20 cases had both pre-treatment and post-treatment nodule volume information. The difference between the diameter after treatment and the diameter before treatment was statistically significant (P<0.01).

[0198] Table 7 Lung nodule diameter evaluation table

[0199]

[0200] 8.5.2 According to the nodule volume

[0201] As shown in Table 8, among the included population, 20 cases had both pre-treatment and post-treatment nodule volume information, and the volume therapeutic effect could be determined. Among them, 3 cases (15%) were completely relieved, 0 cases were partially relieved, 3 cases (15%) were improved, 13 cases (65%) were stable, and 1 case (5%) was progressive. Through the effective rate calculation formula, the effective rate was 30%. The volume before treatment was 314.62 (151.46, 981.78) mm 3 , and the volume after treatment was 261.07 (85.29, 578.8) mm 3 . There was no statistical difference between the volume after treatment and the volume before treatment (P>0.05).

[0202] Table 8 Lung nodule volume evaluation table

[0203]

[0204] 8.6 Evaluation of TCM symptom score

[0205] 8.6.1 TCM symptom score

[0206] As shown in Table 9, according to the therapeutic effect evaluation standard, among the 79 cases with TCM symptom score >0 before treatment, 35 cases (44.3%) were markedly effective, 22 cases (27.8%) were effective, and 22 cases (27.8%) were ineffective. According to the effective rate calculation formula, the effective rate was 72.2%. The TCM symptom score before treatment was 3 (1, 6) points, and the TCM symptom score after treatment was 1 (0, 3) points. After treatment, the TCM symptom score of the patients decreased significantly, and the difference was statistically significant (P<0.01).

[0207] Table 9 TCM symptom score evaluation table

[0208]

[0209] 8.6.2 Changes in TCM symptoms

[0210] As shown in Table 10, the cough symptom score of patients after TCM treatment was significantly lower than that before treatment, and the difference was statistically significant (P<0.05), among which the proportion of patients with no cough and mild cough increased significantly.

[0211] The chest tightness symptom score of patients after TCM treatment was significantly lower than that before treatment, and the difference was statistically significant (P<0.05), among which the proportion of patients with no chest tightness increased significantly, and the proportion of patients with moderate chest tightness decreased significantly.

[0212] The symptom score of patients with fatigue after TCM treatment was significantly lower than that before treatment, and the difference was statistically significant (P<0.05), among which the proportion of patients with no fatigue increased significantly, and the proportion of patients with mild, moderate and severe fatigue decreased significantly.

[0213] The symptom score of patients with anorexia after TCM treatment was significantly lower than that before treatment, and the difference was statistically significant (P<0.05), among which the proportion of patients with no anorexia increased significantly, and the proportion of patients with moderate anorexia decreased significantly.

[0214] The symptom score of patients with heart palpitations and insomnia after TCM treatment was significantly lower than that before treatment, and the difference was statistically significant (P<0.05), among which the proportion of patients with no heart palpitations and insomnia increased significantly, and the proportion of patients with moderate and severe heart palpitations and insomnia decreased significantly.

[0215] The symptom score of patients with chest pain after TCM treatment was not significantly different from that before treatment, and the difference was not statistically significant (P>0.05).

[0216] Table 10 Changes in TCM symptom classification before and after treatment

[0217] 8.7 Analysis of factors related to efficacy

[0218] 8.7.1 Correlation analysis of treatment efficacy and patient general information and medical history

[0219] As shown in Table 11, the efficacy of lung nodules in different gender, elderly and non-elderly population, tumor family history and no tumor family history population, contact history and no contact history population, history of other tumors and no history of other tumors population, and lung cancer history and no lung cancer history population had no statistically significant difference (P>0.05). The efficacy of lung nodules in patients with and without smoking history had a difference, and the difference was statistically significant (P<0.05).

[0220] Table 11 Correlation analysis of treatment efficacy and patient general information and history [number (%)]

[0221] 8.7.2 Relationship between treatment efficacy and imaging information of patients

[0222] As shown in Table 12, there was no statistically significant difference in the efficacy of lung nodules between the population with malignant CT signs and the population without malignant CT signs, and the population with nodules located in the upper lobe of the lung and the population without nodules located in the upper lobe of the lung (P>0.05). There was a difference in the efficacy of lung nodules between the medium-risk nodules and the high-risk nodules, and the three density types of lung nodules, and the difference was statistically significant (P<0.05).

[0223] According to the single factor logistic regression analysis of whether the included population was effective and the pre-treatment diameter, the regression coefficient β=0.168, OR=1.183, P=0.012, so the difference in the pre-treatment diameter has an impact on the efficacy, and the difference is statistically significant. When the pre-treatment diameter increases by one unit, the possibility of improving the treatment efficacy is 1.183 times the original.

