85 results about "Supramolecular assembly" patented technology

The invention discloses a chiral supramolecular fiber structure design based on glutamic acid derivative and pyrazine co-assembly, a preparation method and application in bone regeneration and vascular regeneration. The chiral supramolecular assembly disclosed by the invention is formed by co-assembling a glutamic acid derivative and pyrazine, is an all-organic three-dimensional spiral fiber material with an accurate and controllable three-dimensional topological configuration, and can realize coupling regeneration of bones and blood vessels by cooperatively regulating and controlling dual action mechanisms of osteogenic differentiation and angiogenesis; the compound can be used for efficiently treating complex bone defects and related bone diseases. In addition, raw materials and reagents are simple and easy to obtain, reaction conditions are mild, the preparation method is simple, and good application prospects are achieved.

The invention relates to the technical field of microelectronic devices, in particular to a single-molecule memristor-rectifier device based on supramolecular assembly and a preparation method thereof. According to the preparation method, the guest molecule B is covalently connected with the tail end of the graphene electrode pair, so that stable and tight interface bonding between the supramolecular functional molecule and the electrode can be ensured; and then soaking the graphene electrode pair connected with the guest molecule B in a solution containing the host molecule A and the guest molecule C to form a supramolecular functional molecule between the graphene electrode pair. The guest molecule C in the supramolecular functional molecule has intrinsic oxidation-reduction activity, and the molecular structure of the guest molecule C can generate a reversible electron gain and loss process, so that controllable and reversible adjustment of charge distribution in the molecule is realized. Under the action of an electric field, through the reversible oxidation-reduction reaction of the guest molecule C, significant changes of intramolecular charge distribution and electron transmission characteristics are triggered, and finally reliable switching of high and low resistance states of the device is achieved.

The invention discloses a recombinant collagen composite nano-liposome as well as a preparation method and application thereof. The composite nano-liposome provided by the invention comprises a liposome which is provided with a closed lipid bilayer molecular layer and a content encapsulated in the closed lipid bilayer molecular layer; and a polyquaternium-51 layer that encapsulates the liposome. A supramolecular assembly, phospholipid wrapping and polyquaternium-51 protective layer is formed on the surface of the protein through a hierarchical wrapping technology, and multiple technologies are superposed, so that the stability and the transdermal absorption effect of the protein and the lipidosome are remarkably improved.

The invention discloses a 4-BrPA / beta-CD supramolecular photosensitizer as well as a preparation method and application thereof, and belongs to the field of biomedical materials. According to the method, beta-cyclodextrin is used as a subject, 4-bromophthalic anhydride is used as an object, and the water-soluble photosensitizer is constructed through a chemically modified supramolecular assembly strategy. The preparation method comprises the following specific steps: reacting beta-cyclodextrin with paratoluensulfonyl chloride to obtain mono-(6-O-paratoluensulfonyl)-beta-cyclodextrin; then carrying out a reaction with ethidene diamine to obtain mono-(6-ethidene diamine-6-deoxy)-beta-cyclodextrin; then reacting with 4-bromophthalic anhydride in N, N-dimethylformamide, and precipitating and purifying through ethyl acetate to obtain a crude product; and finally, carrying out ultrasonic treatment, centrifugal separation and freeze drying to obtain a pure product. The prepared 4-BrPA / beta-CD supramolecular photosensitizer is excellent in water solubility, has at least 7 excitation centers in a visible light region of 400-520 nm, correspondingly generates at least 7 emission centers in a range of 500-780 nm, has a maximum excitation wavelength of about 460 + / -10 nm and a maximum emission wavelength of about 620 + / -10 nm, has an extremely wide visible light response characteristic, and can be used for antibacterial photodynamic therapy.

This invention provides an organic ferroelectric eutectic material, its preparation method, and its applications, relating to the field of ferroelectric materials technology. The organic ferroelectric eutectic material constructs a crystal system with "rigid constraint and flexible adaptation coexisting, dipole order and controllable polarization synchronously" through "molecular selection-supramolecular assembly-crystal structure regulation," achieving a synergistic effect of high Curie temperature, strong polarization characteristics, and excellent flexibility. The preparation method of the organic ferroelectric eutectic material utilizes a simplified "solvent dissolution-solvent evaporation" process, leveraging the mediating effect of the solvent to promote the supramolecular self-assembly of donor and acceptor molecules. This achieves the preparation of an organic ferroelectric eutectic material possessing both high Curie temperature, strong polarization characteristics, and excellent flexibility. The preparation method has multiple advantages, including "stable process, low cost, and suitability for large-area processing," making it a simple, efficient, and universally applicable preparation method suitable for large-scale industrial production.

