50results about How to "Avoid adverse reactions" patented technology

The invention provides a preparation method and application of a high-efficiency encapsulated pH-responsive drug-loaded liposome. According to the method, two-phase fluid of a medicine aqueous solution and a lipid component organic solution in a micro-channel is accurately controlled, and the efficiently encapsulated liposome is prepared from bottom to top by utilizing a micro-mixing technology. Compared with a conventional passive drug loading method which is relatively low in encapsulation efficiency in preparation of hydrophilic drug nano-liposomes, the method provided by the invention can improve the encapsulation efficiency to be close to 95% under optimized prescription and process conditions. According to the invention, by adjusting the proportion of each component in the prescription and the preparation process, the release behavior of liposome drugs such as adriamycin and the like can be adjusted, and the drug release shows pH responsiveness. Through efficient encapsulation of adriamycin and the like and pH-responsive release of the liposome dosage form, the effects of efficacy enhancement and toxicity reduction are achieved in the anti-tumor treatment aspect.

The invention relates to an injectable skin filler. The injectable skin filler comprises hydrophilic modified adhesive polyester microspheres, a suspending agent and a synergist, the mass ratio of the hydrophilic modified adhesive polyester microspheres to the suspending agent to the synergist is (1-5): 1: (0.1-2); the hydrophilic modified adhesive polyester microsphere is an amphiphilic polymer composite polyester microsphere, and the amphiphilic polymer is a catechol-terminated amphiphilic polymer. The invention further provides a preparation method of the injectable skin filling agent. Polyester microspheres are modified through the amphiphilic polymer terminated by catechol. The device can be widely applied to medical cosmetology.

The invention relates to application of mouse combined lactobacillus. According to the application disclosed by the invention, the lactobacillus murins DSM 28683 can be applied to the preparation of a product for treating type 2 diabetes mellitus or a product for reducing body fat. A T2D mouse is subjected to intragastric administration by using the Ligilbacillus murins DSM 28683, and it is found that the Ligilbacillus murins DSM 28683 can significantly improve metabolism of the T2D mouse, effectively improve insulin sensitivity of the T2D mouse, reduce body weight and improve fatty liver, and has a good application prospect in treatment of type 2 diabetes mellitus.

The invention relates to the field of preparation of animal husbandry vaccines, in particular to a porcine circovirus, mycoplasma hyopneumoniae and haemophilus parasuis triple vaccine which comprises 30-50 parts of first bacterial liquid containing inactivated haemophilus parasuis; an adjuvant; 40 to 60 parts of a culture solution of a mycoplasma hyopneumoniae culture; 30-40 parts of a second bacterial liquid containing inactivated porcine circovirus; 1 to 10 parts of tween-80; 2-6 parts of aluminum stearate; 1 to 3 parts of interleukin; and 2-4 parts of squalane. The vaccine is mainly applied to prevention of porcine circovirus, mycoplasma hyopneumoniae and haemophilus parasuis for boars and piglets in a pig farm, reduces the multi-system failure syndrome, mycoplasma hyopneumoniae, polyserositis, arthritis and meningitis of weaned piglets in the pig farm and the morbidity of multi-infection-source successive infection, and improves the survival efficiency of the piglets.

The invention discloses an oxcarbazepine quantitative pharmacological model based on genetic polymorphism and a construction method thereof, and belongs to the field of pharmacokinetics. The model construction method comprises the following steps: collecting steady-state blood drug valley concentration data and clinical data of an epileptic child patient, establishing a population pharmacokinetic model of oxcarbazepine active metabolites by adopting a nonlinear mixed effect model method, and quantitatively investigating the influence of physiological factors, combined medication and genetic factors on pharmacokinetic characteristic parameters of drugs; and finally, performing internal verification and evaluation on the model by using a goodness-of-fit diagram, a bootstrap method and visual prediction inspection. The quantitative pharmacological model constructed by the method has stable and accurate prediction performance; according to the present invention, the weight and the gene polymorphism ABCC2rs2273697 are determined as the effective covariants affecting MHD CL / F, and the oxcarbazepine dosage optimization scheme is established based on the weight and the genotype of the patient so as to improve the treatment effect and avoid the adverse reaction;

