25 results about "Wound inflammation" patented technology

A novel strategy for wound healing involving the coating of oxygen nanobubbles with exosomes and incorporating them into a polyvinyl alcohol (PVA) / gelatin hybrid hydrogel. In this work, we not only mitigate wound hypoxia but importantly have an efficient delivery method of exosomal nanoparticles, which to date has been confounded by very low to lack of uptake by cells in hypoxia. Furthermore, the self-healing properties of the hydrogel, along with its gelatin component, aids in hemostasis, thereby benefiting acute and surgical wound healing. Additionally, the crosslinking bonds within the hydrogel facilitate the decomposition of hydrogen peroxide (H2O2), alleviating wound inflammation. The multifunctional hydrogel provides for enhanced wound healing through increased angiogenesis, enhanced exosome delivery, hypoxia mitigation, and inflammation inhibition.

The invention provides a chitosan-based hydrogel nano material as well as a preparation method and application thereof, and belongs to the technical field of chemical synthesis and biomedicine. The method comprises the following steps: firstly, dissolving pyropheophorbide A and copper chloride in a solvent, and carrying out heating reflux reaction to obtain PPA-Cu; then, the PPA-Cu is grafted to chitosan (CS), and CS-PPA-Cu is obtained; arginine is added into the prepared CS-PPA-Cu solution, and CS-PPA-Cu (at) Arg is obtained; finally, the CS-PPA-Cu-coated Arg and the prepared PF solution are mixed and stirred, standing is conducted at the room temperature, and the chitosan-based CS-PPA-Cu / PF-coated Arg hydrogel is obtained. The hydrogel nano material has excellent bioluminescence performance, and can specifically recognize the position of wound inflammation. The prepared hydrogel nano material has the combined antibacterial ability of photodynamic, photothermal and NO gas release, and achieves the effect of promoting wound healing.

The invention belongs to the technical field of biomedical materials, and discloses light-controlled liquefied hydrogel for inhibiting wound scar formation and a preparation method and application thereof.The light-controlled liquefied hydrogel is prepared from 6-18 parts of PVA hydrogel, 3-9 parts of borax boric acid buffer solution and 1-3 parts of PDA (at) CeO2-SAB nano-particle suspension.The hydrogel has the advantages that light-controlled liquefaction can be achieved, and the hydrogel can be applied to wound scar formation. The material has the characteristics of uniform particle size, accurate drug release, inhibition of CD36 expression, good biocompatibility, biodegradability and the like, can be used for infected wounds, and provides a novel, simple and effective material for wound inflammation inhibition and scar repair resistance treatment.

The invention discloses a preparation method and application of hydrogen sulfide donor modified polylysine responding to myeloperoxidase. The hydrogen sulfide donor modified polylysine has the effects of eliminating hypochlorous acid and releasing hydrogen sulfide, and a final product C, namely the hydrogen sulfide donor modified polylysine, is obtained by combining the biological material A with a polylysine molecule B modified with the hydrogen sulfide donor based on myeloperoxidase response. A donor capable of releasing hydrogen sulfide molecules under the action of hypochlorous acid generated by myeloperoxidase is modified into a polylysine structure, so that the functions of effectively relieving wound inflammation and promoting angiogenesis are realized. Specifically, polylysine is widely applied to the field of wound repair due to excellent biocompatibility and antibacterial activity. Besides, donor molecules capable of responding to hydrogen sulfide release of myeloperoxidase are introduced, so that the anti-inflammatory effect is further enhanced, the proinflammatory factor level is remarkably reduced, and angiogenesis is promoted.

The utility model relates to the technical field of medical instruments, and discloses a clamping device which is used for clamping a suture needle, the clamping device comprises a clamping body, a magnetic unit, a power supply unit and a control unit, the power supply unit is arranged in the clamping body, so that a wire connected with an external power supply in related technologies does not need to be arranged outside the clamping device, and the clamping device is convenient to use. The situation that the wound of a patient is worsened to be inflamed due to the fact that the wire makes contact with the patient is avoided, and therefore the technical effects that the safety of the clamping device in the using process is improved, and meanwhile the structural conciseness of the clamping device can be improved are achieved.