[0224] Table 12 Correlation analysis of treatment efficacy and imaging information of patients [number (%)]

[0225] 8.7.3 Relationship between treatment efficacy and detection time of lung nodules and medication duration of patients

[0226] As shown in Table 13, there was a significant difference in the efficacy of the population with nodules appearing within six months and the population with nodules appearing more than six months, and the difference was statistically significant (P<0.05). The difference in the efficacy distribution ratio of the population with medication time of more than three months and the population with medication time of less than three months was not statistically significant (P>0.05).

[0227] Table 13 Correlation analysis of treatment efficacy and detection time of lung nodules and medication duration of patients [number (%)]

[0228]

[0229] 8.8 Safety evaluation

[0230] During the long-term follow-up and treatment, all patients did not have severe allergic reactions such as diarrhea, skin rash and itching, and difficulty breathing, and did not have obvious discomfort and serious adverse events. The blood, urine routine and liver and kidney function of the patients showed no obvious abnormalities.

[0231] Example 3 Clinical cases

[0232] Case 1

[0233] Patient: male, 69 years old

[0234] Initial diagnosis: February 21, 2023

[0235] Chief complaint: Found lung nodule 10 days

[0236] Present illness:

[0237] The patient was treated for chest pain, and lung lesions were found on February 10, 2023. The patient requested traditional Chinese medicine treatment.

[0238] Present symptoms:

[0239] Cough and sputum, sometimes yellow, sometimes shortness of breath, chest pain, sleep, normal bowel and body strength.

[0240] Past history: atrial fibrillation.

[0241] Auxiliary examination:

[0242] Chest CT on February 10, 2023: Compared with August 27, 2021, a new nodule was found in the posterior basal segment of the left lower lobe, which was malignant. The size was about 1.3 x 1.2 cm, with lobulation, multiple spicules, traction of the pleura, and local pleural thickening.

[0243] Electrocardiogram: sinus tachycardia, occasional supraventricular premature beats, ST depression, non-specific ST-T abnormalities.

[0244] Tongue: dark red, large, white and greasy fur. Pulse: stringy and slippery.

[0245] Diagnosis:

[0246] TCM: lung accumulation, phlegm and blood stasis

[0247] Western medicine: lung diagnostic imaging abnormalities

[0248] Treatment: tonifying lung and spleen, resolving phlegm and removing stasis

[0249] Prescription:

[0250] Radix Astragali seu Hedysari 30g, Radix Pini 15g, Fritillariae Thunbergii 15g, Curcuma 15g, Zanthoxylum 10g, Forsythia 15g, Rhizoma Anemarrhenae 15g, Sargassum 15g, Radix Glycyrrhizae 6g, Radix Bupleuri 10g, Fagopyrum 15g, Pericarpium Citri Reticulatae 12g. 24 doses in total.

[0251] Usage and dosage: 1 dose per day, decocted in water and taken warm, 200ml each in the morning and evening.

[0252] Treatment effect:

[0253] After the patient continued to take the original prescription for 3 months, chest CT was rechecked.

[0254] Chest CT on June 15, 2023: The ground glass opacity in the posterior basal segment of the left lower lobe has been absorbed and dissipated, and the solid micro-nodule in the dorsal segment of the left lower lobe is 5 x 4 mm.

[0255] Case 2

[0256] Patient: female, 58 years old.

[0257] Initial diagnosis: February 18, 2021

[0258] Past medical history: Pulmonary ground glass nodule found for more than 2 years, no special treatment.

[0259] January 7, 2021 CT: Right upper lobe posterior segment (Im 20) shows a nodule-like ground glass density shadow, about 1.0 cm in diameter, with blood vessel shadow running through it; a triangular solid small nodule is visible in the medial segment of the right middle lobe (Im 29); a small ground glass density nodule is visible in the medial segment of the right lower lobe (thin layer Im 298), about 3 mm in diameter. Multiple ground glass nodules are found in both lungs. A few cord shadows are visible in the medial segment of the right middle lobe. A patchy low-density shadow is visible in the thyroid, with multiple small lymph nodes visible in the bilateral sublobes. Multiple small nodule-like calcified density shadows are visible in the right breast, with clear boundaries. A circular low-density is visible in the S6 segment of the liver, with a CT value of about 20 HU.

[0260] January 19, 2021, the patient had lobar pneumonia and is now cured.

[0261] Current symptoms:

[0262] Fatigue, occasional dry cough, no sputum, sleep and defecation are normal.

[0263] Tongue: dark tongue with white fur, pulse: thin pulse.

[0264] Diagnosis:

[0265] TCM: Cough with phlegm and blood stasis

[0266] Western medicine: cough

[0267] Treatment: resolving phlegm and removing blood stasis.

[0268] Prescription:

[0269] Honey mulberry bark 20g, cortex 15g, fishy grass 20g, forsythia 20g, reed root 20g, winter melon seed 15g, zedoary 15g, prepared rhizoma 15g, dried tangerine peel 12g, rhizoma 15g, soapstick 10g, south saussurea 20g, solanum nigrum 20g, half branch orchid 20g, fried licorice 15g, perilla seed 15g, white front 15g. 18 doses.

