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233 results about "Micellar solutions" patented technology

A micellar solution consists of a dispersion of micelles in a solvent (most usually water). Micelles consist of aggregated amphiphiles, and in a micellar solution these are in equilibrium with free, unaggregated amphiphiles. Micellar solutions form when the concentration of amphiphile exceeds the critical micellar concentration (CMC) or critical aggregation concentration - CAC, and persist until the amphiphile concentration becomes sufficiently high to form a lyotropic liquid crystal phase.

Aqueous based surfactant compositions

The use of a stabiliser comprising a hydrophilic polymeric chain of more than four hydrophilic monomer groups and / or having a mass greater than 300 amu, linked at one end to a hydrocarbon-soluble hydrophobic group to reduce or prevent the flocculation of systems comprising a flocculable surfactant and a liquid medium which is capable of flocculating the surfactant and in which the stabiliser is capable of existing as a micellar solution at a concentration of at least 1% by weight.
Owner:HUNTSMAN INT LLC

Aqueous based surfactant compositions

The use of a stabiliser comprising a hydrophilic polymeric chain of more than four hydrophilic monomer groups and / or having a mass greater than 300 amu, linked at one end to a hydrocarbon-soluble hydrophobic group to reduce or prevent the flocculation of systems comprising a flocculable surfactant and a liquid medium which is capable of flocculating the surfactant and in which the stabiliser is capable of existing as a micellar solution at a concentration of at least 1% by weight.
Owner:HUNTSMAN INT LLC

Polymer micelle lyophilized agent encapsulating insoluble antitumor drug

The invention belongs to the field of pharmaceutical agents, relates to a polymer micelle lyophilized agent encapsulating an insoluble antitumor drug as well as a preparation method and an application thereof. The polymer micelle lyophilized agent is prepared by carrying out molecular self-assembly on a methoxy poly(ethylene glycol) 2000-polyester block copolymer to form micelles, and then encapsulating the insoluble antitumor drug in a hydrophobic core formed by the polyester. The lyophilized agent has high encapsulation rate, high drug loading and small particle size, can significantly improve the water solubility of the insoluble drug and result in passive targeting of more antitumor drugs to concentrate in the tumor tissues, thus improving an anti-tumor treatment effect and reducing the toxic and side effects of drugs, and can be used to prepare the drugs used for the treatment of lung cancer, intestinal cancer, mammary cancer, ovarian cancer, etc. The lyophilized agent can also be quickly dissolved and dispersed to form a transparent micellar solution after water for injection, normal saline solution and the like are added, and is used for the preparation of the drugs for treating primary intestinal cell carcinoma.
Owner:上海谊众药业股份有限公司

Tungstic oxide nano-wire and method for preparing tungstic oxide nano-wire gas-sensitive sensor

The invention relates to a method for preparing a tungsten oxide nano-wire and a tungsten oxide nano-wire ammonia-sensitive sensor, belonging to the one dimensional nano oxide material preparation and gas-sensitive technical field. The method comprises the following steps that: sodium tungstate is dissolved in deionized water to prepare a sodium tungstate solution; a hydrochloric acid is dripped slowly to prepare a flaxen micellar solution which is then centrifugally separated; products are uniformly dispersed in a potassium sulfate solution which is then transferred into a reaction kettle for hydrothermal reaction, and then the tungsten oxide nano-wire is prepared; adhesives and frit are added into the tungsten oxide nano-wire, and then the tungsten oxide nano-wire ammonia-sensitive sensor is prepared after element sintering and ageing. The method has simple steps, easily controlled technological parameters during the preparation process, and very low energy consumption during the whole preparation process; the tungsten oxide nano-wire prepared has a large specific surface area and high thermal stability; and the tungsten oxide nano-wire ammonia-sensitive sensor prepared has high sensitivity on low-concentration (between 1 and 100 pars per million) H2, CO and NH3, good repeatability and high stability.
Owner:TSINGHUA UNIV

