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140results about How to "Reduce biodegradation" patented technology

Bone graft material incorporating demineralized bone matrix and lipids

One embodiment of the invention is demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty acids. The putty composition is moldable, biocompatible, slowly resorbable, insoluble in tissue fluids, and non-extrudable. The composition delivers a biologically active product to animals and humans that will enhance bone formation at sites where bone is lost, deficient, or present in suboptimal amounts. The composition can further comprise calcium, an antioxidant such as Vitamin E or Vitamin C, or a hydrophilic polymer such as methylcellulose, a methylcellulose derivative, carboxymethyl cellulose, or hydroxypropyl methylcellulose. A second embodiment of the invention is a demineralized bone paste composition comprising: (1) about 15% to about 75% of an emulsion carrier, such as an aqueous phase; and (2) a bone-material-containing phase comprising: (a) demineralized bone matrix (DBM); and (b) an emulsifier component that is compatible with lipids. This bone paste composition is moldable, biocompatible, slowly resorbable, miscible with bone graft materials, soluble or partially soluble in tissue fluids, and extrudable.
Owner:BIOMET MFG CORP

Hyperbranched polyamino acid, preparation method and application thereof

The invention relates to hyperbranched polyamino acid. The chemical composition is as follows: in the formula of (Lys-)a-(-Arg-)b-(-His-)c-(-X)d, Lys, Arg and His are respectively lysine, arginine and histidine, X is one of or a plurality of any amino acids except for the amino acids above, wherein a is not less than 0.2 and not more than 0.95, b is not less than 0 and not more than 0.8, c is not less than 0 and not more than 0.8, d is not less than 0 and not more than 0.3, and the sum of a, b, c and d is 1. The preparation method is as follows: uniformly mixing lysine or lysine salt with other amino acids or the amino acid salts contained in the hyperbranched polyamino acid to react for 2-64h at the temperature of 130-180 DEG C and then obtain yellow solid, and finally purifying the coarse product with a precipitation method to obtain the hyperbranched polyamino acid. The hyperbranched polyamino acid obtained in the invention can be used as nonviral gene carrier for the transduction of huamn or animal cell gene, and the hyperbranched polyamino acid nonviral gene carrier provided by the invention is reasonable in design, simple in preparation method, high in transfection efficiency, low cytotoxicity and favorable transduction efficiency in the presence of blood serum.
Owner:WUHAN UNIV

Mitomycin double sustained release film of implanted antineoplastic agents and its preparation method

The invention discloses a double controlled release film agent of implanted antineoplastic agent mitomycin and a manufacturing method; the invention relates to a medicinal controlled release film agent. The invention provides a double controlled release film agent of implanted antineoplastic agent mitomycin, which relates to a medicinal controlled release film agent with high enveloping ratio, long continuous release duration, small incidence of burst release, few toxic and side effects, high medicine concentration on tumor lesions and low recrudescence probability of tumor, and a manufacturing method. The film agent includes mitomycin, polymer, lecithin, chitosan and collagen. The mitomycin and the lecithin are dissolved, lyophilized in order to obtain a colloidal mixture; the polymer is dissolved in organic solvent in order to obtain a polymer solution; the polymer solution is then added in the colloidal mixture in order to obtain a reverse micelle; the reverse micelle is further added to a polyvinyl alcohol solution, and an O/W latex is obtained by emulsification; the latex is lyophilized in order to obtain carrier micro-spheres; the collagen is dissolved in the acid solution in order to obtain a collagen solution; the chitosan is dissolved in the acid solution in order to obtain a chitosan solution; the collagen solution and the chitosan solution are mixed in order to obtain a collagen-chitosan mixture solution; finally the carrier micro-spheres are dispersed in the collagen-chitosan mixture solution which is then poured in a mould and dried.
Owner:XIAMEN UNIV

Medicament for fast preventing and controlling malignant aquatic weed and algae and uses thereof

The invention relates to a medicament for fast preventing the malignant float grasses and the water algae and the application thereof, belonging to the pesticide formulation technical field, which is characterized in that the medicament comprises from 40% to 90% of a plant vinegar fluid, from 5% to 35% of an organic acid, and from 1% to 20% of pesticide addition agent, the plant vinegar fluid is either a bamboo vinegar fluid, a wooden vinegar fluid, and (or) grass vinegar fluid, the organic acid is one of or a mixture of more than one of a formic acid, an acetic acid, a propionic acid, a 2-methyl propionic acid, an ethyl acetic acid, a 4-hydroxy ethyl acetic acid, a pentanoic acid, a benzoic acid, a 2,6-hydroxy benzoic acid, a 3-hydroxy-4-methoxy benzoic acid or a 3-methoxy-4-hydroxy benzoic acid. The medicament has the advantages of fast destroying the chlorophyll, stopping the plant to do the photosynthesis, commonly killing the water algae in a half hour and the float grass in three hours by spraying, having low production cost, strong killing capability, wide adaptable temperature range and pH value range. The active component of the invention has the advantages of being the natural-occurring substance, no corrosion, nonirritant, safe use, and reliability, easy biodegradation, and no secondary pollution.
Owner:ZHEJIANG FORESTRY UNIVERSITY

Method for casting large investment pattern through rapid reversing and 3D printing

The invention relates to a method for casting a large investment pattern through rapid reversing and 3D printing. The method comprises the following steps that firstly, a reversed object is subjected to three-dimensional scanning through a scanner; secondly, rapid reverse three-dimensional modeling is conducted through software; thirdly, a three-dimensional model is subjected to data treatment through hierarchical processing software; fourthly, model manufacturing data obtained after data treatment are conveyed into a rapid forming machine, and rapid forming of a 3D printing model is conducted; fifthly, the 3D printing model serves as a lost foam casting to conduct investment pattern casting, and an investment pattern casting of the 3D printing model is obtained; and sixthly, the investment pattern casting is machined. Consumables used in a 3D printer are ordinary consumables PLA which are low-energy-consumption ecological environment-friendly materials most commonly used by the 3D printer, biodegradability is achieved, and bad influences on the human body and the environment are avoided. Due to the fact that the consumables PLA are made of corn, are renewable resources and have an extremely low shrinking percentage, it means that the consumables PLA are resistant to deformation even in a very large printing size.
Owner:青岛西班港环保科技有限公司
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