1086results about How to "Avoid adverse reactions" patented technology

The invention relates to sutures and surgical staples useful in anastomoses. Various aspects of the invention include wound closure devices that use amphiphilic copolymer or parylene coatings to control the release rate of an agent, such as a drug or a biological material, polymerizing a solution containing monomers and the agent to form a coating, using multiple cycles of swelling a polymer with a solvent-agent solution to increase loading, microparticles carrying the agent, biodegradable surgical articles with amphiphilic copolymer coatings, and sutures or surgical staples the deliver a drug selected from the group consisting of triazolopyrimidine, paclitaxol, sirolimus, derivatives thereof, and analogs thereof to a wound site.

The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

The invention relates to sutures and surgical staples useful in anastomoses. Various aspects of the invention include wound closure devices that use amphiphilic copolymer or parylene coatings to control the release rate of an agent, such as a drug or a biological material, polymerizing a solution containing monomers and the agent to form a coating, using multiple cycles of swelling a polymer with a solvent-agent solution to increase loading, microparticles carrying the agent, biodegradable surgical articles with amphiphilic copolymer coatings, and sutures or surgical staples the deliver a drug selected from the group consisting of triazolopyrimidine, paclitaxol, sirolimus, derivatives thereof, and analogs thereof to a wound site.

A method and apparatus for treating persons suffering from an eating disorder includes direct or indirect stimulation of selected areas of the brain associated with a symptom of the eating disorder. The stimulation regimen is programmable to enable physician optimization of stimulation signal parameters to ameliorate at least one symptom of bulimia or another eating disorder. Certain embodiments employ deep brain stimulation and / or sensing together with cranial nerve stimulation and / or sensing.

The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

Disclosed is a cross-linked branched poly(alkylenimine) and compositions thereof and nucleotide molecules. Also disclosed are methods for preparing the cross-linked branched poly(alkylenimine).

Oral compositions including an encapsulated active component(s) are provided. The oral compositions include a carrier composition including a first reactive component. The oral compositions also include an active composition. The active composition includes at least one active component encapsulated in a coating. The coating includes a hydrophilic material and at least one second reactive component, wherein an interaction between the first and second reactive components preserves the activity and / or availability of the active.

The invention provides lithium ion battery high-voltage anode material preparation and surface coating method. The method adopts high-voltage anode material spinel-type LiNi0.5Mn1.5O4 prepared by a two-step method and comprises the following steps of: firstly, evenly mixing nickel source and manganese source solutions with a surface active agent solution, then drying and roasting in the air of 350-450 DEG C to obtain a precursor of a nickel and manganese oxide; mixing the precursor with a lithium source through liquid phase ball milling, drying and finally roasting in the air of 400-900 DEG Cto obtain an anode active material; and adding the anode active material to a soluble aluminum solution containing a lithium source, sufficiently and evenly mixing under controlling the lithium source, the soluble aluminum source and the anode active material to be at the proper mol, drying and carrying out high-temperature roasting treatment to obtain a final product which is the lithium ion battery high-voltage anode material which is coated with a layer of lithium-contained transition metal oxide on the surface. The high-voltage anode material prepared by the method has the characteristicsof high initial capacity, good cycle performance and the like.

The invention relates to a micro-ecological regulator, which belongs to the category of micro-ecological preparations. The product contains Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium adolesentis, lactobacillus acidophilus, fructo-oligosaccharides, galacto-oligosaccharides, vitamins and the like. A concrete production process comprises the following steps: 1. bacterial strains are respectively or jointly subjected to liquid deep high-density cultu, so as to obtain fermentation liquid; 2. after the fermentation liquid is centrifuged, bacterial sludge is collected, added to protective agents and made into freeze-dried powder; 3. the freeze-dried powder is added to microcapsule materials and made into microcapsules through air suspension treatment; and 4. the microcapsules are mixed with oligosaccharides, vitamins and the like and then are made into a synbiotics pharmaceutical composition. By directly replenishing human intestines with Bifidobacterium and lactobacillus acidophilus, and by simultaneously providing prebiotics for ensuring that beneficial bacteria after entering intestines can be activated rapidly and proliferate, the product adjusts and improves intestinal micro-ecosystem, so as to achieve the aims of regulating organism immunity, delaying senility, inhibiting tumors, regulating blood lipid and improving intestines and stomach. A preparation method of the product can solve the technical problem that the prior probiotics medicine is difficult to keep the stability of probiotics at normal temperature and unstable under acidic conditions, and provides a pharmaceutical composition which can be stably stored at normal temperature.