Preparation method of polyene-containing taxol nanoparticle mixed micelle preparation and freeze-drying agent

The invention discloses a preparation method of a polyene-containing taxol nanoparticle mixed micelle preparation and a freeze-drying agent, which prepares docetaxel PLA-PEG nanoparticles or micelle or nanoparticle mixed micelle through a modified solvent evaporation method, takes PLA-PEG copolymer as a carrier, and wraps docetaxel in a PLA hydrophobic core. When in use, the docetaxel PLA-PEG containing long cycle freeze-dried preparation only needs to be added with water and is dissolved, and uniform nanoparticle suspension, micellar solution or mixed micellar nanoparticle suspension can be prepared. The preparation method does not need tween-80 and ethanol solubilization, only takes the biodegradable PLA-PEG as the carrier, and does not contain any surfactant; and compared with the docetaxel injection on sale, the preparation can reduce the toxicity and the adverse reactions of the medicine, and improve the clinical application safety of the medicine.
Owner:SHANDONG UNIV

Preparation method of ternary polymer molecular brushes heavy metal capture agent

The invention relates to a preparation method of a ternary polymer molecular brushes heavy metal capture agent. The preparation method is characterized by comprising the following steps: dissolving 5-10 parts of ternary polymer molecular brushes in 10-50 parts of water; and stirring at 20-30 DEG C for 1-10 h to obtain a nanometer heavy metal capture agent micellar solution. The ternary polymer molecular brushes contain multi-sulfur polymer and flocculation polymer simultaneously. Each molecular chain can provide hundreds of coordination sites to carry out coordination crosslinking with heavy metal ions so as to generate micron-level aggregate. Under the action of the flocculation polymer, millimeter level and above of aggregate is rapidly generated and is rapidly deposited and separated from the water body. The generated aggregate has good stability, is not easy to decompose, and is not easy to generate secondary pollution.
Owner:SHUNDE POLYTECHNIC

Non-polyether type demulsifying agent and preparation method thereof

Disclosed are a novel non-polyether demulsifier for oil field crude oil demulsification and preparation thereof. The demulsifier disclosed is prepared by adding hydrophilic monomers and hydrophobic monomers alternately and continuously for multiple steps as following: mixing alkyl-acrylate and methyl acrylate as raw material at a certain ratio to prepare a hydrophobic monomer mixture, mixing methyl acrylate and acrylic acid as raw material at a certain ratio to prepare hydrophilic monomer mixture, dripping said hydrophobic monomer mixture and said hydrophilic monomer mixture into stable micelle solution continuously and alternately at certain temperature to prepare the product of non-polyether demulsifier, In which the ratio of monomer methacrylate ester is 30-60% of the total weight, the ratio of monomer acrylic ester is 15-40% of the total weight, the ratio of methacrylic acid is 5-30% of the total weight, the ratio of monomer acroleic acid is 5-30% of the total weight. The non-polyether demulsifier disclosed has excellent hydrophilicity and lipophilicity, and a good demulsification effect.
Owner:CHINA PETROLEUM & CHEM CORP +1

Stable polymeric micelle-type drug composition and method for the preparation thereof

A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a freeze-dried product comprising a hydrophobic drug, i.e. paclitaxel, and an amphiphilic block copolymer wherein a hydrophobic group having affinity or attraction with the hydrophobic drug, such as paclitaxel, is incorporated on its end.
Owner:SAMYANG HLDG CORP

Copolymer with temperature/PH dual-sensibility and preparation and application thereof

