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40 results about "Platycodin D" patented technology
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Platycodin D is a bio-active isolate from roots of Platycodon grandiflorus. It has been studied for its spermicidal effects as a contraceptive in humans.
Saponin with immunoadjuvant function, preparation method, vaccine preparation containing the saponin as adjuvant and uses thereof
InactiveCN101402666ASimple preparation processSimple methodAntiinfectivesSteroidsDiseaseCell immune response
The invention relates to a saponin with immune adjuvant function and a preparation method thereof, a vaccine preparation containing the saponin as an adjuvant, and applications of the saponin and the vaccine preparation in the prevention and treatment of infectious diseases and cancers of human and animals. The saponin is platycodin D, platycodin D2, or a total-saponin containing the two saponin compounds. The platycodin D and platycodin D2 are both extracted and separated from balloonflower, a Chinese medicine. The saponin can induce an organism to generate Th1-type and Th2-type immune responses, show the capability of inducing the organism to generate stronger cell immune response and humoral immune response to a vaccine than the alhydrogel adjuvant known in the prior art, and can be taken as the immune adjuvant for a plurality of vaccines and achieve an ideal immunity effect. The vaccine which takes the saponin as the adjuvant has simple preparation technology and simple and convenient method, and the quality is easy to control and the saponin can be reserved by freezing.
Owner:ZHEJIANG UNIV
Preparation method, application and QC (Quality Control) detection method of platycodon grandiflorum active site
InactiveCN101904890AComprehensive evaluationGood reproducibilitySugar derivativesComponent separationCompound aReactive site
The invention provides a preparation method and a new application of a platycodon grandiflorum active site, in particular the application of a platycodon grandiflorum active site in an antineoplastic drug. The invention also relates to two new triterpenoidal saponin compounds (compounds A and B) separated from the platycodon grandiflorum active site by a phytochemical separation way and a preparation method thereof. The invention further provides a detection method for QC (Quality Control) of the platycodon grandiflorum by platycodin D, polygala saponin D2, platycodin D3, deapiose platycodin D3, platycodin D2, deapiose platycodin D2, deapiose platycodin E and platycodin E, and the method has excellent repeatability and is capable of comprehensively evaluating the quality of the platycodon grandiflorum, platycodon grandiflorum extracts and the platycodon grandiflorum active site.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Medicament for killing sperms in vitro
The invention discloses a medicament for killing sperms in vitro, which comprises the raw materials in percentage by weight: 3-7mg of platycodin D, 3-5mg of divaricate saposhnikovia extract, 3-5mg of cassia twig extract, 1-3mg of malaytea scurfpea extract and 130-170ml of 0.9 percent physiological saline. The platycodin D, the divaricate saposhnikovia extract, the cassia twig extract, and the malaytea scurfpea extract are added into a vessel for uniformly mixing and then 130-170ml of 0.9 percent physiological saline is added into the vessel for uniformly shaking to obtain the medicament. The medicament is prepared from pure traditional Chinese medicine, can rapidly achieve the aim of killing the sperms in vitro and has better antimicrobial effect and sterilizing effect. The medicament can be prepared into emulsion, suppository and other forms for external contraception of vagina, or can be prepared into sustained-release capsules which are placed in an intrauterine device and are carried to enter a human body, so that the contraception effect of the intrauterine device can be enhanced and no toxic and side effect are generated.
Owner:SHANDONG PROVINCIAL FAMILY PLANNING INST OF SCI & TECH
Quality control method of platycodon grandiflorum fluid extract
ActiveCN103995065AQuality reflectionResolve uncertaintyComponent separationFluid phaseTraditional medicine
The invention relates to the field of medicine quality control and in particular relates to a quality control method of a platycodon grandiflorum fluid extract. The quality control method of the platycodon grandiflorum fluid extract comprises the following steps: step A, pretreating the platycodon grandiflorum fluid extract; step B, measuring the content W of platycodin D in the platycodon grandiflorum fluid extract by adopting a high performance liquid chromatography; step C, evaluating whether the quality of the platycodon grandiflorum fluid extract is qualified according to the content W of the platycodin D. By utilizing the quality control method of the platycodon grandiflorum fluid extract, the purpose of quantitatively evaluating the quality of the platycodon grandiflorum fluid extract is realized by quantitatively detecting the content of the platycodin D. Because the main effective constituent of the platycodon grandiflorum fluid extract is the platycodin D and the content is high, the quality of the platycodon grandiflorum fluid extract can be quantitatively and accurately reflected by quantitatively detecting the content of the platycodin D so as to avoid the problem of uncertainty of quality control.