The invention discloses a flaky supramolecular chiral copper catalyst based on molecular self-assembly and application thereof, and belongs to the technical field of asymmetric catalysis, the flaky supramolecular chiral copper catalyst is prepared by the following preparation method: dissolving L-ThrC10-20 in a solvent, and stirring to obtain a methanol solution of the L-ThrC10-20; adding ultrapure water into the system, and stirring to obtain a sheet-shaped supramolecular assembly body L-ThrC10-20-NS; and adding Cu < 2 + >, and stirring to obtain the flaky supramolecular chiral copper catalyst L-ThrC16-NS-Cu (II). According to the invention, the flaky supramolecular chiral copper catalyst L-ThrC10-20-NS-Cu (II) assembled on the basis of L-ThrC10-20 and Cu < 2 + > is successfully constructed for the first time, and the catalyst shows obvious enantioselectivity in a Diels-Alder reaction and can be used for efficiently catalyzing to generate an S-endo configuration product.

The invention relates to the technical field of gelators and functional cosmetics, in particular to a porphyrin core-based gelator, preparation thereof and application of the porphyrin core-based gelator in preparation of products for removing skin glycated toxins. The gel factor provided by the invention is a C2 symmetric chiral gel factor: L-Por-Phe. A central core (porphyrin ring) of the gelator provides strong hydrophobic acting force and pi-pi stacking driving force, is not only a driving core for supramolecular self-assembly, but also is a key site for adsorbing aromatic AGEs toxins; a natural chiral source and an additional benzene ring side group are introduced into a side chain, the hydrophilic-hydrophobic balance of molecules is adjusted, and a supramolecular assembly is induced to form a single chiral spiral nanofiber; the connecting arms provide intermolecular hydrogen bonds to stabilize the three-dimensional network structure of the hydrogel; the terminal group endows the molecule with pH responsiveness, so that the gel can maintain a stable gel state in a skin physiological pH environment, and has good moisture retention.

The invention discloses a circularly polarized light-emitting supramolecular self-assembly crystalline material as well as a preparation method and application of the circularly polarized light-emitting supramolecular self-assembly crystalline material. The supramolecular assembly crystalline material comprises a three-dimensional structure, and the three-dimensional structure is connected through a hydrogen bond formed between a hydrogen atom in a chiral secondary structure unit and an oxygen atom in a sulfonic acid group of 4, 4 '-bis (2-sulfostyryl) biphenyl disodium CBS. The crystalline material disclosed by the invention shows excellent chiral optical properties, good solvent stability and a remarkable luminous asymmetric factor; the circularly polarized light-emitting film material prepared from the material can effectively realize transmission and amplification of crystal optical performance.

The application discloses a supramolecular lotus leaf peptide-narcotic alkaloid Pickering emulsion as well as a preparation method and application thereof. The water phase of the supramolecular lotus leaf peptide-narcotic alkaloid Pickering emulsion is a purified lotus leaf peptide aqueous solution, and the oil phase is camellia seed oil loaded with narcotic alkaloids. The camellia seed oil not only serves as a fat-soluble carrier to improve the solubility of the narcotic alkaloids, but also has nursing effects due to the unsaturated fatty acids, vitamin E and phytosterols contained therein. The supramolecular assembly technology is used to mediate the lotus leaf peptide and the narcotic alkaloids to form high-performance emulsified particles, to replace synthetic surfactants to stabilize the Pickering emulsion, and to construct a natural emulsion system with high emulsification efficiency, high stability and high performance, so that the performance and the nursing effect of the emulsion are optimized.

