252 results about "Supramolecular assembly" patented technology

A supramolecular insulin assembly and supramolecular exendin-4 assembly, which is useful as a protein therapeutic agent for the treatment of metabolic disorders particularly diabetes. The supramolecular assemblies disclosed in the present invention consists of insoluble and aggregated oligomers the protein. The invention also provides pharmaceutical compositions comprising the supramolecular assembly.

The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.

The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl (alkyl)acrylate-co-(alkyl)acrylic acid) that is capable of forming supramolecular assemblies or micelles under favourable conditions. The supramolecular assemblies or micelles formed from said polymers associate or dissociate reversibly upon changes in the environmental pH. The pharmaceutical compositions of the present invention contain hydrophobic drugs, cations or polycationic compounds, which can be delivered to the body by oral route or other routes of administration.

The invention is a process useful for providing a treated support comprising a porous nanoweb coating wherein the treated support is characterized by a biofilm cell count of less than 50% that of an untreated porous support control. The process is useful for modifying porous materials, such as filter media and barrier fabrics to provide resistance to biofouling. The porous nanoweb coating is comprised of fibrous structures derived from gelation and drying of supramolecular assemblies of non-covalently bonded organogelators. Typical organogelators useful in the invention include those that assemble via hydrogen bonding and π-stacking.

An optical device that comprises an input waveguide, an output waveguide, a high-Q resonant or photonic structure that generate slow light connected to the input waveguide and the output waveguide, and an interface, surface or mode volume modified with at least one material formed from a single molecule, an ordered aggregate of molecules or nanostructures. The optical device may include more than one input waveguide, output waveguide, high-Q resonant or photonic structure and interface, surface or mode volume. The high-Q resonant or photonic structure may comprise at least one selected from the group of: microspherical cavities, microtoroidal cavities, microring-cavities, photonic crystal defect cavities, fabry-perot cavities, photonic crystal waveguides. The ordered aggregate of molecules or nanostructures comprises at least one selected from the group of: organic or biological monolayers, biological complexes, cell membranes, bacterial membranes, virus assemblies, nanowire or nanotube assemblies, quantum-dot assemblies, one or more assemblies containing one or more rhodopsins, green fluorescence proteins, diarylethers, lipid bilayers, chloroplasts or components, mitochondria or components, cellular or bacterial organelles or components, bacterial S-layers, photochromic molecules. Further, the molecular aggregate may exhibit a photoinduced response.

The invention discloses a graphene/hyaluronic acid assembly taking cyclodextrin as a medium. The graphene/hyaluronic acid assembly is a nano supermolecule assembly synthesized based on beta-cyclodextrin-modified graphene and adamantine-modified hyaluronic acid, wherein graphene is modified by beta-cyclodextrin; by virtue of strong host-guest interaction between beta-cyclodextrin and adamantine, graphene and hyaluronic acid are combined together to form the supermolecule assembly. The graphene/hyaluronic acid assembly has the advantages that the supermolecule assembly greatly improves stability and biocompatibility of the cyclodextrin-modified graphene under physiological conditions; by utilizing targeted recognition action of hyaluronic acid on tumor cells, the supermolecule assembly can selectively kill the cancer cells, and has anti-cancer activity higher than that of pure drug camptothecin; the targeted drug transmission system is simple in preparation process, easy to implement and low in material cost, and has potential application prospect in clinic treatment of cancers.

The invention relates to a method for constructing a monatomic catalyst based on lignin/metal supramolecular assembly and belongs to the technical fields of preparation method of a catalytic materialand application of lignin. The method mainly comprises the following steps: 1) mixing a lignin and metal ionic solution with a certain concentration uniformly and adjusting the pH to form lignin/metalsupramolecular assembly precipitate; 2) centrifuging and drying to obtain a catalyst precursor; and 3) mixing the precursor and a nitrogen source and performing program high-temperature sintering under the protection of inert gas to obtain the monatomic catalyst. Compared with the prior art, the method has distinct characteristics of low raw material cost (the lignin serves as a ligand and a carrier), simple process (pH regulation and control of the precursor and stripping without acid washing), metal dispersing uniformity (coordinated complexation and increment of defect site regulation andcontrol) and the like, and large-scale production of the monatomic catalyst is easily realized.

