A traditional Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application thereof

Abstract

The application provides a Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application, and relates to the technical field of animal medicine. The Chinese medicine compound preparation is composed of 10 Chinese medicines, i.e. honeysuckle, forsythia, inula flower, platycodon grandiflorum, euphorbia helioscopia, xiaochangqing, fresh eucalyptus globulus, fried stemona, cat's claw and augustifolia, follows the principle of Chinese medicine syndrome differentiation and treatment, is reasonably matched, and the medicines are coordinated with each other to increase the efficacy. The Chinese medicine compound preparation can significantly reduce the levels of TNF-alpha and IL-6 in serum, increase the level of IFN-gamma, obviously alleviate the clinical symptoms of livestock and poultry respiratory tract infection, reduce the mortality, has a good treatment effect on the related diseases of livestock and poultry respiratory tract infection, can improve the drug resistance of antibiotic drugs, reduce the drug residues of chemical agents in livestock and poultry, and guarantees the health of livestock and poultry and the safety of animal source food.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of animal medicine, in particular to a traditional Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application thereof. BACKGROUND

[0002] Livestock and poultry respiratory disease is caused by one or several bacteria, viruses, parasites, chlamydia, environmental factors and other mutual synergies, which is an acute, highly contagious livestock and poultry disease, often accompanied by cough, nose, respiratory rale, asthma, dyspnea and other symptoms. Livestock and poultry respiratory infection related diseases are one of the biggest production problems faced by the breeding industry for a long time, which poses a serious threat to China's livestock breeding industry and causes huge economic losses. Moreover, some livestock and poultry respiratory infection diseases are zoonoses, which also pose a threat to public health and safety.

[0003] Traditional Chinese veterinary medicine has a long history in China, which can improve the body's own disease resistance and non-specific immune function, and has a good preventive effect on respiratory diseases. Traditional Chinese veterinary medicine believes that livestock and poultry respiratory infection related diseases belong to "epidemic" diseases, which are caused by six poisons. The clinical manifestations are acute onset, large number of diseases, and similar symptoms in the same batch of sick animals. The treatment principle is to use heat-clearing and detoxifying drugs to support the body and eliminate evil. At present, antibiotics and antipyretic analgesics, cough medicines and other western medicines are mainly used in veterinary clinics to treat such respiratory diseases. The antibiotics commonly used to treat livestock and poultry respiratory diseases are tylosin, florfenicol, amoxicillin, ampicillin, doxycycline, etc. However, due to the abuse of antibiotics, bacterial drug resistance is becoming more and more serious, which leads to poorer treatment effect of antibiotics, and a large amount of drug residues in livestock and poultry, which seriously affects food safety and is directly related to the health of the people. Therefore, it is urgent to develop safe and efficient traditional Chinese veterinary medicine prevention and treatment products, which are increasingly valued and concerned by the market. SUMMARY

[0004] (I) Technical problems to be solved

[0005] In view of the deficiencies in the prior art, the present application provides a traditional Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application thereof.

[0006] (II) Technical solutions

[0007] To achieve the above object, the present application is realized by the following technical solutions:

[0008] The application provides a Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, which is prepared from the following raw materials in parts by weight: honeysuckle 40-60 parts, forsythia 40-60 parts, inula flower 30-50 parts, platycodon 30-55 parts, aleuritidis 30-50 parts, long-jointed willow 20-40 parts, fried stemona 10-40 parts, cat's claw 5-25 parts and August 5-20 parts.

[0009] Further, the Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: honeysuckle 45-55 parts, forsythia 45-50 parts, inula flower 35-45 parts, platycodon 40-50 parts, aleuritidis 35-45 parts, long-jointed willow 25-35 parts, fried stemona 20-30 parts, cat's claw 10-20 parts and August 8-15 parts.

[0010] Further, the Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: honeysuckle 50 parts, forsythia 48 parts, inula flower 40 parts, platycodon 45 parts, aleuritidis 40 parts, long-jointed willow 28 parts, fried stemona 22 parts, cat's claw 13 parts and August 10 parts.

[0011] The application provides a preparation method of the Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, which comprises the following steps:

[0012] (1) the raw materials are weighed according to the above weight parts, washed, crushed and uniformly mixed for use;

[0013] (2) the Chinese medicine coarse powder obtained in step (1) is decocted twice, the first time is 2 h, the second time is 1 h, filtered, the decocting liquid is combined and concentrated to the relative density of 1.1-1.3 to obtain the Chinese medicine compound preparation.