[0270] Usage and dosage: 1 dose per day, decocted with water and taken warm, 200ml each morning and evening.

[0271] First follow-up: March 4, 2021

[0272] Current symptoms:

[0273] Sleep and defecation are normal.

[0274] Auxiliary examinations:

[0275] Chest CT scan (thin-slice, 3D reconstruction) on February 18, 2021: Multiple ground-glass opacities in both lungs. Compared with a CT scan from another hospital on January 19, 2021, the lesion in the posterior segment of the left lower lobe has significantly decreased in size, and the remaining lesions have slightly shrunk. Continued follow-up is recommended. Note: Right breast calcification.

[0276] Tongue appearance: Dark tongue with a thin yellow coating. Pulse appearance: Thready and slippery.

[0277] diagnosis:

[0278] Traditional Chinese Medicine: Cough, Phlegm and Blood Stasis Syndrome

[0279] Western medicine: Cough

[0280] Treatment: Resolve phlegm and promote blood circulation

[0281] prescription:

[0282] 20g of honey-processed mulberry bark, 20g of lycium bark, 15g of fritillaria thunbergii, 15g of prepared arisaema, 15g of turmeric, 15g of tangerine peel, 15g of poria cocos, 15g of stir-fried atractylodes macrocephala, 20g of houttuynia cordata, 20g of forsythia, 40g of raw astragalus membranaceus, 15g of gleditsia sinensis thorns, 20g of scutellaria barbata, 30g of scutellaria barbata, 15g of privet fruit, 15g of prepared licorice root, 2g of croton tiglium, and 6g of amomum villosum (added later).

[0283] Dosage and administration: One dose per day, decocted in water and taken warm, 200ml each time in the morning and evening.

[0284] Second follow-up visit: May 6, 2021

[0285] Current symptoms:

[0286] No specific discomfort was reported, but the patient experienced fatigue, bitter taste in the mouth, normal appetite and sleep, and regular bowel movements.

[0287] Tongue appearance: Dark tongue with a thick, greasy yellow coating. Pulse appearance: Deep and slippery pulse.

[0288] diagnosis:

[0289] Traditional Chinese Medicine: Cough, Phlegm and Blood Stasis Syndrome

[0290] Western medicine: Cough

[0291] Treatment: Resolve phlegm and promote blood circulation

[0292] prescription:

[0293] Raw Astragalus 30g, stir-fried Atractylodes macrocephala 15g, Fritillaria thunbergii 15g, processed Arisaema heterophyllum 15g, Curcuma zedoaria 15g, Gleditsia sinensis thorns 10g, Forsythia suspensa 15g, Sargassum fusiforme 15g, processed Ephedra sinica 6g, vinegar-processed Bupleurum chinense 10g, Fagopyrum dibotrys 15g, Citrus reticulata peel 12g, Hirudo medicinalis 3g, Dioscorea nipponica 15g.

[0294] Dosage and administration: One dose per day, decocted in water and taken warm, 200ml each time in the morning and evening.

[0295] Treatment effect:

[0296] On June 24, 2021, during a follow-up visit, the patient reported no particular discomfort, fatigue, no cough or phlegm, bitter taste in the mouth, good appetite and sleep, decreased urination, and regular bowel movements.

[0297] On May 28, 2021, liver and kidney function tests conducted at our hospital showed that carcinoembryonic antigen (CEA), cytokeratin 19, neuron-specific enolase, and squamous cell carcinoma-associated antigen were all negative.

[0298] Chest CT: The original multiple ground-glass opacities in both lungs have been largely absorbed, and the lesion in the apical segment of the right upper lobe has been absorbed compared to before.

[0299] Case 3

[0300] Patient: Female, 63 years old.

[0301] Initial consultation: September 26, 2023

[0302] Chief complaint: Lung nodules discovered 1 year ago.

[0303] Past history:

[0304] Breast hyperplasia, thyroid nodules, hepatic hemangioma, cervical nabothian cysts.

[0305] Present illness:

[0306] A 6mm ground-glass nodule was found in the right lung during a physical examination in September 2022.

[0307] A nodule was discovered in the left lung during a physical examination in August 2023.

[0308] On August 4, 2023, a follow-up examination revealed a ground-glass nodule in the right lung measuring 8×6mm.

[0309] I have taken cephalosporins intermittently. I started having a fever on September 23, 2023, with a maximum temperature of 38°C. I took ibuprofen and the fever has now subsided.

[0310] Current symptoms:

[0311] Cough with copious, sticky, white phlegm that is easy to expectorate. Occasionally experiences chest tightness and shortness of breath, but no dry mouth, bitter taste, dizziness, good appetite, poor sleep, difficulty falling asleep, and normal bowel movements.

