10results about How to "Avoid adverse reactions" patented technology

The invention discloses an efficient anti-wear and anti-friction additive and a preparation method thereof, and relates to the technical field of lubricating materials. The additive comprises at least one metal composite compound, and metal elements in the metal composite compound comprise one or a combination of at least two of Ni, Cu, Zn, Ti or Ce; by controlling the mass ratio of each element, the synergistic interaction is realized; the preparation method comprises the following steps: mixing a metal composite compound, then carrying out ball milling treatment, and then carrying out calcination and surface modification to prepare the additive, the additive provided by the invention can form a high-strength protective film on a friction interface through the synergistic effect of a specific metal composite compound, so that the anti-wear and anti-friction performance and high-temperature stability of the lubricating oil are remarkably improved.

The application provides an AI treatment decision system for liver cirrhosis acute variceal hemorrhage, relates to the technical field of treatment decision, extracts a transient characteristic indicator of blood flow pressure from a pressure fluctuation signal, predicts a transient pressure peak of the portal vein blood flow during acute variceal hemorrhage through the transient characteristic indicator and a blood flow dynamic model, predicts a quasi-steady pressure field of the portal vein blood flow during acute variceal hemorrhage according to the gradient distribution of the portal vein blood flow pressure and an initial treatment strategy of acute variceal hemorrhage, performs multi-scale coupling on the transient pressure peak and the quasi-steady pressure field to obtain a coupling characteristic of the portal vein blood flow, and then uses the coupling characteristic of the blood flow pressure to perform hierarchical coupling adjustment on the treatment strategy of liver cirrhosis acute variceal hemorrhage. Based on the above scheme, hierarchical coupling of the treatment strategy of liver cirrhosis acute variceal hemorrhage can be realized, so that the prediction accuracy of the portal vein blood flow pressure during acute variceal hemorrhage can be improved.

The embodiment of the present application relates to the technical field of heavy-duty coating, and discloses a marine facility corrosion protection layer regulation and control method suitable for strong salt spray environment, which comprises preparing a self-activated intermediate paint and applying it between a primer and a topcoat to form a composite protective layer; the core is that a double-triggered mineralization precursor is contained in the main agent of the self-activated intermediate paint, the precursor is composed of BF4 ‑ loaded hydrophobic modified zeolite and zinc phosphate coated water glass microparticles; when the coating is damaged, the corrosion microenvironment of the damaged area can synergistically trigger the zeolite to release BF4 ‑ to buffer the pH, at the same time trigger the dissolution of the coated water glass microparticles and release silicate ions; the released silicate ions react in situ with cations in the environment to generate mineralization products, plugging the damaged area. The present application can actively inhibit corrosion propagation and cathodic delamination after coating damage, significantly improving the long-term reliability and service life of the protective layer.

The invention discloses enhanced sodium-calcium-silicon medicinal glass with a magnesium-aluminum-silicon composite structure and a preparation method of the enhanced sodium-calcium-silicon medicinal glass. The glass comprises the following components in percentage by mole: 60.0%-67.0% of Si < 4 + >; 1.0%-2.0% of Al < 3 + >; the content of the [Mg (AlO4) 4] cluster is 1.0%-2.0%; the content of the [Mg (SiO4) 4] cluster is 0.5%-1.0%; the content of the [Mg (AlO6) 6] cluster is 0.6%-1.5%; the content of Na < + > is 14.5%-19.5%; 7.0%-9.0% of Ca < 2 + >; 2.0%-4.0% of Mg < 2 + >; and anions comprise the following components in percentage by mole: 65%-75% of bridge oxygen and 25%-35% of non-bridge oxygen. The coating is prepared by adopting a high-temperature melting-annealing process, and has relatively high water resistance and chemical stability. The invention develops a magnesium-aluminum-silicon composite structure reinforced sodium-calcium-silicon medicinal glass with good water resistance.

The invention belongs to the technical field of medical instruments, and relates to a thrombus blockage prevention infusion pump which comprises a pump body, an infusion pipeline and a main control assembly, the pump body is provided with a pipeline clamping groove, an operation panel and an installation cavity, the infusion pipeline is installed in the pipeline clamping groove in a matched mode, and the main control assembly is fixed in the installation cavity. The operation panel is electrically connected to the main control assembly, and the main control assembly is used for basic infusion control and simple signal feedback; the anti-thrombus infusion pump further comprises a mechanical anti-thrombus mechanism, a pipeline sealing and fixing assembly and an auxiliary supporting assembly, and the mechanical anti-thrombus mechanism and the pipeline sealing and fixing assembly are both installed on the pump body and matched with the infusion pipeline. Wherein the mechanical anti-thrombus mechanism comprises a pulse type mechanical liquid pushing piece and a pipeline micro-vibrator mechanism, and the pipeline micro-vibrator mechanism is integrated on the inner wall of a pipeline clamping groove; the system has the effects of precise thrombus monitoring, active intervention, intelligent adjustment and blockage reduction.

