57 results about "Micellar solutions" patented technology

The present invention relates to the field of oilfield chemical technology, and proposes a fast-soluble hydrophobic associating polymer for reinjection water for fracturing and a preparation method thereof. Hydrophobic functional monomers and non-ionic polarity regulators are prepared into polymerizable hydrophobic associating micelles, and the polymerizable hydrophobic associating micelle solution and conventional monomer aqueous solution are mixed. The molecular weight of the copolymer is regulated by a molecular weight regulator, and the fast-soluble hydrophobic associating polymer for reinjection water is obtained after reaction, granulation, drying and crushing. It comprehensively utilizes the synergistic effect of the multi-component supramolecular forces of the ternary hydrophobic functional monomers to achieve stability regulation of the associating micelles, and obtains a three-dimensional network structure of salt-resistant polymers with a dense associating network and a strong associating effect; introduces a polarity regulator containing a non-ionic hydrophilic structure, and utilizes self-assembly to form a hydration layer on the surface of the associating micelles, thereby weakening the water-phase aggregation effect and ion shielding effect of the hydrophobic structure, which is beneficial to the stretching of the molecular chain in the water phase, and obtaining the online mixing and fast-dissolving efficiency of the reinjection water, and having both high salt resistance and strong sand carrying performance.

The invention relates to the technical field of oilfield chemistry, and provides a reinjection water instant hydrophobic association polymer for fracturing and a preparation method thereof. The preparation method comprises the following steps: preparing a polymerizable hydrophobic association micelle from a hydrophobic functional monomer and a nonionic polarity regulator, mixing the polymerizable hydrophobic association micelle solution with a conventional monomer aqueous solution, regulating the molecular weight of the copolymer by a molecular weight regulator, reacting, granulating, drying and crushing to obtain the reinjection water instant hydrophobic association polymer. By comprehensively utilizing the synergistic effect of multi-element supramolecular force of a ternary hydrophobic functional monomer, the stability of associated micelles is regulated and controlled, and a salt-resistant polymer three-dimensional network structure with a dense association network and a strong association effect is obtained; a polarity regulator containing a nonionic hydrophilic structure is introduced, a hydration layer is formed on the surface of associated micelles by utilizing a self-assembly effect, a water phase aggregation effect and an ion shielding effect of a hydrophobic structure are weakened, stretching of a molecular chain in a water phase is facilitated, online mixing instant efficiency of reinjection water is obtained, and high salt resistance and strong sand-carrying performance are achieved.

The invention relates to the field of inorganic material preparation, and provides a bismuth hydroxide material and a preparation method thereof. The bismuth hydroxide is sphere-like nano-particles with the particle size of 85-175 nm, the dispersity is good, and the purity exceeds 99.8%. The preparation method comprises the following steps: preparing a micelle solution from a polyethylene glycol-polylactic acid (PEG-PLA) block copolymer, adding bismuth salt into the micelle solution, carrying out a reaction, and carrying out centrifugation, washing and vacuum drying to obtain the product. Due to the unique amphipathy of the PEG-PLA micelle, bismuth ions are uniformly distributed, and the uniformity of particles is improved; the hydrophilic chain segment forms steric hindrance to inhibit particle aggregation; meanwhile, the reaction rate is slowed down, and high-concentration ammonia water is combined to ensure high purity of the product. The method overcomes the problems of uneven particle size and agglomeration in traditional preparation.

The invention belongs to the field of luminescent materials, and relates to stimuli-responsive self-repairing fluorescent hydrogel. In particular to stimuli-responsive self-repairing fluorescent hydrogel as well as a preparation method and anti-counterfeiting application thereof. According to the method, firstly, hydrophobic anthryl fluorophore 9-anthracene methyl methacrylate is wrapped by an aggregate formed by a surfactant hexadecyl trimethyl ammonium chloride to form micelles, and then, a micelle solution and polymer monomers acrylic acid and zirconium chloride are subjected to free radical-initiated copolymerization to obtain the stimuli-responsive fluorescent hydrogel. The hydrogel has self-repairing capability and fluorescence stimulation response capability, and is expected to be applied to the fields of bionic intelligent materials and information.