The invention discloses acetal-substituted glucosamide, a preparation method and a method for preparing a supramolecular gel. The acetal-substituted glucosamide is as shown in formula I (as shown in Specification), wherein n is selected from 1-10, 12, 14, 16 or 18. The supramolecular gel formed from the acetal-substituted glucosamide disclosed by the invention in a solution is thixotropic, high in recovery rate and controllable. The gel factors are capable of achieving oil and water separation, dye wastewater purification and the like. The supramolecular gel can be used for preparing coatings, ink and lubricants.

The invention belongs to the fields of supramolecular polymer polymer chemistry and drop formation control, and particularly relates to supramolecular hydrogel microsphere modified with cyclodextrin water-solubility polymer and adamantine water-solubility polymer and formed by assembling subjective and objective bodies in a liquid drop, and a preparation method and application thereof. The first purpose of the invention is to provide novel supramolecular hydrogel microsphere formed by assembling subjective and objective bodies and a preparation method thereof method, the second purpose of the invention is to adopt liquid drop as a template to realize supramolecular assembly and achieve uniform particle size and controllable dimension of the supramolecular hydrogel microsphere, and the third purpose of the invention is to provide application of the type of supramolecular hydrogel microsphere in adriacin doxorubicin and taxol water-solubility antitumor drug sustained release, so as to achieve the purpose that a drug can keep a high concentration level for a long time.

The invention relates to preparation of sulfonated calix [4] arene-based nano supramolecular vesicles. According to the construction unit, sulfonated calix [4] arene is used as a subject (C4AS), asymmetrical purpurine is used as an object (MVC12), and a supramolecular assembly is constructed by including and coordinating interaction of the subject and the object. The preparation method comprises the following steps of: dissolving the C4AS and the MVC12 into water, and uniformly mixing the C4AS and the MVC12. The invention has the advantages that: the preparation method is simple and convenient; the consumption of raw materials of the subject and the object is low, and the subject and the object have high medicament load rate; the supramolecular vesicles have good response to the stimulus of external temperature, oxidation and reduction, addition of cyclodextrin and the like in short time; the supramolecular vesicles can load hydrophilic anti-cancer adriamycin; compared with pure adriamycin, the killing effect of the loaded adriamycin on cancer cells is not changed, and the toxic effect of the loaded adriamycin on normal cells is obviously reduced; and the supramolecular vesicles have broad application prospect in the fields of load, transport and targeted release of anti-cancer medicaments.

The invention provides a supramolecular self-assembly biological chip. The supramolecular self-assembly biological chip comprises a substrate (1), first chain molecules (3) which are fixed on the surface of the substrate, and second chain molecules (4) which are fixed on the surface of the substrate, wherein the first chain molecules and the second chain molecules are fixed on the substrate at intervals; part of one end, which is far away from the substrate, of each first chain molecule is included by cyclodextrin (2); the cyclodextrin comprises a functional group which can be directly or indirectly bound with protein molecules; and each second chain molecule is not longer than each first chain molecule. Poly(pseudo)rotaxane which is formed by coating the cyclodextrin and the first chain molecules and the second chain molecules which are arranged uniformly at the intervals are arranged on a self-assembly layer on the surface of the biological chip, a three-dimensional space has a dense, controllable and changeable structure, and compared with a two-dimensional surface, the three-dimensional space can fix more detection molecules such as the protein molecules. Moreover, the invention also provides a preparation method and application of the biological chip.

A method for detecting trypsin using unmarked fluorescence belongs to the technical field of interdisciplinary subjects of material, biology, and analytical chemistry, and particularly relates to the method for detecting the trypsin based on disassembly of supramolecular assemblies under enzymatic hydrolysis. The method is characterized by including: firstly, determining critical micellar concentration of a surfactant; secondly, forming the supramolecular assemblies with the surfactant and polyelectrolyte with opposite charges through hydrophobic and electrostatic interaction, and embedding hydrophobic dyes serving as fluorescent probes into the inner cavities of the supramolecular assemblies; thirdly, adding enzyme which can lead to hydrolysis in the polyelectrolyte so as to lead the disassembly of the supramolecular assemblies and release the embedded hydrophobic dyes, and detecting enzyme activity by lowering fluorescence intensity. The method is simple to prepare, low in cost, real-time in detection, and wide in application prospect in fields such as diagnosis and detection of biomolecules, and biosensors.