[0312] Auxiliary examinations:

[0313] Tongue appearance: Dark tongue with a thick, greasy white coating and a red tip.

[0314] Pulse characteristics: The pulse is wiry and thready, and weak in both cun positions.

[0315] diagnosis:

[0316] Traditional Chinese Medicine: Cough due to Qi stagnation and phlegm accumulation

[0317] Western medicine: Diagnostic imaging abnormalities of the lungs

[0318] prescription:

[0319] Raw Astragalus 30g, stir-fried Atractylodes macrocephala 15g, Fritillaria thunbergii 15g, processed Arisaema heterophyllum 15g, Curcuma zedoaria 15g, Gleditsia sinensis thorns 10g, Forsythia suspensa 15g, Sargassum fusiforme 15g, processed Ephedra sinica 6g, vinegar-processed Bupleurum chinense 10g, Triticum aestivum 15g, Citrus reticulata peel 12g, Perilla frutescens seed 15g, Cynanchum paniculatum 15g, Platycodon grandiflorus 15g, Paeonia lactiflora 15g, processed Glycyrrhiza uralensis 12g. A total of 14 doses.

[0320] Dosage and administration: One dose per day, decocted in water and taken warm, 200ml each time in the morning and evening.

[0321] Treatment effect:

[0322] On November 22, 2023, during a follow-up visit, the patient reported that their cough and phlegm had significantly decreased compared to before.

[0323] Case 4

[0324] Patient: Female, 45 years old.

[0325] Initial consultation: December 29, 2022

[0326] Chief complaint: Lung nodules were discovered 1 week ago.

[0327] Past history:

[0328] Rhinitis. Underwent uterine fibroid removal surgery in March 2022.

[0329] Allergy history:

[0330] Metronidazole allergy; occasional allergies to sulfonamides and penicillin.

[0331] Present illness:

[0332] One week ago, a lung CT scan revealed multiple nodules in both lungs, the largest being a mixed ground-glass opacity, located in the lateral basal segment of the right lower lobe (thick slice, IMG 40), measuring approximately 13mm × 10mm, with indistinct margins. Myocardial enzymes were negative. Echocardiography showed no significant abnormalities.

[0333] Current symptoms:

[0334] Cough with yellow phlegm, shortness of breath, fatigue, and a dull pain in the chest, accompanied by palpitations. Poor sleep, taking zopiclone for sleep aid. Poor appetite, two formed bowel movements per day, normal urination. Dry mouth at night.

[0335] Tongue appearance: Dark tongue with a thick white coating. Pulse appearance: Thready and slippery.

[0336] diagnosis:

[0337] Traditional Chinese Medicine: Cough, Lung and Spleen Qi Deficiency Syndrome

[0338] Western medicine: abnormal diagnostic imaging of the lung

[0339] Prescription:

[0340] Radix Astragali seu Hedysari 30 g, Poria Cocos 15 g, Fritillariae Thunbergii 15 g, Rhizoma Anemarrhenae 15 g, Curcuma 15 g, Combretum 10 g, Forsythia Suspensa 15 g, Sargassum 15 g, Ephedra sinica 6 g, Radix Bupleuri 10 g, Fagopyrum Cymosum 15 g, Citrus Reticulata 12 g. A total of 14 doses.

[0341] Usage and dosage: 1 dose per day, decocted in water and taken in the morning and evening, 200 ml each time.

[0342] Re-examination: January 12, 2023

[0343] Carved down symptoms:

[0344] Cough, coughing yellowish sputum, shortness of breath, palpitation, anterior chest pain, loss of appetite, poor sleep with the help of Zolpidem, occasional unformed stools, 2-3 times per day, and urine. Lmp (last menstrual period): January 6, 2023

[0345] Tongue: dark teeth marks, white fur. Pulse: slippery.

[0346] Prescription:

[0347] Radix Astragali seu Hedysari 30 g, Poria Cocos 15 g, Fritillariae Thunbergii 15 g, Rhizoma Anemarrhenae 15 g, Curcuma 15 g, Combretum 10 g, Forsythia Suspensa 15 g, Sargassum 15 g, Ephedra sinica 6 g, Radix Bupleuri 10 g, Fagopyrum Cymosum 15 g, Citrus Reticulata 12 g, Radix Adenophorae 20 g, Radix Morindae Officinalis 20 g, Perilla Frutescens 15 g, Peucedanum 15 g, Platycodon 15 g, Glycyrrhiza 10 g. A total of 14 doses.

[0348] Usage and dosage: 1 dose per day, decocted in water and taken in the morning and evening, 200 ml each time.

[0349] Treatment effect:

[0350] November 9, 2023, recheck chest CT: right lower lobe of lung, 7 x 5 mm, smaller than initial diagnosis.

[0351] Case 5

[0352] Patient: male, 63 years old

[0353] Initial diagnosis: May 27, 2021

[0354] Chief complaint:

[0355] Found a small nodule in the right lower lobe of the lung for more than 3 months. The patient was found to have a small nodule in the lung during a new coronavirus infection screening 3 months before the visit.