A coating for an implant surface comprising one or more nanoparticles of less than or equal to 500 nanometers and an implant surface capable of receiving the nanoparticles, the implant selected from the group consisting of metal, carbon, graphite, polymer, protein, nucleic acid, microorganisms, hydrogel, liquid, porous and polymer blend particles, and combinations thereof. The coating promotes characteristics on the implant surface such as reducing protein unfolding, preventing inflammatory and fibrotic cell accumulation, reducing the number of such cell attachment sites and preventing other adverse biological reactions. The coating may be applied on any material via physical and / or chemical binding. The coating may further comprise a surfactant and may include a tag, adsorbed, absorbed or incorporated onto the nanoparticle. The coating on an implant surface is used for purposes that may be cosmetic, therapeutic, preventative, reconstructive, monitoring and replacement. The coating may also be used for in vitro purposes.

The invention refers to a preparation method of ginseng polysaccharide. The method includes the following step: extract it from the ginseng or the marc of the ginseng decocted, filtrate, concentrate and deposit the extracting solution, get the precipitate after centrifugence and dry it with low temperature to get the crude product of ginseng polysaccharide. We get the polysaccharide product after the ginseng polysaccharide goes through the boiling, depositing, filtration, trash extraction, frost thawing, getting rid of the protein and getting the supernatant and the supernatant passes through the concentration with low pressure and drying with low temperature. We can make it into all kinds of forms of prepared drugs after the ginseng polysaccharide passes through the experiments in pharmaceutics. The invention effectively increases the quality of the ginseng polysaccharide injection, fully exerts the immunoloregulation function of the ginseng polysaccharide, increases the anti tumor effect of chemotherapy medicament and is used to reduce the side effect caused by the knubbly radiotherapy and chemotherapy as well as adjuvant for curing the tumor.

A method and apparatus for treating persons suffering from an eating disorder includes direct or indirect stimulation of selected areas of the brain associated with a symptom of the eating disorder. The stimulation regimen is programmable to enable physician optimization of stimulation signal parameters to ameliorate at least one symptom of bulimia or another eating disorder. Certain embodiments employ deep brain stimulation and / or sensing together with cranial nerve stimulation and / or sensing.

The invention relates to a method for enhancing the running period of a poor-quality naphtha hydrogenising device. The invention adopts the method that a reactor is additionally arranged before a heating furnace, and the poor-quality naphtha first performs a selective diene hydrogenising and removing organosilicon compounds reaction at a lower reaction temperature, and then passes through a main reactor and performs a hydrogenising reaction to remove sulphur and nitrogen impurity and olefin saturation. Compared with the prior art, the method has the advantages that the process is simple, the heating furnace tube and the heat exchanger shell side coking are effectively alleviated and the organosilicon compounds are removed, and the running period of the device is prolonged. The method can be applied to various secondary processing naphtha hydrofining processes.

The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight / weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

An adjuvant composition is provided that is comprised of a calcium compound, lecithin, and an acrylic polymer. Pharmaceutical compositions are provided which include an antigen and the adjuvant. Methods are provided for stimulating an immune response in a human or animal subject by administering a composition comprising an antigen and the adjuvant composition to human or animal subjects.