The invention discloses a polymer material, a drug-loaded micelle solution, a drug-loaded micelle composite hydrogel, and a preparation method and application of the drug-loaded micelle composite hydrogel. The polymer material is obtained by reacting oxidized dextran and oleylamine; wherein the oxidized dextran is obtained by oxidizing dextran with the molecular weight of 35000 to 45000; the oxidation degree of the oxidized dextran is 55-70%; the mass ratio of the oxidized dextran to the oleylamine is 1: (1.2-2.0). The polymer material provided by the invention can form a micelle as a carrier to entrap a hydrophobic drug, such as prednisolone. The drug-loaded micelle composite hydrogel provided by the invention can be used for treating inflammatory bowel disease IBD, can avoid damage of an acid environment to a greater extent, and prolongs the administration time.

The method comprises the following steps: dissolving lipoic acid and a drug in an organic solvent to form a homogeneous solution, dropwise adding deionized water while stirring, then adding a reducing agent, initiating lipoic acid polymerization and drug co-assembly in situ at 20-40 DEG C to form a drug-loaded micelle solution, and carrying out freeze drying on the drug-loaded micelle solution to obtain the nano-preparation drug based on polylipoic acid. And dialyzing and purifying to obtain the nano preparation medicine based on polylipoic acid. The preparation method is characterized in that lipoic acid has dual characteristics of a drug carrier matrix and a dynamic crosslinking monomer, carrier synthesis and efficient drug encapsulation are synchronously realized through one-step in-situ polymerization-co-assembly, and the technical bottleneck that a traditional nano-carrier needs pre-synthesis and step-by-step drug loading is broken through. The method has the following practicability: (1) the process is simple and efficient, complex equipment is not needed, and reaction conditions are mild; (2) the drug loading performance is excellent, and the particle size is uniform and adjustable (50-300 nanometers); (3) a polylipoic acid skeleton endows the nano-drug preparation with environmental responsiveness, and intelligent drug release can be realized; and (4) the method is suitable for hydrophobic drugs and compound preparations. The method provides a high-load, high-stability and stimuli-responsive nanocrystallization solution for hydrophobic drug delivery, and has application value in the field of nano-medicines.

The invention relates to an MPL composite adjuvant and a preparation method thereof, and belongs to the technical field of vaccine adjuvants. The composite adjuvant comprises neutral phospholipid, anionic phospholipid, cholesterol, monophosphoryl lipid A, QS-21 and surface modified lipid. The preparation method comprises the following steps: dissolving a lipid component in an organic solvent to form a mixed solution, evaporating the solvent to form a lipid film, adding a buffer solution, hydrating to form a liposome suspension, performing ultrasonic treatment to obtain small single-layer liposome, and mixing the small single-layer liposome with a QS-21 micelle solution. By introducing the surface modified lipid, the stability of the adjuvant is remarkably improved, the adjuvant is small in particle size, uniform in distribution, high in Zeta potential negative value and good in stability in a serum environment, can induce high-level antibody immune response, and is suitable for vaccine development.

The invention relates to the field of stem cell biomedicine, and provides a stem cell biological preparation, a preparation method and application of the preparation as a rhinitis treatment medicine in order to solve the problem that when a Syk inhibitor is independently used, the recovery time of rhinitis is long, and the preparation method comprises the steps that S100, a lipidosome entrapped with the Syk inhibitor is prepared through a film dispersion method; s200, mixing the monoclonal antibody with N-hydroxysuccinimide ester according to a molar ratio of 1: (20-40), and obtaining a micelle solution through an incubation process; s300, mixing the liposome and the micelle solution according to a volume ratio of (40-70): 1 to obtain a first effective preparation; and S400, mixing the first effective preparation with the stem cell solution to obtain the stem cell biological preparation. Through cooperation of the Syk inhibitor and the stem cell repair function, the rhinitis recovery effect is improved, the Syk inhibitor is coated with the isolation layer, the action time and the action position of the Syk inhibitor are regulated and controlled, and the influence on the stem cells is reduced; due to modification of the lipidosome, the lipidosome has targeting property, and the influence on the stem cells can be reduced.