The invention relates to a cyclodextrin-Fe-based MOFs (Metal-Organic Frameworks) supramolecular assembly with synergistic stimulation response as well as a preparation method and application thereof. The assembly comprises an NH2-MIL-88B (at) Au carrier core, a stimuli-responsive link bridge covalently grafted on the surface of the carrier, an anti-tumor drug loaded on the pore channel and the surface of the carrier, and a functionalized cyclodextrin nano valve encapsulated on the surface of the assembly under the action of a subject and a guest. The functionalized cyclodextrin is targeted beta-cyclodextrin modified by biotin / folic acid. The invention also provides a preparation method of the assembly. The preparation method comprises the following five steps: preparation of Au NPs, preparation of the NH2-MIL-88B at Au carrier, modification of the linked bridge, drug loading and encapsulation of the nano valve. Furthermore, the invention also provides application of the assembly in a drug delivery system and preparation of anti-tumor drugs.

The invention provides a preparation method and application of a cucurbit [6] uril-based supramolecular fluorescent probe material. The fluorescent probe material is experimented in a reaction kettle by adopting a solvothermal synthesis method, and a novel supramolecular assembly fluorescent probe is successfully prepared by taking cucurbit [6] uril (CB [6]) as a main body and 3-amino isonicotinic acid as a structure inducer. The invention has the advantages of simple synthesis method, cheap raw materials, high detection sensitivity, strong anti-interference capability, fast response speed and the like. The supramolecular assembly is of great significance for monitoring water pollution.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

The application discloses a kind of pentapeptide-based supramolecular assembly particles and its application as drug delivery carrier, belong to the field of biological assembly material.The TGCP of the present application, TGCP / nHA are prepared from TP5, HA and GA into carrier particles with drug loading performance and potential anti-inflammatory performance, it has spontaneous fluorescence performance, and can exist stably in neutral and alkaline environment, can be decomposed in acidic environment, can be loaded with small molecules with different solubility, and has certain programmed response performance at physiological and pathological pH.The present application is found through in-vitro experiment exploration that the carrier particles have good biocompatibility, and for in-vitro induced inflammatory cell experiment, it is found that TGCP and TGCP / nHA both have certain anti-inflammatory activity, can inhibit the expression of cell inflammatory factor IL-6, and play the role of inhibiting inflammation.

The present application relates to the technical field of molecular sieve, in particular to a kind of molecular sieve self-assembly light response membrane and its preparation method and application.Utilize the supramolecular assembly based on dithiophene ethylene derivative and calabash urea as basic functional unit, after being coated on substrate, it is introduced into oil phase solution, and composite polyamide membrane is formed on substrate surface using interfacial polymerization reaction.Based on the host-guest recognition ability of dithiophene ethylene derivative and calabash urea, a dynamic adjustable recognition system is formed.Under light condition, the recognition ability of the whole system to molecule is influenced by changing the configuration of molecule.The self-assembly light response membrane has good dye interception effect and small cut-off molecular weight, and can realize accurate screening of similar molecular weight dye molecules, and is expected to be widely applied in wastewater treatment field.

A food product comprising one or more foodstuff, an anti-crystallizing component and a sweetener component is disclosed, the sweetener component comprising sugar alcohol. A method for producing a food product, and the use of supramolecular assemblies and a sweetener composition, are also disclosed.

The invention discloses a multi-target self-assembly cyclic peptide with tumor microenvironment regulation and control, belongs to the technical field of nano medicine, and aims to solve the problems of short blood vessel normalization period, inconsistent action time of combined medicines and the like in a traditional clinical combined treatment scheme. The self-assembly cyclic peptide comprises a TIGIT blocking unit, a self-assembly unit and a blood vessel regulation and control targeting unit which are connected in sequence, the blood vessel regulation and control targeting unit comprises a Tie2-VEGF targeting fragment and a corner structure fragment, and the Tie2 targeting fragment, the VEGF targeting fragment and the corner structure fragment are coupled through disulfide bonds to form an annular peptide. The synthesized multi-target self-assembly cyclopeptide can be quickly self-assembled to form a nanofiber network with a beta-folding structure after being enriched at a tumor site, and the nano reticular supramolecular assembly structure has the effects of strong combination and long-acting retention at a target protein, so that the functions of long-acting blocking and regulation and control of tumor blood vessels and immune microenvironment are achieved.