Owner:华润三九(郴州)制药有限公司
Non-irritant contraceptive gel with function of inhibiting bacteria and preparation method thereof
ActiveCN105749149ANo greasy feelingApplicable careAntibacterial agentsOrganic active ingredientsChlorhexidine AcetateSide effect
The invention provides a non-irritant contraceptive gel with a function of inhibiting bacteria and a preparation method thereof, relates to contraceptive gel and a preparation method thereof, and aims to improve the nonoxinol spermicidal effect and solve the problem of side effect caused when existing nonoxinol is used for killing sperms. The gel is prepared from the following main components: chlorhexidine acetate, aloe gel, nonoxinol, pomegranate powder, turmeric extract and platycodin D. The method comprises the following steps of: 1, adding water into Carbomer to swell to obtain a Carbomer solution; regulating the pH value to obtain gel; 2, dissolving aloe gel with water to obtain aloe gel solution; and 3, adding ethanol and tween 80 into chlorhexidine acetate, uniformly stirring to obtain a mixed solution, adding pure water, uniformly stirring, adding into gel and nonoxinol to obtain mixture; and 4, adding pomegranate powder, turmeric extract and platycodin D, and uniformly mixing to obtain a contraceptive gel. The contraceptive gel has a good sperm killing effect, does not have side effect if being used for a long time, and is used in the field of contraceptive medicines.
Owner:黑龙江成功药业有限公司
Application of platycodin D to preparation of medicine for preventing and treating porcine reproductive and respiratory syndrome
InactiveCN105769890AInhibit synthesisGood anti-PRRSV activityOrganic active ingredientsAntiviralsImmunofluorescenceImmunofluorescent microscopy
The invention discloses application of platycodin D to the preparation of medicine for resisting PRRSV (porcine reproductive and respiratory syndrome virus) and preventing and treating porcine reproductive and respiratory syndrome. The platycodin D is separated from the roots of platycodon grandiflorum. Methods such as immunofluorescence microscopic analysis, RT-PCR and Western blot prove that the platycodin D has good PRRSV resisting activity on Marc-145 cells and can hopefully become medicine for preventing and treating the porcine reproductive and respiratory syndrome. The fact that the platycodin D has the PRRSV resisting activity is discovered for the first time, and the platycodin D is evident in curative effect on pigs infected with PRRSV.
Owner:SOUTH CHINA AGRI UNIV +1
Application of platycodin D in preparing medicaments for inhibiting angiogenesis
InactiveCN104161765AHas anti-angiogenic activityPrevent proliferationOrganic active ingredientsSkeletal disorderDiseasePharmaceutical drug
The invention relates to a new application of platycodin D, namely, an application of platycodin D in preparing medicaments for inhibiting angiogenesis. The application disclosed by the invention has the advantages that a situation that platycodin D has anti-angiogenesis activity is found for the first time, so that the platycodin D can be used as an angiogenesis inhibitor; and the platycodin D can be used as an angiogenesis inhibitor, and applied to the preparation of anti-angiogenesis drugs so as to treat new vessel depended and new vessel related diseases such as cancers, arthritis, psoriasis, ophthalmic diseases, atherosclerosis, and the like.