The invention discloses a graphene asphalt modifier based on a micelle coating technology and a preparation method thereof, and belongs to the technical field of road materials. The modifier is prepared from reduced graphene oxide (rGO) serving as a core function phase, a micelle coating phase (compounded by polystyrene-polyoxyethylene block copolymer and ionic liquid) and an auxiliary modification phase (nano silicon dioxide and a silane coupling agent) according to the mass ratio of 10: (30-50): (5-10). The preparation method comprises the following steps: preparation and reduction of graphene oxide, preparation of an amphiphilic micelle solution, preparation of micelle-coated rGO composite particles and compounding of an auxiliary modified phase. The modifier can significantly improve the dispersibility and compatibility of graphene in asphalt, effectively prevent agglomeration, and synchronously improve the high and low temperature performance, aging resistance, water damage resistance and self-ice-melting performance of asphalt. The process is simple and convenient, is compatible with an existing asphalt production line, and is suitable for high-grade pavement engineering.

The invention discloses a double-drug-loading cationic mixed micelle as well as a preparation method and application thereof, and belongs to the field of pharmaceutics. The micelle is composed of a cationic polymer PEI-stearamide (PSA), an amphiphilic polymer DSPE-PEG2000, a hydrophobic drug resveratrol (RES) and a hydrophilic drug catalase (CAT). The preparation method comprises the following steps: 1) synthesizing PSA; the preparation method comprises 1, dissolving RES, PSA and DSPE-PEG2000 in an organic phase, injecting the obtained solution into a water phase, and carrying out rotary evaporation to obtain RES-loaded micelle (RES / PSA-PEG), and 3, adding a CAT solution to the micelle solution in a dropwise manner to obtain co-loaded micelle (RES / PSA-PEG / CAT). The micelle can effectively penetrate a corneal barrier and target a retinal pigment epithelial layer and a choroidal membrane.Through eye drop administration, RES anti-oxidation and anti-inflammatory effects and CAT hydrogen peroxide removal effects can be synergistically exerted, and an AMD curative effect can be substantially enhanced.

The application discloses a kind of ceramic artificial bone materials and preparation method thereof, belong to ceramic material preparation technical field.The method is constructed amphiphilic micellar system by PEG-PLA block copolymer, first preparation micellar solution, then it is used for precursor slurry preparation and PLGA pore former pretreatment (solve compatibility and agglomeration problem) in stages, after forming and drying, by gradient sintering (low temperature to aid agent, high temperature promotes densification) obtain product.The application solves the problem that pore former and precursor are compatible in traditional process, powder agglomeration, pore structure is uneven, and the obtained material has three-dimensional connected and uniformly distributed micropore structure, and uniform composition.

The invention discloses an intestinal targeted controlled-release microalgae pharmaceutical composition which comprises a hydrophobic drug, a micelle material and microalgae, the solubility of the hydrophobic drug is improved by loading the hydrophobic drug on the micelle material to form drug-loaded micelles, and the drug-loaded micelles permeate into microalgae cells through the passive water absorption process of the dried microalgae, so that the drug-loaded micelles are formed, the solubility of the hydrophobic drug is improved, and the intestinal targeted controlled-release microalgae pharmaceutical composition is prepared. The coating is not attached to the surface of the microalgae. The solid and acid-resistant natural cell wall of the microalgae is used as a first physical barrier to prevent the release of the hydrophobic drug in a gastric acid environment, and the effective concentration and residence time of the hydrophobic drug in an intestinal action part are remarkably improved, so that the treatment effect is better played, and the microalgal polysaccharide can be used for preparing drugs for treating intestinal diseases and nephropathy.