The invention discloses a novel hydrogen sulfide donor, a preparation method and application of the novel hydrogen sulfide donor in preparation of drugs for treating inflammatory diseases, and belongs to the technical field of biological medicines. The hydrogen sulfide donor comprises hydrogen sulfide synthetase, a drug carrier loaded with the hydrogen sulfide synthetase, and a functional coating coated outside the drug carrier. The drug carrier is a metal organic framework material, a polymer nano material, a liposome material, an exosome material or a hydrogel material, and can provide protection, slow release, enrichment and other functions for biological enzyme according to the characteristics of different inflammatory diseases. The functional coating is a surfactant, a polymer, an edge active agent, a biological membrane or a lipid double layer, and is used for improving the physicochemical properties of the drug carrier, so that the drug carrier is further endowed with special properties such as in-vivo targeting, long circulation, transdermal drug delivery and the like. According to the invention, an accurate, safe and lasting hydrogen sulfide supply means is realized, and the method has a wide application prospect. And a new treatment thought and strategy are expected to be provided for treatment of inflammatory diseases.

The invention provides a developable hydrogel. The developable hydrogel comprises a first component and a second component, the first component is maleimide group end capped multi-arm polyethylene glycol; and the second component is a sulfydryl modified iodine-containing contrast agent. The components of the hydrogel can be prepared into a neutral solution, the reaction is mild in a physiological environment, the safety is high, and the formed hydrogel is good in biocompatibility. The hydrogel disclosed by the invention does not cause a hypertonic phenomenon in vivo, and the degraded hydrophilic iodine molecule unit is easy to metabolize and exclude from the body. The use concentration of the two components of the hydrogel is low, the raw material concentration is greatly reduced, the use amount is reduced, the cost can be reduced, and the hydrogel is more friendly to a human body and has better clinical safety. The hydrogel provided by the invention can realize accurate adjustment of a wide gelation time window of 2-120s, the development value can be quantitatively regulated and controlled within 80-400Hu, the hydrogel is adaptive to application requirements of different tissues, and the degradation period of the hydrogel in vivo can be adjusted within 1-24 weeks.

The invention discloses a pH-sensitive coaxial nanofiber membrane loaded with enoxacin as well as a preparation method and application of the pH-sensitive coaxial nanofiber membrane. The electrostatic spinning nanofiber membrane is composed of a shell layer and a core layer, the shell layer comprises ethyl cellulose and Eudragit L100, the core layer comprises ethyl cellulose and enoxacin, and the electrostatic spinning nanofiber membrane is prepared through the electrostatic spinning technology. Results show that the coaxial nanofiber has a good core-shell structure, is good in water absorption, can keep a wound surface wet, has certain tensile strength, is obvious in in-vitro bacteriostasis, and can effectively promote healing of the wound surface and revascularization. The research hot spot in the field of materials is creatively applied to a pharmaceutical preparation delivery system, the prepared pH-sensitive electrostatic spinning nanofiber membrane is used for tissue regeneration and repair, and a good effect is achieved in animal experiments. The defect that an existing wound field depends on a traditional treatment means is overcome, and a basis is provided for existing industrial production.

The present invention discloses a reinforced polyethylene oxide solid electrolyte and a preparation method thereof. Part of the thiol groups in the thiol polyethylene glycol thiol group reacts with the propenyl group in the three-dimensional framework LLZAO containing a propenyl group, and the remaining part of the thiol groups in the thiol polyethylene glycol thiol group reacts with the propenyl group in cerium acrylate to play a cross-linking role. The multi-level solid electrolyte structure design effectively isolates the direct contact between succinonitrile and the lithium anode, prevents adverse reactions at the interface, and thus prolongs the service life and stability of the battery. The solid electrolyte prevents the growth of lithium dendrites through its physical barrier effect, because its higher modulus can effectively inhibit the irregular diffusion of lithium in the electrolyte and improve the safety of the battery.