[0356] March 2021, high-resolution CT of the lung in Peking Union Medical College Hospital showed: right lower lobe posterior basal segment small ground glass nodule, diameter about 6.2mm, right lower lobe small nodule.

[0357] April 2021, CT recheck in Peking Union Medical College Hospital showed that the nodule was about 8mm x 11mm, slightly fuller than the previous slice.

[0358] Symptoms:

[0359] Right limb cold, occasional right chest pain, occasional cough, little sputum, dry lips, sleep and diet normal.

[0360] Dark red tongue, thin white fur, stringy pulse.

[0361] Diagnosis:

[0362] TCM: phlegm accumulation, phlegm coagulation syndrome;

[0363] Western medicine: lung diagnostic imaging abnormalities (pulmonary nodules)

[0364] Treatment: regulating qi, reducing phlegm, tonifying qi and activating blood.

[0365] Prescription:

[0366] Cassia bark 12g, red peony root 15g, dried ginger 6g, jujube 15g, fried licorice 10g, tuckahoe 15g, fried white atractylodes 15g, Zhebei 15g, raw astragalus 30g, soapstick 10g, forsythia 15g, dandelion 15g, dried tangerine or orange peel 12g, ginger pinellia 12g. A total of 14 doses. Usage and dosage: 1 dose per day, decocted with water and taken warm, 200ml each in the morning and evening.

[0367] First follow-up visit: June 10, 2021

[0368] Symptoms:

[0369] Cough decreased, still right limb cold, dry lips, no other discomfort.

[0370] Prescription:

[0371] Cassia bark 12g, red peony root 15g, dried ginger 6g, jujube 15g, fried licorice 10g, tuckahoe 15g, fried white atractylodes 15g, Zhebei 15g, raw astragalus 30g, soapstick 10g, forsythia 15g, dandelion 15g, dried tangerine or orange peel 12g, ginger pinellia 12g, wind-preventing 12g, su mu 12g. A total of 18 doses, decoction method same as before.

[0372] Second follow-up visit: July 29, 2021

[0373] Right limb cold improved, tongue red, thin white fur, stringy and slightly slippery pulse.

[0374] Third follow-up visit: July 19, 2021

[0375] Recheck lung CT in Peking Union Medical College Hospital showed: right lower lobe posterior basal segment nodule about 5mm x 8mm, unclear border, the rest was basically the same as before.

[0376] Prescription:

[0377] Cassia Bark 12g, Red Peony Root 15g, Dried Ginger 6g, Jujube 15g, Fried Licorice 10g, Poria 15g, Fried White Atractylodes 15g, Zhejiang Fritillaria 15g, Radix Astragali 30g, Soapwort 10g, Forsythia 15g, Tangerine Peel 12g, Pinellia 12g, Saposhnikovia 12g, Red Sandalwood 12g, Solanum Nigrum 20g, Bartramia 20g, Prepared Rhizoma Anemarrhenae 15g, Honey Mulberry Bark 20g, Platycodon 15g. 18 doses in total, decoction method as before.

[0378] Fourth visit: October 28, 2021

[0379] Occasionally cough and sputum, sputum white with yellow, thick, not much, dry mouth, red tongue, white and thick fur, slippery pulse.

[0380] Prescription:

[0381] Radix Astragali 30g, Fried White Atractylodes 15g, Zhejiang Fritillaria 15g, Prepared Rhizoma Anemarrhenae 15g, Curcuma 15g, Soapwort 10g, Forsythia 15g, Sea Silkweed 15g, Fried Ephedra 6g, Vinegar Radix Bupleuri 10g, Fagopyrum 15g, Tangerine Peel 12g, Rhizoma Phragmitis 20g, Radix Euryale 30g. 18 doses in total. Decoction method as before.

[0382] Treatment effect:

[0383] After catching a cold, it is easy to have nasal congestion, sneezing and clear nasal discharge, occasionally coughing, and a small amount of white sputum. Red tongue, thin white fur, and tight pulse. Chest CT recheck on November 16, 2021 in our hospital showed that the right lower lobe posterior basal segment nodule was about 6mm in diameter (AI analysis size was 5.2mm x 3.9mm), which was smaller than before.

[0384] Case 6

[0385] Patient: Female, 68 years old

[0386] Initial diagnosis: September 8, 2022

[0387] Chief complaint: Found lung nodule for more than 1 year

[0388] Present illness:

[0389] One year ago, on December 20, 2020, the patient underwent chest thin CT in Peking University First Hospital and found a ground glass nodule in the left upper lobe posterior segment, with a length of 1.1cm. A ground glass density nodule was also found in the right middle lobe lateral segment, with a diameter of 0.4cm. There were scattered solid micro nodules in both lungs, with a diameter of 0.2-0.4cm. AAH and AIS were not excluded.