This invention relates to the field of graphite anode material technology, specifically disclosing a surface-coated natural graphite, its preparation method, and its applications. The surface-coated natural graphite comprises a negatively charged natural spherical graphite core, which is coated with a positively charged micelle solution. A negatively charged MOF is grown on the positively charged micelles through electrostatic adsorption and crystal orientation induction. After curing and drying, a hard carbon source is coated on top, and high-temperature calcination is performed to prepare a natural spherical graphite core, an onion-like carbon framework and a nanocrystalline intercalation structure, an electrostatically coupled intermediate layer, and a hard carbon shell. The graphite anode material of this invention achieves optimized ion diffusion channels, optimized conductive networks, and expanded lithium intercalation sites. This structure significantly improves cycle life and specific capacitance, making it suitable for long-life lithium batteries.

A cosmetic composition in the form of a solidified gel comprising: (a) about 0.5 wt.% or more of gellan gum; (b) one or more polyols having from 2 to 10 carbon atoms; (c) one or more surfactants; and (d) water. The cosmetic composition is useful in methods for topically treating and cleansing the body, for example, the skin. Also described is a cosmetic kit having a container and a shaving cap. The container comprises interior chamber containing a solidified gel of a micellar solution and a dispensing opening that exposes an outer surface of the solidified gel. The cosmetic kit is particularly useful for hygienically cleansing the skin.

The invention discloses a preparation method for forming a mesoporous material by stacking CdS nanosheets. The preparation method comprises the following steps: S1, adding a long-chain amine template agent into a proper amount of ethanol to obtain a solution A; s2, preparing a solution B based on a cadmium source precursor; s3, mixing the solution A and the solution B, and stirring to form a micelle solution; s4, adding a sulfur source into the micelle solution obtained in S3, and stirring; s5, stirring or transferring a product obtained in the S4 into a reaction kettle with a polytetrafluoroethylene lining for reaction and cooling; and S6, centrifugally collecting solids, washing with water, washing with ethanol, and drying in vacuum to obtain the CdS nanosheet material. Compared with the prior art, the method disclosed by the invention has the advantages that the obtained CdS ultrathin nanosheet shows different catalytic activities in the process of reducing carbon dioxide into reaction gas under an illumination condition.

An article is contacted with a micellar solution, antibacterial compound and binder, dried and then treated with water repellent. Preferably the solution comprises saponin and the binder comprises pol

The invention discloses a stable vitamin K1 micelle solution and a preparation method thereof, the vitamin K1 micelle solution comprises 0.75%-1.25% of vitamin K1, 5%-6% of egg yolk lecithin or soybean lecithin, 5.5%-6.5% of polyethylene glycol 1000 vitamin E succinate, a pH regulator and water for injection, and the pH value of the micelle solution is 4.5-6.5. According to the invention, phospholipid and polyethylene glycol 1000 vitamin E succinate (TPGS) are selected as emulsifiers, so that the dissolution of vitamin K1 is solved, the degradation of vitamin K1 is avoided, and the stability of the product is improved; according to the invention, the polyethylene glycol 1000 vitamin E succinate (TPGS) is used, the tocopherol structure of the TPGS has a relatively strong antioxidant function, the content of related impurities of the vitamin K1 is remarkably reduced, and the vitamin K1 has better stability; by controlling the particle size of the micelle to be 65-80 nm, the obtained solution is milky white to faint yellow, and the influence of illumination on the stability of the product is avoided.

The invention relates to a multi-effect synergistic pharmaceutical composition for bone repair and a preparation method thereof, and belongs to the technical field of biological medicine, the pharmaceutical composition comprises five-black chicken yolk peptide, tegillarca granosa peptide, epimedium extract and rhizoma drynariae extract. The five-black chicken egg yolk peptide is obtained by carrying out enzymolysis on five-black chicken egg yolk freeze-dried powder by lipase and trypsin, then carrying out enzymolysis by ficin and bromelain, and then sequentially purifying by a macroporous adsorption resin column and a phenyl agarose gel column. The tegillarca granosa peptide is obtained by fermenting tegillarca granosa meat through bacillus marinus; the herba epimedii extract is obtained by purifying an upper phase extracted from herba epimedii powder through an aqueous two-phase system through a sephadex chromatographic column; the rhizoma drynariae extract is obtained by performing enzymolysis on rhizoma drynariae powder with cellulase, extracting with a sodium dioctyl sulfosuccinate-isooctane reverse micelle solution, taking an upper organic phase, breaking micelles, taking a lower water phase and performing ultrafiltration. The four components are matched according to a specific proportion to realize multi-effect regulation of promoting formation, inhibiting bone resorption and regulating hormone.