The invention relates to the technical field of medical apparatus and instruments, and discloses a skin operation scar prevention and nursing device based on intelligent temperature control, which comprises a soft shell, a temperature conduction plate and a temperature adjusting assembly. A wound inflammation early warning and partition targeting temperature control system based on a thermal image matrix is arranged in the temperature conduction plate, a pulse type zero-energy-consumption endurance management strategy system based on PCM latent heat state observation is arranged in the temperature adjusting assembly, and the inner side of the soft shell is fixedly connected with an air bag and a scale temperature conduction array. Skin contact surface array temperature data are collected through the flexible temperature measurement array layer, the partition logic control circuit independently regulates and controls the current on-off states of different areas, and targeted cooling of an inflammation area and hot compress of a normal area are achieved. The latent heat characteristic of the solid-liquid phase change composite material is matched with a logic judgment circuit to control the start and stop of active equipment, so that pulse type zero-energy-consumption operation is realized; the air bag drives the medical silica gel layer to be attached to the limb, and the heat conduction efficiency and the wearing comfort are improved in cooperation with the scale structure.

The present invention discloses an anti-inflammatory and healing-promoting electrospun wound dressing, a preparation method and an application thereof, belonging to the technical field of medical dressings, and comprising a double-layer structure of an inner layer and an outer layer; wherein, the outer layer is a hydrophilic nanofiber membrane prepared by single-nozzle electrospinning, and is used to absorb wound exudate; the inner layer is a nanofiber membrane with a core-shell structure prepared by coaxial electrospinning, and the shell layer of the core-shell structure is a hydrophobic material, and is used to guide the exudate to the outer layer; the core layer of the core-shell structure comprises hydrophilic thermosensitive macromolecules, healing-promoting growth factors and anti-inflammatory drugs; the shell layer is hydrophobic, and guides the wound exudate to the outer hydrophilic nanofiber membrane; the gelatin hydrophilic thermosensitive macromolecules in the core layer, when the wound inflammation causes the local temperature to be ≥37°C, the temperature change causes the drug-loaded thermosensitive phase change macromolecules to undergo different degrees of phase change, thereby achieving timely and controllable release of drugs and ensuring the healing of the wound surface.

The invention discloses an animal fracture auxiliary recovery device for animal husbandry veterinarians, and relates to the technical field of animal fracture auxiliary recovery, the animal fracture auxiliary recovery device comprises a first arc plate, a vertical strip is fixed in the middle of the right side of the first arc plate, two bandages are fixed to the back of the vertical strip, and a hook-and-loop fastener is fixed to the outer wall of each bandage. A second arc plate is arranged on the left side of the first arc plate, two U-shaped plates are fixed to the middle of the left side of the second arc plate, the bandages penetrate through the interiors of the U-shaped plates respectively, two concentric-square-shaped frames are fixed to the right side of the vertical strip, the bandages penetrate through the interiors of the concentric-square-shaped frames respectively, the bandages are bent forwards, and the hook-and-loop fasteners are used for fixing the sides, away from the vertical strip, of the bandages. According to the device, the arc-shaped sheet plate is arranged between the first arc-shaped plate and the second arc-shaped plate in a covering mode, the air holes are used for ventilation of the fracture position of the animal, and therefore the problem that the wound of the fracture position of the animal is stuffy and inflamed, and consequently the wound of the animal is inflamed and infected is solved.

This invention discloses a glycosylated carbon dot functionalized fiber-gel composite dressing and its applications, belonging to the fields of functional materials and biomedicine. First, this invention develops a novel glycosylated carbon dot CS-ACD using a one-step hydrothermal method. This CS-ACD exhibits significantly enhanced antibacterial and anti-inflammatory activity, primarily killing bacteria through a membrane-dissolving mechanism. It also promotes the transformation of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type, thereby reducing the expression and secretion of inflammatory cytokines. Furthermore, this invention combines electrospun nanofibers loaded with this CS-ACD with an in-situ sprayable fibrin gel to prepare an innovative "sandwich" structured fiber-gel dressing. In an experimental mouse model of infected wounds, this dressing effectively reduces bacterial load, regulates the immune response, alleviates wound inflammation, and promotes collagen deposition and angiogenesis, ultimately accelerating wound healing and tissue repair.

