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Preparation method of supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent

A triple-response, supramolecular technology, applied in the fields of polymer materials and biomedical engineering, can solve problems such as the lack of precise drug loading and release, and poor controllability.

Inactive Publication Date: 2016-07-27
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although there are many research reports on stimuli-responsive β-cyclodextrin supramolecular assemblies, most of them are limited to one or two external stimuli, and the controllability is poor, and the precise loading and release of drugs cannot be achieved. requirements

Method used

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  • Preparation method of supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent
  • Preparation method of supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent
  • Preparation method of supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent

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Embodiment 1

[0032] Specific steps are as follows:

[0033] (1) p-toluenesulfonyl chloride modified β-cyclodextrin

[0034] Weigh and weigh 50g of β-cyclodextrin, dissolve it in 500mL of sodium hydroxide solution with a concentration of 0.4mol / L, place the solution in an ice-water bath and stir vigorously, slowly add 35g of p-toluenesulfonyl chloride, white insoluble matter generate. mixture in 5 o C under stirring for 30 minutes, and suction filtered to obtain a clear filtrate. Under stirring, add hydrochloric acid to the above solution until a white precipitate is formed, continue stirring for 1 hour, filter with suction, and wash with water three times. The resulting white precipitate was at 60 o C oven dry.

[0035] (2) β-CD-N 3 Synthesis

[0036] Get last step gained product 15g and dissolve in water, be heated to 80 o C, add sodium azide solution to this solution, raise the temperature to 105 o C, stirred for 6 hours. Subsequent precipitation in iced acetone solution gave a...

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Abstract

The invention relates to a preparation method of a supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent. The preparation method comprises the following steps of using a beta-cyclodextrin-modified thermo-sensitive copolymer (beta-CD-P(MEO2MA-co-OEGMA)) as a host molecule, and using an azobenzene-terminated amphiphilic blocking copolymer (Azo-PCL-SS-PEG) as a guest molecule, and building a supermolecular assembly with a mutual electrostatic action of the host molecule and the guest molecule; using a sulfonation and bromination product of the beta-cyclodextrin to initiate ATRP (atom transfer radical polymerization) reaction, so as to obtain the host molecule; using chain-extended 4-hydroxyazobenzene to open a loop of caprolactone, and performing a two-step esterification reaction, so as to obtain the guest molecule; respectively dissolving the host molecule and the guest molecule into water, and uniformly mixing, so as to obtain a supermolecular self-assembly micellar solution. The preparation method has the advantages that by applying outside irritation to the system, the shape and size of the micelle can be reversibly and controllably transformed; the application prospect in the fields of medicine loading and controllable release, biological intelligent switches, nanometer intelligent reactors and the like is wide.

Description

technical field [0001] The invention belongs to the field of polymer materials and biomedical engineering, especially the technical field of nano supramolecular materials, and specifically relates to a preparation method of supramolecular nano-aggregates with triple responses to temperature, UV and reducing agent. Background technique [0002] The self-assembly behavior of responsive amphiphilic polymers has attracted more and more attention in recent years. An important property of this type of polymer is that when the external environment changes, the chemical structure of the polymer will change, and the shape of its assembly will also change. Common assembly forms include vesicles and micelles. , tubular, fibrous, stick, etc. Therefore, if smart nanoreactors based on responsive amphiphiles can reversibly open and close under external stimuli, and controllably carry and release drugs, it will bring new application prospects for targeted delivery of drugs. See: 1) Yan, X...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L51/02C08L87/00C08B37/16C08F251/00C08F220/28C08G63/08C08G63/91C08G81/00
CPCC08B37/0012C08F220/28C08F251/00C08G63/08C08G63/91C08G81/00C08L51/02C08L87/00C08F220/286
Inventor 袁伟忠陆叶强
Owner TONGJI UNIV
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