The invention relates to a novel temperature / PH dual-sensibility self-assembly segmented copolymer, i.e. polyhistidine-polylactic-co-glycolic acid-polyethyleneglycol-polylactic-co-glycolic acid-polyhistidine (OLH-b-PLGA-b-PEG-b-PLGA-b-OLH), belonging to the technical field of medicine. The self-assembly segmented copolymer accords with the structural features of a temperature / PH unika polymer, and a molecular structure of the self-assembly segmented copolymer respectively comprises a polylactic-co-glycolic acid-polyethyleneglycol-polylactic-co-glycolic acid (PLGA-b-PEG-b-PLGA) chain link which responds to temperature change and a low polyhistidine chain link which responds to PH change; copolymers can be dissolved into water under room temperature to form a free-pouring micellar solution,and when the temperature and the PH of an external environment change, the copolymers with different structural proportions are respectively expressed as follows: (1) the phase variation of solution-gelatin, and (2) the response action of the dissociation of a micellar structure, wherein the copolymer with the response action of the (1) can be taken as a carrier of an injection type sustained controlled-release drug delivery system, and the copolymer with the response action of the (2) can be taken as a carrier of a micellar target drug delivery system.
Owner:SHENYANG PHARMA UNIVERSITY

Self-assembly of water-soluble nanocrystals

A method for forming an ordered array of nanocrystals where a hydrophobic precursor solution with a hydrophobic core material in an organic solvent is added to a solution of a surfactant in water, followed by removal of a least a portion of the organic solvent to form a micellar solution of nanocrystals. A precursor co-assembling material, generally water-soluble, that can co-assemble with individual micelles formed in the micellar solution of nanocrystals can be added to this micellar solution under specified reaction conditions (for example, pH conditions) to form an ordered-array mesophase material. For example, basic conditions are used to precipitate an ordered nanocrystal / silica array material in bulk form and acidic conditions are used to form an ordered nanocrystal / silica array material as a thin film.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC

Hydrophobic POSS (Polyhedral Oligomeric Silsesquioxane)-based hybridization fluorinated acrylate resin as well as preparation method and application thereof

The invention discloses a hydrophobicPOSS (Polyhedral Oligomeric Silsesquioxane)-based hybridization fluorinated acrylate resin as well as a preparation method and an application thereof. The formula of the hydrophobic POSS-based hybridization fluorinated acrylate resin comprises the following raw materials in percentage by weight: 2-12% of POSS-based monomer, 2-11% of hard monomer, 3-16% of soft monomer, 1.5-7% of fluoroacrylate monomer, 3-11% of crosslinking monomer, 0.4-1.3% of triggering agent and 50-79% of solvent. The application of the hydrophobic POSS-based hybridization fluorinated acrylate resin is characterized in that a crosslinking-type copolymer is mixed with a curing agent, the hydrophobic POSS-based hybridization fluorinated acrylate resin aggregates and is self-assembled in a film-forming solvent so as to form a micellar solution, then a phase isolation technology is used for ensuring that the solvent volatilizes on filter paper or a metal screen to form a film so as to construct a composite multi-scale structure, so that a super-hydrophobic coating is prepared. The preparation method has the advantages that a free radical solution polymerization method is adopted, synthetic conditions are simple, reaction routes are simple, raw materials are simple and easy to get, and the preparation technological processes of organic / inorganic hybrid materials are greatly simplified; the hydrophobic POSS-based hybridization fluorinated acrylate resin has wide application prospect in the field of waterproof and dampproof coating and the like.
Owner:SOUTH CHINA UNIV OF TECH

Preparation method of binary polymer molecule brush heavy metal chelating agent

ActiveCN106430499ASolve poor precipitation effectSolve the incomplete precipitation defectWater contaminantsWater/sewage treatment by flocculation/precipitationCoordination sitePolysulfide
The invention relates to a preparation method of binary polymer molecule brush heavy metal chelating agent. The preparation method is characterized by comprising steps of dissolving 5-10 parts by weight of binary polymer molecule brush in 10-50 parts of water; stirring for 1-10 hours under 20-30 DEG C, and obtaining micellar solution of nanometer heavy metal chelating agent. The invention solves the defects that the settling effect of heavy metal ion is bad and the settlement is completed by micromolecule polysulfide; every molecular chain can provide hundreds and even thousands of coordination sites to match and crosslink with heavy metal ions, and thereby obtaining micron order to millimeter aggregation, and effectively settling and separating from water body. The generated aggregation is good in stability, not easy to decompose and generate the secondary pollution.
Owner:西安领伯环保科技有限公司