Owner:SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
Preparation method for dendritic cell (DC) tumor vaccine
ActiveCN110283787AGood treatment effectFully exposedCulture processCancer antigen ingredientsDendritic cellPhosphate
The invention relates to a preparation method for a DC tumor vaccine. The method comprises the following steps: (1) adding a tumor cell body to a serum-containing culture solution, then adding a platycodin D culture solution, and placing in a carbon dioxide incubator to be cultured for more than 2h; (2) digesting tumor cells cultured in the step (1) with trypsin, performing centrifugation, abandoning the culture solution, resuspending by adding DMEM, then adding DCs to be co-cultured for more than 2h, and adding lipopolysaccharide LPS to be cultured continuously, thereby making DCs suspended; (3) sucking out suspended DCs, carrying out centrifugation, abandoning the culture solution, resuspending by adding DMEM, then performing separation and purification to obtain mature DCs; (4) preparing the DC tumor vaccine by taking mature DCs and adding to isotonic saline or a phosphate buffer solution or serum-free DMEM. The tumor vaccine prepared by the method can promote the immune response of tumor antigens, and the antitumor effect is remarkable.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
Method for extracting platycodin D from platycodon grandiflorum
The invention provides a method for extracting platycodin D from platycodon grandiflorum and aims to mainly solve the problems that the prior art is complex to operate, low in product content, low in recycle rate and unsuitable for large-scale production operation. The method for extracting platycodin D from the platycodon grandiflorum comprises the following steps: (1) extraction; (2) primary ultrafiltration; (3) secondary nanofiltration; and (4) recrystallization. The method for extracting platycodin D from the platycodon grandiflorum can be used for preparing a platycodin D product of which the purity is higher than 98% by just a plurality of steps, and is convenient to operate, high in product content, high in recycle rate, small in harms caused by solvents and suitable for large-scale production operation.
Owner:SHAANXI JIAHE PHYTOCHEM
Preparation method and application of deapio-platycodin D
PendingCN111394266APromote safe productionHigh yieldOrganic active ingredientsFungiBiotechnologyBacterial strain
The invention belongs to a preparation method of deapio-platycodin D. The preparation method for preparing the deapio-platycodin D is characterized in that the deapio-platycodin D is prepared by two or more bacterial strains, including a pichia kudriavzevii bacterial strain and a bacillus velezensis bacterial strain. According to the preparation method, two bacterial strains of different transformation mechanisms are used for the first time, and platycodin is transformed in a mixed fermentation manner, so that the yield of the deapio-platycodin D is effectively increased. Biotransformation ofthe platycodin is performed through the fermentation characteristics of the bacterial strains, so that safe and environment-friendly production of the platycodin can be realized, platycodon resourcescan also be sufficiently used, and the platycodin being low in bioactivity contained in the platycodon resources is transformed into saponin being high in bioactivity, and the effect of turning wasteinto wealth is achieved.
Owner:YANBIAN UNIV
Pharmaceutical composition for treating tympanitis and preparation method thereof
InactiveCN105596599AEffective treatmentOrganic active ingredientsSenses disorderAucubinCurative effect
The invention discloses a pharmaceutical composition for treating tympanitis and a preparation method thereof. The pharmaceutical composition is prepared by taking herb of lepidium virginicum L., Chinese galls, honeycombs, herba taraxaci, rhizoma alismatis, herba periliae, aucubin and platycodin D as bulk pharmaceuticals in proportion and can be prepared into preparations of various forms according to a conventional preparation technology, and the tympanitis treating effect is significant.
Owner:JINAN XINGYI MEDICAL TECH
Preparation method and application of platycodin D
ActiveCN111394265APromote safe productionImprove biological activityOrganic active ingredientsFungiBiotechnologyBacterial strain
The invention belongs to a preparation method for platycodin D, and adopts a mixed bacterial strain which includes a Pichia kudriavzevii bacterial strain and a Bacillus velezensis bacterial strain toprepare the platycodin D. According to the preparation method, two types of bacterial strains with different conversion mechanisms are used for the first time to convert platycodin in a mixed fermentation way, and the yield of the platycodin D and deapioplatycodin D can be effectively improved. By use of bacterial strain fermentation characteristics, the platycodin can be subjected to biological transformation, the safe and environmentally-friendly production of the platycodin can be realized, platycodon grandiflorum resources can be fully utilized, and the platycodin which is contained in theplatycodon grandiflorum resources and has low biological activity can be converted into saponin with high biological activity so as to achieve an effect of recycling waste materials.