[0390] On July 11, 2022, the CT of the left upper lobe of the lung showed a ground-glass nodule with a length of 12 mm, which was slightly larger than before. The right middle lobe ground-glass nodule was roughly the same as before.

[0391] Current symptoms include:

[0392] No cough, expectoration, fear of cold, occasional dry mouth and bitter taste, rib distension, easy to get angry and anxious, normal appetite, frequent dreams, 2-3 times of nocturia, dry stool, 1 time a day, occasional odor, pale yellow color.

[0393] Past medical history: hyperlipidemia, lung cancer.

[0394] Auxiliary examination:

[0395] On June 6, 2022, the neuron-specific enolase (NSE) test was 16.7 ng / ml. Glycation was 6.2%.

[0396] Tongue: dark red and thin, thin fur; pulse: fine and rapid.

[0397] Diagnosis:

[0398] TCM: cough, qi stagnation and phlegm accumulation

[0399] Western medicine: lung diagnostic imaging abnormalities

[0400] Treatment:

[0401] Prescription:

[0402] Radix Astragali 30g, Fried Atractylodes 15g, Zhebeimu 15g, Radix Anemarrhenae 15g, Curcuma 15g, Soapwort 10g, Forsythia 15g, Sea Algae 15g, Fried Ephedra 6g, Vinegar Radix Bupleuri 10g, Fagopyrum 15g, Orange Peel 12g. Total of 14 doses.

[0403] Usage: 1 dose per day, decocted in water and taken warm, 200ml each morning and evening.

[0404] First follow-up visit: February 16, 2023

[0405] Current symptoms include:

[0406] Tinnitus, occasional shortness of breath, rib pain, lower extremity weakness, fear of cold, no dry mouth, no bitter taste, abdominal distension, easy to get angry and anxious, rib distension pain improved, tinnitus, normal appetite, frequent dreams, 1 time of nocturia, formed stool, 1 time a day, frequent urination in the afternoon

[0407] Tongue: dark, thin white fur; pulse: thin and rapid.

[0408] Prescription:

[0409] Raw Astragalus membranaceus 30g, stir-fried Atractylodes macrocephala 15g, Fritillaria thunbergii 15g, processed Arisaema heterophyllum 15g, Curcuma zedoaria 15g, Gleditsia sinensis thorns 10g, Forsythia suspensa 15g, Sargassum fusiforme 15g, processed Ephedra sinica 6g, vinegar-processed Bupleurum chinense 10g, Fagopyrum dibotrys 15g, Citrus reticulata peel 12g, Aconitum carmichaelii 10g, dried ginger 6g, Morinda officinalis 15g. A total of 18 doses.

[0410] Usage: One dose per day, decocted in water and taken warm, 200ml each time in the morning and evening.

[0411] Treatment effect:

[0412] On March 9, 2023, during a follow-up visit, the patient reported relief from fatigue, reduced tinnitus, stiffness in the joints of both hands, and relief from radiating pain in the ribs. The patient also reported no bitter taste in the mouth, good appetite, frequent sleep with dreams, formed stools once a day, and normal urination.

[0413] Case 7

[0414] Patient: Male, 68 years old

[0415] Initial consultation: March 2, 2023

[0416] Present illness:

[0417] Lung nodules were discovered at the end of July 2022.

[0418] On August 12, 2022, a chest CT scan was performed at the Cancer Hospital of the Chinese Academy of Medical Sciences: a 1.4×1.1cm nodule in the left lung apex, irregular in shape, partially solid, adjacent to and pulling on the pleura of the lung apex; multiple ground-glass nodules in both lungs, the largest being 0.6×0.6cm in the upper lobe of the right lung, containing vacuoles; a few solid micronodules in both lungs, 0.3cm linear nodules in the lower lobes of both lungs; emphysema in both lungs; and thyroid nodules.

[0419] In September 2022, the patient underwent surgery at the Cancer Hospital of the Chinese Academy of Medical Sciences to remove a nodule at the left apex of the lung. Postoperatively, lung cancer was diagnosed. Pathology revealed microinvasive adenocarcinoma of the lung, with a maximum diameter of 0.9 cm. No vascular emboli or nerve invasion was observed, and the visceral pleura was not involved. No cancer was found at the lung resection margins. No radiotherapy, chemotherapy, or targeted therapy were administered postoperatively.

[0420] Chest CT on January 11, 2023: Changes after partial resection of the left upper lobectomy. Multiple ground-glass opacities in the right lung, the largest of which is located in the upper lobe of the right lung, about 0.6×0.6cm, with cavitation visible inside. A few solid micronodules in both lungs, the largest of which is about 0.3cm. Emphysema in both lungs.

[0421] Current symptoms:

[0422] Fatigue, dull pain below the xiphoid process, abdominal distension, occasional radiating pain in the left abdomen, no obvious cough, shortness of breath at night, occasional waking up feeling suffocated, light sleep and easy to wake up, normal bowel movements and urination.