Inflammatory microenvironment responsive smart drug-loaded hydrogel and preparation method and application thereof

The invention provides an inflammatory microenvironment responsive smart drug-loaded hydrogel and a preparation method and application thereof. The preparation method for the inflammatory microenvironment responsive smart drug-loaded hydrogel comprises the following steps: a functional polymer containing ortho-hydroxyl reacts with phenylboronic acid containing amino or carboxyl to prepare a phenylboronic acid polymer; an amphiphilic drug carrier is prepared; the prepared amphiphilic drug carrier and a hydrophobic drug are dissolved with a good solvent, and then, water is added thereinto understirring to prepare a drug-loaded micellar solution; and the hydrophilic drug and the prepared phenylboronic acid polymer are dissolved in the prepared drug-loaded micellar solution, and then, the pHvalue of a mixed solution is regulated to 8-9 to prepare the smart drug-loaded hydrogel. The hydrogel responsively releases drugs through pH and reactive oxygen, and has the advantages that the preparation components are few and the synthesis operation is simple.
Owner:SICHUAN UNIV

Mitomycin double sustained release film of implanted antineoplastic agents and its preparation method

The invention discloses a double controlled release film agent of implanted antineoplastic agent mitomycin and a manufacturing method; the invention relates to a medicinal controlled release film agent. The invention provides a double controlled release film agent of implanted antineoplastic agent mitomycin, which relates to a medicinal controlled release film agent with high enveloping ratio, long continuous release duration, small incidence of burst release, few toxic and side effects, high medicine concentration on tumor lesions and low recrudescence probability of tumor, and a manufacturing method. The film agent includes mitomycin, polymer, lecithin, chitosan and collagen. The mitomycin and the lecithin are dissolved, lyophilized in order to obtain a colloidal mixture; the polymer is dissolved in organic solvent in order to obtain a polymer solution; the polymer solution is then added in the colloidal mixture in order to obtain a reverse micelle; the reverse micelle is further added to a polyvinyl alcohol solution, and an O / W latex is obtained by emulsification; the latex is lyophilized in order to obtain carrier micro-spheres; the collagen is dissolved in the acid solution in order to obtain a collagen solution; the chitosan is dissolved in the acid solution in order to obtain a chitosan solution; the collagen solution and the chitosan solution are mixed in order to obtain a collagen-chitosan mixture solution; finally the carrier micro-spheres are dispersed in the collagen-chitosan mixture solution which is then poured in a mould and dried.
Owner:XIAMEN UNIV

Method for using amphipathy hyperbranched polymer to prepare quantum dots

A method for using amphipathy hyperbranched polymer to prepare quantum dots in the technical field of photoelectric materials includes the following steps: dissolving hyperbranched polymer in chloroform and obtaining amphipathy unimolecule nanometer micellar solution after stirring; adding cadmium precursor water solution in the amphipathy unimolecule nanometer micellar solution and obtaining lower-layer chloroform solution through separation after stirring and standing; and after conducting nitrogen protection on the lower-layer chloroform solution, adding Na2S water solution to carry out secondary nitrogen protection, stirring under normal temperature, standing and separating and obtaining chloroform solution of CdS quantum dots. The synthesized CdS quantum dots have narrower dimension distribution and better stability, integrate the advantages of hyperbranched polymer and quantum dots, benefit the adjustment of mechanical, optical and electrical performances and other performances of quantum dots, and can be used for preparing photoelectric materials and the like.
Owner:SHANGHAI JIAO TONG UNIV