The invention discloses an efficient anti-wear and anti-friction additive and a preparation method thereof, and relates to the technical field of lubricating materials. The additive comprises at least one metal composite compound, and metal elements in the metal composite compound comprise one or a combination of at least two of Ni, Cu, Zn, Ti or Ce; by controlling the mass ratio of each element, the synergistic interaction is realized; the preparation method comprises the following steps: mixing a metal composite compound, then carrying out ball milling treatment, and then carrying out calcination and surface modification to prepare the additive, the additive provided by the invention can form a high-strength protective film on a friction interface through the synergistic effect of a specific metal composite compound, so that the anti-wear and anti-friction performance and high-temperature stability of the lubricating oil are remarkably improved.

A PK catalyst production system comprises a palladium acetate feeding tank, a ligand feeding tank, an organic acid feeding tank and a catalyst reaction kettle, and the palladium acetate feeding tank, the ligand feeding tank, the organic acid feeding tank and the catalyst reaction kettle are each provided with a heat exchange interlayer and a stirring device. A feeding hole of the palladium acetate feeding tank is connected with a palladium acetate source and an N-methyl pyrrolidone source, a feeding hole of the ligand feeding tank is connected with a 4, 6-dihydroxy-2-methylpyrimidine source and an N-methyl pyrrolidone source, a feeding hole of the organic acid feeding tank is connected with a maleic acid source and an N-methyl pyrrolidone source, and a feeding hole of the organic acid feeding tank is connected with a reaction kettle. The palladium acetate feeding tank, the ligand feeding tank and the organic acid feeding tank are respectively used for feeding materials to the catalyst reaction kettle. The device is simple in structure and low in maintenance cost, and can be used for efficiently synthesizing the PK catalyst.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical preparation for treating hyperplasia of mammary glands and a preparation method thereof, and the pharmaceutical preparation for treating hyperplasia of mammary glands comprises a drug-loaded microneedle layer, a backing layer connected with the drug-loaded microneedle layer and a medical blank adhesive plaster adhered to the backing layer. The prepared medicine preparation is a traditional Chinese medicine compound microneedle patch, the designed traditional Chinese medicine compound has the effects of soothing liver-qi stagnation, promoting blood circulation to remove blood stasis, reducing swelling and removing stasis and the like, a micro-emulsion system formed through the synergistic effect of the traditional Chinese medicine compound and a soluble microneedle matrix has the effects of moisturizing, diminishing inflammation, resisting bacteria and resisting oxidation, the skin permeability of the medicine is improved, and meanwhile, the effect of improving the skin quality is achieved. The drug sustained release and skin protection effects are realized, the effective concentration of the drug at the hyperplasia part of mammary glands can be maintained, and the treatment effect is enhanced.

An "I"-shaped frame, comprising a base, a connecting beam and a contact surface, wherein the connecting beam is curved and elastic; the base and the contact surface are connected by the connecting beam; the base is provided with an adhesive layer for adhering to the eyeglass lens and / or a through hole for installation. The "I"-shaped frame is different from the position and shape of all eyeglass brackets currently on the market. Since the frame can ensure that the support position is on both sides of the root of the nose, it is ensured that the glasses using the frame can effectively meet the needs of all people wearing glasses.

The invention discloses an accompanying interactive intelligent health care system which comprises a multifunctional intelligent medicine chest, an accompanying interactive intelligent robot and an intelligent display processing terminal. Wherein the multifunctional intelligent medicine chest is used for displaying medicine names and medicine quantity information, prompting medicine grids corresponding to medicines and recording medicine use information; the accompanying interaction intelligent robot integrates voice, expressions and actions and is used for reminding the old to take medicine on time according to the dosage through various sensory interactions, providing emotional accompanying and remotely communicating with family members. And the intelligent display processing terminal is used for operating system software, acquiring and / or storing and / or analyzing data, and remotely checking and / or monitoring medication records of old people. The invention further discloses an intelligent medication management method based on the accompanying interactive intelligent health care system, and the method has a wide application scene.