[0014] Further, the dosage form of the Chinese medicine compound preparation prepared by the preparation method can be granules, oral liquid or injection and the like.

[0015] The application provides application of the Chinese medicine compound preparation in preparation of products for preventing and / or treating diseases related to respiratory tract infection of livestock and poultry.

[0016] The pharmacological effects of the Chinese medicine compound preparation in the application are as follows:

[0017] Honeysuckle: sweet, cold, lung, heart, stomach meridian; has the effects of clearing heat and resolving toxicity, dispelling wind and heat, and is used for treating carbuncle, sore, laryngalgia, erysipelas, dysentery, wind-heat cold and warm disease fever.

[0018] Forsythia suspensa: bitter in taste, slightly cold in nature, enters the lung, heart, and small intestine meridians; has the effects of clearing away heat and detoxifying, reducing swelling and dispersing stagnation, and evacuating wind-heat. It is used for carbuncle, scrofula, mastitis, erysipelas, wind-heat cold, the initial stage of febrile disease, warm and heat entering the blood, high fever, thirst, coma and rash, and hot urethritis with astringent pain.

[0019] Inula flower: bitter, pungent, and salty in taste, slightly warm in nature, enters the lung, spleen, stomach, and large intestine meridians; has the effects of descending qi, eliminating phlegm, promoting water circulation, and stopping vomiting, and is used for wind-cold cough, phlegm accumulation, chest tightness, cough and asthma with excessive phlegm, vomiting and belching, and hardness under the heart.

[0020] Platycodon grandiflorum: bitter and spicy in taste, neutral in nature, enters the lung meridian; has the effects of clearing the lungs, relieving sore throat, removing phlegm, and discharging pus, and is used for cough with excessive phlegm, chest tightness, sore throat and hoarseness, and lung abscess with vomiting pus.

[0021] Trichosanthes kirilowii: pungent and bitter in taste, very cold in nature, enters the lung and bladder meridians; has the effects of clearing the lungs and relieving asthma, promoting water circulation and reducing swelling, and is used for phlegm blocking the lungs, coughing and wheezing with excessive phlegm, fullness in the chest and ribs, inability to lie flat, edema of the chest and abdomen, and difficulty urinating.

[0022] Xu Changqing: spicy in taste, warm in nature, enters the liver and stomach meridians; has the effects of dispelling wind, removing dampness, relieving pain and relieving itching, and is used for rheumatic pain, stomach pain and bloating, toothache, low back pain, falls and injuries, rubella, and eczema.

[0023] Fresh Eucalyptus globulus: spicy and bitter in taste, neutral in nature, and has the effects of dispelling wind and heat, inhibiting bacteria and inflammation, and preventing and relieving itching. It is used to prevent influenza, epidemic cerebrospinal meningitis, treat upper respiratory tract infections, pharyngitis, bronchitis, pneumonia, acute and chronic pyelonephritis, enteritis, dysentery, and filariasis.

[0024] Roasted Stemona: sweet and bitter in taste, slightly warm in nature, enters the lung meridian; has the effects of moistening the lungs, lowering qi and relieving cough, killing insects and killing lice, used for new and long-term coughs, tuberculosis coughs, sudden coughs, externally used for head lice, body lice, pinworm disease, vaginal itching, honey Stemona moistens the lungs and relieves coughs, and is used for yin deficiency and fatigue coughs.

[0025] Cat's Claw: sweet and spicy in taste, warm in nature, enters the liver and lung meridians; has the effects of resolving phlegm and dispersing nodules, detoxifying and reducing swelling, and is used for scrofula, carbuncle swelling and toxins, and snake and insect bites.

[0026] August Notes: slightly bitter in taste, neutral in nature, enters the liver and stomach meridians; has the effects of soothing the liver and stomach, promoting blood circulation and relieving pain, softening and dispersing lumps; used for liver and stomach qi stagnation, abdominal distension and pain in the chest and ribs, indigestion, diarrhea, hernia pain, low back pain, amenorrhea, dysmenorrhea, goiters and scrofula.

[0027] (3) Beneficial effects

[0028] The application provides a traditional Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application.

