2 results about "Antibacterial protein" patented technology

Embodiments herein relate to engineered antimicrobial probiotics for the treatment of gastrointestinal tract pathogens. In an embodiment, a composition for treatment of an animal is included. The composition can include a first genetically engineered bacterium comprising a first exogenous polynucleotide. The first exogenous polynucleotide can include a first heterologous promoter and a first polynucleotide that encodes a first antimicrobial protein. The composition can also include a second genetically engineered bacterium comprising a second exogenous polynucleotide. The second exogenous polynucleotide can include a second heterologous promoter and a second polynucleotide that encodes a second antimicrobial protein. The first heterologous promoter can be induced by one set of exogenous environmental conditions found in the gastrointestinal tract of the animal and the second heterologous promoter can be induced by a second set of exogenous environmental conditions found in the gastrointestinal tract of the animal. Other embodiments are also included herein.

The application provides an expression system and application of tilapia antibacterial protein Mptx, and belongs to the technical field of recombinant proteins.The tilapia Mptx eukaryotic protein is obtained by the method of gene cloning and eukaryotic expression vector construction, the binding and agglutination effect of Mptx on related pathogenic bacteria of tilapia are detected by ELISA and agglutination experiment, and it is proved that the obtained Mptx has the effects of inhibiting the proliferation of pathogenic bacteria and protecting the organism by the methods of bacteriostatic experiment and survival rate detection.The application proves that the Mptx eukaryotic protein can significantly reduce the death of tilapia caused by streptococcus agalactiae infection, and has important significance in the aquaculture industry.