The utility model is applicable to the technical field of breathing masks, and provides an oxygen supply mask for a plateau working environment, which comprises a mask body with a multi-layer structure and a telescopic bandage, and the two ends of the telescopic bandage are respectively and fixedly connected to the two ends of the mask body. According to the oxygen supply mask for the plateau working environment, the mask body and the device box are arranged, when the oxygen supply mask is used, due to the fact that a main body of the oxygen supply mask is the mask body, the oxygen supply mask is convenient to wear, and when the oxygen supply mask is used, the device box is connected with an oxygen bottle or an oxygen vest, and oxygen enters the oxygen bottle; then oxygen is fed into an air inlet frame at the front end of the mask body of the device through an air feeding pipe communicated with the air bottle, the air inlet frame is located at the nose part of the face, and the oxygen entering the air inlet frame can be directly inhaled by a wearer, so that smooth conveying of the oxygen is guaranteed; oxygen can be humidified, and adverse reactions caused by the fact that a wearer inhales dry oxygen are prevented.

The invention relates to the field of medical instruments, in particular to a closing system with a split type supporting structure, which comprises a supporting recovery system, a first conveying system and a second conveying system, the supporting recovery system comprises the split type supporting structure and a traction assembly, the split type supporting structure comprises a supporting structure and a capturing part, and the supporting structure and the capturing part are detachably connected; the first conveying system and the second conveying system are configured to convey the first connecting piece and the second connecting piece to penetrate through the two pieces of tissue to be closed respectively, and the far end of the first connecting piece and / or the far end of the second connecting piece are / is connected with the capturing piece.

The application provides an AI treatment decision system for liver cirrhosis acute variceal hemorrhage, relates to the technical field of treatment decision, extracts a transient characteristic indicator of blood flow pressure from a pressure fluctuation signal, predicts a transient pressure peak of the portal vein blood flow during acute variceal hemorrhage through the transient characteristic indicator and a blood flow dynamic model, predicts a quasi-steady pressure field of the portal vein blood flow during acute variceal hemorrhage according to the gradient distribution of the portal vein blood flow pressure and an initial treatment strategy of acute variceal hemorrhage, performs multi-scale coupling on the transient pressure peak and the quasi-steady pressure field to obtain a coupling characteristic of the portal vein blood flow, and then uses the coupling characteristic of the blood flow pressure to perform hierarchical coupling adjustment on the treatment strategy of liver cirrhosis acute variceal hemorrhage. Based on the above scheme, hierarchical coupling of the treatment strategy of liver cirrhosis acute variceal hemorrhage can be realized, so that the prediction accuracy of the portal vein blood flow pressure during acute variceal hemorrhage can be improved.

The utility model provides an infusion heating assembly which comprises a heating shell, an infusion tube is arranged in a cavity of the heating shell, the infusion tube is of a U-shaped tube structure which is arranged in a multi-time roundabout mode, and a liquid inlet and a liquid outlet of the infusion tube both penetrate through the side walls of the corresponding positions of the heating shell. The tube wall of the infusion tube is covered with a heating film, and a heating wire is arranged on the heating film; a plug is arranged on one side of the heating shell, one end of the plug can be connected with a power line, the other end of the plug is connected with a heating wire through a control device, the heating wire is heated in an electric heating mode, then liquid in an infusion tube is heated, the mode is even and continuous in heating, and meanwhile a plurality of temperature sensors and temperature control switches are additionally arranged, so that the heating effect is good. The temperature of each area of the infusion tube is monitored and controlled in real time, automatic control is achieved, labor cost is saved, and the device is suitable for large-scale industrial use and popularization.