This invention discloses a carbon nitride homojunction photocatalyst for the selective conversion of methane to ethanol, its preparation method, and its application, belonging to the field of photocatalysis. The carbon nitride homojunction photocatalyst for the selective conversion of methane to ethanol is made of carbon nitride semiconductor CNC. I Axially oxygen-coordinated copper single-atom co-catalyst and carbon nitride semiconductor CN II Composition. Based on carbon nitride semiconductor CN. I The first semiconductor is formed by supramolecular assembly and thermal polymerization, on which an axially oxygen-coordinated copper single-atom co-catalyst and a second semiconductor CN are simultaneously introduced. II The carbon nitride homojunction photocatalyst for the selective conversion of methane to ethanol, denoted as Cu-CN, was prepared. II / CN I The catalyst used in this invention is made from abundant and inexpensive raw materials, and its preparation route is simple. The prepared catalyst significantly promotes the separation of charge carriers and exhibits excellent catalytic performance in the photocatalytic conversion of methane to ethanol, showing broad application prospects.

The invention relates to the technical field of high-performance textile composite materials, in particular to a novel anti-wear curtain fabric and a preparation method thereof. The preparation method comprises the following steps: carrying out surface modification on nano aluminum oxide by virtue of a biomimetic mineralization technology, and constructing an organic-inorganic hybrid layer on the surface of nano particles by virtue of a dopamine-alginic acid composite system; adopting a supramolecular assembly technology to enable calixarene derivatives and cyanate ester resin to form a host-guest compound system; a silicon carbide fiber reinforced composite material base material is prepared through innovative processes such as photo-thermal dual curing and electric field assisted hot-pressing curing; and finally, constructing a gradient ceramic protection system on the surface of the base material by adopting surface treatment technologies such as a laser micro-texturing technology, a magnetron sputtering and plasma spraying composite technology, plasma enhanced chemical vapor deposition and the like. The prepared curtain fabric has the advantages of wear resistance, flame retardance and the like, and the technical problems that a traditional curtain fabric is poor in wear resistance, insufficient in flame retardance and short in service life are solved.

An aerosol-generating article comprising an aerosol-generating element; a downstream section provided downstream of the aerosol-generating element; an upstream section provided upstream of the aerosol-generating element; and a supramolecular assembly. The supramolecular assembly comprises a flavourant and at least one dicarboxylic acid compound. The flavourant is releasable from the supramolecular assembly upon heating the supramolecular assembly. The downstream section comprises a hollow tubular element provided immediately downstream of the aerosol-generating element. The downstream section further comprises an aerosol-cooling element. The supramolecular assembly is provided in the upstream section, the hollow tubular element or the aerosol-cooling element.

The invention relates to the technical field of papermaking, in particular to a preparation method of ultrathin high-strength paper-based adhesive tape base paper. The preparation method comprises the following steps: mixing softwood pulp and hardwood pulp, forming base paper by adopting a double-net dehydration process, and forming a covalent cross-linked network in a paper sheet by adopting a cellulose reactive coupling agent with an o-benzoquinone structure and a multi-sulfydryl compound based on a sulfydryl-benzoquinone click chemistry and interface supramolecular assembly multi-bonding enhancement system; meanwhile, a dual intelligent enhancement system based on a biomacromolecule self-assembly body and a dynamic metal coordination network is established, and dynamic reversible crosslinking is constructed through a polyelectrolyte compound and a Fe < 3 + >-tannic acid coordination network; a multifunctional surface treatment technology combining a zwitterionic polymer brush and bionic in-situ mineralization is developed, a sulphobetaine methacrylate polymer brush grows through a surface-initiated atom transfer radical polymerization method, amorphous silicon dioxide is induced to be mineralized, and the adhesive tape body paper prepared through the method is high in strength.

The invention discloses an engineered adoptive macrophage based on a nano battery as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method disclosed by the invention comprises the following steps: taking an immunologic adjuvant working solution as a raw material, and obtaining nanoparticles with high drug loading capacity through an assembly effect; as the main energy of ChARM comes from an immunologic adjuvant, the high-drug-loading nano-particle is also called a high-energy-density nano-battery. Diluting the obtained nano particles with a cell culture medium, and co-incubating the diluted nano particles and macrophages to obtain engineered macrophages loaded with the anti-tumor or anti-inflammatory nano battery; the assembly mode is any one of supramolecular assembly, prodrug assembly or metal coordination assembly; the high-density drug-loaded nano battery can endow engineered cells with excellent biological functions. The method solves the technical problems that the preparation of the existing CAR-M is expensive, the gene modification is complex, and the nano-drug delivery system is unstable.