Owner:YANBIAN UNIV
Near infrared spectrum detection method for detecting platycodon grandiflorum medicine
InactiveCN108562556ASolve complex processApplicable determinationMaterial analysis by optical meansInfraredImage resolution
The invention discloses a near infrared spectrum detection method for detecting a platycodon grandiflorum medicine. The method comprises the following steps: (1) smashing and sieving the platycodon grandiflorum medicine; (2) acquiring a near-infrared spectrogram of the platycodon grandiflorum medicinal powder; and (3) inputting an established standard near-infrared spectroscopy model according toa standard near-infrared spectrum and the acquired near-infrared spectrum of the platycodon grandiflorum medicine, and calculating water content of the platycodon grandiflorum medicine and the contentof platycodin D. The spectral conditions are as follows: scan times is 32, and the resolution is 8 cm<-1>, with the built-in background of the instrument as a reference, the scanning spectrum range is 4000-10000cm<-1>.
Owner:WUXI JIMIN KEXIN SHANHE PHARMA +1
Application of platycodin D to preparation of drug for treating melanoma metastasis
InactiveCN104887692AAnti-tumor metastasis hasInhibitory activityOrganic active ingredientsAntineoplastic agentsMelanomaVascular endothelium
The invention discloses application of platycodin D to preparation of a drug for treating melanoma metastasis. Platycodin D can be used for remarkably inhibiting melanoma metastasis and has the effects of reducing the in-vitro cellular activity of melanoma, inhibiting cell migration and invasion capacities of the melanoma, inhibiting the adhesive capacity of a melanoma cell and a vascular endothelial cell and reducing the amount of pulmonary metastasis foci in bodies of rats. A pharmacodynamic method proves that platycodin D has the advantages of multiple approaches and multiple target points in anti-tumor metastasis, so that the clinical application of platycodin D on the aspect of anti-tumor metastasis has the scientific basis.
Owner:INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
Radix platycodonis composition for relieving coughs and eliminating phlegm and preparation method thereof
InactiveCN105902606ARespiratory disorderNatural extract food ingredientsFOOD EFFECTTraditional medicine
The invention discloses a radix platycodonis composition for relieving coughs and eliminating phlegm and a preparation method thereof. The preparation method comprises the following process steps that 10 parts by mass of radix platycodonis extract and 1-20 parts by mass of radix glycyrrhizae extract are selected, mixed to be uniform and prepared into a corresponding oral preparation, and the radix platycodonis composition is obtained, wherein the content of platycodin D in the radix platycodonis extract is not lower than 1.0%, and the content of glycyrrhizic acid in the radix glycyrrhizae extract is not lower than 20%. According to the radix platycodonis composition, traditional Chinese medicine with both pharmaceutical and food effects is preferred, a modern extraction technology is adopted for preparation, the formulation is screened and optimized through in-vivo pharmacological tests, it is proved that definite cough relieving and phlegm eliminating effects are achieved, and therefore the radix platycodonis composition can be applied to preparation of drugs and healthcare food with corresponding functions.
Owner:CHANGSHU QIUSHI TECH CO LTD
Platycodin D sperm-killing contraceptive suppository for external use and placing device thereof
InactiveCN103006542AStrong spermicidal effectNo unwanted pregnancyOrganic active ingredientsSuppositories deliveryObstetricsLiquid state
The invention discloses a platycodin D sperm-killing contraceptive suppository for external use. The contraceptive suppository is characterized in that the active ingredient of the suppository is platycodin D diluent; the platycodin D diluent is different concentrations of physiological saline solution of platycodin D extracts; and the suppository is solid at normal temperature. When the contraceptive suppository is used, the contraceptive suppository is quickly dissolved in vaginas at body temperature, is in a semi-liquid state and can quickly kill sperms after being in contact with the sperms and deactivate the sperms, thus playing a role in contraception. The invention also discloses a matched placing device of the contraceptive suppository. The contraceptive suppository has a good contraceptive effect and can avoid unplanned pregnancy.
Owner:王磊光
Composite water-soluble animal vaccine adjuvant, vaccine and preparation method of vaccine
ActiveCN113082202AImprove immunityPromote proliferationViral antigen ingredientsAntiviralsDendritic cellCellular antigens
The invention discloses a composite water-soluble animal vaccine adjuvant, a vaccine and a preparation method of the vaccine, and relates to the technical field of vaccine adjuvants. The composite water-soluble animal vaccine adjuvant is prepared from a lactic acid-glycolic acid copolymer (PLGA), a dendritic cell targeted induction peptide DCpep, platycodin D, a B cell antigen peptide BP-8 of neisseria meningitidis PorB protein and a T cell antigen peptide TP-7 of neisseria meningitidis PorB protein. Compared with the conventional oil adjuvant, the oil adjuvant disclosed by the invention not only can stimulate the generation of humoral immune response such as neutralizing antibody, but also can promote T cell proliferation, improve the level of cytokines (IFN-gamma and IL-6) and stimulate the cellular immune response. Meanwhile, adverse reactions such as granuloma at an injection site caused by an oil adjuvant vaccine are avoided, and the immune effect of animal vaccines is effectively improved.
