Composite water-soluble animal vaccine adjuvant, vaccine and preparation method of vaccine

A vaccine adjuvant and water-soluble technology, which is applied in the fields of compound water-soluble animal vaccine adjuvant and vaccine and vaccine preparation, can solve the problems of affecting popularization and use and high cost of vaccines, and achieves promoting T cell proliferation, improving immune effect, avoiding Granuloma effect

Active Publication Date: 2021-07-09
QINGDAO AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high price of its raw materials, the cost of the vaccine will be much higher than that of the traditional mineral oil adjuvant vaccine, which will affect its promotion and use

Method used

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  • Composite water-soluble animal vaccine adjuvant, vaccine and preparation method of vaccine
  • Composite water-soluble animal vaccine adjuvant, vaccine and preparation method of vaccine
  • Composite water-soluble animal vaccine adjuvant, vaccine and preparation method of vaccine

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Embodiment Construction

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] The inventive idea of ​​the present invention is as follows:

[0026] Through research, it is found that the dendritic cell targeting molecule DCpep is one of the dendritic cell targeting molecules, which consists of 12 amino acids (FYPSYHSTPQRP), plays an important role in inducing humoral immunity and cellular immunity, and can specifically bind DC and promote presentation.

[0027] Further studies have found that a vaccine formulated with Neisseria ...

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Abstract

The invention discloses a composite water-soluble animal vaccine adjuvant, a vaccine and a preparation method of the vaccine, and relates to the technical field of vaccine adjuvants. The composite water-soluble animal vaccine adjuvant is prepared from a lactic acid-glycolic acid copolymer (PLGA), a dendritic cell targeted induction peptide DCpep, platycodin D, a B cell antigen peptide BP-8 of neisseria meningitidis PorB protein and a T cell antigen peptide TP-7 of neisseria meningitidis PorB protein. Compared with the conventional oil adjuvant, the oil adjuvant disclosed by the invention not only can stimulate the generation of humoral immune response such as neutralizing antibody, but also can promote T cell proliferation, improve the level of cytokines (IFN-gamma and IL-6) and stimulate the cellular immune response. Meanwhile, adverse reactions such as granuloma at an injection site caused by an oil adjuvant vaccine are avoided, and the immune effect of animal vaccines is effectively improved.

Description

technical field [0001] The invention relates to the technical field of vaccine adjuvants, in particular to the technical field of a composite water-soluble animal vaccine adjuvant, a vaccine and a preparation method of the vaccine. Background technique [0002] Vaccine adjuvant refers to a substance that can non-specifically enhance the body's specific immune response to the vaccine antigen, enhance the immunogenicity of the antigen or change the type of immune response before or at the same time as the vaccine antigen, but has no antigenicity itself. Plays an important role in the development and production of For a variety of animal infectious diseases, the lack of suitable vaccine adjuvants has affected the development of bacterin vaccines, virus vaccines, recombinant proteins, polypeptides and DNA vaccines. Therefore, in addition to the development of efficient and safe vaccines for the prevention and control of animal infectious diseases, the development of adjuvants a...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/12A61P31/20
CPCA61K39/39A61K39/12A61P31/20A61K2039/552A61K2039/55511A61K2039/55516A61K2039/55577A61K2039/575C12N2750/10034Y02A50/30
Inventor 张洪亮单虎宋晓明温永俊刁志凯黄娟秦志华蔡秀磊
Owner QINGDAO AGRI UNIV
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