This invention discloses a method and apparatus for preparing dihydroporphyrin supramolecular assemblies, belonging to the field of functional nanomaterials technology. By designing a Y+S composite microfluidic chip, this invention utilizes Dean's vortex induced by an S-shaped flow channel to precisely control the nucleation and growth kinetics of Ce6 molecules, achieving the directional preparation of nanospherical Ce6 supramolecular assemblies. Simultaneously, it ensures that the assemblies have a narrow particle size distribution (PDI < 0.1), completely solving the problems of large morphological heterogeneity and poor controllability in traditional methods, and providing technical support for the standardized preparation of Ce6-based nanodelivery systems.

The application discloses a phenylpyridine salt derivative G, a room-temperature phosphorescent supramolecular gel and a preparation method and application thereof. The preparation method of the room-temperature phosphorescent supramolecular gel comprises the following steps: taking Cucurbit[8]uril (CB[8]) as a host, a phenylpyridine salt derivative containing a urea-based pyrimidone (UPy) quadruple hydrogen bond site as a guest, self-assembling a supramolecular assembly phosphorescent material in a 1:2 molar ratio in an aqueous solution; and introducing the assembly into a polyvinyl alcohol (PVA) matrix to obtain a humidity-responsive room-temperature phosphorescent supramolecular gel. The assembly and the supramolecular gel both present phosphorescent emission at room temperature. Under the dual constraints of macrocycle limitation and multiple hydrogen bonds on the phosphorescent molecules, the phosphorescent intensity and lifetime of the supramolecular gel are greatly enhanced compared with the assembly. Meanwhile, the phosphorescent intensity and the light-emitting color of the supramolecular gel change with the water content of the gel or the environmental humidity, realizing a visual response from green to blue, and the supramolecular gel can be applied to humidity sensing, anti-counterfeiting and information encryption.

The invention discloses an organic integer charge transfer eutectic material, nanoparticles as well as a preparation method and application of the organic integer charge transfer eutectic material, in the eutectic material, a donor is TEBD, a receptor is TCNQ, FTCNQ, F2TCNQ or F4TCNQ, and the integer charge transfer eutectic nanoparticles TEBD-F4TCNQ are prepared through supramolecular assembly and a nanoprecipitation method and are used for ferroptosis and photo-thermal synergistic treatment of tumors. The eutectic nano-particles show wide spectrum absorption, high photothermal conversion efficiency (56%) and biological mercaptan response capability, and show good tumor treatment effects in vivo and in vitro.

The invention relates to nano copper paste based on pillararene host-guest interaction and a preparation method and application thereof, and belongs to the technical field of conductive copper paste. The nano copper paste based on the pillararene host-guest interaction is prepared from the following components in parts by weight: 92 to 95 parts of nano copper powder coated with a pillararene supramolecular assembly, 4 to 8 parts of resin, 2 to 6 parts of an organic solvent, 0.1 to 1 part of a thixotropic agent, 0.1 to 1 part of a dispersing agent, 0.1 to 1 part of a coupling agent and 0.1 to 1 part of other auxiliaries. The nano-copper powder coated with the pillararene supramolecular assembly is of a core-shell structure, a host-guest compound serves as a shell, and nano-copper powder serves as a core; the host-guest compound takes glycidyl methacrylate grafted pillararene as a host and benzyltrialkyl quaternary ammonium salt as a guest; and the object is connected with the surface of the nano copper powder through a coordinate bond. The nano copper paste disclosed by the invention has the characteristics of good conductivity, low sintering temperature, strong adhesive force, excellent oxidation resistance and the like.