The invention relates to the technical field of new nano materials, and discloses a liquid colloid photonic crystal, a photonic crystal film and a preparation method and application of the liquid colloid photonic crystal film. The liquid colloid photonic crystal is a composite micelle solution containing a plurality of composite micelles which are uniform in size and are arranged in order; the composite micelle is of a liquid core / stretched shell structure; the stretching shell layer is a two-block polymer, and the material of the liquid core is a liquid which has selectivity to the two-block polymer and can be separated from a solvent of the composite micelle solution. The preparation method comprises the following steps: preparing a composite micelle of a liquid core / stretching shell layer by self-emulsifying a two-block polymer; the special structure of the composite micelle does not change the property of the micelle brush layer, and the refractive index of the system is effectively increased; the size of the liquid core can be regulated and controlled by regulating the content of the liquid in the composite micelle; by adjusting the concentration of the composite micelle, the dynamic fusion and splitting of the composite micelle can be adjusted, the dynamic regulation and control of the liquid photonic crystal are realized, and the liquid colloid photonic crystals with different structural colors are obtained.

The invention discloses a preparation method of a toughness and conductivity synergistically enhanced high-performance hydrogel wearable sensor based on hydrophobic association, which comprises the following steps: mixing a gelatin aqueous solution with MXene, and then adding lauryl sodium sulfate, NaCl and octadecyl methacrylate to prepare a micelle solution; adding acrylamide into the micelle solution, stirring and cooling, and then adding ammonium persulfate, N, N '-methylene bisacrylamide and N, N, N', N '-tetramethylethylenediamine; and finally, transferring the solution into a mold, and carrying out gelation reaction at room temperature. Therefore, the high-performance hydrogel with synergistically enhanced toughness and conductivity based on hydrophobic association is obtained. The gelatin / polyacrylamide / MXene hydrogel is obtained by introducing micelles into the hydrogel, utilizing a hydrophobic association method and adopting thermal initiation polymerization, and the gelatin / polyacrylamide / MXene hydrogel has the advantages of simple process, easiness in operation, controllable reaction conditions, high sensing sensitivity and large strain monitoring range, and can be applied to various occasions.

This invention discloses a cerium sulfosalicylate sulfonate for use as a coal combustion catalyst, its preparation method, the catalyst itself, and its applications. The preparation method includes: S10, mixing cerium nitrate and sulfosalicylic acid dihydrate with water to obtain a cerium sulfosalicylate complex solution; S20, adding the cerium sulfosalicylate complex solution to a first reverse micelle solution to obtain a first mixed solution, then adding n-butanol in batches to obtain a first microemulsion; S30, adding ammonia to a second reverse micelle solution, then adding n-butanol in batches to obtain a second microemulsion; S40, mixing the first and second microemulsions and stirring to obtain a pale blue, opalescent colloidal solution, thus obtaining a second mixed solution; S50, drying and grinding the second mixed solution to obtain cerium sulfosalicylate. This cerium sulfosalicylate coal combustion catalyst is easily dispersed and can catalyze the pyrolysis and oxidation processes of coal from within, improving the utilization rate and calorific value of coal.