This invention relates to the modification of bitumen by polymeric materials used particularly for the preparation of asphalt mixtures with enhanced mechanical properties, wherein the polymeric materials are selected from additives capable of forming a supramolecular assembly. The modified bitumen may be used for the fabrication of asphalts mixtures with mineral aggregates used in construction or maintenance of sidewalks, roads, highways, parking lots or airport runaways and service roads and any other rolling surfaces.

The invention provides substituted tricarbonal chloride [2-(2-pyridyl) benzimidazole] co-rhenium complexes or substituted tricarbonal chloride (2,2'-dipyridyl amine) co-rhenium, which are tricarbonal chloride [1-(4-5'-phenyl-1,3,4-oxadiazole phenyl)-2-(2-pyridyl) benzimidazole] co-rhenium (I), tricarbonal chloride [1-(4-N-carbazolyl phenyl)-2-(2-pyridyl) benzimidazole] co-rhenium (I), tricarbonal chloride [N-(4-5'-phenyl-1,3,4-oxadiazole phenyl)-2,2'-dipyridyl amine] rhenium co (I) and tricarbonal chloride [N-(4-N-carbazolyl phenyl)-2,2'-dipyridyl amine] co-rhenium (I). The complexes have a structural formula as follows. The tricarbonal rhenium (I) complexes having the advantages of simple synthesis, help to purification, high yield and stable properties in air can be applied to molecular catalysis, solar energy conversion, colorimetric analysis, molecular recognition, supramolecular assembly, optical information storage, photoluminescence probes in organisms, and other fields. The invention discloses a preparation method for the complexes.

The invention relates to a supermolecular assembly for small interfering RNA targeting delivery. The supermolecular assembly is a four-element supermolecular assembly synthesized on the basis of beta-cyclodextrin modified hyaluronic acid, an adamantine polyamine compound, cucurbituril [6] and small interfering RNA. The four-element supermolecular assembly is based on the strong non-covalent interaction between beta-cyclodextrin and adamantine and between adamantine polyamine chain and cucurbituril [6], and the electrostatic interaction between the adamantine polyamine chain and small interfering RNA, and forms supermolecular nanoparticles with hydrophilic hyaluronic acid as the shell. The supermolecular assembly provided by the invention has the advantages of simple synthesis and construction route, low production cost and high yield, and is suitable for amplified synthesis and actual production application. Through the endocytosis of a malignant tumor cell surface overexpressed hyaluronic acid receptor as a medium, the four-element supermolecular assembly can be brought into cancer cells targetedly, thus realizing effective silencing to exogenous gene expression and significantly reducing the toxic and side effect at the same time.

The present invention provides a regenerative nanosensor device for the detection of one or more analytes of interest. In certain embodiments, the device comprises a nanostructure having a reversible functionalized coating comprising a supramolecular assembly. Controllable and selective disruption of the assembly promotes desorption of at least part of the reversible functionalized coating thereby allowing for reuse of the regenerative device.

The invention discloses application and an application method of a cucurbit(10)uril-based supramolecular self-assembly. The cucurbit(10)uril-based supramolecular self-assembly captures, precipitates and releases metal ions. Effective wide-spectrum trap and precipitation of metal ions can be achieved, and specific metal ions can be captured in a specific system. After capturing, crystals can be dissolved in a nitric acid system to obtain cucurbit(10)uril with no metal ions.

The invention discloses a super-molecule assembled carbon quantum dot nano sensor for detecting phosphorus containing pesticides and manufacture and use methods thereof. The fluorescent nano sensor takes alkyl ammonium carbon quantum dots assembled at the surfaces of nano particles of sulfonatocalixarene as a substrate, and terbium ions are coordinated on the surface of the nano particles in situ. When the sensor is used for detection, whether a detected pesticide contains phosphorus can be determined according to the change of characteristic emission peaks of terbium ions in a detection result. The sensor has the advantages of being low in cost and simple in detection operation, is free of any toxicity as excellent water soluble matter, and is high in detection sensitivity.