Method simultaneously extracting lipid and protein from corn plantule

The invention discloses a method for extracting grease and protein simultaneously from cereal germs, and pertains to the technical field of comprehensive utilization of agricultural byproducts. The method comprises the comprehensive utilization of technologies of reversed micellar extraction, ultrasonic-associated extraction, protein refining, grease refining, drying and so on. Cereal germs are sieved after crushing, added into reversed micellar solution, stirred or ultrasonic forward extracted and centrifugated to obtain forward extraction solution, and the forward extraction solution is processed by ultrasonic backward extraction and centrifugation, the upper layer is extracted by ethanol to remove a residual surfactant, a solvent is removed to obtain grease and after water, salt and the surfactant are removed from the lower layer, cereal germ protein product is obtained; or the solvent in the forward extraction solution is directly removed, protein in a residual solid substance is precipitated by a mixed solvent, and then washing and drying are carried out to obtain the cereal germ protein product. The method has simple technology and low cost, solves the problem that the traditional grease production causes damage to protein, improves reutilization value of cereal germ protein, and is an environmental friendly production method. The product has the advantages of high yield rate, high purity, low chemical modification and the like.
Owner:JIANGNAN UNIV

Cross-linked fluorine (methyl)-containing acrylic segmented copolymer and its preparation method and use

The invention discloses a cross-linked fluorine (methyl)-containing acrylic segmented copolymer and its preparation method and use, and belongs to the field of chemical materials. The preparation method comprises that various (methyl) acrylate functional monomers are copolymerized into the cross-linked fluorine (methyl)-containing acrylic segmented copolymer by an atom transfer radical polymerization (ATRP) method. A structure, molecular weight and molecular weight distribution of the cross-linked fluorine (methyl)-containing acrylic segmented copolymer can be controlled. The molecular weight of the cross-linked fluorine (methyl)-containing acrylic segmented copolymer is in a range of 10000 to 35000 and the molecular weight distribution is less than 1.4. The cross-linked fluorine (methyl)-containing acrylic segmented copolymer is mixed with a curing agent according to a certain ratio and the mixture self-assembles in a selective solvent so that a micellar solution having an average particle size of about 100 to 450nm is formed. Through a solvent evaporation film-forming method, the micellar solution is prepared into a super-hydrophobic coating film having a contact angle of more than 150 degrees, hardness H and second-level adhesion. The preparation method has simple and feasible operation processes, a low cost and a wide application prospect in the field of water-proofing and moisture-proofing coatings.
Owner:SOUTH CHINA UNIV OF TECH

Mesoporous metal oxides and processes for preparation thereof

A process for preparing a mesoporous metal oxide, i.e., transition metal oxide, Lanthanide metal oxide, a post-transition metal oxide and metalloid oxide. The process comprises providing a micellar solution comprising a metal precursor, an interface modifier, a hydrotropic ion precursor, and a surfactant; and heating the micellar solution at a temperature and for a period of time sufficient to form the mesoporous metal oxide. A mesoporous metal oxide prepared by the above process. A method of controlling nano-sized wall crystallinity and mesoporosity in mesoporous metal oxides. The method comprises providing a micellar solution comprising a metal precursor, an interface modifier, a hydrotropic ion precursor, and a surfactant; and heating the micellar solution at a temperature and for a period of time sufficient to control nano-sized wall crystallinity and mesoporosity in the mesoporous metal oxides. Mesoporous metal oxides and a method of tuning structural properties of mesoporous metal oxides.
Owner:UNIV OF CONNECTICUT

Supramolecular hydrogel gene vector material, and preparation method and application thereof