The application discloses a preparation method of barbed silk suture, which comprises the following steps: after degumming and activation, the silk suture is immersed in a ginsenoside finishing liquid for padding treatment, and then is baked and dried; the drug-loaded silk suture is put into a mold, a silk fibroin solution is poured into the mold, and after removing bubbles, the silk suture is dried; the dried silk suture is taken out and subjected to wet heat treatment to obtain the barbed silk suture; during the degumming process, an alkali solution with a mass concentration of 0.02-0.08% is used for degumming; and during the activation process, a strong alkali solution with a concentration of 5g / L-50g / L is used for activation. The preparation method of the barbed silk suture applies ginsenoside and silk fibroin to the production and formation of the barbed suture; the polysaccharide chain in the ginsenoside can form stable hydrogen bonds with the silk fibroin, so that the ginsenoside can act on a wound for a long time (long-term sustained release), the drug effect is prolonged, the inflammation of the wound is effectively improved, and the wound healing is promoted.

The invention provides a biomass-based carbon-loaded transition metal monatomic catalyst as well as a preparation method and application thereof. The preparation method of the catalyst comprises the following steps: fully dispersing biomass and transition metal salt in deionized water, aging, centrifuging and drying to obtain a biomass-transition metal precursor; and grinding and uniformly mixing the biomass-transition metal precursor and a nitrogen source, and calcining to obtain the catalyst. The preparation process is simple, low in cost, green and sustainable; in the obtained catalyst, the transition metal is uniformly loaded on the biomass-based carbon in a monatomic site form; the obtained biomass-based carbon-loaded transition metal monatomic catalyst has good biocompatibility, and has great application extendable potential in the aspects of biological sterilization and wound inflammation diminishing.

This invention belongs to the field of biomedical materials technology and discloses a photocontrolled liquefaction hydrogel that inhibits wound scar formation, its preparation method, and its application. The photocontrolled liquefaction hydrogel is composed of the following raw materials: 6-18 parts PVA hydrogel, 3-9 parts borax-boric acid buffer solution, and 1-3 parts PDA@CeO2-SAB nanoparticle suspension. The hydrogel of this invention has the characteristics of photocontrolled liquefaction, precise drug release, inhibition of CD36 expression, good biocompatibility, and biodegradability. It can be used for infected wounds, providing a new, simple, and effective material for inhibiting wound inflammation and promoting scar repair.

The application discloses a barbed silk suture, which comprises a thread body in the inside, a silk surface body wrapped on the surface of the thread body, and a plurality of barbs protruding outward from the silk surface body; the barbed silk suture is prepared by the following method: after degumming and activation, the silk suture is immersed into a ginsenoside finishing liquid for padding treatment, and then baked and dried; the drug-loaded silk suture is put into a mold, a silk fibroin solution is poured into the mold, and after removing bubbles, the silk suture is dried; the dried suture is taken out and subjected to wet heat treatment to obtain the barbed silk suture. The barbed silk suture of the application applies ginsenoside and silk fibroin to the preparation and formation of the barbed suture; the polysaccharide chain in the ginsenoside can form stable hydrogen bonds with the silk fibroin, so that the ginsenoside can act on the wound persistently (long-term sustained release), prolong the drug effect, effectively improve the inflammation of the wound, and promote the wound healing.

The utility model discloses a thoracic operation multifunctional ligation fixing band which comprises a main body unit, the main body unit comprises a thoracic protecting band, the thoracic protecting band is used for surrounding the thoracic of a patient for protection, two bonding pieces are fixedly connected to the thoracic protecting band, and two connecting pieces are bonded to the bonding pieces. The hollow convex disc is operated to enable the movable block to drive the air bag protection pad to move to the wound of a patient, the skin-friendly piece is attached to the wound, then the connecting piece is connected with the bonding piece, the position of the skin-friendly piece can be fixed conveniently to prevent deviation, meanwhile, the inflation ball is squeezed by the hand, air is conveyed into the air bag protection pad through the connecting pipe to be expanded, and therefore the skin-friendly piece can be fixed conveniently. The skin-friendly piece is in a honeycomb shape and has a ventilation effect on the wound, so that air circulation of the wound is facilitated through the air guide pipe, wound inflammation and ulceration caused by air tightness are avoided, and dust is prevented from entering the wound to affect healing of the wound through the annular net.