[0029] The traditional Chinese medicine compound preparation can significantly reduce the levels of TNF-α and IL-6 in serum of livestock and poultry with diseases, increase the level of IFN-γ, obviously relieve the clinical symptoms of respiratory tract infection of livestock and poultry, and reduce the mortality rate. DETAILED DESCRIPTION

[0030] In order to make the objects, technical schemes and advantages of the embodiments of the application clearer, the technical schemes in the embodiments of the application will be described clearly and completely below in combination with the embodiments of the application.

[0031] Embodiment 1

[0032] A traditional Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 50 parts, forsythia 48 parts, inula flower 40 parts, platycodon 45 parts, aleuritopteris 40 parts, xuchangqing 28 parts, fresh eucalyptus 25 parts, fried comfrey 22 parts, cat's paw grass 13 parts, and August 10 parts.

[0033] The preparation method of the traditional Chinese medicine compound preparation comprises the following steps:

[0034] (1) The raw materials are weighed according to the above weight parts, washed, crushed and mixed uniformly for standby;

[0035] (2) The traditional Chinese medicine coarse powder obtained in step (1) is decocted with water for two times, the first time is decocted for 2 hours, and the second time is decocted for 1 hour, filtered, and the decocting liquid is combined and concentrated to the relative density of 1.1-1.3;

[0036] (3) The concentrated extract obtained in step (2) is mixed with starch in a ratio of 1:1, moistened with 70% ethanol, made into soft material, granulated, and dried at low temperature to obtain the traditional Chinese medicine compound preparation of the present application.

[0037] Example 2

[0038] The difference between this example and Example 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 40 parts, forsythia 40 parts, inula 30 parts, platycodon 30 parts, aleuritopteris 30 parts, long-jointed willow 20 parts, fried stemona 10 parts, catclaw grass 7 parts, and August 5 parts.

[0039] Example 3

[0040] The difference between this example and Example 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 45 parts, forsythia 45 parts, inula 38 parts, platycodon 42 parts, aleuritopteris 38 parts, long-jointed willow 27 parts, fried stemona 15 parts, catclaw grass 9 parts, and August 6 parts.

[0041] Example 4

[0042] The difference between this example and Example 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 60 parts, forsythia 60 parts, inula 50 parts, platycodon 55 parts, aleuritopteris 50 parts, long-jointed willow 40 parts, fried stemona 40 parts, catclaw grass 25 parts, and August 20 parts.

[0043] Example 5

[0044] The difference between this example and Example 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 52 parts, forsythia 50 parts, inula 43 parts, platycodon 48 parts, aleuritopteris 43 parts, long-jointed willow 32 parts, fried stemona 28 parts, catclaw grass 18 parts, and August 12 parts.

[0045] Example 6

[0046] The difference between this example and Example 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 58 parts, forsythia 55 parts, inula 47 parts, platycodon 52 parts, aleuritopteris 48 parts, long-jointed willow 37 parts, fried stemona 33 parts, catclaw grass 21 parts, and August 15 parts.

[0047] Example 7

[0048] The difference between the embodiment and embodiment 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 43 parts, forsythia 41 parts, inula 31 parts, platycodon 33 parts, aleuritidis 31 parts, long-jointed willow 22 parts, fried stemona 13 parts, catclaw grass 8 parts, and August 8 parts.

[0049] Example 8

[0050] The difference between the embodiment and embodiment 1 is that the traditional Chinese medicine compound preparation is composed of the following raw materials in parts by weight: honeysuckle 43 parts, forsythia 41 parts, inula 31 parts, platycodon 33 parts, aleuritidis 31 parts, long-jointed willow 22 parts, fried stemona 13 parts, catclaw grass 8 parts, and August 8 parts.

[0051] Test example 1

[0052] 1 Material

[0053] 1.1 Test drug

[0054] Florfenicol soluble powder;

[0055] The traditional Chinese medicine compound preparation is prepared according to embodiment 1 of the application.

[0056] 1.2 Test animals

[0057] 250 chickens with respiratory infection caused by E. coli infection, showing clinical symptoms of dyspnea, cough, depression, and mucus overflow in the oral cavity, and diarrhea.