Owner:QINGDAO AGRI UNIV
Planting method for improving platycodon grandiflorum yield and medicine effect ingredient content
InactiveCN110073909AIncrease total saponin contentIncrease platycodon saponin-D contentPlant cultivationCultivating equipmentsDry weightMedicine
The invention discloses a planting method for improving the platycodon grandiflorum yield and the medicine effect ingredient content, and belongs to the technical field of traditional Chinese medicinal material planting. According to the used method, DA-6 is sprayed for treatment; the combined treatment of the DA-6 spray application and the bud picking topping treatment is preferably selected. A method of combining DA-6 spray application and bud picking topping treatment is used, so that the single plant fresh weight and dry weight of platycodon grandiflorum can be improved by 50 percent or above; the diameter of platycodon grandiflorum roots can be increased by 45 percent or above; meanwhile, the lateral root number can be obviously reduced; the total platycodin content in the platycodongrandiflorum can also be increased by 56 percent or above; the platycodin-D content in the platycodon grandiflorum can be increased by 150 percent or above; the yield of the platycodon grandiflorum, particularly Zhongjiang platycodon grandiflorum, and the effective ingredient content in the medicinal material are obviously improved; the obvious economic benefits are achieved.
Owner:MIANYANG TEACHERS COLLEGE
Chinese patent medicine preparation for pneumonia and preparation method thereof
InactiveCN113082071AAvoid adverse effects such as drug resistanceGood effectOrganic active ingredientsRespiratory disorderAntibiotic drugChinese patent medicine
The invention discloses a Chinese patent medicine preparation for pneumonia and a preparation method thereof. The Chinese patent medicine preparation for pneumonia is prepared from the following raw materials in parts by weight: 40-50 parts of dry honeysuckle extract powder, 8-10 parts of forsythoside A, 5-10 parts of arctigenin, 1-5 parts of platycodin D, 2-5 parts of saikoside, 2-6 parts of amygdalin and 1-10 parts of licoflavone. According to the Chinese patent medicine preparation for pneumonia, pure traditional Chinese medicinal materials are used as raw materials, and effective components directed at pneumonia are extracted; and compared with direct taking of traditional Chinese medicines, the effect of the the Chinese patent medicine preparation is faster, taking of the the Chinese patent medicine preparation is convenient, adverse effects such as body weight losing and drug resistance generation caused by large-amount taking of western antibiotic medicines are avoided, and pneumonia can be fundamentally treated and is not prone to relapse.
Owner:南京康天生物科技有限公司
Skin-whitening agent containing platycodin D
The present invention relates to cosmetic and pharmaceutical compositions used for whitening skin which include platycodin-D as an effective constituent. The platycodin-D can be used safely without side effect to skin, and has an excellent effect for restraining melanin from generating and preventing pigmentation. Therefore, the compositions using platycodin-D as an effective constituent can be used effectively for releasing splashes and flecks, and whitening skin.
Owner:BIOSPECTRUM
Application of platycodin D in treatment of acute lung injury caused by viral pneumonia
PendingCN114344316AWith syndrome differentiationImmune regulationOrganic active ingredientsAntiviralsInflammatory factorsALI - Acute lung injury
The invention relates to application of platycodin D in treatment of acute lung injury caused by viral pneumonia. The invention establishes a severe infection mouse model induced by influenza virus infection, explores the application of platycodin D in treatment of acute lung injury caused by viral pneumonia, and finds that platycodin D can obviously improve the survival rate of the severe infection mouse model induced by PR8 infection and obviously relieve lung injury caused by infection. The invention also observes the influence of the platycodin D on the secretion of proinflammatory factors and anti-inflammatory factors of R837-induced Raw264.7 cells, mouse primary peritoneal macrophages and mouse macrophages directly infected by influenza virus PR8, wherein the R837-induced Raw264.7 cells, the mouse primary peritoneal macrophages and the mouse macrophages are directly infected by influenza virus PR8. The traditional Chinese medicine composition has the beneficial effect that an effective medicine is provided for treating acute lung injury caused by viral pneumonia, especially severe cases of viral pneumonia.