The invention belongs to the field of biological medicines, and particularly discloses a mesenchymal stem cell and cytokine preparation having treatment effects on premature ovarian failures and perimenopausal syndromes, and a preparing method for the preparation. The preparation is composed of umbilical cord or placenta mesenchymal stem cells and cytokines, as well as hyaluronate which is used for bearing the umbilical cord or placenta mesenchymal stem cells and cytokines and has the slow-release and anti-inflammatory effects; and the preparation is injected into a part of the endometrium and ovary in a targeted manner to be slowly released and absorbed. The curative effect of repairing the ovary and endometrium can be achieved, functional ovulation can be promoted, the premature ovarian failures can be treated, and the various perimenopausal syndromes can be remitted. Compared with an existing intravenous re-transfusion and intervention path, untoward effects of intravenous transfusion are avoided through the preparation and a using method of the preparation, abdomen and local wounds caused by interventional treatment are avoided, and side effects and hurts caused by treatment to a patient can be effectively prevented, so that the preparation is safer and more effective, is high in practicability and easy to popularize, and has the huge application value.

The invention relates to a medicine metabolic relevant loci detection method, which comprises the following steps: extracting genome DNA from human samples; respectively designing a Taqman probe pair and a primer pair according to at least two medicine metabolic relevant genes; respectively marking the 5' end and the 3'end of the Taqman probe pair with fluorescence reporting genes and fluorescence quenching genes; carrying out fluorescence quantitative PCR augmentation on the genome DNA; and judging whether the medicine metabolic relevant genes have the mutation according to the fluorescence quantitative PCR augmentation results. Preferably, the number of the medicine metabolic relevant genes is four, the Taqman probe pair and the primer pair are used for detecting a loci rs1057910 of a gene CYP2C9, a loci rs4244285 of a gene CYP2C19, a loci rs4986893of a gene CYP2C19, a loci rs1065852 of a gene CYP2D6 and a loci rs28371759 of a gene CYP3A4. The invention has the advantages of ingenious design, simple operation and accurate and reliable detection results, and provides the reference frame for determining whether professional doctors are needed to be consulted so as to make sure the medicine can be taken or not or the proper dosage and the like when a certain medicine is taken.

An improved power tool system includes a power tool and an external power supply connected via a cable to provide utility and safety in a hazardous operation such as loading ammunition into a weapon in an environment of flammable materials and extreme environmental exposure. The power tool includes a sparkless motor, a sparkless controller and sparkless switches, in a sealed enclosure with improved heat transfer means. The power tool has improved torque controlling means to mitigate reaction torque to the operator and equipment when starting or stopping highly inertial loads. A sealed enclosure is provided to prevent liquids from entering the motor and controller cavity and includes a thermally conductive path to conduct heat from the motor and controller through the enclosure to cooling fins and a coolant path formed between the fins and an entrapment wall.

The invention discloses a method for recycling active ingredients in the amoxicillin mother liquor synthesized by an enzymatic method. The method includes synthesizing the amoxicillin mother liquor by the enzymatic method; separating the amoxicillin mother liquor through a macro-porous resin column, eluting the separated amoxicillin mother liquor by deionized water, and collecting an eluant rich in D-4-Hydroxyphenylglycine and an eluant rich in 6-amino penicillanic acid (APA) respectively; filtering the eluant rich in D-4-Hydroxyphenylglycine with Daltonian ultrafiltration membranes with a cutoff molecular weight of 150 to 200; performing nanofiltration concentration on the Daltonian ultrafiltration membranes for the filtered liquor with the cutoff molecular weight of 150 to 200, and standing, crystallizing and filtering the concentrated liquor to obtain solids, and drying the solids to obtain the D-4-Hydroxyphenylglycine. According to the method, the technological design is reasonable, the operation is convenient, the recycling effect is good, and energy is saved and the environment is protected.

The invention relates to an improved mesenchyme stem cell protection solution as well as application and a preparation method thereof. The protection solution can effectively prolong the activity remaining time of mesenchyme stem cells, reduces preparation cost, and has the advantages of wide raw material source, simple preparation, safe and reliable direct clinical application; and after the mesenchyme stem cells are preserved for 48 hours in the protection solution, the cell activity is still above 90 percent, the cell morphology is normal, and the multiplication capacity and mesenchyme stem cell phenotype characteristics are not influenced.