The embodiment of the present application relates to the technical field of heavy-duty coating, and discloses a marine facility corrosion protection layer regulation and control method suitable for strong salt spray environment, which comprises preparing a self-activated intermediate paint and applying it between a primer and a topcoat to form a composite protective layer; the core is that a double-triggered mineralization precursor is contained in the main agent of the self-activated intermediate paint, the precursor is composed of BF4 ‑ loaded hydrophobic modified zeolite and zinc phosphate coated water glass microparticles; when the coating is damaged, the corrosion microenvironment of the damaged area can synergistically trigger the zeolite to release BF4 ‑ to buffer the pH, at the same time trigger the dissolution of the coated water glass microparticles and release silicate ions; the released silicate ions react in situ with cations in the environment to generate mineralization products, plugging the damaged area. The present application can actively inhibit corrosion propagation and cathodic delamination after coating damage, significantly improving the long-term reliability and service life of the protective layer.

The invention discloses enhanced sodium-calcium-silicon medicinal glass with a magnesium-aluminum-silicon composite structure and a preparation method of the enhanced sodium-calcium-silicon medicinal glass. The glass comprises the following components in percentage by mole: 60.0%-67.0% of Si < 4 + >; 1.0%-2.0% of Al < 3 + >; the content of the [Mg (AlO4) 4] cluster is 1.0%-2.0%; the content of the [Mg (SiO4) 4] cluster is 0.5%-1.0%; the content of the [Mg (AlO6) 6] cluster is 0.6%-1.5%; the content of Na < + > is 14.5%-19.5%; 7.0%-9.0% of Ca < 2 + >; 2.0%-4.0% of Mg < 2 + >; and anions comprise the following components in percentage by mole: 65%-75% of bridge oxygen and 25%-35% of non-bridge oxygen. The coating is prepared by adopting a high-temperature melting-annealing process, and has relatively high water resistance and chemical stability. The invention develops a magnesium-aluminum-silicon composite structure reinforced sodium-calcium-silicon medicinal glass with good water resistance.

The medicine feeding device comprises an outer shell, a first medicine feeding mechanism, a second medicine feeding mechanism and a mixing mechanism, firstly, medicine is added into two mixing boxes through a material conveying opening, then a micro motor is started, the micro motor drives a rotating rod to rotate, and then the medicine is fed into the mixing boxes; then, a first pump body and a second pump body are started, and the first pump body and the second pump body convey liquid medicine in the mixing box into a cavity chamber and a first medicine storage cavity through a first output pipe and a second output pipe which are arranged at the upper ends of the first pump body and the second pump body correspondingly; the utility model relates to a gynecological medicine feeding device which is simple and reasonable in structural design and convenient and fast to use and operate.

The invention relates to the field of preparation of poultry vaccines, in particular to a triple vaccine for avian yellow glands and a preparation method thereof, and the triple vaccine for avian yellow glands comprises 90-95 parts of mineral oil; 5 to 20 parts of a surfactant; 2-8 parts of a complexing agent; 1-10 parts of a divalent inorganic salt; 30-50 parts of a first virus liquid containing inactivated avian influenza virus; 30-40 parts of a second virus liquid containing inactivated fowl adenovirus; 40-60 parts of a third virus liquid containing inactivated chicken flavivirus; 5 to 10 parts of span-80; 5 to 10 parts of tween-80; and 1-3 parts of aluminum stearate. The vaccine prepared by the invention does not generate any adverse reaction on chickens, is high in experimental safety, and can induce high-level neutralizing antibodies in immunized chickens, which indicates that the immunized chickens can effectively resist virus attacks of chicken flavivirus, avian influenza and fowl adenovirus.

The invention discloses a method for preparing a biological fertilizer by using a high-purity threonine preparation process, and relates to the technical field of biological fertilizer preparation, and the method has the advantages that a specific adsorption slow-release agent is prepared, the specific adsorption slow-release agent is prepared from nano-scale hydroxyapatite and polyglutamic acid, and the specific adsorption slow-release agent is prepared from the nano-scale hydroxyapatite and the polyglutamic acid; the nano-scale hydroxyapatite strongly adsorbs threonine, nutrient components such as nitrogen, phosphorus and potassium and trace elements such as iron, zinc and copper in the fermentation waste liquid by virtue of high specific surface area and good adsorption performance, and is gradually degraded along with the action of microorganisms in soil and the change of the surrounding environment of a plant root system in the use process of the biological fertilizer; nutrients are continuously provided for different growth stages of plants, so that resource waste is effectively reduced, long-acting and stable supply of nutritional ingredients is realized, and rapid loss of the nutrients is avoided, so that the utilization rate of the fertilizer is remarkably improved, fermentation waste liquid which is possibly abandoned originally is successfully converted into valuable biological fertilizer resources, and environmental pollution is reduced. And continuous power and solid guarantee are provided for healthy growth of plants.

