16 results about "Biodegradable implants" patented technology

The invention relates to a biodegradable Zn alloy and a preparation method thereof. The preparation method comprises the following steps that (1) a Zn-Cu-Sr ternary alloy melt is prepared, the mass ratio of Cu ranges from 0.5 wt% to 2.5 wt%, and the mass ratio of Sr is smaller than or equal to 0.5 wt%; and 2) pouring the ternary alloy melt at the set temperature in the step 1) onto a base plate, and feeding the base plate into a casting and rolling machine for casting and rolling to obtain the target biodegradable Zn alloy. The biomedical degradable Zn-Cu-Sr ternary alloy is prepared by adopting a liquid casting and rolling technology, alpha-Zn and a second phase CuZn4 and SrZn13 can be remarkably refined by adopting the liquid casting and rolling technology, meanwhile, the mechanical property is remarkably improved, and the mechanical property requirement of a degradable implant can be met through one-time forming. Compared with a traditional method that rolling or extruding is conducted after casting, the technology is simple, the advantages of the casting technology and the rolling technology are integrated, the beneficial effects of being comprehensive, efficient, energy-saving, short in process, low in production cost and capable of achieving near-net-shape forming are achieved, and later-period tedious technologies are reduced.

The invention relates to a biodegradable implant comprising a surface coated magnesium alloy or zinc alloy product, whereby the coating layer comprises oxides and / or phosphates of from rare-earth elements, Mg, Ca, Zn, Zr, Cu, Fe, Sr, Li, Mn or Ag wherein the coating is preferably generated by plasma electrolytically oxidation (PEO). The invention further comprises a method for preparing the coated magnesium or zinc alloy product of the implant.

Methods for making an implant scaffold, comprising providing a 3D template generated according to an image of a lesion site, contacting the 3D template with a solution comprising a polymeric precursor, and evaporating the solution, thereby obtaining an implant scaffold, are provided. Further, implant scaffolds, comprising a water-soluble template in the form of a 3D geometrical array and a polymeric material are provided.

Injectable depot compositions, consisting of a biocompatible polymer, which is a polymer or a copolymer based on lactic acid and / or lactic acid together with glycolic acid with a ratio of lactic acid to glycolic acid monomers in a range of 48:52 to 100:0, a water-miscible solvent with a dipole moment of about 3.7-4.5 D and a dielectric constant between 30 and 50 and a drug, were deemed suitable for the in situ formation of biodegradable implants that can induce therapeutic levels of the drug in the plasma from the first day and for at least days.

The invention relates to a biodegradable implant comprising a surface-coated magnesium alloy product, wherein the coating layer contains oxides and / or phosphates of rare earth elements, Mg, Ca, Zn, Zr, Mn, or Ag, and wherein the coating is preferably produced by plasma electrolytic oxidation (PEO). The invention further comprises a method for producing the coated magnesium alloy product of the implant.

The invention discloses an amorphous nano-material on a magnesium-based metal surface and a preparation process of the amorphous nano-material, and belongs to the technical field of metal surface treatment. Current-carrying friction is carried out on the magnesium-based metal surface, and directional formation of the amorphous layer on the magnesium-based metal surface is achieved by regulating and controlling the load, the current and the friction time in the current-carrying friction process. The method breaks through the harsh requirement of traditional amorphous preparation for the cooling rate, does not need to change magnesium matrix metal components, is simple in process and low in cost, is suitable for the high-end fields of aerospace lightweight parts, electronic packaging heat dissipation devices, biodegradable implants and the like, and has remarkable industrial application value and commercial production prospects.

The present invention relates to the development of a composite material consisting of two biopolymers, Silane and Chitosan, reinforced by graphene oxide nanosheets. This composite is applied as a coating to magnesium alloy surfaces using the spin-coating technique. The synthesized material is distinguished by optimized mechanical properties, excellent biocompatibility, and delayed and controlled biodegradation, meeting the requirements of biodegradable implants in the biomedical field.

This invention relates to a biodegradable Zn-Cu-Ca alloy for biomedical use, its preparation method, and its applications. It pertains to the field of biomedical materials, particularly zinc alloys. The Zn-Cu-Ca alloy comprises Zn, Cu, and Ca, with Cu content ranging from 0.05 to 3.0 wt%, Ca content from 0.05 to 2.0 wt%, and the remainder being Zn. This invention successfully prepares the Zn-Cu-Ca alloy using alloy ingots and a remelting method. By rationally designing the alloy composition, this invention significantly improves the alloy's mechanical properties and biodegradability. The addition of copper enhances the alloy's strength, while the addition of calcium regulates the degradation rate and improves biocompatibility. This alloy material is suitable for the biomedical field, especially as a biodegradable implant material, and has broad application prospects.