The invention relates to an ammoniation granulator and a compound fertilizer production technology by an amino acid method, aiming at solving the technical problems in the compound fertilizer production process that: biuret is easy to generate, the granulating effect is not good, the production efficiency is low and the energy consumption is high. An amino acid distributor of the ammoniation granulator is respectively and independently arranged, an amino spraying branch pipe provided with an inclined plane spout has an angle of 30 to 60 degrees with a vertical line on the cross section of a cylinder, the rotating directions of the inclined plane spout and the cylinder are consistent; the spout of an acid spraying branch pipe is correspondingly arranged in the opening direction of the inclined spout of the amino spraying branch pipe; and when ammoniation granulating, the granulator sprays liquid ammonia in a material layer with the pressure of 0.5 to 1.0MPa through the amino distributor, an acid distributor sprays sulphuric acid of 50 to 70 percent in the material layer with the pressure of 0.2 to 0.5Mpa, and each ton of solid material is injected with 15 to 25kg of liquid ammonia and 16.8 to 39.2kg of dilute sulphuric acid. The invention is applied in various raw materials and suitable for the scale production of various compound fertilizers; and the finished products have perfectly round and solid particles, are water resistant and movement resistant and not easy to be crushed and agglomerated.

The invention relates to a preparation method of a soluble rice protein, comprising the following steps: mixing size, smashing, removing amide, chelating, neutralizing, desalting, carrying out spray drying and the like. The invention also relates to a soluble rice protein obtained with the preparation method, the dissolubility of the soluble rice protein is more than or equal to 70%, the emulsion stability index is more than or equal to 1.2, and the foamability is more than or equal to 60.

An improved power tool system includes a power tool and an external power supply connected via a cable to provide utility and safety in a hazardous operation such as loading ammunition into a weapon in an environment of flammable materials and extreme environmental exposure. The power tool includes a sparkless motor, a sparkless controller and sparkless switches, in a sealed enclosure with improved heat transfer means. The power tool has improved torque controlling means to mitigate reaction torque to the operator and equipment when starting or stopping highly inertial loads. A sealed enclosure is provided to prevent liquids from entering the motor and controller cavity and includes a thermally conductive path to conduct heat from the motor and controller through the enclosure to cooling fins and a coolant path formed between the fins and an entrapment wall.

The invention provides a derivate of low molecular weight fucosylated glycosaminoglycan (dLFG) and a medical composition containing the dLFG or pharmaceutically acceptable salt and application of the dLFG and the medical composition for preparing medicines for treating thrombotic diseases.

A novel under-bump metallization (UBM) structure for providing electrical communication is described. The UBM structure includes a plurality of metallic layers, which are deposited onto a bonding pad of a semiconductor device, such as a semiconductor chip. The UBM structure may be provided as an interface between the bonding pad and a solder bump deposited over the UBM structure. In one example, the UBM structure includes layers of nickel and copper in which nickel is the upper layer in contact with the solder bump and copper is the lower layer in contact with the bonding pad. The nickel layer is formed to include a downwardly depending perimeter portion, which serves as a cover to the copper layer of the UBM structure. Accordingly, the copper layer is shielded from contact with the solder material during the reflow process, thereby avoiding undesirable reactions between the copper and solder.