The invention belongs to the technical field of biological medicines, and particularly relates to a process applied to preparation of isiomerazole and used for inhibiting drug insoluble particles. In the production process, a metal ion complexing agent edetate disodium is added, insoluble particles of the medicine are inhibited, and adverse reactions are effectively avoided. According to the present invention, the edetate disodium can effectively enhance the stability of the drug, and the principle is that the edetate disodium can form the stable water-soluble chelate with the metal ions so as to prevent the oxidation of the edetate disodium, such that the stability of the drug during the preparation, storage and clinical preparation process can be easily improved;

The invention discloses a high-low voltage switch cabinet with an automatic monitoring function, and relates to the technical field of switch cabinets. The device comprises a device body, an information module is arranged in the device body and communicates with an intelligent APP, multifunctional monitoring assemblies are arranged on the left side and the right side of the information module, a breathable plate is fixedly installed in the device body, an electric telescopic column is fixedly installed at the top of the breathable plate, and the telescopic end of the electric telescopic column penetrates through the top of the device body. Symmetrical plates are fixedly installed at the tops of the telescopic ends of the electric telescopic columns, the bottoms of the left and right sides of the symmetrical plates are hinged to the edge of the top of the device body, and short-circuit prevention devices used for preventing water vapor from being difficult to discharge and affecting a power transmission line are arranged on the outer sides of the electric telescopic columns. The inclined angles of the inclined planes of the symmetrical plates are enlarged, the downstream speed of acid rain is accelerated, discharge of the acid rain is further accelerated through the water guide grooves, and the phenomenon that the outer wall of the device body is eroded by the acid rain and damaged is avoided.

The present invention discloses a drug delivery device in a human cavity, which comprises: an inflatable balloon, at least a portion of the outer wall of the balloon is provided with a protective shell, the balloon has an inner cavity, and the protective shell can be dissolved by a specific body fluid in the human cavity; a triggering part arranged in the inner cavity of the balloon, the triggering part can react with the body fluid to generate a fluid to inflate the balloon when in contact with the body fluid, so that the inflated balloon is close to the body cavity wall; a propulsion part in the inner cavity of the balloon, the propulsion part includes a tissue penetrating member, the triggering part can generate power to propel the tissue penetrating member; and a containing part for containing a drug preparation, wherein the triggering part can push the liquid drug preparation contained in the containing part into the propulsion part after the balloon is inflated, and inject the liquid drug preparation into the inner wall tissue of the human cavity through the tissue penetrating member. The device of the present invention can be used to inject macromolecular drugs or preparations into the inner wall of the human cavity, such as the tissue of the intestinal wall.

The invention belongs to the technical field of medical instruments, and relates to a thrombus blockage prevention infusion pump which comprises a pump body, an infusion pipeline and a main control assembly, the pump body is provided with a pipeline clamping groove, an operation panel and an installation cavity, the infusion pipeline is installed in the pipeline clamping groove in a matched mode, and the main control assembly is fixed in the installation cavity. The operation panel is electrically connected to the main control assembly, and the main control assembly is used for basic infusion control and simple signal feedback; the anti-thrombus infusion pump further comprises a mechanical anti-thrombus mechanism, a pipeline sealing and fixing assembly and an auxiliary supporting assembly, and the mechanical anti-thrombus mechanism and the pipeline sealing and fixing assembly are both installed on the pump body and matched with the infusion pipeline. Wherein the mechanical anti-thrombus mechanism comprises a pulse type mechanical liquid pushing piece and a pipeline micro-vibrator mechanism, and the pipeline micro-vibrator mechanism is integrated on the inner wall of a pipeline clamping groove; the system has the effects of precise thrombus monitoring, active intervention, intelligent adjustment and blockage reduction.