[0058] 2 Method

[0059] 2.1 Grouping and administration

[0060] The 250 chickens with respiratory infection caused by E. coli infection were randomly divided into 5 groups, 50 in each, namely a blank control group, a traditional Chinese medicine compound preparation low-dose group, a traditional Chinese medicine compound preparation medium-dose group, a traditional Chinese medicine compound preparation high-dose group, and a florfenicol group. The blank control group was not given any drug, the traditional Chinese medicine compound preparation low-dose group was given the traditional Chinese medicine compound preparation of the application, at a dose of 500 kg of feed per 100 g of feed, the traditional Chinese medicine compound preparation medium-dose group was given the traditional Chinese medicine compound preparation of the application, at a dose of 500 kg of feed per 200 g of feed, the traditional Chinese medicine compound preparation high-dose group was given the traditional Chinese medicine compound preparation of the application, at a dose of 500 kg of feed per 300 g of feed, and the florfenicol group was given florfenicol soluble powder, mixed with water, at a dose of 150 mg per 1 L of water. The administration was continued for 7 days, and the rest of the feeding mode and environment was kept consistent. The test chickens were clinically observed every day, and their spirit, cough, and death were recorded.

[0061] 2.2 Therapeutic efficacy determination standard

[0062] Ineffective: There is no effect or the effect is not obvious during the administration and observation period.

[0063] Effective: Various clinical symptoms were relieved during the administration and observation period, respiratory symptoms were significantly improved, and appetite and mental state improved.

[0064] Cure: All clinical symptoms disappear, breathing returns to normal, appetite and mental state are good, and there is no recurrence after one week of stopping the medication.

[0065] 2.3 Effects of each group of drugs on inflammatory factors in the serum of chickens with respiratory tract infection

[0066] Five sick chickens in each group were randomly selected for cardiac blood sampling after treatment. The blood was placed in a 2-8°C refrigerator for 1-2 hours and centrifuged at 3500 rpm for 15 minutes to separate the serum. The levels of TNF-α, IL-6, and IFN-γ in the serum were detected by ELISA.

[0067] 2.4 Statistical methods

[0068] GraphPad Prism 8.0 statistical analysis software was used for processing. Data are expressed as ± standard deviation (s). Comparisons between groups were performed using one-way analysis of variance. The Bonferroni test was used when variances were equal, and the Dunnett's T3 test was used when variances were unequal. The test level was α = 0.05.

[0069] 3 Results

[0070] 3.1 Therapeutic effects of each group of drugs on chickens with respiratory tract infection

[0071] Table 1 shows the therapeutic effects of each group of drugs on chickens suffering from respiratory tract infections caused by E. coli infection. The self-healing rate of the blank control group was 40%. Compared with the blank control group, the low-, medium-, and high-dose groups of the Chinese herbal compound preparation all had different degrees of therapeutic effects on chickens suffering from respiratory tract infections caused by E. coli, and the mortality rate was significantly reduced; compared with the florfenicol group, the cure rate of the high-dose group of the Chinese herbal compound preparation was significantly increased, reaching 78%, indicating that the Chinese herbal compound preparation of the present invention has a good therapeutic effect on chickens suffering from respiratory tract infections caused by E. coli.

[0072] Table 1 The therapeutic effect of each group of drugs on chickens with respiratory tract infection

[0073]

[0074] 3.2 Effects of each group of drugs on inflammatory factors in the serum of chickens with respiratory tract infection

[0075] As shown in Table 2, compared with the blank control group, the low, medium and high dose groups of the traditional Chinese medicine compound can significantly reduce the levels of inflammatory factors TNF-α and IL-6 in the serum of the infected chickens, and increase the level of IFN-γ (P<0.01), and the effect of the medium dose group of the traditional Chinese medicine compound is comparable to that of the florfenicol group, and the effect of the high dose group of the traditional Chinese medicine compound is obviously better than that of the florfenicol group.

[0076] Table 2 Effects of drugs on inflammatory factors in serum of respiratory infection chickens

[0077]

[0078] Compared with the blank control group, * P<0.05, ** P<0.01.

[0079] Test Example 2

[0080] 1 Materials

[0081] 1.1 Test drugs

[0082] Tylosin furoate soluble powder;

[0083] The traditional Chinese medicine compound preparation is prepared according to Example 1 of the present application.

[0084] 1.2 Test animals

[0085] 100 pigs naturally infected with mycoplasma pneumonia, with clinical manifestations of depression, loss of appetite, elevated body temperature, dyspnea, abdominal breathing, cough, asthma, and nasal discharge.