The application provides a metal organic coordination polymer-mediated silver nanowire preparation method, and comprises the following steps: preparing a supramolecular assembly agent, a high molecular polymer protective agent, a halide salt and a soluble silver salt solution respectively; the supramolecular assembly agent is at least one of cinnamic acid, p-coumaric acid, coffee acid and tannin; the halide salt and the supramolecular assembly agent are sequentially added into the soluble silver salt solution to form a silver ion-supramolecular assembly coordination polymer solution; the high molecular polymer protective agent is added into the silver ion-supramolecular assembly coordination polymer solution, stirring is conducted, and the reaction is carried out at-20-80 DEG C under light shielding for 0.1-10 h; after the reaction is completed, centrifugation, washing, vacuum drying and re-dispersion are conducted, and the silver nanowire is obtained. The silver nanowire prepared by the technical scheme of the application is superfine in diameter, has a curled morphology at the end, contains defects inside, the reaction can be carried out in water, the production capacity is high (more than 80 g / L), the process is simple, and the application is more environmentally friendly.

The application relates to the technical field of biomedical functional materials, and discloses a cyclodextrin-sanshool supramolecular assembly material and a preparation method and application thereof. The preparation method comprises the following steps: dissolving cyclodextrin in an organic solvent to prepare solution A; dissolving sanshool in an organic solvent to prepare solution B; slowly adding solution B into solution A, uniformly stirring, and evaporating and removing the organic solvent to obtain a crude product; dissolving the crude product in deionized water, filtering and collecting the filtrate; and performing freeze-drying treatment on the filtrate after freezing to obtain the cyclodextrin-sanshool supramolecular assembly material. The application forms a complex supramolecular system by encapsulating the sanshool molecules into the hydrophobic cavity of the cyclodextrin through host-guest supramolecular interaction, and obtains the nanoscale cyclodextrin-sanshool supramolecular assembly material which has high stability, good biocompatibility and high solubility, and also has good ultraviolet absorption capacity and good free radical scavenging capacity.

The invention belongs to the technical field of biological medicine and nano delivery, and particularly relates to a supramolecular assembly as well as a preparation method and application thereof. The supramolecular assembly constructed by the invention is based on mediation of a polyphenol molecular adhesive, the polyphenol molecular adhesive can generate relatively strong interaction with a target protein, so that the surface of the target protein is modified with a catechol group, and the catechol group on the surface of the target protein can be combined with a functional polypeptide modified with a phenylboronic acid group; dynamic chemical bonds are formed through catechol and phenylboronic acid, a compound beneficial to endocytosis of cells is formed, and therefore the binding problem of cationic polypeptide and target protein is solved. According to the invention, the functional polypeptide modified with phenylboronic acid is constructed by utilizing the principle, and a nano-scale supramolecular assembly is formed by virtue of multiple interaction synergistic driving of the polyphenol molecular adhesive and the target protein, so that an efficient, universal and safe new scheme is provided for intracellular delivery of protein drugs.

The invention relates to synthesis of a circularly polarized light isonitrile material with multi-stimulus response and all-light-white light regulation and control, and belongs to the field of intelligent high polymer materials. According to the covalent construction strategy, multi-adjustable CPL from molecular design to supramolecular assembly is achieved, and due to the fact that the azobenzene side group is subjected to reversible cis-reflective isomerization under stimulation of light, pH, metal ions and humidity, the material is endowed with various responsive CPL characteristics; the method has potential application value in multicolor dynamic display, anti-counterfeiting security, information encryption and chiral logic gate application. This work provides a basic insight for covalently constructing static helical polymers with dynamically tunable CPL.

The invention relates to the technical field of chiral molecule detection and analysis, in particular to an SERS (Surface Enhanced Raman Scattering) substrate based on a supramolecular plasma gold nanoparticle-mirror surface as well as a preparation method and application of the SERS substrate. The SERS substrate based on the supramolecular plasma gold nanoparticle-mirror surface sequentially comprises a substrate, an AuF thin film layer, an MPBA-beta-CD complex layer and a nanoparticle Au NPs layer from bottom to top, the MPBA-beta-CD complex layer is formed by adsorbing an MPBA-beta-CD complex on the surface of the AuF thin film layer, and a nano gap is formed between the AuF thin film layer and the Au NPs layer. According to the SERS substrate based on the supramolecular plasma gold nanoparticle-mirror surface, beta-CD captures enantiomer molecules to form a supramolecular assembly, nanoscale gap hot spots are accurately manufactured between gold nanoparticles and a gold film, and synchronous recognition and identification of aromatic amino acid enantiomers can be achieved.