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Biodegradable implant and method for manufacturing same

a biodegradable and implant technology, applied in bone implants, prostheses, coatings, etc., can solve the problems of difficult processing, disadvantages of metal implants, and easy breakage of ceramic implants, so as to reduce the young's modulus, increase the bone formation rate, and control the biodegradation rate. the effect of very low ra

Inactive Publication Date: 2012-02-09
U & I INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019]According to the present invention, a biodegradable implant can be advantageously present for a long period of time in vivo because its biodegradation rate is controlled to be very low.
[0020]Also according to the present invention, in the case where the biodegradable implant includes a porous structure, blood vessels that pass through pores are formed, thus increasing the rate of bone formation and decreasing Young's modulus thereby reducing stress shielding.
[0021]Also according to the present invention, the biodegradable implant can have enhanced mechanical strength and impact resistance.
[0022]Also according to the present invention, the biodegradable implant can be simultaneously improved in terms of corrosion resistance and mechanical properties.
[0023]Thus, the implant according to the present invention is adapted to be used in bone replacements or treatment for bone, and can be used for orthopedics, dental care, plastic surgery or blood vessels.

Problems solved by technology

However, metallic implants are disadvantageous because of stress shielding, image degradation and implant migration.
However, ceramic implants are easily broken by external impact, and are difficult to process.
Also, polymeric implants have relatively weak strength compared to the other implant materials.
However, such porous implants have low mechanical strength and are weak to external impact.
However, biodegradable polymers have low mechanical strength, produce acids upon decomposition, and have the disadvantage that it is difficult to control their biodegradation rate, and thus they have limited applications.
In particular, the biodegradable polymers are difficult to apply to orthopedic implants that have to withstand a strong load or dental implants because of the properties of polymers having low mechanical strength.
However, mechanical properties of such materials are not much higher than those of biodegradable polymers.
In particular, poor impact resistance of the ceramic material is regarded as very disadvantageous in a biomaterial.
Also, the actual usability of such materials is open to question, because it is difficult to control the biodegradation rate.
However, when the amounts of added elements are increased, the metal for the implants may easily create a galvanic circuit that increases the corrosion rate attributable to an increase in the non-uniformity of the composition thereof and the non-uniformity of a fine framework, undesirably increasing the corrosion rate of implants.
Hence, it is very difficult to design alloy materials which have high strength and low biodegradation rate to be applied to implants.

Method used

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  • Biodegradable implant and method for manufacturing same
  • Biodegradable implant and method for manufacturing same
  • Biodegradable implant and method for manufacturing same

Examples

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Effect test

examples 12 to 14

Manufacturing of Biodegradable Implant

[0157]Mg and Mn in the amounts shown in Table 7 below were charged in a crucible having an inner diameter of 50 mm that was made of stainless steel (SUS 410). Subsequently, while Ar gas was allowed to flow around the crucible so that Mg and Mn in the crucible did not come into contact with air, the temperature of the crucible was increased to about 700˜750° C. inside a resistance heating furnace, so that the Mg and Mn melted. The crucible was stirred so that the molten Mg and Mn were well mixed. The completely molten Mg alloy was cooled, thus preparing an Mg alloy in the solid phase. Also upon cooling, the crucible was immersed in water to enhance the mechanical strength of Mg, whereby the molten Mg alloy was rapidly cooled, resulting in a biodegradable implant

TABLE 7Mg (wt %)Mn (wt %)Ex. 12Remainder0.0015Ex. 13Remainder0.097Ex. 14Remainder0.51Mg: purity 99.98% Mg, MP21-31-31 (available from TIMMINCO)

example 15

Manufacturing of Biodegradable Implant

[0166]Mg and MgO in the amounts shown in Table 8 below were charged in a crucible having an inner diameter of 50 mm made of stainless steel (SUS 410). Subsequently, while Ar gas was allowed to flow around the crucible so that Mg and MgO in the crucible did not come into contact with air, the temperature of the crucible was increased to about 700˜750° C. inside a resistance heating furnace, so that the Mg and MgO melted. The crucible was stirred so that the molten Mg and MgO were well mixed. The completely molten Mg alloy was cooled, thus preparing an Mg alloy in the solid phase. Also upon cooling, the crucible was immersed in water to enhance the mechanical strength of Mg, whereby the molten Mg alloy was rapidly cooled, resulting in a biodegradable implant

TABLE 8Mg (wt %)MgO (wt %)Ex. 15Remainder10Mg: purity 99.98% Mg, MP21-31-31 (available from TIMMINCO)

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Abstract

This invention relates to a biodegradable implant including magnesium, wherein the magnesium contains, as impurities, (i) manganese (Mn); and (ii) one selected from the group consisting of iron (Fe), nickel (Ni) and mixtures of iron (Fe) and nickel (Ni), wherein the impurities satisfy the following condition: 0< / (i)≦5, and an amount of the impurities is 1 part by weight or less but exceeding 0 parts by weight based on 100 parts by weight of the magnesium, and to a method of manufacturing the same.

Description

TECHNICAL FIELD[0001]The present invention relates to a biodegradable implant and a method of manufacturing the same, and more particularly to a biodegradable implant, whose biodegradation rate is easily controlled, the strength and an interfacial force to bone tissue of which are high, in which a rate of bone formation is increased, and that has simultaneously improved corrosion resistance and mechanical properties, and to a method of manufacturing the same.BACKGROUND ART[0002]Typical materials used in implants to be used in medical treatment include metal, ceramic and polymer. Among these, metallic implants have superior mechanical properties and processability. However, metallic implants are disadvantageous because of stress shielding, image degradation and implant migration. Also, ceramic implants have superior biocompatibility compared to the other implants. However, ceramic implants are easily broken by external impact, and are difficult to process. Also, polymeric implants ha...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/28B23P17/04B05D5/00
CPCA61L27/047A61L27/446A61L27/48A61L27/56A61L27/58C22C23/00Y10T29/49B22F3/1121B22F7/06B22F3/26B22F2998/10C22C23/02C22F1/06A61L27/427A61L27/42
Inventor KOO, JA-KYOHYUN-KWANG, SEOKYANG, SEOK-JOKIM, YU-CHANCHO, SUNG-YOUNKIM, JONG-TACK
Owner U & I INC
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