This application provides an adaptive biodegradable implant shaping patch for breast reconstruction, belonging to the fields of medical biodegradable materials and breast reconstruction medical devices. It includes an arc-shaped cover and a base cover that unfold into a porous, sheet-like integrated structure. The arc-shaped cover contains a radially distributed array of flaps around a central reference point and an elastic buffer zone located between the central reference point and the root of the flap array. The flap array bends and encloses to form a hemispherical covering space that conforms to the outer curved surface of the implant. The base cover is a disc-shaped structure that adapts to and covers the lower end face of the implant, and connects to the extended ends of the flaps to achieve conformal coverage. This invention's patch has a reasonable structure, good fit to the implant, can simulate the physiological and mechanical characteristics of the breast, is easy to operate, and provides reliable fixation. It can adapt to different implant sizes and can reduce postoperative complications, meeting the personalized breast reconstruction needs of different patients, and has high clinical application value.

The disclosure relates to a biodegradable implant, comprising magnesium or a magnesium alloy, which is covered with a calcium phosphate, in particular hydroxyapatite, coating, wherein the implant has an impedance measured with electrochemical impedance spectroscopy (100 kHz-0.1 Hz) of Zim>10,000Ω, preferably >15,000Ω, in particular 10,000-60,000Ω, preferably 25,000-60,000Ω, and / or Zre>50,000Ω, preferably >100,000Ω, in particular 50,000-300,000Ω, preferably 250,000-300,000Ω.

The present invention describes a non-biodegradable implant in the shape of a plug for replacing and regenerating biological tissue, the non-biodegradable implant comprising a base section (2), a middle section (3) and a top section (4), the base section being configured to be anchored in bone tissue, the middle section being configured to replace cartilage tissue in a mid-deep region of a cartilage layer and having a thickness of at least 0.2 mm, the top section being configured to allow cartilage tissue to grow onto and into the top section, thereby regenerating a superficial region of the cartilage layer, wherein the middle section and the top section comprise the same thermal a thermoplastic elastomeric material that is porous in the top segment and non-porous in the middle segment, wherein the thermoplastic elastomeric material comprises a linear block copolymer comprising urethane groups and urea groups, and the thermoplastic elastomeric material is substantially free of additional peptide compounds having cartilage regeneration properties, and wherein the base segment material comprises one of the following: a biocompatible metal such as titanium or a titanium alloy, a ceramic such as sintered crystalline hydroxyapatite, a mineral such as a phosphate mineral, and a polymer, optionally a hydrogel polymer, and combinations thereof.

Disclosed are sustained biodegradable implant (a depot) that releases high drug doses directly into the tumor for treating cancer. The depot comprises a biodegradable polymer and a STING agonist and / or a PARP inhibitor (PARPi); wherein the STING agonist or the PARPi is distributed in the biodegradable polymer. The depot activates anticancer innate and adaptive immunity within the tumor microenvironment and promote immune infiltration of secondary, metastatic sites.

The invention relates to a biomedical degradable Zn-Cu-Ca alloy, a preparation method and application, and relates to the field of biomedical materials, in particular to the field of zinc alloys.The Zn-Cu-Ca alloy comprises Zn, Cu and Ca, the content of Cu is 0.05-3.0 wt%, the content of Ca is 0.05-2.0 wt%, and the balance is Zn; and the Zn-Cu-Ca alloy is successfully prepared by adopting an alloy ingot and a remelting method. By reasonably designing the components of the alloy, the mechanical property and biodegradability of the alloy are remarkably improved. The addition of copper enhances the strength of the alloy, and the addition of calcium adjusts the degradation rate and improves the biocompatibility. The alloy material is suitable for the field of biomedicine, is particularly used as a biodegradable implant material, and has a wide application prospect.

The invention relates to a biodegradable implant comprising a surface coated magnesium alloy or zinc alloy product, whereby the coating layer comprises oxides and / or phosphates of from rare-earth elements, Mg, Ca, Zn, Zr, Cu, Fe, Sr, Li, Mn or Ag wherein the coating is preferably generated by plasma electrolytically oxidation (PEO). The invention further comprises a method for preparing the coated magnesium or zinc alloy product of the implant.

Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant.

The invention discloses a surface treatment method for a biodegradable zinc-magnesium-silver-titanium alloy and a zinc-magnesium-silver-titanium alloy material with a zinc phosphate Hopeite conversion film. The conversion solution is prepared from the phosphoric acid solution and the nitrate solution, then the zinc phosphate Hopeite conversion film is prepared on the surface of the zinc-magnesium-silver-titanium alloy through a chemical conversion method, Zn3 (PO4) 2.4 H2O of a uniform and compact structure is successfully formed on the surface of the zinc-magnesium-silver-titanium alloy, namely, the zinc phosphate Hopeite conversion film, and the zinc phosphate Hopeite conversion film has excellent adhesive force and stability. The material disclosed by the invention solves the problems of poor surface biocompatibility and poor degradability of a traditional metal material. Through formation of a zinc phosphate Hopeite conversion film, the biocompatibility of the zinc-magnesium-silver-titanium alloy is improved, cell attachment and growth can be promoted when the zinc-magnesium-silver-titanium alloy is implanted into a human body, the corrosion resistance and biodegradability of the zinc-magnesium-silver-titanium alloy are remarkably improved, and the zinc-magnesium-silver-titanium alloy is suitable for the field of biological medicine of biodegradable implants and has wide application prospects.