The invention discloses a supramolecular structural hydrogel gene vector material and a preparation method and application thereof. The method comprises the following operation steps: synthesizing a multi-block copolymer with cation chain segments through modification of a terminal group of triblock copolymer of a polyethylene glycol-polypropylene glycol-polyethylene glycol which is modified by polylysine; then, mixing the copolymer with DNA solution to obtain DNA compound micelle; further, mixing and then stirring the micelle solution and solution of alpha-cyclodextrin; and keeping mixed solution at the room temperature to obtain hydrogel. The hydrogel can be used for preparing an injectable gene vector. The method has the advantages that the method has simple operation, can adjust the strength of the hydrogel and the gelatination time, can mold at the room temperature and does not relate to chemical crosslinking reaction and the use of organic solvent; and the obtained hydrogel has the advantages of temperature sensitivity, good bio-compatibility, obvious transfection effect and the like; and the method is hopeful to be widely applied in the field of a biomedical engineering material.
Owner:SUN YAT SEN UNIV

Electrocatalyst and method of manufacturing the same

An electrocatalyst contains a conductive support which loads a noble metal thereon. In the electrocatalyst of the present invention, the noble metal is formed by adding a reducing agent for an ion of the noble metal to a reversed micellar solution containing an aqueous solution of the noble metal ion, and the noble metal is loaded with a mean particle diameter ranging from 1 to 10 nm.
Owner:NISSAN MOTOR CO LTD

Substrate surface structured with thermally stable metal alloy nanoparticles, method for preparing the same and uses thereof, in particular as catalyst

The invention relates to a method for preparing a substrate surface structured with thermally stable metal alloy nanoparticles. The method comprises providing a micellar solution of amphiphilic molecules such as organic diblock or multiblock copolymers in a suitable solvent; loading the micelles of said micellar solution with metal ions of a first metal salt; loading the micelles of said micellar solution with metal ions of at least one second metal salt; depositing the metal ion-loaded micellar solution onto a substrate surface to form a (polymer) film comprising an ordered array of (polymer) domains; co-reducing the metal ions contained in the deposited domains of the (polymer) film by means of a plasma treatment to form an ordered array of nanoparticles consisting of an alloy of the metals used for loading the micelles on the substrate surface.The invention also provides a nanostructured substrate surface obtainable by said method as well as the use of said nanostructured substrate surface as a catalyst.
Owner:MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV

Two-dimensional gold membrane self-assembly preparation method with surface enhanced Raman scattering effect

The invention relates to a two-dimensional gold membrane self-assembly preparation method with a surface enhanced Raman scattering effect, belonging to the preparation methods of two-dimensional gold membranes. The two-dimensional metal membrane with good stability, good signal repeatability and surface enhanced Raman scattering effect can not be prepared in the prior art. The method comprises the steps of: cleaning indium tin oxide glass, dipping into a phytic acid micellar solution, and assembling for 30min; diluting a 2.0ml 0.0010g m1-1 chloroauric acid solution with distilled water for 10times, stirring and heating to be boiled; dropping a 0.4m1, 1 percent sodium citrate solution, reacting for 45min at a temperature of 80 DEG C to prepare uniformly dispersed nano gold gel; and dipping the assembled indium tin oxide glass into the nano gold gel for 2h to prepare the two-dimensional gold membrane. The preparation method has the advantages of simple preparation method and low cost; and the prepared two-dimensional gold membrane has the advantages of stronger enhanced Raman scattering effect, good stability and long storage time.
Owner:SHANGHAI NORMAL UNIVERSITY

Method for coating II-VI group semiconductor quantum dots by silicane

The invention relates to a method of silane enwrapping II-VI semiconductor quantum dots. The invention comprises the preparation of the II-VI semiconductor quantum dots, inorganic enwrapping and silane enwrapping. The silane enwrapping of the II-VI semiconductor quantum dots comprises the steps that: dissolving polyoxyethylene nonyl phenyl ether into cyclohexane to form stable reversed micellar solution, then, adding trichloromethane solution of the II-VI semiconductor quantum dots which are inorganically enwrapped into the reversed phase micellar solution of the step a, then, adding gamma-mercaptopropyltrimethoxysilane, regulating the pH value range to 8.0-10.0, adding ethyl orthosilicate, then, functionalizing, and lastly, obtaining the II-VI semiconductor quantum dots which are wrapped by the silane and functionalized. The invention increases the stability of the quantum dots in buffering liquid through controlling the thickness of the quantum dots silane layer, the fluorescence can be kept well, the photobleaching and the optical quenching effect of the quantum dots can be reduced, the surface functionalization decoration of the quantum dots can be realized through selecting different functionalized radical, the biological application basis is provided after the quantum dots are dissolved in water, and the quantum dots which are treated by the saline can be the first choice in the application of thebiological fluorescence labeling field.
Owner:JIANGSU TIANCHENG BIOCHEM PROD