The invention relates to emulsion polymerization chloride ion doped PEDOT nanoparticles as well as a preparation method and application thereof. The preparation method comprises the following steps: adding dodecyl trimethyl ammonium chloride into water, and uniformly stirring to obtain a micelle solution; adding EDOT into the micelle solution, and stirring to form an emulsion; under a stirring condition, dropwise adding an oxidant solution into the emulsion; after dropwise adding the oxidant solution, carrying out emulsion polymerization reaction to obtain a mixture; and S5, carrying out solid-liquid separation, washing and drying on the mixture to obtain the chloride ion doped PEDOT nano-particles. According to the invention, the cationic surfactant dodecyl trimethyl ammonium chloride is used as an emulsifier and a dopant, the formed micelle wraps the EDOT, so that the reaction can be carried out in a water phase, the high-performance pure chloride ion doped PEDOT can be prepared through emulsion polymerization reaction, the method process is simple, the requirement on equipment is low, and the synthesized PEDOT has good conductivity.

The application is suitable for the technical field of hard carbon preparation, and provides a synthesis method of high-crystallinity hard carbon based on intermolecular hydrogen bond, which comprises the following steps: dispersing PEA solution in aqueous solution to obtain micellar dispersion liquid; weighing a proper amount of glucose and dissolving the glucose in water to obtain a glucose precursor solution; adding the micellar dispersion liquid into the glucose precursor solution drop by drop to form a complex micellar solution; performing hydrothermal treatment on the complex micellar solution to obtain a pre-carbonization precursor; cleaning the pre-carbonization precursor with water and ethanol alternately, and placing the pre-carbonization precursor in an oven to dry overnight; and placing the dried sample in a crucible to anneal under a nitrogen atmosphere, so that the hard carbon ball with adjustable crystallinity is obtained. The application realizes accurate control of the structure and composition of the precursor at the molecular level, and improves the crystallinity of the hard carbon; by freezing the carbon atom before migration, it is ensured that the carbon atom will not migrate a lot in the subsequent carbonization process, so that the relative order of the carbon structure is ensured.

The invention discloses a hydrogel bioelectronic device and a preparation method thereof, and belongs to the technical field of high polymer materials. The preparation method of the polyacrylate anti-swelling hydrogel comprises the following steps: mixing a hydrophilic acrylate monomer, a hydrophobic or amphiphilic acrylate monomer and water to obtain a micelle solution; or mixing an amphiphilic acrylate monomer with water to obtain a micelle solution; adding a photoinitiator into the micelle solution, and uniformly dispersing to obtain a hydrogel precursor solution; the hydrogel precursor solution is subjected to ultraviolet light curing firstly, then dialysis is conducted, and finally the polyacrylate anti-swelling hydrogel is obtained. The hydrogel disclosed by the invention has good anti-swelling performance, high flexibility, high stretchability and good biocompatibility, and a bioelectronic device prepared based on the anti-swelling hydrogel can be implanted in a living body for a long time without causing immune response.

The present invention discloses a preparation method of a nitrogen and phosphorus co-doped three-dimensional porous carbon material, comprising the following steps: pretreating aniline; preparing an aniline phytate micelle solution; preparing an oxidant solution; respectively cooling the prepared solutions for standby; rapidly dropping the cooled oxidant solution into the cooled aniline phytate micelle solution, and continuously reacting for a period of time under low-temperature conditions to obtain a polyaniline hydrogel; collecting the obtained sample using a dialysis bag with a molecular weight cut-off of 8000-14000, and repeatedly washing with deionized water, with a total of three dialysis washes, each dialysis for one day; vacuum freeze-drying the sample obtained from the dialysis bag to obtain a polyaniline aerogel; pyrolyzing the polyaniline aerogel in a reducing atmosphere of a mixed gas of argon and hydrogen using a rapid heating furnace to obtain the nitrogen and phosphorus co-doped three-dimensional porous carbon material. The present invention can prepare a nitrogen and phosphorus co-doped three-dimensional porous carbon material with regular structure and multi-level pores.