[0423] Auxiliary examinations:

[0424] 2023-01-05 Neuron-specific enolase (NSE) test: 23.2 ng / m1 (preoperative test: 14.90 ng / m1)

[0425] Tongue: dark red tongue, thin yellow fur. Pulse: thin pulse.

[0426] Diagnosis:

[0427] TCM: lung cancer, qi stagnation and phlegm accumulation

[0428] Western medicine: left upper lobe malignant tumor

[0429] Prescription:

[0430] Radix Astragali 30g, Fried Atractylodes 15g, Zhebeimu 15g, Prepared Rhizoma Anemarrhenae 15g, Curcuma 15g, Soapberry 10g, Forsythia 15g, Sea Algae 15g, Fried Ephedra 10g, Vinegar Radix Bupleuri 12g, Fagopyrum 15g, Orange Peel 12g, Vinegar Rhizoma Zedoariae 12g, Fructus Aurantii 15g, White Peony Root 15g, Perilla Fruit 10g. 30 doses in total

[0431] Usage and dosage: 1 dose per day, decocted in water and taken warm, 200ml each in the morning and evening.

[0432] Treatment effect:

[0433] 2023-04-06 Re-examination complained of still weakness, sword clamp under the hidden pain, abdominal distension and left abdominal pain relief, no obvious cough, shortness of breath at night, sometimes wake up, can eat, sleep well recently, two excrements are adjusted. The method and dosage of the same prescription.

[0434] Case 8

[0435] Patient: male, 71 years old

[0436] First visit: June 15, 2023

[0437] Chief complaint: found lung nodule for more than 3 months.

[0438] Past medical history: diabetes.

[0439] Present illness:

[0440] 2023-03-CT: left upper lobe of lung ground glass shadow lesion, 21x16mm.

[0441] 2023-04-PET / CT: left upper lobe of lung ground glass density nodule with mild metabolism, tend to lung cancer, multiple ground glass density nodules in the rest of the lungs, left ischium high metabolism.

[0442] Present symptoms:

[0443] Can eat, not easy to sleep after waking up, self-medication with estazolam to assist sleep, usually dry stool, cough yellow sputum.

[0444] Tongue: red tongue, white fur, peeled fur, cracks. Pulse: left pulse fine, right pulse slippery

[0445] Diagnosis:

[0446] TCM: accumulation of lung, phlegm and blood stasis

[0447] Western medicine: lung space-occupying lesion

[0448] Prescription:

[0449] Sea Algae 15g, Fried Licorice 10g, Wood Bitter 10g, Zhebeimu 15g, Zedoary 15g, Soapstick 10g, Stone See Through 20g, Half Branch Lotus 20g, Black Smooth Piece 10g, First Fried Ephedra 6g, Snakeberry 20g, Poria 15g, Fried White Atractylodes 15g, Raw Huangqi 30g, North Bean Root 9g, Prepared White Fuzi 9g, Tangerine Peel 12g. Total 14 doses.

[0450] Usage and dosage: 1 dose per day, decocted with water and taken warm, 200ml each morning and evening.

[0451] Therapeutic effect:

[0452] Regular follow-up after, cough and sputum after taking medicine, improved defecation.

[0453] November 3, 2023, recheck chest CT suggests nodules 21x11mm, smaller than the initial diagnosis nodules.

Claims

1. A traditional Chinese medicine composition for treating pulmonary nodule, which is made from the following traditional Chinese medicines by weight: the monarch drug is selected from one or more of the following: Radix Astragali 10-45 parts, Sargassum 10-25 parts, and Rhizoma Paris 10-25 parts; the ministerial drug is selected from one or more of the following: Fritillariae Thunbergii 10-25 parts, Forsythia 10-25 parts, Poria 10-25 parts, Leech 1-10 parts, Dioscorea 10-25 parts, South Salvia 10-35 parts, White Mulberry Bark 10-35 parts, Perilla 10-25 parts, Peucedanum 10-25 parts, Phragmites 10-35 parts, Radix Eurycommi 10-45 parts, Vinegar Cyperus 5-25 parts, Fructus Aurantii 10-25 parts, Radix Paeoniae Alba 10-25 parts, Herba Euphorbiae Humifusae 10-35 parts, Rubus 10-35 parts, Herba Humifusae 10-35 parts, Radix Sophorae 5-20 parts, Sphaerocarya 5-20 parts, Curcuma 10-25 parts, and Soap Sticks 5-20 parts; the auxiliary drug is selected from one or more of the following: Vinegar Bupleurum 5-25 parts, Tangerine Peel 5-25 parts, Perilla 10-25 parts, Fried Ephedra 2-12 parts, White Front 10-25 parts, White Fuzi 5-20 parts, Dried Ginger 2-12 parts, Radix Morindae Officinalis 10-35 parts, Herba Euphorbiae Humifusae 10-35 parts, Black Smooth Tablets 10-45 parts, and Prepared White Fuzi 10-25 parts; the assistant drug is selected from one or more of the following: Fagopyrum 5-20 parts, Platycodon 10-25 parts, Radix Paeoniae Alba 10-25 parts, and Fried Licorice 5-25 parts.