[0086] 2 Test method

[0087] 2.1 Test pig grouping and drug administration

[0088] The 100 pigs naturally infected with mycoplasma pneumonia were randomly divided into 5 groups, 20 pigs in each group, which were blank control group, low dose traditional Chinese medicine compound preparation group, medium dose traditional Chinese medicine compound preparation group, high dose traditional Chinese medicine compound preparation group, and tylosin furoate group, respectively. Among them, the blank control group was not given any drug, the low dose traditional Chinese medicine compound preparation group was given the traditional Chinese medicine compound preparation of the present application, the dosage was 500 kg of feed per 100 g of feed, the medium dose traditional Chinese medicine compound preparation group was given the traditional Chinese medicine compound preparation of the present application, the dosage was 500 kg of feed per 200 g of feed, the high dose traditional Chinese medicine compound preparation group was given the traditional Chinese medicine compound preparation of the present application, the dosage was 500 kg of feed per 300 g of feed, and the tylosin furoate group was given tylosin furoate soluble powder, mixed with water, 50 mg per 1 L of water; continuous administration for 7 days, the rest of the feeding mode and environment were kept consistent, and the test pigs were observed clinically every day, and the spirit, cough, death and other conditions were recorded.

[0089] 2.2 Clinical efficacy evaluation criteria

[0090] Ineffective: no effect or no obvious effect during the administration and observation period.

[0091] Effective: various clinical symptoms are relieved, respiratory symptoms are obviously improved, and appetite and mental state are improved during the administration and observation period.

[0092] Cured: various clinical symptoms disappear, respiration returns to normal, appetite and mental state are good, and no recurrence occurs after one week of drug withdrawal.

[0093] 3. Treatment effects of various drugs on pigs with mycoplasma pneumonia

[0094] As shown in Table 3, the self-healing rate of pigs in the blank control group is 30%, compared with the blank control group, the low-, medium-, and high-dose groups of the traditional Chinese medicine compound preparation have different degrees of treatment effects on the diseased pigs, and the mortality is obviously reduced; compared with the ceftriaxone group, the cure rate of the high-dose group of the traditional Chinese medicine compound preparation is obviously improved, which can reach 76.7%, indicating that the traditional Chinese medicine compound preparation has a good treatment effect on pigs with mycoplasma pneumonia.

[0095] Table 3. Treatment effects of various drugs on pigs with mycoplasma pneumonia

[0096]

[0097]

[0098] Test Example 3

[0099] 1. Materials

[0100] 1.1 Test drug

[0101] Tylvalosin tartrate soluble powder;

[0102] The traditional Chinese medicine compound preparation is prepared according to Example 1 of the present application.

[0103] 1.2 Test animals

[0104] 250 naturally infected chickens with mycoplasma gallisepticum, which clinically showed dyspnea, cough, listlessness, mucus overflow in the oral cavity, and diarrhea.

[0105] 2. Test method

[0106] 2.1 Test chicken grouping and drug administration

[0107] 250 natural infection of Mycoplasma gallisepticum disease chickens were randomly divided into 5 groups, 50 in each group, which were blank control group, traditional Chinese medicine compound preparation low-dose group, traditional Chinese medicine compound preparation medium-dose group, traditional Chinese medicine compound preparation high-dose group, and tylosin tartrate group; wherein, the blank control group was not given any drug, the traditional Chinese medicine compound preparation low-dose group was given the traditional Chinese medicine compound preparation of the application, the dosage was 500 kg of feed per 100 g of feed, the traditional Chinese medicine compound preparation medium-dose group was given the traditional Chinese medicine compound preparation of the application, the dosage was 500 kg of feed per 200 g of feed, the traditional Chinese medicine compound preparation high-dose group was given the traditional Chinese medicine compound preparation of the application, the dosage was 500 kg of feed per 300 g of feed, and the tylosin tartrate group was given tylosin tartrate soluble powder, mixed with water, 500 mg per 1 L of water; the continuous administration lasted for 7 days; the rest of the feeding mode and environment were kept consistent, and the test chickens were observed clinically every day, and the spirit, cough, death and other conditions were recorded.

[0108] 2.2 Clinical efficacy evaluation criteria

[0109] Ineffective: no effect or no obvious effect during the administration and observation period.