Fabric non-water dyeing method

ActiveCN107326700ADyeing is effectiveSave fadingDyeing processOrganic solventSURFACTANT BLEND
The invention relates to a fabric non-water dyeing method. The method comprises the following steps: pre-mixing a nonionic surfactant and a co-surfactant, dissolving the mixture into an organic solvent to prepare a reversed micelle solution; slowly adding an active dye solution into the reversed micelle solution, at the same time, stirring the solution until the turbid reversed micelle solution becomes clear to obtain a reversed micelle encapsulated active dye solution; soaking fabrics in the reversed micelle encapsulated active dye solution, vibrating the dye solution continuously to carry out adsorption dyeing at a constant temperature until a balance of adsorption dyeing is reached; adding a color fastening agent solution to obtain reversed micelle encapsulated fastening agent solution; and vibrating the solution continuously so as to fix the color of fabrics at a constant temperature. The fabrics are dyed by a one bath method based on a nonionic surfactant. The cost is reduced, and the dyeing effect is guaranteed. At the same time, an organic solvent is taken as the medium; the using amount of water is reduced, moreover, the organic solvent can be recovered effectively, and the environmental pollution is reduced.
Owner:THE HONG KONG POLYTECHNIC UNIV

Preparation method of supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent

InactiveCN105802106AEnd-groupUltraviolet
The invention relates to a preparation method of a supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent. The preparation method comprises the following steps of using a beta-cyclodextrin-modified thermo-sensitive copolymer (beta-CD-P(MEO2MA-co-OEGMA)) as a host molecule, and using an azobenzene-terminated amphiphilic blocking copolymer (Azo-PCL-SS-PEG) as a guest molecule, and building a supermolecular assembly with a mutual electrostatic action of the host molecule and the guest molecule; using a sulfonation and bromination product of the beta-cyclodextrin to initiate ATRP (atom transfer radical polymerization) reaction, so as to obtain the host molecule; using chain-extended 4-hydroxyazobenzene to open a loop of caprolactone, and performing a two-step esterification reaction, so as to obtain the guest molecule; respectively dissolving the host molecule and the guest molecule into water, and uniformly mixing, so as to obtain a supermolecular self-assembly micellar solution. The preparation method has the advantages that by applying outside irritation to the system, the shape and size of the micelle can be reversibly and controllably transformed; the application prospect in the fields of medicine loading and controllable release, biological intelligent switches, nanometer intelligent reactors and the like is wide.
Owner:TONGJI UNIV

Compound clobetasol propionate mixed micellar solution and preparation method thereof

The invention provides a compound clobetasol propionate mixed micellar solution. Phosphatide and cholate are mainly utilized to prepare the mixed micellar solution which is used for packaging clobetasol propionate and tretinoin. The mixed micelle solution can be simply prepared, and the medicament stability can be guaranteed in the process of preparation. By preparing a mixed micelle system from the phosphatide and the cholate, the problem of medicament dissolution is solved. Compared with a common ointment, the mixed micelle solution has a higher retention volume on skins, and the quantity of the medicament on local skins and the therapeutic index can be increased. The mixed micelle solution can be further prepared into an ointment and a gel, and is mainly used for treating psoriasis vulgaris, dermatitis, eczema, etc.
Owner:JIANGSU SEMPOLL PHARMA
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