2. The traditional Chinese medicine composition for treating pulmonary nodule according to claim 1, which is made from the following traditional Chinese medicines by weight: the monarch drug is selected from one or more of the following: Radix Astragali 10-40 parts, Sargassum 10-20 parts, and Rhizoma Paris 10-20 parts; the ministerial drug is selected from one or more of the following: Fritillariae Thunbergii 10-20 parts, Forsythia 10-20 parts, Poria 10-20 parts, Leech 1-6 parts, Dioscorea 10-20 parts, South Salvia 10-30 parts, White Mulberry Bark 10-30 parts, Perilla 10-20 parts, Peucedanum 10-20 parts, Phragmites 10-30 parts, Radix Eurycommi 10-40 parts, Vinegar Cyperus 5-20 parts, Fructus Aurantii 10-20 parts, Radix Paeoniae Alba 10-20 parts, Herba Euphorbiae Humifusae 10-30 parts, Rubus 10-30 parts, Herba Humifusae 10-30 parts, Radix Sophorae 5-15 parts, Sphaerocarya 5-15 parts, Curcuma 10-20 parts, and Soap Sticks 5-15 parts; the auxiliary drug is selected from one or more of the following: Vinegar Bupleurum 5-20 parts, Tangerine Peel 5-20 parts, Perilla 10-20 parts, Fried Ephedra 2-8 parts, White Front 10-20 parts, White Fuzi 5-15 parts, Dried Ginger 2-8 parts, Radix Morindae Officinalis 10-30 parts, Herba Euphorbiae Humifusae 10-30 parts, Black Smooth Tablets 10-40 parts, and Prepared White Fuzi 10-20 parts; the assistant drug is selected from one or more of the following: Fagopyrum 5-15 parts, Platycodon 10-20 parts, Radix Paeoniae Alba 10-20 parts, and Fried Licorice 5-20 parts.

3. The traditional Chinese medicine composition for treating pulmonary nodule according to claim 1, which is made from the following traditional Chinese medicines by weight: the monarch drug is selected from one or more of the following: Radix Astragali 10-35 parts, Sargassum 10-15 parts, and Rhizoma Paris 10-15 parts; the monarch drug is selected from one or more of Zhebeimu 10-15 parts, Lianqiao 10-15 parts, Chao Baishu 10-15 parts, Shuijia 1-4 parts, Chuanshenglong 10-15 parts, Nansha- shen 10-25 parts, Misanbaip i 10-25 parts, Zisu 10-15 parts, Qianhu 10-15 parts, Lugen 10-25 parts, Shengyiyiren 10-35 parts, Cixiangfu 5-15 parts, Zhike 10-15 parts, Baishao 10-15 parts, Banzhen- l an 10-25 parts, Shehe 10-25 parts, Shijiancha n 10-25 parts, Beidou- gen 5-10 parts, Mubiezi 5-10 parts, E zhu 10-15 parts, and Zaoc i 5-10 parts; the assistant drug is selected from one or more of Cichaihu 5-15 parts, Chenpi 5-15 parts, Zisu 10-15 parts, Zhamaohuang 2-6 parts, Baiqian 10-15 parts, Bai- fuzi 5-10 parts, Ganjiang 2-6 parts, Bagutian 10-25 parts, Banzhenlian 10-25 parts, Hei- shunpian 10-35 parts, and Zhbai- fuzi 10-15 parts; the auxiliary drug is selected from one or more of Jin- qiaomai 5-10 parts, Ju- jiang 10-15 parts, Baishao 10-15 parts, and Zhigan- cao 5-15 parts.

4. A traditional Chinese medicine preparation made from the traditional Chinese medicine composition of any one of claims 1-3, wherein the traditional Chinese medicine preparation is selected from one or more of a paste, a pill, a pellet, a decoction, a granule, a capsule, a powder, or a tablet.

5. The traditional Chinese medicine preparation made from the traditional Chinese medicine composition of claim 4, wherein the traditional Chinese medicine preparation comprises pharmaceutically acceptable excipients required for the corresponding preparation, and the excipients are medicinal excipients that have the effects of enhancing the efficacy of the main drug, reducing the toxicity, and / or reducing the side effects.

6. Use of a traditional Chinese medicine composition in the preparation of a drug for treating pulmonary nodules.

7. Use of the traditional Chinese medicine composition of claim 6 in the preparation of a drug for treating pulmonary nodules, wherein the pulmonary nodules include one or more of solid nodules, partially solid nodules, ground glass nodules, pure ground glass nodules, and / or non-solid nodules.

Images