[0110] Effective: various clinical symptoms were relieved, respiratory symptoms were obviously improved, and appetite and mental state were improved during the administration and observation period.

[0111] Cured: various clinical symptoms disappeared, respiration returned to normal, appetite and mental state were good, and no recurrence occurred after stopping the drug for one week.

[0112] 3. Treatment effects of various drugs on Mycoplasma gallisepticum infected chickens

[0113] As shown in Table 4, the self-healing rate of the chickens in the blank control group was 44.0%, although the mortality rate was not high, but the clinical symptoms were eliminated slowly, compared with the blank control group, the traditional Chinese medicine compound preparation low-dose group, the traditional Chinese medicine compound preparation medium-dose group and the traditional Chinese medicine compound preparation high-dose group had different degrees of therapeutic effects on Mycoplasma gallisepticum, the mortality rate was obviously reduced, and showed a dose-dependent effect; compared with the tylosin tartrate group, the cure rate of the traditional Chinese medicine compound preparation high-dose group was obviously improved, which could reach 84%, indicating that the traditional Chinese medicine compound preparation of the application had a good treatment effect on Mycoplasma gallisepticum infected chickens.

[0114] Table 4. Treatment effects of various drugs on Mycoplasma gallisepticum infected chickens

[0115]

[0116] In summary, the traditional Chinese medicine compound preparation of the application can significantly reduce the levels of TNF-α and IL-6 in serum, and increase the level of IFN-γ; can obviously relieve the clinical symptoms of respiratory tract infection of livestock and poultry, reduce the mortality rate, improve the drug resistance caused by long-term use of antibiotics, reduce the drug residues of chemical agents in livestock and poultry, protect the health of livestock and poultry and the safety of animal source food, and has a good application prospect.

[0117] The above examples are only used to illustrate the technical solutions of the present application, but not to limit the present application; although the present application has been described in detail with reference to the foregoing examples, those ordinarily skilled in the art should understand: the technical solutions recorded in the foregoing examples can be modified, or some technical features can be replaced equivalently; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A traditional Chinese medicine compound preparation for preventing and treating respiratory infections of livestock and poultry, characterized in that, The Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: honeysuckle 40-60 parts, forsythia 40-60 parts, inula flower 30-50 parts, platycodon 30-55 parts, euphorbia helioscopia 30-50 parts, longleaf eucalyptus 20-40 parts, fried stachys 10-40 parts, catclaw grass 5-25 parts, and eight-month aralia 5-20 parts.

2. The Chinese medicine compound preparation for preventing and treating respiratory infection of livestock and poultry according to claim 1, characterized in that, The Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: honeysuckle 45-55 parts, forsythia 45-50 parts, inula flower 35-45 parts, platycodon 40-50 parts, euphorbia helioscopia 35-45 parts, longleaf eucalyptus 20-30 parts, fried stachys 20-30 parts, catclaw grass 10-20 parts, and eight-month aralia 8-15 parts.

3. The Chinese medicine compound preparation for preventing and treating respiratory infection of livestock and poultry according to claim 1, characterized in that, The Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: honeysuckle 50 parts, forsythia 48 parts, inula flower 40 parts, platycodon 45 parts, euphorbia helioscopia 40 parts, longleaf eucalyptus 25 parts, fried stachys 22 parts, catclaw grass 13 parts, and eight-month aralia 10 parts.

4. The preparation method of the Chinese medicine compound preparation for preventing and treating respiratory infections of livestock and poultry according to any one of claims 1 to 3, characterized in that, The method comprises the following steps: (1) the raw materials are weighed according to the above weight proportions, washed, crushed, mixed and used; (2) the Chinese medicine coarse powder obtained in step (1) is boiled twice, the first boiling is for 2 hours and the second boiling is for 1 hour, filtered, the boiling liquids are combined, and concentrated to a relative density of 1.1-1.3 to obtain the Chinese medicine compound preparation.

5. The preparation method of the traditional Chinese medicine compound for preventing and treating respiratory infections of livestock and poultry according to claim 4, characterized in that, The Chinese medicine compound preparation can be prepared into granules, oral liquid or injection.

6. The Chinese medicine compound preparation according to any one of claims 1-5 for use in the preparation of a medicament for preventing and / or treating respiratory tract infection of livestock and poultry.

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