This invention proposes a lyophilized exosome protective dressing and its preparation method, belonging to the field of dressing technology. A protective agent is mixed with exosomes and embedded in chitosan-sodium tripolyphosphate microcapsules to obtain embedded exosomes. MXene and graphene-modified extracellular matrix, along with calcium peroxide microspheres and the embedded exosomes, are added to poly(α,β-aspartic acid hydrazine)-C16 copolymer-silver hydrogel and freeze-dried to obtain the lyophilized exosome protective dressing. The lyophilized exosome protective dressing prepared by this invention has good biocompatibility, can rapidly promote wound healing, reduce wound inflammation, exert antibacterial and bacteriostatic effects, prevent wound deterioration, and is convenient for storage and transportation. It retains good activity even after long-term storage, showing broad application prospects in the field of rapid wound healing.

A method for wound treatment includes administering a subject in need thereof with a pharmaceutical composition. The pharmaceutical composition includes: an effective amount of a fatty acid-binding protein 4 (FABP4) antagonist and / or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. The wound treatment may include promoting wound angiogenesis, enhancing wound healing, reducing wound inflammation, and / or inhibiting wound scarring.

The invention belongs to the technical field of trauma repair, and particularly relates to a temperature-sensitive material for wound repair and application, the temperature-sensitive material for wound repair comprises a temperature-sensitive repair base material and a drug component for wound inflammation diminishing; the weight percentage ratio of the temperature-sensitive repairing base material to the medicine component is (60%-99.8%): (0.2%-40%), so that the weight percentage of the temperature-sensitive material is 100%. According to the technical scheme, the 3D exosome is added into the temperature-sensitive hydrogel to prepare the temperature-sensitive repair base material, the anti-inflammatory drug component is added into the temperature-sensitive repair base material, and the temperature-sensitive repair base material not only has the characteristics of the conventional temperature-sensitive hydrogel, but also adheres to the surface of a wound, provides stable drug supply for the surface of the wound, and has the performance of rapidly repairing the wound.

The application provides a preparation method of giant salamander skin in-situ collagen hydrogel dressing and application thereof in promoting burn wound healing, and belongs to the technical field of wound repair dressing. The in-situ collagen hydrogel dressing prepared from 1-3-year-old giant salamander skin through pretreatment, decolorization, removal of impure protein, degreasing and other steps has a natural three-dimensional honeycomb porous structure. The water vapor transmission rate of the dressing is 2000-2500 g / (m 2 24h), the dressing has excellent water retention and dynamic fitting properties, can realize efficient drug loading and slow release, has a significant bacteriostatic effect on escherichia coli and staphylococcus aureus, and has no cytotoxicity. Animal experiments show that the dressing can effectively reduce wound inflammation, promote granulation tissue growth and re-epithelialization, and significantly improve the healing speed and quality of deep Ⅱ degree burn wounds and other wounds. The application has simple process, good biocompatibility, good mechanical and functional adaptability, and is suitable for the repair and nursing of infected wounds and burn wounds, and has good clinical transformation and application prospect.

The invention relates to a preparation method of a pH-sensitive antibacterial hydrogel spray for wound inflammation repair based on anthocyanin and Cu < 2 + > complexation. The pH-sensitive antibacterial hydrogel spray is used for promoting wound inflammation repair and dynamic monitoring. The preparation method comprises the following steps: mixing a polyvinyl alcohol (PVA) solution and a CuSO4 solution according to a certain volume ratio to prepare a solution 1; mixing a sodium alginate (SA) solution with an anthocyanin solution to prepare a solution 2; then, the solution 1 and the solution 2 are mixed for use at normal temperature, and the hydrogel with soft texture is formed through a cross-linking reaction of polyvinyl alcohol (PVA) and sodium alginate (SA). The hydrogel prepared by the method has the characteristics of softness and skin fitting, and the time for preparing the hydrogel by the method is short. The hydrogel disclosed by the invention shows good application potential in wound care and inflammation monitoring, and provides a beneficial reference for developing a novel multifunctional wound inflammation repair material.