The invention relates to the technical field of metal fluoride lithium ion batteries, in particular to a preparation method and application of a high-surface-capacity ferrous fluoride positive electrode. The method mainly comprises the following steps: (1) reacting reduced iron powder with a fluosilicic acid solution to obtain a precursor solution; (2) adding deionized water into the precursor solution for dilution, then adding conductive carbon nanotubes to obtain a mixed solution, and drying to obtain solid powder; and (3) calcining the solid powder at 250 DEG C in a protective atmosphere to obtain the nanoscale spherical ferrous fluoride. (4) mixing ferrous fluoride with polyvinylidene fluoride, anhydrous dextrose, polyacrylonitrile, conductive carbon and carbon nanotubes according to a certain proportion to obtain slurry; and (5) coating: the thickness of a metal scraper is 750 microns, and drying is performed in a vacuum drying oven at 60 DEG C to obtain the high-surface-capacity ferrous fluoride pole piece. The preparation method of the high-surface-capacity ferrous fluoride positive electrode is simple in process, mild in condition and low in cost, cracking of a pole piece under the load of a high-activity substance is avoided, a ferrous fluoride positive electrode material and loss thereof are effectively protected, and adverse reaction between the ferrous fluoride positive electrode material and electrolyte is prevented, so that the cycling stability of a liquid lithium ion battery is better improved, and the service life of the liquid lithium ion battery is prolonged. The battery life is prolonged.

The application provides a synergistic hair growth microneedle based on active oxygen scavenging and nitric oxide delivery and a preparation method thereof. The hair growth microneedle comprises a substrate layer and a plurality of microneedles arranged on the substrate layer, and at least comprises: an active oxygen scavenging component arranged on a needle root part of the microneedle, which is used for scavenging excessive active oxygen under a pathological oxidative environment around a hair follicle; a nitric oxide delivery component arranged on a needle tip part of the microneedle, which is used for continuously releasing nitric oxide after the microneedle is inserted into the skin; a mass ratio of the active oxygen scavenging component to the nitric oxide delivery component is (0.01-10):1; and the active oxygen scavenging component and the nitric oxide delivery component in the microneedle have a synergistic effect.

This invention provides a biomarker for neovascularization, miR-1910-5p, and its application in the diagnosis and treatment of neovascularization. Detecting miR-1910-5p expression levels helps in the early prediction of neovascularization, greatly improving the timeliness of diagnosis and treatment. Detecting its expression level provides a reference for the diagnosis and prognosis of neovascularization. This invention also provides a drug for treating neovascularization, a miR-1910-5p antagonist, and its application. This miR-1910-5p antagonist reduces the silencing effect on genes related to angiogenesis inhibition by inhibiting miR-1910-5p expression, thereby slowing the occurrence and development of early angiogenesis and achieving the goal of inhibiting the development of neovascularization. Compared with other drugs, it avoids the adverse reactions of other drugs and can effectively and safely inhibit the occurrence and development of pathological angiogenesis.

This invention relates to the field of phototherapy technology, and more particularly to a method and system for intelligent adjustment and monitoring of phototherapy dose. An initial dose plan is generated based on the initial physiological state information of the skin area to be treated. The area is divided into multiple spatial sub-regions, and baseline tolerance thresholds and conduction coefficients are recorded. The response intensity of each sub-region is monitored in parallel. The cross-influence between adjacent sub-regions is calculated using a diffusion-response coupling equation. A cumulative matrix of cross-influence is constructed and superimposed on the baseline tolerance threshold to obtain the predicted tolerance threshold and remaining tolerance margin. While maintaining a constant overall cumulative energy density, the differentiated light intensity adjustment amount is calculated based on the remaining tolerance margin and then executed. This achieves intelligent and personalized phototherapy dose adjustment, improving treatment safety and effectiveness.

This invention provides a wearable postoperative pain assessment and analgesia pump linkage system, belonging to the field of medical rehabilitation equipment technology. The system includes a perception layer, an edge computing layer, a collaborative decision engine, and an execution feedback layer. The perception layer synchronously collects multimodal signals of patient movement, local wound mechanics, and pain physiological responses through a wearable motion sensing unit, wound biomechanical sensing patch, and physiological signal acquisition module. The edge computing layer completes spatiotemporal alignment of multimodal data, action recognition based on temporal convolutional networks, and quantitative calculation of wound stress risk index and action-pain response index. The collaborative decision engine incorporates a four-level risk assessment model to classify the risk of postoperative activities and performs dual-modal quantitative verification of occult wound risks using drug-masked and sleep-masked methods, outputting differentiated intervention decisions. The execution feedback layer achieves graded drug administration through an intelligent analgesia pump and pushes real-time physical intervention guidance via patient-side interactive devices.