Mitomycin double sustained release film of implanted antineoplastic agents and its preparation method

A technology of drug mitomycin and double sustained release, which is applied in the direction of antitumor drugs, drug combinations, non-active components of polymer compounds, etc. problem, to achieve the effect of improving burst release phenomenon, easy repeatability, and delaying biodegradability

Inactive Publication Date: 2008-06-25
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, to design an ideal chemotherapeutic drug implant, the problems that need to be solved are: 1) the drug loading of the preparation is small; 2) the sustained drug release time is short; 3) the problem of drug burst release and post-burst release

Method used

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  • Mitomycin double sustained release film of implanted antineoplastic agents and its preparation method
  • Mitomycin double sustained release film of implanted antineoplastic agents and its preparation method

Examples

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Effect test

Embodiment 1

[0038] Take 40g of collagen stock solution (collagen solid content 1.25%), dissolve in 0.1% acetic acid solution, stir well, and prepare collagen solution; take 125mg of chitosan (molecular weight 400,000, degree of deacetylation 85%) stirring in the acetic acid solution to prepare a chitosan solution; mixing the collagen solution and the chitosan solution and stirring evenly to prepare a collagen-chitosan solution for later use. Dissolve 300 mg of lecithin in 5.0 ml of DMSO, dissolve 60 mg of mitomycin in 1.0 ml of DMSO, mix the two, and lyophilize to obtain a gel-like mixture. Dissolve 600 mg of PLA with a molecular weight of 50,000 in 10 ml of dichloromethane, and add the PLA solution dropwise to the colloidal mixture under stirring conditions to form a uniform reverse micellar solution; Slowly inject 45ml of 0.5% PVA solution to make O / W emulsion. Stir the O / W emulsion at room temperature for more than 6 hours to volatilize the organic solvent, centrifuge, and freeze-dry ...

Embodiment 2

[0041] Take 20g of collagen stock solution (collagen solid content 1.25%), dissolve in 0.3% malonic acid solution, stir well, and prepare collagen solution; get chitosan (molecular weight: 400,000, degree of deacetylation: 85%) stirring in 1% acetic acid solution to prepare a chitosan solution; mixing the collagen solution and the chitosan solution and stirring evenly to prepare a collagen-chitosan solution for later use. Dissolve 100 mg of lecithin in 5.0 ml of DMSO, dissolve 10 mg of mitomycin in 0.5 ml of DMSO, mix the two, and lyophilize to obtain a gel-like mixture. Dissolve 300 mg of PLA with a molecular weight of 5000 in 6 ml of dichloromethane, and add the PLA solution dropwise to the colloidal mixture under stirring to form a uniform reverse micellar solution; ultrasonicate the gained reverse micellar solution in an ice bath (200w, Slowly inject 30ml of 0.5% PVA solution under the condition of 60s) to prepare O / W emulsion. Stir the emulsion at room temperature for mo...

Embodiment 3

[0043] Take 60g of collagen stock solution (collagen solid content 1.25%), dissolve in 0.1% acetic acid solution, stir well, and prepare a collagen solution; take 125mg of chitosan (molecular weight 500,000, degree of deacetylation 85%) stirring in the acetic acid solution to prepare a chitosan solution; mixing the collagen solution and the chitosan solution and stirring evenly to prepare a collagen-chitosan solution for later use. Dissolve 200 mg of lecithin in 5.0 ml of DMSO, dissolve 30 mg of mitomycin in 1.0 ml of DMSO, mix the two, and lyophilize to obtain a gel-like mixture. Dissolve 500 mg of PLGA with a molecular weight of 30,000 in a mixture of 10 ml of dichloromethane and acetone (volume ratio 3:1), and add the PLA solution dropwise to the colloidal mixture under stirring conditions to form a uniform reverse micellar solution; The obtained reverse micellar solution was slowly injected into 45 ml of 0.5% PVA solution under the stirring condition of 6000 r / min to prepa...

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Abstract

The invention discloses a double controlled release film agent of implanted antineoplastic agent mitomycin and a manufacturing method; the invention relates to a medicinal controlled release film agent. The invention provides a double controlled release film agent of implanted antineoplastic agent mitomycin, which relates to a medicinal controlled release film agent with high enveloping ratio, long continuous release duration, small incidence of burst release, few toxic and side effects, high medicine concentration on tumor lesions and low recrudescence probability of tumor, and a manufacturing method. The film agent includes mitomycin, polymer, lecithin, chitosan and collagen. The mitomycin and the lecithin are dissolved, lyophilized in order to obtain a colloidal mixture; the polymer is dissolved in organic solvent in order to obtain a polymer solution; the polymer solution is then added in the colloidal mixture in order to obtain a reverse micelle; the reverse micelle is further added to a polyvinyl alcohol solution, and an O/W latex is obtained by emulsification; the latex is lyophilized in order to obtain carrier micro-spheres; the collagen is dissolved in the acid solution in order to obtain a collagen solution; the chitosan is dissolved in the acid solution in order to obtain a chitosan solution; the collagen solution and the chitosan solution are mixed in order to obtain a collagen-chitosan mixture solution; finally the carrier micro-spheres are dispersed in the collagen-chitosan mixture solution which is then poured in a mould and dried.

Description

technical field [0001] The invention relates to a slow-release film preparation for medicine, in particular to an implantable anti-tumor drug mitomycin double slow-release film preparation for preventing postoperative recurrence of malignant solid tumors and a preparation method thereof. Background technique [0002] Among the various treatments for malignant tumors, drug chemotherapy still occupies an extremely important position. However, due to the difficulty of new drug development, long cycle, high cost, and slow progress, secondary development of existing anti-tumor drugs by changing dosage forms, especially controlled-release preparations, has become a new era in the field of anti-tumor drug research and development in recent years. One of the hotspots. Therefore, some developed countries in the world have given great attention and huge investment to the development of new formulations of antineoplastic drugs. [0003] Sustained release drugs (sustained release drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/407A61K47/42A61K47/34A61P35/00
Inventor 张其清王倩王衍戈侯振清叶社房
Owner XIAMEN UNIV
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