The application belongs to the technical field of electrode materials, and discloses a two-dimensional mesoporous nanosheet composite, a preparation method and application thereof, and the composite comprises single-layer uniform spherical mesoporous structures regularly arranged on two sides of MXene nanosheets, and the method comprises the following steps: (1) preparing a single-micelle solution; (2) preparing a 2-5 mg / mL MXene@micelle single-micelle superstructure alcohol solution; (3) preparing a composite of MXene@micelle single-micelle wrapped by polydopamine; (4) preparing a two-dimensional mesoporous nanosheet composite constructed by spherical mesoporous units; and application of the two-dimensional mesoporous nanosheet composite to batteries. The application greatly improves the specific surface area of the two-dimensional mesoporous nanosheet composite, increases active sites of chemical reactions, can provide better material transmission channels, and has fast mass transfer kinetics; and the assembled aqueous zinc ion battery has high discharge specific capacity and stable long cycle performance.

The invention discloses polyacrylate anti-swelling hydrogel, a preparation method thereof, a bioelectronic device and application, and belongs to the technical field of high polymer materials. The preparation method of the polyacrylate anti-swelling hydrogel comprises the following steps: mixing a hydrophilic acrylate monomer, a hydrophobic or amphiphilic acrylate monomer and water to obtain a micelle solution; or mixing an amphiphilic acrylate monomer with water to obtain a micelle solution; adding a photoinitiator into the micelle solution, and uniformly dispersing to obtain a hydrogel precursor solution; the hydrogel precursor solution is subjected to ultraviolet light curing firstly, then dialysis is conducted, and finally the polyacrylate anti-swelling hydrogel is obtained. The hydrogel disclosed by the invention has good anti-swelling performance, high flexibility, high stretchability and good biocompatibility, and a bioelectronic device prepared based on the anti-swelling hydrogel can be implanted in a living body for a long time without causing immune response.

The invention discloses a preparation process of vitamin K1 injection mixed micelles, which belongs to the technical field of pharmaceutical preparations, and comprises the following preparation steps: under the protection of inert gas, taking part of water for injection, adding glycocholic acid, stirring and dispersing; s2, under the stirring condition, soybean lecithin and vitamin K1 in the prescription dosage are added into the solution obtained in the S2 at the same time, the stirring rotating speed is controlled to be 800-1000 rpm, and stirring is continuously conducted till the solution becomes a uniform and clear micelle solution; supplementing the water for injection to full dose, and adjusting the pH value of the system to 5.5-6.5 by using a sodium hydroxide solution; performing sterile filtration on the liquid medicine obtained in the step S4 through a 0.22 mu m filter membrane; and filling the filtered liquid medicine into a sealed container under the protection of inert gas, and carrying out terminal sterilization. The process parameters are clear and easy to control, key quality control points are clear, the process transfer and amplification process from laboratory test to industrial mass production is stable and reliable, and batch-to-batch consistency is high.

Provided herein are micellar solutions comprising a plurality of artificial casein micelles, wherein the artificial casein micelles comprise; a. one or more α-caseins, and one or more κ-caseins, and are substantially free of β-caseins, wherein the one or more κ-caseins have at least 80% sequence identity to SEQ ID NO: 2, provided the one or more κ-caseins have no more than one cysteine residue; or b. one or more phosphorylated β-caseins, and one or more dephosphorylated β-caseins, and are substantially free of α-caseins and κ-caseins; and methods for producing such micellar solutions, with applicability in the manufacture of substitute dairy products.

The application discloses an intestinal-targeted controlled-release microalgae pharmaceutical composition, which comprises a hydrophobic drug, a micellar material and microalgae, wherein the hydrophobic drug is first loaded on the micellar material to form a drug-loaded micelle, the solubility of the hydrophobic drug is improved, and the drug-loaded micelle solution penetrates into the interior of the microalgae cells through a passive water absorption process of dried microalgae instead of being attached to the surface of the microalgae. The natural cell wall of the microalgae itself is solid and acid-resistant, which is used as a first physical barrier to prevent the release of the hydrophobic drug in a gastric acid environment, and the effective concentration and residence time of the hydrophobic drug in the intestinal action site are significantly improved, so that the treatment effect is better, and the intestinal disease and kidney disease drug can be prepared.