The invention discloses a reagent for detecting HLA alleles and application thereof, and belongs to the technical field of gene detection. The reagent can be used for independently detecting the HLA-B * 15: 02, the HLA-A * 31: 01, the HLA-B * 58: 01 and the HLA-B * 57: 01, or the HLA-B * 31: 01, the HLA-B * 58: 01 and the HLA-B * 57: 01 and the HLA-B * 51: 01 and the HLA-B * 51: 01 and the HLA-B * 51: 01 and the HLA-B * 51: 01 and the HLA-A * 31: 01 and the HLA In addition, when the reagent is used for simultaneously detecting HLA-B * 15: 02, HLA-A * 31: 01, HLA-B * 58: 01 and HLA-B * 57: 01, a detection scheme that one color corresponds to multiple targets is implemented by utilizing a two-dimensional PCR (Polymerase Chain Reaction) technology. According to the scheme, in a single closed reaction tube, four HLA alleles, namely HLA-B * 15: 02, HLA-A * 31: 01, HLA-B * 58: 01 and HLA-B * 57: 01, can be rapidly, accurately and efficiently identified at the same time, so that the urgent requirements of a high-throughput gene detection technology on the aspects of simplicity and convenience in operation and low cost at present are met, and adverse reactions caused by clinical drugs can be effectively avoided, thereby guiding clinical safe medication.

The invention relates to the technical field of metal fluoride lithium ion batteries, in particular to a preparation method and application of a high-surface-capacity ferrous fluoride positive electrode. The method mainly comprises the following steps: (1) reacting reduced iron powder with a fluosilicic acid solution to obtain a precursor solution; (2) adding deionized water into the precursor solution for dilution, then adding conductive carbon nanotubes to obtain a mixed solution, and drying to obtain solid powder; and (3) calcining the solid powder at 250 DEG C in a protective atmosphere to obtain the nanoscale spherical ferrous fluoride. (4) mixing ferrous fluoride with polyvinylidene fluoride, anhydrous dextrose, polyacrylonitrile, conductive carbon and carbon nanotubes according to a certain proportion to obtain slurry; and (5) coating: the thickness of a metal scraper is 750 microns, and drying is performed in a vacuum drying oven at 60 DEG C to obtain the high-surface-capacity ferrous fluoride pole piece. The preparation method of the high-surface-capacity ferrous fluoride positive electrode is simple in process, mild in condition and low in cost, cracking of a pole piece under the load of a high-activity substance is avoided, a ferrous fluoride positive electrode material and loss thereof are effectively protected, and adverse reaction between the ferrous fluoride positive electrode material and electrolyte is prevented, so that the cycling stability of a liquid lithium ion battery is better improved, and the service life of the liquid lithium ion battery is prolonged. The battery life is prolonged.

The invention relates to the technical field of medical interventional therapy materials, and particularly discloses cross-linked sodium hyaluronate microspheres, non-cross-linked sodium hyaluronate composite gel and a preparation method of the cross-linked sodium hyaluronate microspheres and the non-cross-linked sodium hyaluronate composite gel. The cross-linked sodium hyaluronate microsphere and non-cross-linked sodium hyaluronate composite gel consists of the following components in percentage by weight: 10-50% of cross-linked sodium hyaluronate microspheres, 10-50% of non-cross-linked sodium hyaluronate microspheres and the balance of water. 2 to 10% of non-crosslinked sodium hyaluronate; 2 to 10% of recombinant III type collagen; the licadoine accounts for 0.05 to 0.2 percent; and the balance of water. The cross-linked sodium hyaluronate microspheres are obtained by taking methylacryloylated sodium hyaluronate as a raw material through polymerization. The cross-linked sodium hyaluronate microspheres and the non-cross-linked sodium hyaluronate composite gel have the advantages that various adverse reactions can be avoided, and long-term effective filling can be realized.