Owner:SHANGHAI DERMATOLOGY HOSPITAL
Noon tea granules and preparation method and application thereof
InactiveCN106110093ASimple structureEasy to operatePharmaceutical product form changeGranular deliveryPheochromocytomaAlcohol
The invention provides noon tea granules. The noon tea granules are prepared through the steps that 50 g of rhizoma atractylodis, 50 g of radix bupleuri, 50 g of notopterygium roots, 50 g of radix saposhnikoviae, 50 g of radix angelicae, 50 g of rhizoma chuanxiong, 50 g of herba pogostemonis, 50 g of radix peucedani, 50 g of fructus forsythiae, 50 g of pericarpium citri reticulatae, 50 g of fructus crataegi, 50 g of fructus aurantii immaturus, 75 g of roasted malt, 50 g of licorice roots, 75 g of radix platycodonis, 50 g of stir-fried medicated leaven, 75 g of folium perillae, 75 g of cortex magnoliae officinalis and 1,600 g of black tea are taken, water extraction and alcohol precipitation are conducted to obtain a concentrated solution, supercritical extraction is conducted to obtain a supercritical extract, and the noon tea granules are prepared through a conventional method. The prepared noon tea granules are high in platycodin D content, and application of the noon tea granules in preparation of drugs for inhibiting rat adrenal pheochromocytoma PC-12 cell proliferation is found.
Owner:NANJING ZHENGKUAN MEDICAL TECH
Preparation method of compound platycodon grandiflorum and moutan bark inhaling preparation for atomization
InactiveCN106822267AAvoid damageEliminates the defect of decocting and then usingPowder deliveryDispersion deliveryAntioxidantBottle
The invention discloses a preparation method of compound platycodon grandiflorum and moutan bark inhaling preparation for atomization. The preparation method comprises the following steps of; adding a co-solvent into water for injection, and uniformly stirring and mixing the two to obtain a solvent; adding 3-100g of platycodon grandiflorum extract, 0.1-10g of paeonol extract, 0.01-0.5g of a corrigent and 0.01-0.5g of an antioxidant, fixing the volume to 1000-10000mL, uniformly stirring the mixture, and adjusting the pH to 4.0 to obtain an initial solution; successively roughly and finely filtering the obtained initial solution to obtain a final solution; and filling an ampoule bottle with the final solution, and performing encapsulation, sterilizing, leakage detection and packaging to obtain a finished product. According to the compound platycodon grandiflorum and moutan bark inhaling preparation obtained by the invention, the content of total saponins per ml is not less than 2mg, the content of platycodin D is not less than 0.1mg, and the content of paeonol is not less than 0.2mg.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
Medicament for killing sperms in vitro
The invention discloses a medicament for killing sperms in vitro, which comprises the raw materials in percentage by weight: 3-7mg of platycodin D, 3-5mg of divaricate saposhnikovia extract, 3-5mg of cassia twig extract, 1-3mg of malaytea scurfpea extract and 130-170ml of 0.9 percent physiological saline. The platycodin D, the divaricate saposhnikovia extract, the cassia twig extract, and the malaytea scurfpea extract are added into a vessel for uniformly mixing and then 130-170ml of 0.9 percent physiological saline is added into the vessel for uniformly shaking to obtain the medicament. The medicament is prepared from pure traditional Chinese medicine, can rapidly achieve the aim of killing the sperms in vitro and has better antimicrobial effect and sterilizing effect. The medicament can be prepared into emulsion, suppository and other forms for external contraception of vagina, or can be prepared into sustained-release capsules which are placed in an intrauterine device and are carried to enter a human body, so that the contraception effect of the intrauterine device can be enhanced and no toxic and side effect are generated.