The invention discloses multifunctional medical biological bone cement. The multifunctional medical biological bone cement is prepared from the following raw materials in percentage by mass: 5%-15% of polyacrylic acid microspheres, 20% of bioactive glass, 64.9%-74.9% of calcium phosphate bone cement and 0.1% of nanometer alendronate sodium microspheres, wherein the sum of the mass percentages of the raw materials is 100%. The multifunctional medical biological bone cement has the function of water absorption self-expansion; the using amount of the bone cement can be reduced, and further the leakage of the bone cement is reduced; the multifunctional medical biological bone cement has relatively good tissue compatibility, can be used for inducing the formation of new bones and enhancing the strength of vertebral bodies, is degradable in vivo without in vivo foreign matter residues; and meanwhile, the controlled-release alendronate sodium has the effects of resisting osteoporosis, reducing the absorption of bones and furthering enhancing the vertebral bodies. Therefore, the multifunctional medical biological bone cement has the advantages of little consumption, promotion of bone formation and bone absorption resistance when applied to vertebroplasty.

The present invention relates to novel methods and kits for monitoring the therapeutic inactivating capacity of a subject. Moreover, the present invention further relates to methods and kits for determining and / or monitoring a therapeutic protocol for a subject afflicted with auto antibodies specific for a natural substance, wherein these auto antibodies develop as a result of therapeutic administration of the natural substance or an analog thereof. These methods and kits can be used, for example, to initiate, terminate, or adjust the level of administration of any of a variety of therapeutic agents.

The invention belongs to the technical field of traditional Chinese medicine preparation method, and provides a preparation method of a traditional Chinese medicine used for treating gastritis caused by insufficiency of spleen-yang. According to prior arts, gastritis caused by insufficiency of spleen-yang is commonly treated by using omeprazole, which causes adverse reactions. The technical scheme of the invention is that: traditional Chinese medicines of ginseng, human milk, common jujube, common yam rhizome, wheat, different leaves pseudostellaria root tuber, balck-bone silky fowl, wild cabbage, dried longan pulp, largehead atractylodes rhizome, radix paeoniae alba, American ginseng, ligusticum, lotus seed, pilose asiabell root, sharpleaf galangal fruit, mongolian milkvetch root, Siberian solomonseal rhizome, nonglutinous rice, edible bird nest, dried ginger, bayberry, garden radish seed, carica papaya, roof iris rhizome, carrot, buckwheat, medicated leaven, cydonia oblonga mill, cerealose, honey, and licorice are soaked in water, and are decocted by using a mild fire; the obtained solution is filtered, a slag is removed, and the obtained medicine liquid is the traditional Chinese medicine used for treating gastritis caused by insufficiency of spleen-yang. The method is advantaged in that: the preparation method is simple; toxic and side-effects of the traditional Chinese medicine liquid are low; a treatment course is short; and a recovery rate is high. According to the invention, a good effect can be obtained with the cooperation of monarch and minister medicines. A traditional Chinese medicine preparation is adopted, such that adverse reactions, allergic reactions and toxic reactions caused by western medicines are avoided.

The invention discloses an oral lung inhalation aerosol powder, which can improve the lung deposition rate of active ingredients of the aerosol powder, avoid the deposition of carrier micropowder in the lung, and increase the stability of the composition. The oral lung inhalation aerosol powder consists of the active ingredients and the carrier micropowder. The oral lung inhalation aerosol powder is characterized in that: the mean grain size of the micropowder of the active ingredients is between 0.5 and 10 mu m, and the mean grain size of the carrier micropowder is between 20 and 45 mu m.

The invention provides a hawthorn vinegar healthy beverage, which is characterized by comprising the following raw materials in weight portion: 40 to 80 portions of hawthorn, 40 to 80 portions of honey, 40 to 80 portions of xylitol, 50 to 100 portions of white vinegar, 0.25 to 0.5 portion of aspartame, and 650 to 850 portions of water, and the hawthorn vinegar is prepared by a certain method. The hawthorn vinegar has disease prevention efficacy of table vinegar, good flavor of juice, palateful sweet and sour and sweet taste, and is suitable to be directly drunk. The hawthorn vinegar is rich in various amino acids, organic acid, vitamin, mineral and other nutritious ingredients, and has efficacies of blood-fat reduction, vessel relaxing, oxidation resistance, immunity regulation, harmful bacteria elimination, balance maintenance for blood acid alkali, weight reduction, digestion help and sobering up and the like.