The invention discloses ready-to-use self-adhesive skin repair hydrogel and a preparation method and application thereof, and belongs to the technical field of biomedical engineering and biomedical materials.The preparation method comprises the following steps that hydrogel precursor mother liquor is prepared; and uniformly mixing the obtained methyltetrazine modified collagen solution, the norbornene modified RGD adhesive peptide solution and the norbornene modified hyaluronic acid solution with a PBS (Phosphate Buffer Solution) to obtain the ready-to-use self-adhesive skin repair hydrogel. The hydrogel has the characteristics of hemolysis resistance, coagulation promotion and tissue adhesion, and can significantly accelerate the healing of the full-thickness skin wound only by injecting the hydrogel into the wound once without adding growth factors. The hydrogel not only can effectively inhibit wound inflammation, but also can promote hair follicle regeneration. In addition, due to the characteristics of ready-to-use, skin self-adhesion, skin adaptability and biodegradability, the hydrogel is very suitable for clinical application.

The present invention discloses a silk absorbable barbed suture and a processing technology, comprising a thread body with a proximal end and a distal end, the thread body comprising a thread body inner core and a thread body outer shell, the thread body inner core comprising at least two natural mulberry silks woven and twisted with each other, the thread body outer shell having biodegradability, biocompatibility and non-toxicity; the thread body having barbs, the barbs protruding from the thread body toward the proximal end or the distal end, the barbs forming an angle between the thread body surfaces, the barbs having an inner end and an outer end, the inner end and the outer end both being formed by inward cutting of the thread body outer shell. The thread body inner core and the thread body outer shell both have good biodegradability, biocompatibility and non-toxicity, reducing human discomfort, and the suture with barbs avoids problems such as knotting during suturing, can act on the wound for a long time, has strong comprehensive mechanical properties, can be effectively absorbed and degraded by the human body, and reduces wound inflammation and the like.

This invention belongs to the field of traditional Chinese medicine (TCM) active ingredient extraction technology, and particularly relates to a TCM compound preparation for treating scalds, large-area burns, deep chemical burns, and gunshot wounds, as well as its preparation method and application. The TCM compound preparation for treating scalds, large-area burns, deep chemical burns, and gunshot wounds comprises, as raw materials, *Solanum lyratum* root extract and silkworm moth polypeptide. The invention also provides a corresponding preparation method for *Solanum lyratum* root extract and silkworm moth polypeptide. This invention further provides a pharmaceutical preparation containing the aforementioned TCM compound preparation. The *Solanum lyratum* root extract and silkworm moth polypeptide of this invention work synergistically, significantly shortening wound healing time while preventing wound inflammation. This provides inspiration for the development of drugs for burns, scalds, chemical burns, and other external injuries.

The invention relates to a multi-channel electronic suture line for monitoring wound space inflammation changes in real time, provides a multi-channel electronic suture line for visualized management of wound inflammation, and belongs to the technical field of biology. Comprising a reference electrode wire and a plurality of polyaniline working electrode wires, the reference electrode wire and the working electrode wires respectively take a conductive fiber bundle as a substrate, and an Ag / AgCl reference electrode sensing unit is arranged on the substrate of the reference electrode wire; a polyaniline working electrode sensing unit is arranged on a substrate of each working electrode wire, protective layers are arranged at the positions of non-sensing units of the reference electrode wires and the working electrode wires, the reference electrode wires and the working electrode wires are arranged in a staggered mode according to the sensing units, and the multi-channel electronic suture line is formed after the non-sensing units are packaged in a unified mode. The pH values of the wound at different spatial positions can be accurately monitored in real time to reflect the inflammation change of the deep wound.

This invention provides a pressure bandaging and fixation device for postoperative vulvar cancer surgery, belonging to the field of medical device technology. The bandaging and fixation device includes absorbent cotton, with an air guide groove extending through its upper outer surface. A pressure component is disposed on the upper side of the absorbent cotton, including a circulation groove embedded in the upper outer surface of the absorbent cotton. An expansion sleeve for applying pressure and fixation to the vulva is fixedly connected to the upper outer surface of the absorbent cotton. The circulation groove is located inside the expansion sleeve, and an adjustment tube is embedded inside the absorbent cotton. In this solution, by setting up the pressure component and coating the upper side of the contact piece with an antibacterial coating, an antibacterial effect can be effectively achieved around the wound, preventing the risk of vulvar wound inflammation and infection. By flexibly adjusting the volume of the expansion sleeve, the pressure applied to the vulvar wound can be effectively adjusted, ensuring hemostasis and nursing care while also reducing discomfort during use of the device to some extent.