Owner:SHANDONG PROVINCIAL FAMILY PLANNING INST OF SCI & TECH
Traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof
ActiveCN108434222AHigh inhibition rateGood effectOrganic active ingredientsAntineoplastic agentsWater bathsBULK ACTIVE INGREDIENT
The invention relates to a traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof. The traditional Chinese medicine compound preparation is prepared by using an alcohol extract of radix notoginseng, spreading hedyotis herb and herba lycopi, platycodin D and geniposide as active ingredients, wherein the alcohol extract is prepared according to the following steps: weighing 20 to 30 parts of radix notoginseng, 20 to 30 parts of spreading hedyotis herb and 5 to 10 parts of herba lycopi, crushing, adding 5 to 10 times of ethyl alcohol with volume fraction of 80% to 90%, soaking for 10 to 20 hours at room temperature, refluxing in a water bath of 80 DEG C to 90 DEG C for two to three times, each time for 1 to 3 h, then combining filtrate, concentrating the filtrate into an extracting solution with the concentration of 1 to 2g / ml, and drying the extracting solution at 40 DEG C to 50 DEG C to be constant in weight. The traditional Chinese medicinecompound preparation provided by the invention has the advantages that tumor growth can be significantly inhibited, the platycodin D and the geniposide have certain synergistic effects, less medicinematerials are used, the medicine efficacy is specialized, the safety is high, and the development and promotion of clinical medicine is facilitated.
Owner:HUANGHUAI UNIV
Method for determining content of platycodin D in Huang's sound tea
InactiveCN113433235ASimple extraction methodShort detection timeComponent separationMedicineWarm water
The invention relates to a method for determining the content of platycodin D in Huang's sound tea, which comprises the following steps: 1) preparing a reference substance solution: taking a proper amount of a platycodin D reference substance, precisely weighing, and adding methanol to prepare the platycodin D reference substance solution; (2) preparing a test solution: taking Huang's sound tea, precisely weighing, adding methanol, dissolving, filtering, washing filter residues with a proper amount of methanol, combining filtrate and washing liquor, placing on a warm water bath to be volatilized, dissolving residues with methanol, and transferring into a measuring flask; and 3) determination: taking the reference substance solution and the test solution, injecting the reference substance solution and the test solution into a high performance liquid chromatograph to obtain a chromatogram, and calculating the content of platycodin D in the test solution according to the peak area of the chromatogram.
Owner:WUXI JIMIN KEXIN SHANHE PHARMA
Culture method for inducing DC-CIK amplification
PendingCN111733130AIncreased proliferationEnhance phagocytosisCulture processBlood/immune system cellsAfter treatmentPhagocytosis
The invention relates to the technical field of culture methods, in particular to a culture method for inducing DC-CIK amplification. The method comprises the following steps: separation and purification of platycodin D, preparation of PCD-DC-CIK cells, feedback of immune cells PCD-DC-CIK, and monitoring on growth characteristics of platycodin D induced PCD-DC-CIK cells and conventionally inducedDC-CIK cells, and evaluating of lifetime of PCD-DC-CIK cells of a tumor-bearing mouse before and after treatment. Platycodin D is utilized to effectively increase proliferation and phagocytosis capacities of macrophages, so that the respective functions of DC and CIK cells are synergistically exerted; in-vitro experiments prove that a proliferation rate of the PCD-DC-CIK cells induced and culturedby the method is remarkably improved compared with conventional induction, and tumor inhibition activity is remarkably enhanced; and animal experiments show that after the tumor-bearing mouse is subjected to treatment by the method, the tumor proportion is obviously reduced, and the lifetime is obviously prolonged.
Owner:湖南科诺康美生命科技有限公司
A kind of traditional Chinese medicine compound preparation for treating ovarian tumor and its application
ActiveCN108434222BHigh inhibition rateGood effectOrganic active ingredientsAntineoplastic agentsGenipinEfficacy
Owner:HUANGHUAI UNIV
Saponin with immunoadjuvant function, preparation method, vaccine preparation containing the saponin as adjuvant and uses thereof
InactiveCN101402666BSimple preparation processSimple methodAntiinfectivesSteroidsDiseaseCell immune response
Owner:ZHEJIANG UNIV
Skin-whitening agent containing platycodin D
Owner:BIOSPECTRUM
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